Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2-Hydroxybenzylamine 是一种有效的 IsoLG 小分子清除剂,可将活性物质作为惰性加合物螯合。 2-Hydroxybenzylamine 可用于通过减少具有天然生物分子的 IsoLG 加合物来减少心房颤动消融后心房颤动和其他心房心律失常的早期复发。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 398 | 现货 | ||
1 g | ¥ 639 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 195 | 现货 |
产品描述 | 2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts. 2-Hydroxybenzylamine may be used to decrease early recurrence of atrial fibrillation and other atrial arrhythmias following atrial fibrillation ablation by decreasing IsoLG adducts with native biomolecules. |
体内活性 | Compared to hypercholesterolemic Ldlr-/- mice treated with vehicle or 4-Hydroxybenzylamine, a nonreactive analogue, 2-Hydroxybenzylamine decreases atherosclerosis by 60% in en face aortas, without changing plasma cholesterol. Ldlr-/- mice treated with 2-Hydroxybenzylamine have reduced MDA-LDL and MDA-HDL levels, and their HDL display increased capacity to reduce macrophage cholesterol. Importantly, 2-Hydroxybenzylamine reduces the MDA- and IsoLG-lysyl content in atherosclerotic aortas versus 4-Hydroxybenzylamine. Furthermore, 2-Hydroxybenzylamine reduces inflammation and plaque apoptotic cells and promotes efferocytosis and features of stable plaques. Dicarbonyl scavenging with 2-Hydroxybenzylamine has multiple atheroprotective effects in a murine FH model[2]. |
分子量 | 123.15 |
分子式 | C7H9NO |
CAS No. | 932-30-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (365.39 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 8.1202 mL | 40.6009 mL | 81.2018 mL | 203.0045 mL |
5 mM | 1.624 mL | 8.1202 mL | 16.2404 mL | 40.6009 mL | |
10 mM | 0.812 mL | 4.0601 mL | 8.1202 mL | 20.3004 mL | |
20 mM | 0.406 mL | 2.03 mL | 4.0601 mL | 10.1502 mL | |
50 mM | 0.1624 mL | 0.812 mL | 1.624 mL | 4.0601 mL | |
100 mM | 0.0812 mL | 0.406 mL | 0.812 mL | 2.03 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
2-Hydroxybenzylamine 932-30-9 Others antioxidant IsoLGs inhibit Inhibitor atherosclerosis scavenger oxidative stress atrial fibrillation arrhythmias o-Hydroxybenzylamine FH model inflammation radical Reactive Oxygen Species 2-HOBA 2 Hydroxybenzylamine 2Hydroxybenzylamine inhibitor