161
51
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1717 |
CEF1, Influenza Matrix Protein M1 (58-66)
CEF1, Influenza Matrix Protein M1 58-66 |
||
CEF1, Influenza Matrix Protein M1 (58-66) is an epitope derived from the matrix protein of the influenza A virus.GILGFVFTL is a HLA-A2-restricted epitope from influenza matrix M1 protein. | |||
T38687 |
Influenza Matrix Protein (61-72)
|
||
Influenza Matrix Protein (61-72) is a peptide derived from the matrix protein of influenza viruses and encompasses amino acids 61-72. This specific epitope, Influenza Matrix Protein (61-72), has the ability to elicit a CD4+ T-cell response. | |||
TP2184 |
matrix protein (3-15) [Zaire ebolavirus]
|
Others | Others |
matrix protein (3-15) [Zaire ebolavirus] is a peptide of the structural proteins linking the viral envelope with the zaire ebolavirus core. Ebola virus (EBOV) is a member of the family Filoviridae in the order Mononegavirales. It is the causative agent of | |||
T69665 |
Zelasudil
|
||
Zelasudil 是一种 Rho 相关 (ROCK) 激酶 抑制剂。Zelasudil 具有 ROCK2结合亲和力。 | |||
T2009 |
SB-3CT
|
MMP | Proteases/Proteasome |
SB-3CT 是一种可透过血脑屏障的、竞争性的金属蛋白酶MMP-2和MMP-9抑制剂,Ki 分别为 13.9 nM、600 nM。他对明胶酶具有高选择性。它具有神经保护和抗癌作用。 | |||
T5361 |
T-26c
|
MMP | Proteases/Proteasome |
T-26c 是高效的、选择性的基质金属蛋白酶-13 抑制剂,IC50=6.75 pM。 | |||
T22115 |
SM-7368
|
NF-κB | NF-κB |
NF-κB Activation Inhibitor III 是一种NF-kB 抑制剂,抑制 TNF-α 诱导的MMP-9上调,靶向抑制下游的MAPK p38,可用于靶向 TNF-α 介导的肿瘤侵袭和转移的化疗研究。 | |||
T14322 |
ARP-100
MMP-2 Inhibitor III |
MMP | Proteases/Proteasome |
ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM),MMP-3 (4.5 μM),MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1'口袋相互作用,并在体外对基质胶的侵袭模型中显示抗侵袭特性。 | |||
T14978 |
CL-82198
|
MMP | Proteases/Proteasome |
CL-82198 是 MMP-13选择性抑制剂。它能够与 MMP-13 的整个 S1' 口袋结合,这是其对 MMP-13 选择性和对其他 MMP 缺乏抑制活性的基础。它可用于研究骨关节炎。 | |||
T4783 |
JNJ0966
|
MMP | Proteases/Proteasome |
JNJ0966 是高选择性 MMP-9酶原抑制剂,其 IC50=440 nM。 | |||
T16966 |
S 3304
|
MMP | Proteases/Proteasome |
S 3304 是一种新型的基质金属蛋白酶抑制剂,能够特异的抑制MMP-2和MMP-9的活性。 | |||
T76555 |
Rabies Virus Matrix Protein Fragment(RV-MAT)
|
||
Rabies VirusMatrix ProteinFragment (RV-MAT)为多肽类化合物,靶向细胞表面乙酰胆碱受体(AChR)。 | |||
T16124 |
MMP13-IN-3
|
MMP | Proteases/Proteasome |
MMP13-IN-3 是口服有效的MMP-13选择性抑制剂,IC50为 1 nM,比其他 MMP 的选择性高 1000倍多。MMP13-IN-3在用于骨关节炎方面有研究的价值。 | |||
T5416 |
T-5224
|
MMP | Proteases/Proteasome |
T-5224 是选择性的转录因子c-Fos/activator protein (AP)-1抑制剂,具有抗炎作用,能够特异性抑制 c-Fos/c-Jun 的 DNA 结合活性,但对其他转录因子的结合活性无影响。它抑制 IL-1β 诱导的 Mmp-3、Mmp-13、Adamts-5 转录上调。 | |||
T6011 |
Batimastat
巴马司他,BB94 |
MMP | Proteases/Proteasome |
Batimastat (BB94) 是广谱MMP 抑制剂,能够抑制MMP-1 (IC50:3 nM),MMP-2 (IC50:4 nM),MMP-9 (IC50:4 nM),MMP-7 (IC50:6 nM) 和 MMP-3 (IC50:20 nM)。 | |||
T5983 |
o-Phenanthroline
1,10-菲罗啉,1,10-Phenanthroline |
MMP; Others | Others; Proteases/Proteasome |
o-Phenanthroline (1,10-Phenanthroline) 是一种金属螯合剂,能够与 Fe2+形成红色螯合物,在 510 nm 处最大吸收,可防止链脲佐菌素诱导染色体畸变。它也是一种MMP 的抑制剂。 | |||
T1891 |
NSC 405020
|
MMP | Proteases/Proteasome |
NSC 405020 是一种 MT1-MMP 的非催化抑制剂,可特异地靶向 MT1-MMP 的 PEX 结构域,不会抑制 MT1-MMP 和 MMP-2的催化活性。 | |||
T83759 |
MMP-3 Fluorogenic Substrate TFA
Mca-RPKPVE-Nval-WR-K(Dnp)-NH2,Matrix Metalloproteinase-3 Fluorogenic Substrate,Stromelysin-1 Fluorogenic Substrate |
||
MMP-3 fluorogenic substrate 是一种针对基质金属蛋白酶-3(MMP-3)的荧光底物。当被MMP-3切割后,7-甲氧基香豆素-4-乙酰基(Mca)会释放并且其荧光可用于量化MMP-3活性。Mca的激发/发射峰值分别为328/420 nm。 | |||
T8310 |
MMP-9-IN-1
|
MMP | Proteases/Proteasome |
MMP-9-IN-1 是特异性的基质金属蛋白酶-9 抑制剂,选择性靶向 MMP-9 的血红素域,对其他 MMP 无影响。 | |||
T2743 |
Ilomastat
Galardin,GM6001,伊洛马司他 |
MMP | Proteases/Proteasome |
Ilomastat (GM6001) 是广谱的基质金属蛋白酶 (MMP) 抑制剂,可抑制 MMP 的活性,IC50值分别为 1.5 nM (MMP-1),1.1 nM (MMP-2),1.9 nM (MMP-3),0.5 nM (MMP-9),对人皮肤成纤维细胞胶原酶 (MMP-1) 的Ki=为 0.4 nM。 | |||
T8961 |
GW280264X
Carbamic acid |
MMP | Proteases/Proteasome |
GW280264X (Carbamic acid) 是一种 ADAM10/TACE (ADAM17)金属蛋白酶抑制剂。它有效阻断 TACE (ADAM17)和 ADAM10的 IC50分别为 8.0 nM 和 11.5 nM。其中ADAM10/17 能够调节胶质母细胞瘤起始细胞的免疫原性。 | |||
T7522 |
GI254023X
GI 254023X |
MMP; Immunology/Inflammation related | Immunology/Inflammation; Proteases/Proteasome |
GI254023X 是MMP9和ADAM10抑制剂,它们的IC50s 分别为 2.5 和 5.3 nM。 | |||
T4282 |
S-methyl-KE-298
|
MMP; Drug Metabolite | Metabolism; Proteases/Proteasome |
S-methyl-KE-298 是 KE-298 的活性代谢物。KE-298 抑制类风湿关节炎滑膜细胞产生基质金属蛋白酶。 | |||
T21806 |
HNHA
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
HNHA 是组蛋白去乙酰化酶抑制剂。它通过 p21诱导将细胞周期阻滞在 G1/S 期,抑制肿瘤生长及肿瘤新生血管形成。HNHA 可能是一种有效的抗乳腺癌药物。 | |||
T15574 |
Incyclinide
COL-3,CMT-3 |
MMP | Proteases/Proteasome |
Incyclinide (COL-3) 是一种基质金属蛋白酶 (MMP) 抑制剂,能够诱导细胞外基质降解,抑制血管生成,肿瘤生长和侵袭以及转移。 | |||
T0407 |
Edaravone
依达拉奉右莰醇,依达拉奉,MCI-186 |
Apoptosis; MMP; Free radical scavengers | Apoptosis; oxidation-reduction; Proteases/Proteasome |
Edaravone (MCI-186) 是一种新型自由基清除剂,能够抑制大鼠与 MMP-9有关的脑出血。 | |||
T7460 |
α-Cyano-4-hydroxycinnamic acid
α-Cyano-4-hydroxycinnamic acid(α-CHCA),2-氰基-4-羟基 |
Monocarboxylate transporter | Membrane transporter/Ion channel |
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) 是非竞争性单羧酸盐转运蛋白 (MCTs) 抑制剂,可抑制线粒体丙酮酸转运蛋白,Ki 值为 6.3 μM。它可作为基质辅助激光解吸电离-飞行时间质谱 (MALDI-TOF) 分析的基质,可以促进肽离子化。 | |||
T7459 |
Abametapir
5 5'-二甲基-2,2-联吡啶,HA-44,BRN 0123183 |
MMP; Others; Parasite | Microbiology/Virology; Others; Proteases/Proteasome |
Abametapir (BRN 0123183) 是一种金属蛋白酶抑制剂,能够靶向对卵孵化和虱子发育至关重要的金属蛋白酶。 | |||
T6885 |
Marimastat
BB2516,马立马司他,KB-R8898,TA2516 |
MMP | Proteases/Proteasome |
Marimastat (BB2516) 是一种血管生成和转移抑制剂,限制血管的生长和生成。它是一种广谱的,具有口服活性的MMPs 抑制剂,有效抑制 MMP-9 , MMP-1, MMP-2, MMP-14, MMP-7,用于癌症的研究。 | |||
T7449 |
o-Phenanthroline monohydrate
Phenanthroline monohydrate,1, 10-Phenanthroline monohydrate,邻菲罗啉 |
MMP | Proteases/Proteasome |
o-Phenanthroline monohydrate (1, 10-Phenanthroline monohydrate) 是一种金属螯合剂,能够与 Fe2+形成红色螯合物,λmax为 510 nm,可防止链脲佐菌素诱导染色体畸变。它也是一种 MMP 的抑制剂。 | |||
T6542 |
Imidapril hydrochloride
Novaloc,Imidapril HCl,盐酸咪达普利,Tanapril,TA-6366 |
RAAS | Endocrinology/Hormones |
Imidapril hydrochloride (Tanapril) 是一种血管紧张素转换酶 (ACE) 抑制剂,具有抗高血压活性。 | |||
T5863 |
Indinavir sulfate
L735524 sulfate,MK-639 sulfate,硫酸茚地那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Indinavir sulfate (L735524 sulfate) 是一种 HIV 蛋白酶抑制剂。它抑制 HIV-1 蛋白酶,IC50 值为 0.41 nM,Ki 值为 0.24 nM。它也是SARS-CoV 3CLpro 抑制剂,IC50为 1.71 μM。 | |||
T6009 |
TAPI1
TAPI 1,TAPI,TAPI-1 |
MMP | Proteases/Proteasome |
TAPI1 (TAPI) 是一种 ADAM17/TACE 抑制剂,可抑制细胞因子受体的脱落。 | |||
T1140 |
Doxycycline hydrochloride
Doxylin,盐酸多西环素,Vibramycin,Hyclate |
MMP; Antibacterial; Antibiotic | Microbiology/Virology; Proteases/Proteasome |
Doxycycline hydrochloride (Hyclate) 是一种四环素抗生素,是口服有效的广谱金属蛋白酶抑制剂,具有抗菌活性。 | |||
T21250L |
Matrixyl Acetate(214047-00-4 free base)
Palmitoyl-KTTKS,Palmitoyl pentapeptide,Pal-Lys-Thr-Thr-Lys-Ser-OH,Matrixyl,五胜肽 |
Others | Others |
Matrixyl Acetate(214047-00-4 free base) (Palmitoyl pentapeptide) 是一种用于抗皱化妆品的 matrikine。 | |||
T21250 |
Matrixyl
五胜肽,Palmitoyl pentapeptide,Palmitoyl-KTTKS,PAL-Lys-Thr-Thr-Lys-Ser,Pal-Lys-Thr-Thr-Lys-Ser-OH |
Others | Others |
Matrixyl (PAL-Lys-Thr-Thr-Lys-Ser) 是一种用于抗皱化妆品的 matrikine。 | |||
T8865 |
ASN03576800
|
Others | Others |
ASN03576800 是 VP40 基质蛋白的抑制剂。 | |||
TP2186L |
PalMitoyl Tripeptide-1 Acetate(147732-56-7 Free base)
PalMitoyl Tripeptide-1 Acetate(147732-56-7 Free base) |
Others | Others |
PalMitoyl Tripeptide-1 Acetate 是一种含有棕榈酸的细胞外基质衍生肽。 | |||
T28394 |
PG-116800
PG-530742,PGE-7113313,PGE 7113313,PG 530742 |
MMP | Proteases/Proteasome |
PG-116800 (PG-530742) 是一种基质金属蛋白酶 (MMP) 抑制剂。 PG-116800 可用于骨关节炎治疗的研究。 | |||
T7566L |
GRGDSPK 2TFA(111119-28-9(free base))
EMD 56574 |
Others | Others |
GRGDSPK 2TFA(111119-28-9(free base)) (EMD 56574) 是一种抑制肽,用于 RGD 介导的整合素和细胞外基质分子之间的粘附。 | |||
TP1741L |
Histatin 5 acetate
Histatin 5 acetate (115966-68-2 Free base) |
MMP | Proteases/Proteasome |
Histatin 5 acetate 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 的活性,IC50 分别为 0.57 和 0.25 μM。 | |||
T12414 |
PF-00356231 hydrochloride
|
MMP | Proteases/Proteasome |
PF-00356231 hydrochloride 是基质金属蛋白酶 MMP-12 的抑制剂,IC50 为 1.4 μM。 | |||
T37048 |
MMP-3 Inhibitor
|
MMP | Proteases/Proteasome |
MMP-3 Inhibitor 是一种多肽基质金属蛋白酶-3(MMP-3)抑制剂,Ki 值为 95 nM。MMP-3 inhibitor 具有抗癌抗肿瘤活性。 | |||
T83168 |
Aderamastat
FP-025 |
MMP | Proteases/Proteasome |
Aderamastat (FP-025) 为口服活性MMP-12抑制剂,适用于哮喘、COPD与肺纤维化研究。 | |||
T6538 |
Hydroxypropyl Cellulose
|
Others | Others |
Hydroxypropyl Cellulose 是纤维素的衍生物,兼具水溶性和有机溶解性,用作食品添加剂和 DNA 分离的筛分基质。 | |||
T72069 |
MMP-9-IN-7
|
||
MMP-9-IN-7抑制前基质金属蛋白酶活化,可用于预防、治疗或改善 MMP9和/或 MMP13介导的综合征。 | |||
T61271 |
MMP2-IN-3
|
MMP | Proteases/Proteasome |
MMP2-IN-3是一种有效的基质金属蛋白酶(MMP-2)抑制剂( IC50 值:31 μM)。MMP2-IN-3 抑制 MMP-9 和 MMP-8 ,其 IC50 分别为 26.6 和 32 μM。 | |||
T19415 |
Medronic acid
亚甲基二磷酸,Methylenediphosphonic acid |
Others | Others |
Medronic acid (Methylenediphosphonic acid) 是一种亚甲基取代的二膦酸盐。它对骨基质中的羟基磷灰石晶体的表面具有亲和力,并且可粘附在其表面。它能够在类骨质矿化的位点累积,可以在骨成像中与放射性同位素复合使用。 | |||
TP1501L |
CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base)
|
MMP | Proteases/Proteasome |
CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base) 是基质金属蛋白酶 (MMP)-2 和 MMP-9 的抑制剂。它也被称为IV 型胶原酶或明胶酶。明胶酶是癌症治疗干预的潜在靶点,这些酶的抑制剂可以防止肿瘤进展。 | |||
T16695 |
Pyrintegrin
|
Integrin | Cytoskeletal Signaling |
Pyrintegrin 是一种 β1 整合素激动剂,也是 2,4-二取代的嘧啶,可促进胚胎干细胞存活。它可用作足细胞保护剂,能增强细胞-细胞外基质 (ECM) 粘附介导的整联蛋白信号传导,具有强大的成脂作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3414 |
Morroniside
莫诺苷,奎宁树 |
Apoptosis; MMP; Pyroptosis | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Morroniside 通过抑制神经元凋亡和 MMP9/2 的表达从而发挥神经保护作用,可作为 db/db 小鼠肝脏炎症反应和脂质代谢的调节剂。它通过抑制高血糖和氧化应激表现出对糖尿病肾损伤和人脐静脉内皮细胞的保护作用。 | |||
T2993 |
Cordycepin
3'-Deoxyadenosine,虫草素 |
MMP; TNF; Antibacterial; Antibiotic; Autophagy | Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome |
Cordycepin (3'-Deoxyadenosine) 是一种核苷衍生物,在类风湿性关节炎滑膜成纤维细胞中,剂量依赖性抑制 IL-1β 诱导的 MMP-1和 MMP-3表达。它也抑制细菌的腺苷激酶从而抗结核分枝杆菌。 | |||
T4115 |
Auraptene
橙皮油内酯,7-geranyloxycoumarin,橙皮油素 |
MMP; BACE | Neuroscience; Proteases/Proteasome |
Auraptene 是一种丰富的天然香叶氧基香豆素。它能够抑制基质金属蛋白酶 2 以及关键炎症因子,包括 IL-6,IL-8 和趋化因子 (C-C 基序) 配体-5 (CCL5)的分泌。 | |||
TN1879 |
Lucideric acid A
Lucidenic acid A,赤芝酸A |
MMP; p38 MAPK; JNK | MAPK; Proteases/Proteasome |
Lucideric acid A (Lucidenic acid A) 是分离自灵芝的天然产物,可抑制 PMA 诱导的MMP-9活性,具有抵抗肝癌细胞侵袭的作用。 | |||
T2967 |
Stigmasterol
Stigmasterin,beta-Stigmasterol,豆甾醇 |
MMP; Endogenous Metabolite | Metabolism; Proteases/Proteasome |
Stigmasterol (Stigmasterin) 是一种植物性甾醇,具有抑制胆固醇的特性,此外在风湿性疾病的研究中被评价为抗硬化因子。 | |||
T8259 |
Doxycycline monohydrate
水合强力霉素,强力霉素一水物 |
MMP; Antibacterial; Antibiotic; Parasite | Microbiology/Virology; Proteases/Proteasome |
Doxycycline monohydrate 是一种四环素抗生素,是广谱金属蛋白酶抑制剂,具有抗菌活性。 | |||
T6S0444 |
Salvianolic acid A
丹酚酸 A,Dan Phenolic Acid A |
MMP | Proteases/Proteasome |
Salvianolic acid A (Dan Phenolic Acid A) 能够提高抑制基质金属钛酶 9 和抗炎作用,进而保护血脑屏障。 | |||
T3860 |
Isoliquiritin apioside
|
MMP; p38 MAPK; NF-κB | MAPK; NF-κB; Proteases/Proteasome |
Isoliquiritin apioside 可抑制癌细胞和内皮细胞的侵袭和血管生成,显著降低 PMA 诱导的MMP9活性增加,并抑制 PMA 诱导的MAPK 和NF-κB 活化。 | |||
T2957 |
Arctigenin
牛蒡苷元,牛蒡子苷元,(-)-Arctigenin |
Apoptosis; MMP; Influenza Virus; Autophagy | Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome |
Arctigenin ((-)-Arctigenin) 是一种存在于牛蒡中的木脂素,具有抗氧化、抗肿瘤、抗炎和抗病毒活性。它可研究代谢紊乱和中枢神经系统功能障碍。 | |||
T3767 |
Polygalacic acid
Virgaureagenin G,毛果一枝黄花皂苷元G,远志酸 |
MMP; AChR; AChE | Neuroscience; Proteases/Proteasome |
Polygalacic acid (Virgaureagenin G) 是一种从远志 Polygala tenuifolia Willd 根中分离出来的三萜,可抑制 MMP 表达。它对认知障碍有显著的神经保护作用,PA 通过抑制乙酰胆碱酯酶活性,增加胆碱乙酰转移酶活性,提高海马和额皮质中的乙酰胆碱水平来提高胆碱能系统反应性。 它可以用于骨关节炎相关研究。 | |||
T2980 |
Chondroitin sulfate
Chonsurid,Chondroitin polysulfate,硫酸软骨素 |
MMP; Others; Endogenous Metabolite; NO Synthase | Immunology/Inflammation; Metabolism; Others; Proteases/Proteasome |
Chondroitin sulfate (Chonsurid) 是一种糖胺聚糖,被广泛用于骨关节炎的研究。它能够减少炎症介质和凋亡过程,并能够减少炎性细胞因子,iNOS 和MMPs 产生。 | |||
T3S0640 |
Triolein
三油酸甘油酯,Glycerol trioleate,甘油三油酸酯,Glycerine Trioleate |
MMP; Others; Endogenous Metabolite | Metabolism; Others; Proteases/Proteasome |
Glycerol trioleate 是一种对称三酰甘油,可减少MMP-1的上调,具有很强的抗氧化、抗炎特性。 | |||
T5S1026 |
Apigenin-7-glucuronide
Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸 |
MMP | Proteases/Proteasome |
Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) 能够抑制基质金属蛋白酶的活性,其对 MMP-3 (IC50:12.87 μM),MMP-8 (IC50:22.39 μM),MMP-9 (IC50:17.52 μM),MMP-13 (IC50:0.27 μM)。 | |||
T5680 |
Aloin(mixture of A&B)
芦荟素,葡糖基蒽酮,芦荟大黄素甙,芦荟苷 |
MMP; IL Receptor; Antibacterial; Antifungal | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Aloin (mixture of A&B) 是一种从芦荟中分离出来的蒽醌衍生物。它是刺激性粒细胞基质金属蛋白酶的有效抑制剂。它具有多种生物活性,如抗炎、抗菌、抗真菌、抗氧化、抗肿瘤、抗糖尿病和免疫活性。 | |||
T2987 |
(-)-Epigallocatechin
表没食子儿茶素,(-)-表没食子儿茶素,l-Epigallocatechin,Epigallocatechin,EGC |
MMP; Autophagy | Autophagy; Proteases/Proteasome |
(-)-Epigallocatechin (Epigallocatechin) 是绿茶中含量最丰富的黄酮类天然产物,可与未折叠的天然多肽结合,阻止转化为淀粉样蛋白原纤维。 | |||
T2750 |
Ginkgolide C
银杏内酯C,BN-52022 |
MMP; Sirtuin; Endogenous Metabolite; AMPK | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ginkgolide C (BN-52022) 是从银杏叶中分离到的一种黄酮类天然产物,可增强体内大鼠的心脏功能,具有减少血小板聚集,改善阿尔兹海默症等作用。 | |||
T2973 |
Astragaloside IV
AST-IV,黄芪甲苷IV,AS-IV,黄芪皂苷 IV |
MMP; ERK; Estrogen/progestogen Receptor; JNK | Endocrinology/Hormones; MAPK; Proteases/Proteasome |
Astragaloside IV (AS-IV) 是从黄芪中分离得到的一种皂苷,抑制ERK1/2和JNK 激活,在乳腺癌细胞 MDA-MB-231 中,下调(MMP)-2和(MMP)-9的信号通路。 | |||
T6S2140 |
β-Anhydroicaritin
Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素 |
MMP; Others; TNF; Interleukin | Apoptosis; Immunology/Inflammation; Others; Proteases/Proteasome |
β-Anhydroicaritin 是从乳香提取的一种天然产物,具有重要的生物学和药理学作用,如抗骨质疏松症,雌激素调节和抗肿瘤特性。它改善牙周组织的降解,抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。它抑制细胞内 Ca2+的升高,并显著降低 iNOS 蛋白的表达。 | |||
T3850 |
Luteolin 7-O-glucuronide
Luteolin-7-glucuronide,木犀草素-7-O-葡萄糖醛酸苷 |
MMP | Proteases/Proteasome |
Luteolin 7-O-glucuronide (Luteolin-7-glucuronide) 是一种自由基清除剂,能够抑制基质金属蛋白酶的活性,其对 MMP-1,MMP-3,MMP-8,MMP-9,MMP-13的IC50值分别为 17.63,7.99,11.42,12.85,0.03 μM。 | |||
T1687 |
Doxycycline
Vibramycin,多西环素,Doxiciclina,Doxytetracycline,Doxycyclinum,强力霉素 |
MMP; ribosome; Antibacterial; Antibiotic; Parasite | Microbiology/Virology; Proteases/Proteasome |
Doxycycline (Doxiciclina) 属于四环素类抗生素,是一种广谱的金属蛋白酶 (MMP) 抑制剂,具有口服活性。Doxycycline 具有抗菌活性和抗肿瘤活性。 | |||
T5S0045 |
Isofraxidin
6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶 |
MMP; ERK; p38 MAPK; TLR; COX | Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome |
Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分,抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞,抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达,还抑制TLR4/髓样分化蛋白 2 复合物的形成。 | |||
T4S21320 |
ISOGINKGETIN
异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮 |
MMP; Others | Others; Proteases/Proteasome |
ISOGINKGETIN (4',4'''-Dimethylamentoflavone) 是一种MMP9抑制剂,也是一种Pre-mRNA Splicing 抑制剂。 | |||
T3813 |
20(R)-Ginsenoside Rh2
20(R)-人参皂苷 RH2,(20R)Ginsenoside Rh2,Ginsenoside Rh2,20(R)-人参皂苷Rh2 |
Apoptosis; MMP; HSV | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
20(R)-Ginsenoside Rh2 (Ginsenoside Rh2) 是人参皂苷 Rh2 的次要立体异构体,具有基质金属蛋白酶抑制作用。它有抗癌、抗炎和抗氧化活性。 | |||
T1687L |
Doxycycline (hyclate)
Doxycycline hydrochloride hemiethanolate hemihydrate,盐酸强力霉素,WC2031,Doxycycline hyclate |
MMP; ribosome; Antibacterial; Antibiotic | Microbiology/Virology; Proteases/Proteasome |
Doxycycline hyclate (WC2031) 属于四环素类抗生素,是一种广谱的金属蛋白酶 (MMP) 抑制剂,具有口服活性。Doxycycline hyclate 具有抗菌活性和抗肿瘤活性。 | |||
T1205 |
Chloramphenicol
Chlornitromycin,Levomycetin,Chloromycetin,氯霉素 |
ribosome; HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic | Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Chloramphenicol (Chloromycetin) 是一种广谱抗生素,有效抑制细菌蛋白质生物合成。它主要作用于细菌 70S 核糖体的 50S 亚基,对肽基转移酶有活性,抑制肽键的形成。 | |||
T2769 |
3-Aminopropionitrile fumarate (2:1)
Di-β-aminopropionitrile fumarate,3-Aminopropionitrile fumarate,3-氨基丙腈,β-Aminopropionitrile fumarate,3-Aminopropionitrile fumarate 2:1,Beta-Aminopropionitrile fumarate,β-Ammoniumpropionitrile hemifumarate |
Others | Others |
3-Aminopropionitrile fumarate (2:1) (β-Aminopropionitrile fumarate) 是一种能抑制胶原蛋白(collagen)交联的山黧豆素。 | |||
T4857 |
Pteridine-2,4(1H,3H)-dione
2,4-Dihydroxypteridine,2,4-二羟基蝶啶,Lumazine |
Others; Endogenous Metabolite | Metabolism; Others |
Pteridine-2,4(1H,3H)-dione (Lumazine) 是内源性代谢产物的一种。 | |||
T5888 |
5-Methoxysalicylic acid
5-MeOSA,5-甲氧基水杨酸 |
Others | Others |
5-Methoxysalicylic acid (5-MeOSA) 是一种天然产物。它同精胺联用后,是低聚核苷酸 MALDI 质谱分析的有效基质。 | |||
T19603 |
Vitamin K
Kephton,维生素K,Vitamin K1(20) |
Endogenous Metabolite | Metabolism |
Vitamin K (Kephton) 具有凝血作用,对凝血因子、基质-Gla 蛋白和骨钙素很重要。 | |||
TN6784 |
ethyl rosmarinate
Methyl rosmarinate,迷迭香酸乙酯 |
MMP; Tyrosinase; Glucosidase | Metabolism; Proteases/Proteasome |
ethyl rosmarinate (Methyl rosmarinate) 抑制酪氨酸酶、α-葡萄糖苷酶和基质金属蛋白酶-1 (MMP-1) 的活性。 | |||
T5565 |
Undecanedioic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
Undecanedioic acid 是存在于人体主动脉的部分区域中,其中晚期动脉粥样硬化病变与细胞间基质大分子相关,特别是与弹性蛋白相关。 | |||
T19355 |
Heparan Sulfate
硫酸乙酰肝素,硫酸类肝素 |
FGFR; Wnt/beta-catenin; Endogenous Metabolite | Angiogenesis; Cytoskeletal Signaling; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors |
Heparan sulfate 是一种复杂的线性多糖。Heparan sulfate 作为硫酸乙酰肝素蛋白聚糖的一部分出现,在细胞外基质和细胞表面表达丰富。 | |||
TN1833 |
Karacoline
|
NF-κB | NF-κB |
Karacoline 是发现于植物Aconitum kusnezoffii 中的一种二萜生物碱,通过 NF-κB 信号通路,抑制椎间盘退变中细胞外基质的降解。 | |||
T4S2157 |
Campesterol
菜油甾醇,(24R)-5-Ergosten-3β-ol |
Endogenous Metabolite | Metabolism |
Campesterol ((24R)-5-Ergosten-3β-ol) 是一种植物甾醇,具有降胆固醇和抗癌的活性。 | |||
TJS0856 |
Dalbergin
黄檀素,6-Hydroxy-7-Methoxy-4-Phenylcoumarin |
Others | Others |
Dalbergin (6-Hydroxy-7-Methoxy-4-Phenylcoumarin) 是一种 Dalbergia Sissoo Linn. knot wood 提取物的成分。它具有强大的抗氧化活性。 | |||
TN1928 |
Methyl rosmarinate
|
MMP; Anti-infection; Tyrosinase | Microbiology/Virology; Proteases/Proteasome |
Methyl rosmarinate 是一种非竞争性 tyrosinase 抑制剂,从 Rabdosia serra 中分离得到的,对蘑菇酪氨酸酶作用的 IC50值为 0.28 mM,也能抑制a-glucosidase。 | |||
T16579 |
Pro-xylane
玻色因,Hydroxypropyl tetrahydropyrantriol |
Others | Others |
Pro-xylane (Hydroxypropyl tetrahydropyrantriol) 是一种在水介质中具有生物活性的 c- 糖苷 (C-glycoside),是粘多糖 (GAGs) 的生物合成活化剂,也是第一种应用于化妆品的“绿色”化学物质。 | |||
T4928 |
L-Kynurenine
L-犬尿氨酸,(S)-Kynurenine |
AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
T7044 |
Norepinephrine
去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol |
MMP; Endogenous Metabolite; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Metabolism; Neuroscience; Proteases/Proteasome |
Norepinephrine (Levophed) 是β1选择性的肾上腺素能受体激动剂,EC50值为 5.37 μM。它可上调鼻咽癌肿瘤细胞中血管内皮生长因子、基质金属蛋白酶MMP-2和MMP-9的表达。 | |||
TN1299 |
Desmethylglycitein
4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone |
PI3K; CDK; PKC | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) 是大豆中苷元的代谢产物,具有抗氧化性和抗癌活性。它是蛋白激酶 C(PKC)α 的直接抑制剂,抑制正常人皮肤成纤维细胞中的太阳紫外线诱导的基质金属蛋白酶1。它在体内直接结合CDK1和CDK2,抑制 CDK1 和 CDK2 活性。 | |||
T5004 |
Hyaluronic acid sodium
透明质酸钠,Sodium Hyaluronate |
Others | Others |
Hyaluronic acid sodium (Sodium Hyaluronate) 是一种生物聚合物,由二糖的重复单元组成,应用领域广泛。 | |||
T3524 |
Halofuginone hydrobromide
卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐 |
Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells |
Halofuginone hydrobromid 是Febrifugine 的衍生物,是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂,并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。 | |||
TN2697 |
2,3-Dihydrohinokiflavone
|
MMP; Parasite; Antifection | Microbiology/Virology; Proteases/Proteasome |
2,3-Dihydrohinokiflavone 是基质金属蛋白酶 (MMP) 基因表达的抑制剂,对利什曼原虫具有很强的活性,IC50 为 1.6 μM。 | |||
TN5050 |
Sprengerinin C
|
NADPH-oxidase; VEGFR; p38 MAPK; ROS; Akt; PI3K; mTOR; p53 | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein endothelial cells, it blocks vascul | |||
TN1832 | Kanzonol C | Others; NF-κB; Tyrosinase | NF-κB; Others; Proteases/Proteasome |
Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it shows the inhibition of matrix metalloproteinase (MMP)-2 secretion from brain tumor-derived glioblastoma cells. | |||
TN2075 |
Pimaric acid
|
MMP; p38 MAPK; NF-κB | MAPK; NF-κB; Proteases/Proteasome |
Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced human aortic smooth muscle cells. | |||
TN4088 |
Futoenone
|
PAFR | GPCR/G Protein |
Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2' site of the enzymes. Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and futoenone variety exhibit both platelet activating factor receptor(PAF)and 5-lipoxygenase antagonist activity. | |||
T39168 |
Epsilon-(gamma-glutamyl)-lysine
Epsilon-(gamma-glutamyl)-lysine,γ-Glu-ε-Lys,H-Glu(H-Lys-OH)-OH |
||
Epsilon-(gamma-glutamyl)-lysine is an N(6)-acyl-L-lysine derivative that forms bonds between extracellular matrix (ECM) components with the assistance of the enzyme tissue transglutaminase (tTg). These bonds are implicated in the pathogenesis of certain diseases like non-diabetic kidney and glaucoma filtration. | |||
T37055 | Cytostatin | ||
Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5. | |||
T71471 |
Chrysotobibenzyl
|
||
Chrysotobibenzyl, a bibenzyl found in the stem of Dendrobium pulchellum, may facilitate anoikis--a form of programmed cell death that occurs in anchorage-dependent cells when they detach from the surrounding extracellular matrix (ECM)-- and inhibit the growth of lung cancer cells in anchorage-independent condition. Preliminary data obtained discloses the inhibitory effect on cancer cell metastasis of the isolated compounds and may provide a new approach for cancer drug development. | |||
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