Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) 是大豆中苷元的代谢产物,具有抗氧化性和抗癌活性。它是蛋白激酶 C(PKC)α 的直接抑制剂,抑制正常人皮肤成纤维细胞中的太阳紫外线诱导的基质金属蛋白酶1。它在体内直接结合CDK1和CDK2,抑制 CDK1 和 CDK2 活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 118 | 现货 | ||
5 mg | ¥ 247 | 现货 | ||
10 mg | ¥ 413 | 现货 | ||
25 mg | ¥ 747 | 现货 | ||
50 mg | ¥ 1,080 | 现货 | ||
100 mg | ¥ 1,630 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 272 | 现货 |
产品描述 | Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities. |
体外活性 |
Molecular studies showed that 6,7,4'-THIF significantly inhibited acetylcholinesterase and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus of scopolamine-induced mice.In addition, immunohistochemistry and Western blot results revealed that 6,7,4'-THIF significantly increased brain-derived neurotrophic factor (BDNF) and phosphor cAMP response element binding (CREB) in the hippocampus of mice.? |
体内活性 |
A single administration of 6,7,4'-THIF significantly improved scopolamine-induced cognitive dysfunction in these in vivo tests.?Moreover, treatment with 6,7,4'-THIF alone enhanced learning and memory performance in the same behavioral tests. 6,7,4'-THIF improves cognitive dysfunction induced by scopolamine and enhances learning and memory by activation of the cholinergic system and the p-CREB/BDNF signaling pathway in mice |
别名 | 4',6,7-三羟基异黄酮, 4',6,7-三羟异黄酮, 6-羟基大豆苷元, 6,7,4'-Trihydroxyisoflavone |
化合物与蛋白结合的复合物 |
Crystal structure of Aedes aegypti Noppera-bo, glutathione S-transferase epsilon 8, in desmethylglycitein and glutathione-bound form |
分子量 | 270.24 |
分子式 | C15H10O5 |
CAS No. | 17817-31-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (462.55 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.7004 mL | 18.5021 mL | 37.0041 mL | 92.5104 mL |
5 mM | 0.7401 mL | 3.7004 mL | 7.4008 mL | 18.5021 mL | |
10 mM | 0.37 mL | 1.8502 mL | 3.7004 mL | 9.251 mL | |
20 mM | 0.185 mL | 0.9251 mL | 1.8502 mL | 4.6255 mL | |
50 mM | 0.074 mL | 0.37 mL | 0.7401 mL | 1.8502 mL | |
100 mM | 0.037 mL | 0.185 mL | 0.37 mL | 0.9251 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Desmethylglycitein 17817-31-1 Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling PI3K/Akt/mTOR signaling PI3K CDK PKC Inhibitor 4',6,7-Trihydroxyisoflavone 4',6,7-三羟基异黄酮 Phosphoinositide 3-kinase Cyclin dependent kinase 4',6,7-三羟异黄酮 6-羟基大豆苷元 inhibit 6,7,4'-Trihydroxyisoflavone Protein kinase C inhibitor