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384

抑制剂 & 化合物

48

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10515	Anti-Heart Failure Agent 1	Others	Others
	Anti-Heart Failure Agent 1 is an orally available compound suitable for the treatment of heart failure without inducing vomiting, nausea, and restlessness.
T74031	Cardiolipin (Heart, Bovine) (sodium)
	Cardiolipin (Heart, Bovine) sodium，一种线粒体专有磷脂，展现出在神经系统疾病研究中的应用潜力。
T21687	Conoidin A	Parasite	Microbiology/Virology
	Conoidin A 是刚地弓形虫过氧化物酶 II 的细胞通透性抑制剂，有杀线虫特性。它共价结合 TgPrxII 的过氧化物催化位点 Cys47，不可逆地抑制其过氧化物活性，IC50为 23 µM。它也抑制哺乳动物 PrxI 和 PrxII 的氧化。它具有抗氧化、神经保护作用，可研究缺血性心脏病。
T22341	GSK-114	Others	Others
	GSK 114 是口服有活性的、高选择性的TNNI3K 抑制剂 (IC50= 25 nM)。其中TNNI3K (又称 CARK) 是酪氨酸样激酶家族的成员，选择性在心脏组织中表达。它对 TNNI3K 的选择性是 B-Raf 激酶的 40 倍 (IC50= 1 µM)。
T5033	Olprinone 奥普力农,Loprinone	PDE	Metabolism
	Olprinone (Loprinone) 是一种有效的磷酸二酯酶(PDE) 3抑制剂，对 PDE1，PDE2，PDE3，PDE4 的IC50分别为 150、100、0.35 和 14 μM，具有抗炎活性。它具有正性肌力和血管扩张作用，可用于心力衰竭的研究。
T2320	Indacaterol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Indacaterol 是一种超长效β-肾上腺素受体激动剂。
T7686	Ramiprilat	RAAS	Endocrinology/Hormones
	Ramiprilat 是 Ramipril 的活性代谢物，是一种口服有活力的血管紧张素转换酶 (ACE) 抑制剂，其 Ki=7 pM。它可用于研究心力衰竭以及高血压。
T16873	SERCA2a activator 1	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	SERCA2a activator 1 是一种肌肉/内质网 Ca2+ 依赖性 ATPase 2a 激活剂。 SERCA2a activator 1 降低受磷蛋白抑制并增强心脏的收缩和舒张功能。
T0154	Nebivolol hydrochloride R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824	Apoptosis; Adrenergic Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂，IC50为0.8 nM。
T6581	Methyclothiazide Duretic,Enduron,甲氯噻嗪,Aquatensen	Others; Carbonic Anhydrase	Metabolism; Others
	Methyclothiazide (Aquatensen) 是一种具有口服活性的利尿剂，也是一种降压剂。它能够拮抗体外的电压依赖性钙通道的 (VDCC) 活性，也可以抑制内源性血管收缩刺激导致的血管反应。
T9022	AZD9977 AZD 9977	Glucocorticoid Receptor	Endocrinology/Hormones
	AZD9977 是一种选择性的，有效的，具有口服活性的盐皮质激素受体 (MR) 调节剂，可用于研究心力衰竭和慢性肾病。
T10066	2',5'-Dideoxyadenosine	Adenylyl cyclase; Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	2',5'-Dideoxyadenosine 是一种非竞争性腺苷酸环化酶抑制剂，通过结合 P 位点，IC50为 3 µM。它是核苷类似物，在心脏中发挥强大的抗肾上腺素作用。
T39789	BMS-986235 BMS-986235,LAR-1219	Others	Others
	BMS-986235 (LAR-1219) 是一种特异性和口服活性的甲酰肽受体 2 (FPR2) 激动剂，对 hFPR2 和 mFPR2 的 EC50 分别为 0.41 nM 和 3.4 nM。 BMS-986235 可用于预防心力衰竭的研究。
T14989	CMPD101	ROCK; GRK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; Stem Cells
	CMPD101 是膜透性的 GRK2/3高选择性小分子抑制剂，IC50分别为 18 nM 和 5.4 nM。它针对 GRK1、GRK5 ROCK-2 和 PKCα 的选择性较小，IC50值分别为 3.1 μM，2.3 μM，1.4 μM 和 8.1 μM，可研究心衰疾病。
T6716	Valsartan Diovan,缬沙坦,Tareg,CGP 48933	RAAS	Endocrinology/Hormones
	Valsartan (CGP 48933) 是一种血管紧张素 II 受体拮抗剂，有用于高血压和心力衰竭的研究潜力。
T0075	Nicorandil SG-75,尼可地尔	Potassium Channel	Membrane transporter/Ion channel
	Nicorandil (SG-75) 是一种有效的钾通道激活剂，靶向血管核苷二磷酸依赖性 K+通道和心脏 ATP 敏感 K+通道 (KATP)。Nicorandil 是一种烟酰胺酯，具有血管舒张和心脏保护作用，并具有治疗心绞痛和缺血性心脏病的潜力。
T1461	Candesartan CV 11974,坎地沙坦	RAAS	Endocrinology/Hormones
	Candesartan (CV 11974) 是一种血管紧张素II 受体拮抗剂(IC50:0.26 nM)。
T24850	Takeda103A CMPD103A,Takeda-103A,Takeda-103-A,CMPD-103A,Takeda 103 A	GRK	GPCR/G Protein
	Takeda103A (CMPD103A) 是 GRK2抑制剂。G 蛋白偶联受体是许多生理过程的核心。Takeda103A 对研究心力衰竭具有潜在的研究价值。
T3465	Vesnarinone 维司力农,OPC-8212,Arkin,Piteranometozine	HIV Protease; PDE	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Vesnarinone (Arkin) 是一种喹啉酮衍生物，可抑制磷酸二酯酶III 活性，增加钙通量和减小钾通量。
T5329	Trandolapril	Angiotensin-converting Enzyme (ACE)	Metabolism
	Trandolapril 是 Trandolaprilat 的前体药物。Trandolapril 是一种口服血管紧张素转换酶抑制剂，在高血压和充血性心力衰竭及心肌梗死领域有研究价值。
T1275	Phentolamine mesylate Phentolamine methanesulfonate,甲磺酸酚妥拉明,Phentolamine mesilate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phentolamine mesylate (Phentolamine methanesulfonate) 是一种非选择性的、可逆的，具有口服活性的 α1 和 α2 肾上腺素能受体阻滞剂，能够扩张使血管，降低周围血管阻力。它可用于研究嗜铬细胞瘤相关的高血压，心力衰竭和勃起功能障碍。
T6551	Isosorbide Devicoran,Isobide,异山梨酯,异山梨醇,Hydronol,Dianhydro-D-glucitol,D-Isosorbide	Others	Others
	Isosorbide (Devicoran) 是一种血管舒张剂，也是一种高渗利尿剂，口服具有活性。可用于研究心力衰竭和心绞痛(胸痛)。
T4574	Sacubitril AHU 377,AHU377,沙库必曲,AHU-377	Neprilysin	Metabolism
	Sacubitril (AHU-377) 是一种有效的NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。
TP1187	C-Type Natriuretic Peptide (CNP) (1-22), human CNP (1-22), human	RAAS	Endocrinology/Hormones
	C-Type Natriuretic Peptide (CNP) (1-22), human 是一种利钠肽受体 B (NPR-B) 激动剂，是一种 CNP 的 1-22 片段。它对生理激动剂组胺和 5-HT 刺激或直接由 Forskolin 刺激的 cAMP 合成具有抑制作用。其中CNP 是一种有效的、内皮衍生的松弛剂和生长抑制因子。
T1410	Torsemide AC-4464,JDL-464,托拉塞米,Torasemide	Na-K-Cl cotransporter	Membrane transporter/Ion channel
	Torsemide (AC-4464) 是具有口服活性的亨氏环利尿剂，也具有抗醛固酮和血管舒张活性。它可用于研究心力衰竭、肾脏疾病、肝硬化。
T0083	Eplerenone Epoxymexrenone,CGP 30083,依普利酮,SC-66110	Glucocorticoid Receptor	Endocrinology/Hormones
	Eplerenone (CGP 30083) 是一种竞争性的、选择性的、具有口服活性的醛固酮 (aldosterone) 拮抗剂，IC50=138 nM。它对孕酮，雄激素，雌激素和糖皮质激素受体的亲和力低，可用于研究高血压和心肌梗死后的心力衰竭。
T1239	Indacaterol maleate 马来酸茚达特罗,QAB149	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Indacaterol maleate (QAB149) 是一种超长效的 β-肾上腺素受体激动剂。
T7714	Temocapil	Tyrosinase	Proteases/Proteasome
	Temocapil 是一种酪氨酸激酶抑制剂。
T2535	Ivabradine hydrochloride 盐酸伊伐布雷定,S 16257-2,Ivabradine HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Ivabradine hydrochloride (S 16257-2) 是一种可口服的，超极化激活的环核苷酸门控离子通道通道阻滞剂。
T6542	Imidapril hydrochloride Novaloc,Imidapril HCl,盐酸咪达普利,Tanapril,TA-6366	RAAS	Endocrinology/Hormones
	Imidapril hydrochloride (Tanapril) 是一种血管紧张素转换酶 (ACE) 抑制剂，具有抗高血压活性。
T20843	Aplodan Nergize,Creatinolfosfate,磷酸肌肉醇,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate	Others	Others
	Aplodan (creatinol-O-phosphate) 表现出抗缺血和抗心律失常的能力以及对细胞膜的保护作用。 Aplodan 可用于缺血性心脏病或伴有持续性室性早搏的缺血性心脏病的研究。
T8867	RO2959 Hydrochloride RO2959 HCl	IL Receptor; Calcium Channel; Interleukin	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	RO2959 Hydrochloride (RO2959 HCl) 是选择性CRAC 通道抑制剂，IC50为 402 nM。它是人IL-2产生的有效抑制剂，有效阻断 T 细胞受体触发的基因表达和 T 细胞功能途径。它是由Orai1/Stim1通道介导的钙存储进入的有效阻滞剂，IC50为 25 nM。
T1462	Captopril SQ 14225,甲巯丙脯酸,卡托普利,SQ-14534,SA333	RAAS	Endocrinology/Hormones
	Captopril (SA333) 是一种含巯基的，具有口服活性的血管紧张素转换酶(ACE)抑制剂，IC50=0.025 μM，广泛应用于高血压和充血性心力衰竭的研究。Captopril 也是NDM-1抑制剂，IC50=7.9 μM。
T1615	Irbesartan 厄贝沙坦,SR-47436,BMS-186295	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂，IC50为1.3 nM。
T6991	Nitroprusside disodium dihydrate 硝普钠二水合物,硝普钠,Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate	Guanylate cyclase; Autophagy	Autophagy; GPCR/G Protein
	Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) 是一种血管扩张剂，通过在血液中自发释放 NO 发挥作用。它可在谷胱甘肽耗竭的成骨细胞中诱导自噬，用于急性高血压和心力衰竭的研究。
T0342	Carvedilol phosphate hemihydrate Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐	VEGFR; Others; Potassium Channel; LDL; Integrin; Gap Junction Protein; NADPH; Adrenergic Receptor; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others; Tyrosine Kinase/Adaptors
	Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) 是一种外消旋混合物，是一种非选择性β/α-1受体阻断剂，具有抗高血压活性且缺乏内在拟交感神经活性。
T2318	Sacubitril/Valsartan Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696	Apoptosis; RAAS; Neprilysin	Apoptosis; Endocrinology/Hormones; Metabolism
	Sacubitril/Valsartan (LCZ696)，以1:1摩尔比由Valsartan（一种ARB）和Sacubitril（AHU377）组成，为创新口服血管紧张素受体-脑啡肽酶（ARN）双重抑制剂，旨在治疗高血压与心力衰竭。其作用机制包括抑制炎症、氧化应激及细胞凋亡，有助于改善糖尿病心肌病。
T6698	Temocapril hydrochloride CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利	RAAS	Endocrinology/Hormones
	Temocapril hydrochloride (CS-622 HCl) 是血管紧张素转化酶 (ACE) 抑制剂。Temocapril HCl 能够用于充血性心力衰竭、急性心肌梗死、高血压、胰岛素抵抗和肾脏疾病的研究。
T16411	Otenzepad AF-DX 116	AChR	Neuroscience
	Otenzepad (AF-DX 116) 是 M2 mAChR 的特异性拮抗剂，对大鼠心脏和兔外周肺的 IC50 分别为 386 nM 和 640 nM。
T2006	Omecamtiv mecarbil CK-1827452	ATPase; Myosin	Cytoskeletal Signaling; Membrane transporter/Ion channel
	Omecamtiv mecarbil (CK-1827452) 是一种心脏特异性的肌球蛋白激活剂，用于研究心脏相关疾病。
T12408	Perhexiline maleate	Others; Mitochondrial Metabolism	Metabolism; Others
	Perhexiline maleate 是一种口服活性的 CPT1和 CPT2抑制剂，可降低脂肪酸的代谢。Perhexiline maleate 对大鼠心脏和肝脏CPT 1的IC50值分别为77 和 148 μM。
T28437L	Pomisartan 2HCl Pomisartan 2HCl(144702-17-0 Free base),BIBR363 2HCL	RAAS	Endocrinology/Hormones
	Pomisartan 2HCl (BIBR363 2HCL) is a small molecule AT1R antagonist used to study heart failure and hypertension.
T31805	Flosequinan	Others	Others
	Flosequinan 是一种动静脉血管扩张剂，已被证明可有效治疗急性心力衰竭。
T31605	Edonentan BMS207940,BMS-207940,BMS 207940	Endothelin Receptor	GPCR/G Protein
	Edonentan 是一种有效的内皮素A（ETA）受体拮抗剂，可用于研究心脏衰竭。
T33600L	(Rac)-Naxifylline (Rac)-Naxifylline（(Rac)-166374-49-8）	Others	Others
	(Rac)-Naxifylline 可用于研究充血性心力衰竭。
T27596	Imazodan hydrochloride CI914 HCl,CI-914 HCl,CI 914 HCl,Imazodan HCl	PDE	Metabolism
	Imazodan hydrochloride (CI-914 HCl) 是一种强效的选择性 III 型磷酸二酯酶抑制剂，用于治疗慢性充血性心力衰竭。
T10631L	Bucindolol Formate Bucindolol Formate (71119-11-4 Free base)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bucindolol Formate 是一种具有内源性拟交感活性的β1 肾上腺素能受体 (β1-adrenergic receptor) 阻滞剂。Bucindolol 可用于心力衰竭疾病研究。
T10631	Bucindolol BMY 13105,MJ 131051,MJ 13105	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bucindolol (BMY 13105) 是一种新型有效的 β1 肾上腺素能受体 (β1-adrenergic receptor) 阻滞剂，可介导血管舒张，可用于研究慢性心力衰竭。
T29687	Afacifenacin Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986	AChR	Neuroscience
	Afacifenacin (SMP-986) fumarate 是一种 M3 毒蕈碱受体选择性拮抗剂，可用于研究缺血性心脏病，尿失禁和膀胱炎和其他疾病。
T23535L	Xanthine amine congener trihydrochloride Xanthine amine congener trihydrochloride (96865-92-8 Free base)	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Xanthine amine congener trihydrochloride 是一种有效的腺苷拮抗剂，可逆转由腺苷激动剂 N6-环己基腺苷产生的尿流量、钠排泄和心率的减少。

化合物

Anti-Heart Failure Agent 1

Cat.No: T10515

Target: Others

Cardiolipin (Heart, Bovine) (sodium)

Cat.No: T74031

Cat.No: T21687

Target: Parasite

Cat.No: T22341

Target: Others

Cat.No: T5033

Synonym: 奥普力农,Loprinone

Target: PDE

Cat.No: T2320

Target: Adrenergic Receptor

Cat.No: T7686

Target: RAAS

SERCA2a activator 1

Cat.No: T16873

Target: Calcium Channel

Nebivolol hydrochloride

Cat.No: T0154

Synonym: R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824

Target: Apoptosis, Adrenergic Receptor

Methyclothiazide

Cat.No: T6581

Synonym: Duretic,Enduron,甲氯噻嗪,Aquatensen

Target: Others, Carbonic Anhydrase

Cat.No: T9022

Synonym: AZD 9977

Target: Glucocorticoid Receptor

2',5'-Dideoxyadenosine

Cat.No: T10066

Target: Adenylyl cyclase, Adrenergic Receptor, AChR

Cat.No: T39789

Synonym: BMS-986235,LAR-1219

Target: Others

Cat.No: T14989

Target: ROCK, GRK, PKC

Cat.No: T6716

Synonym: Diovan,缬沙坦,Tareg,CGP 48933

Target: RAAS

Cat.No: T0075

Synonym: SG-75,尼可地尔

Target: Potassium Channel

Cat.No: T1461

Synonym: CV 11974,坎地沙坦

Target: RAAS

Cat.No: T24850

Synonym: CMPD103A,Takeda-103A,Takeda-103-A,CMPD-103A,Takeda 103 A

Target: GRK

Cat.No: T3465

Synonym: 维司力农,OPC-8212,Arkin,Piteranometozine

Target: HIV Protease, PDE

Cat.No: T5329

Target: Angiotensin-converting Enzyme (ACE)

Phentolamine mesylate

Cat.No: T1275

Synonym: Phentolamine methanesulfonate,甲磺酸酚妥拉明,Phentolamine mesilate

Target: Adrenergic Receptor

Cat.No: T6551

Synonym: Devicoran,Isobide,异山梨酯,异山梨醇,Hydronol,Dianhydro-D-glucitol,D-Isosorbide

Target: Others

Cat.No: T4574

Synonym: AHU 377,AHU377,沙库必曲,AHU-377

Target: Neprilysin

C-Type Natriuretic Peptide (CNP) (1-22), human

Cat.No: TP1187

Synonym: CNP (1-22), human

Target: RAAS

Cat.No: T1410

Synonym: AC-4464,JDL-464,托拉塞米,Torasemide

Target: Na-K-Cl cotransporter

Cat.No: T0083

Synonym: Epoxymexrenone,CGP 30083,依普利酮,SC-66110

Target: Glucocorticoid Receptor

Indacaterol maleate

Cat.No: T1239

Synonym: 马来酸茚达特罗,QAB149

Target: Adrenergic Receptor

Cat.No: T7714

Target: Tyrosinase

Ivabradine hydrochloride

Cat.No: T2535

Synonym: 盐酸伊伐布雷定,S 16257-2,Ivabradine HCl

Target: Adrenergic Receptor

Imidapril hydrochloride

Cat.No: T6542

Synonym: Novaloc,Imidapril HCl,盐酸咪达普利,Tanapril,TA-6366

Target: RAAS

Cat.No: T20843

Synonym: Nergize,Creatinolfosfate,磷酸肌肉醇,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate

Target: Others

RO2959 Hydrochloride

Cat.No: T8867

Synonym: RO2959 HCl

Target: IL Receptor, Calcium Channel, Interleukin

Cat.No: T1462

Synonym: SQ 14225,甲巯丙脯酸,卡托普利,SQ-14534,SA333

Target: RAAS

Cat.No: T1615

Synonym: 厄贝沙坦,SR-47436,BMS-186295

Target: Apoptosis, RAAS

Nitroprusside disodium dihydrate

Cat.No: T6991

Synonym: 硝普钠二水合物,硝普钠,Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate

Target: Guanylate cyclase, Autophagy

Carvedilol phosphate hemihydrate

Cat.No: T0342

Synonym: Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐

Target: VEGFR, Others, Potassium Channel, LDL, Integrin, Gap Junction Protein, NADPH, Adrenergic Receptor, Autophagy

Sacubitril/Valsartan

Cat.No: T2318

Synonym: Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696

Target: Apoptosis, RAAS, Neprilysin

Temocapril hydrochloride

Cat.No: T6698

Synonym: CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利

Target: RAAS

Cat.No: T16411

Synonym: AF-DX 116

Target: AChR

Omecamtiv mecarbil

Cat.No: T2006

Synonym: CK-1827452

Target: ATPase, Myosin

Perhexiline maleate

Cat.No: T12408

Target: Others, Mitochondrial Metabolism

Pomisartan 2HCl

Cat.No: T28437L

Synonym: Pomisartan 2HCl(144702-17-0 Free base),BIBR363 2HCL

Target: RAAS

Cat.No: T31805

Target: Others

Cat.No: T31605

Synonym: BMS207940,BMS-207940,BMS 207940

Target: Endothelin Receptor

(Rac)-Naxifylline

Cat.No: T33600L

Synonym: (Rac)-Naxifylline（(Rac)-166374-49-8）

Target: Others

Imazodan hydrochloride

Cat.No: T27596

Synonym: CI914 HCl,CI-914 HCl,CI 914 HCl,Imazodan HCl

Target: PDE

Bucindolol Formate

Cat.No: T10631L

Synonym: Bucindolol Formate (71119-11-4 Free base)

Target: Adrenergic Receptor

Cat.No: T10631

Synonym: BMY 13105,MJ 131051,MJ 13105

Target: Adrenergic Receptor

Cat.No: T29687

Synonym: Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986

Target: AChR

Xanthine amine congener trihydrochloride

Cat.No: T23535L

Synonym: Xanthine amine congener trihydrochloride (96865-92-8 Free base)

Target: Adenosine Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T4903	Heptadecanoic acid	Others; Endogenous Metabolite	Metabolism; Others
	Heptadecanoic acid 是奇链饱和脂肪酸，与一些疾病（如冠心病、糖尿病前期和 2 型糖尿病以及多发性硬化症）有关。
T8149	Dobutamine hydrochloride 盐酸多巴酚丁胺,Dobutamine (hydrochloride)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Dobutamine hydrochloride (Dobutamine(hydrochloride)) 是一种合成的儿茶酚胺，可作用于肾上腺素能受体α1-AR、β1-AR 和β2-AR，是一种选择性的 β1-AR 受体激动剂，对 α1-AR 和 β2-AR 作用相对较弱。它能够增加心输出量，矫正低灌注。
T8183	Deslanoside 洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C	ATPase; Drug Metabolite	Membrane transporter/Ion channel; Metabolism
	Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷，可抑制Na-K-ATPase 膜泵，导致细胞内钠和钙浓度增加。它用于研究充血性心力衰竭和因折返机制引起的室上性心律失常，并在研究慢性心房颤动时控制心室率。
T3212	Digoxigenin 地谷新配基,异羟基洋地黄毒苷元	Others	Others
	Digoxigenin, a therapeutic drug belonging to the group of cardiac glycosides, is widely used in the management of congestive heart failure and other cardiac diseases
T21418	Lisinopril Linopril,赖诺普利,Zestril,Prinivil,Lisipril	RAAS	Endocrinology/Hormones
	Lisinopril (Prinivil) 是一种血管紧张素转化酶抑制剂，能够作用于高血压，充血性心力衰竭和心脏病等。
T14840	Butyrylcarnitine	Endogenous Metabolite	Metabolism
	Butyrylcarnitine 是血浆中的代谢物，是疾病引起异常代谢的指标，可用于诊断心力衰竭和胰腺囊肿。
T3S0128	Hydroprotopine 氢化原阿片碱,氢化物碱	Others	Others
	Hydroprotopine 是一种来自Hypecoum leptocarpumand 的生物碱，能够有效的治疗冠心病及心绞痛。
T10584	Bovinic acid (9Z,11E)-Octadecadienoic acid,Rumenic acid	Endogenous Metabolite	Metabolism
	Bovinic acid ((9Z,11E)-Octadecadienoic acid) 是一种具有抗癌和抗动脉硬化的活性的共轭亚油酸，可用于研究老年冠心病和肥胖。
T2925	Schisandrin B gamma-Schisandrin,Schizandrin B,五味子素B,五味子乙素,Schisandrin B (Sch B),Wuweizisu-B	ATM/ATR; Reactive Oxygen Species; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	Schisandrin B (Schisandrin B (Sch B)) 是从五味子中分离联苯环辛二烯衍生物，对啮齿类动物的肝脏和心脏的抗氧化作用。
T5543	TriacetonaMine 四甲基哌啶酮,Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone	Others	Others
	TriacetonaMine (Vincubine) 是一种合成医药产品、农药和聚合物光稳定剂的中间体。它是热解油的主要组分。它是植物和真菌提取物的人工制品，使用丙酮和氢氧化铵，或在分离过程的不同步骤中天然出现铵盐。
T1694	Oxypurinol Oxipurinol,羟基嘌呤	ROS; Xanthine Oxidase; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Oxypurinol 是一种黄嘌呤氧化酶 (xanthine oxidase) 抑制剂，是 Allopurinol 的主要特性代谢产物。它能够用于调节血尿酸水平，有潜力用于痛风的研究。
T4073	Kaempferol-7-O-β-D-glucopyranoside 山奈酚-7-O-葡萄糖苷,Kaempferol-7-O-D-glucopyranoside	Others	Others
	Kaempferol-7-O-β-D-glucopyranoside (Kaempferol-7-O-D-glucopyranoside) 是一种黄酮类化合物，分离自Malus pumilaMill. 花朵中，具有抗氧化、抗炎和促凝血作用。
T7938	Quinidine 奎尼丁,奎宁树	Parasite	Microbiology/Virology
	Quinidine 是一种抗心律失常剂，也是 K+通道的有效阻断剂，其 IC50值为 19.9 μM。它是一种选择性细胞色素 P450db 的有效抑制剂，也可研究疟疾。
T6S1495	Ginsenoside Rk3 人参皂苷Rk3,人参皂甙 Rk3	Others; NF-κB	NF-κB; Others
	Ginsenoside Rk3 是存在于 Panax notoginseng 的根中。它能够抑制 HepG2 细胞中 TNF-α 诱导的 NF-κB 转录活性，IC50=14.24±1.30 μM。
T4S1518	Pseudoginsenoside RT1 拟人参皂苷 RT1,假人参皂苷RT1	Others	Others
	Pseudoginsenoside RT1 是分离自 Randia siamensis 中，具有鱼毒素作用。它可导致血压下降、心率加快和子宫自发收缩力增加。
T6S1930	Schisanhenol 五味子酚,Schizanhenol,Gomisin-K3	Antioxidant	oxidation-reduction
	Schisanhenol (Schizanhenol) 是一种UGT2B7的抑制剂，是一种天然化合物。
T5645	Nerol Cis-Geraniol,橙花醇,Neryl alcohol	Apoptosis; Reactive Oxygen Species; Mitochondrial Metabolism; Endogenous Metabolite; Antifungal	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Nerol (Neryl alcohol) 是橙花油的一种单萜, 它通过增强 Ca2+和ROS 来触发线粒体功能障碍并诱导凋亡，具有抗真菌活性。它可减轻哺乳动物心脏中哇巴因引发的心律失常的严重程度。
T1670	Lanatoside C Cedilanid,Ceglunate,Isolanid,毛花甙丙,毛花苷C	ATPase; Virus Protease; Autophagy	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Lanatoside C (Ceglunate) 是一种可用于治疗充血性心力衰竭和心律失常的强心苷类药物。它作用于 HuH-7细胞，可抗登革病毒感染， IC50为0.19 μM。
T3765	L-asarinin 細辛素,(-)-Episesamin	Others	Others
	L-asarinin ((-)-Episesamin) 降低外周血 IL-12 浓度并抑制 CXCR3 和 TLR4 的表达，这意味着 Asarinin 可能在 TLR4 通路中发挥作用，并延长同种异体心脏的存活时间。
T2S1778	DL-Goitrin DL-甲状腺肿素,板蓝根,Goitrin,(R,S)-告依春	Others	Others
	DL-Goitrin 也称为 (R,S)-Goitrin，由 epigoitrin (R-Goitrin) 和告依春 (S-Goitrin) 两种异构体组成，是板蓝根的成分。
T3920	Pseudoginsenoside F11 Ginsenoside A1,拟人参皂苷 F11,拟人参皂苷F11	Others; Endogenous Metabolite	Metabolism; Others
	Pseudoginsenoside F11 (Ginsenoside A1) 从人参根和叶中分离得到。PF11在一系列心血管和中枢神经系统疾病中具有广泛的保护作用。
TN1895	Luteolinidin chloride	CD38	Immunology/Inflammation
	Luteolinidin chloride 是天然的脱氧花青素，分离自苔藓和蕨类植物中。它是一种有效的 CD38 抑制剂，可以保留 eNOS 功能并预防体内内皮功能障碍，同时可以保护心脏免受 I/R 损伤。
T2939	Forskolin 毛喉素,Coleonol,Colforsin	FXR; Adenylyl cyclase; AChR; Autophagy	Autophagy; Metabolism; Neuroscience
	Forskolin (Coleonol) 属于天然产物，是一种腺苷酸环化酶激活剂 (EC50=0.5 μM)。Forskolin 可以增加 cAMP 水平，可以激活 PXR 和 FXR，也可以诱导细胞自噬。Forskolin 对心脏产生正性肌力作用，具有血小板抗凝集和降压作用。
T5S0890	Oleandrin Neriostene,Folinerin,Foliandrin,欧夹竹桃苷	Apoptosis; ATPase; Potassium Channel; Sodium Channel	Apoptosis; Membrane transporter/Ion channel
	Oleandrin (Folinerin) 是夹竹桃属中的一种类固醇，可抑制Na+/K+-ATPase 活性，IC50为 620 nM。
T0962	L-Hyoscyamine Daturine,Hyoscyamine,L-莨菪碱,L-天仙子胺	AChR	Neuroscience
	L-Hyoscyamine (Daturine) 是从山莨菪中提取的一种托烷生物碱，是竞争性的毒蕈碱受体拮抗剂。它是 Atropine 的左旋异构体。
T3243	Betaine Abromine,glycine betaine,oxyneurine,trimethylglycine,lycine,甜菜碱	Others; Endogenous Metabolite	Metabolism; Others
	Betaine (trimethylglycine) 是许多食物中发现的天然化合物，也是能够维持正常 DNA 甲基化模式的特性甲基供体。它广泛存在于植物，动物，微生物和丰富的膳食来源中。它能够促进各种肠道微生物抵抗渗透变化，从而改善微生物发酵特性。它也能够作为渗透物，通过防止脱水和渗透失活来维持禽类的细胞水和离子平衡，从而提高禽类对热应激的能力。
T4S1619	L-Hyoscyamine sulfate Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate,硫酸天仙子胺水合物,L-莨菪碱硫酸盐	AChR	Neuroscience
	L-Hyoscyamine sulfate (Levsin Sulfate) 是来自山莨菪的一种托烷生物碱，是竞争性的毒蕈碱受体拮抗剂。它是 Atropine 的左旋异构体。
TJS1779	Protosappanin A 原苏木素A,PTA	NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells
	Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物，通过下调 JAK2和 STAT3的磷酸化，抑制 JAK2/STAT3依赖的炎症通路。
T4776	Glycerol Glycerin,甘油	Endogenous Metabolite	Metabolism
	Glycerol 是甘油三酯（即脂肪和油）和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。
TN2743	2,7-Dihydrohomoerysotrine	Others	Others
	2,7-Dihydrohomoerysotrine possesses cardiodepressant activities on the heart of B. glabrata.
TMA0763	Methyl 3,4,5-trimethoxycinnamate	Potassium Channel; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Methyl 3,4,5-trimethoxycinnamate may protect the heart from arrhythmias via its inhibitory effect on calcium channel.
T29599	Acetyldigitoxin Acylanide
	Acetyldigitoxin is a derivative of lanatoside A or of DIGITOXIN and can be used for fast digitalization in congestive heart failure.
T13933	Toringin	Others	Others
	Toringin is a bioflavonoid isolated from the bark of Docyniopsis tschonoski, and have various biological activities and beneficial actions against cancers, coronary heart disease, among other pathologies.
T10913	Cyclobuxine D	Others	Others
	Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclostatin D has obvious bradycardia effect on rat heart, and inhibits acetylcholine and Ba ++ induced longitudinal muscle contraction isolated from rabbit jejunum.
TN3181	6''-O-Acetylastragalin	Others	Others
	Kaempferol 7-O-beta-d-glucopyranoside (6''-O-Acetylastragalin) is a novel supercoolant, to sub-zero non-freezing rat heart preservation.
TN1367	Alismol 泽泻醇	Potassium Channel; Calcium Channel; PI3K	Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks.
TN1412	Astringin trans-Astringin,白皮杉醇葡萄糖苷	IL Receptor; Others	Immunology/Inflammation; Others
	Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, the beneficial effects of astringinin in the ischemic and ischemic-reperfused hearts may be correlated with its antioxidant activity and upregulation of NO production.
T20123	L-Carnitine hydrochloride L-Carnitine chloride,LC 80,Levocarnitine chloride,(R)-Carnitine hydrochloride,LC-80,LC80
	Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. Carnitine is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It has also been used to allow the en
T4863	DL-Homocysteine DL-高半胱氨酸,2-Amino-4-mercaptobutyric acid	Endogenous Metabolite	Metabolism
	DL-Homocysteine (2-Amino-4-mercaptobutyric acid) 是弱神经毒素，能够影响犬尿酸的产生。
TN4860	Pueroside B	COX; PPAR	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience
	Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A receptor (HMGR), cyclooxygenase-2 (COX2
T80016	Aurachin D	Antibiotic	Microbiology/Virology
	Aurachin D为一种具备抑菌活性的抗生素，对革兰氏阳性细菌及部分真菌种类显示出抑制效果，能够阻断牛心脏亚线粒体颗粒中的NADH氧化过程。
T36791	Lysophosphatidylcholine 18:2
	1-Linoleoyl-2-hydroxy-sn-glycero-3-PC (LGPC) is a lysophospholipid containing linoleic acid at thesn-1 position that has been found in mouse heart, lung, liver, spleen, kidney, plasma, and serum.1Serum levels of LGPC decrease with increasing insulin resistance and dysglycemia in humans.2 1.Okudaira, M., Inoue, A., Shuto, A., et al.Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MSJ. Lipid Res.55(10)2178-2192(2014) 2.Gall, ...
T2O2683	L-Proline L-(-)-Proline,proline,脯氨酸,L-脯氨酸	Endogenous Metabolite	Metabolism
	L-Proline (proline) 是人体非必需氨基酸。它是胶原蛋白的重要组成部分，对关节和肌腱的正常运作很重要。它还有助于维持和加强心脏肌肉。
TN4616	N-Methyltaxol C	Others	Others
	N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. They can induced conduction arrhythmias and reduce coronary flow and left ventricular systolic pressure in the isolate
T35667	Napyradiomycin A1 Napyradiomycin A1
	Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg/ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 μM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM...
T37714	Fuscin
	Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 μM in a radioligand binding assay. Fuscin (20 μM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-...
T4883	Creatine Methylguanidoacetic acid,肌酸	Endogenous Metabolite	Metabolism
	Creatine (Methylguanidoacetic acid) 是一种内源性氨基酸代谢物，在细胞能量中发挥重要作用，尤其是在肌肉和大脑中。
T37291	Lyso-Globotriaosylceramide (d18:1) Lyso-Globotriaosylceramide (d18:1)
	Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas...

天然产物

Heptadecanoic acid

Cat.No: T4903

Target: Others, Endogenous Metabolite

Dobutamine hydrochloride

Cat.No: T8149

Synonym: 盐酸多巴酚丁胺,Dobutamine (hydrochloride)

Target: Adrenergic Receptor

Cat.No: T8183

Synonym: 洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C

Target: ATPase, Drug Metabolite

Cat.No: T3212

Synonym: 地谷新配基,异羟基洋地黄毒苷元

Target: Others

Cat.No: T21418

Synonym: Linopril,赖诺普利,Zestril,Prinivil,Lisipril

Target: RAAS

Butyrylcarnitine

Cat.No: T14840

Target: Endogenous Metabolite

Cat.No: T3S0128

Synonym: 氢化原阿片碱,氢化物碱

Target: Others

Cat.No: T10584

Synonym: (9Z,11E)-Octadecadienoic acid,Rumenic acid

Target: Endogenous Metabolite

Cat.No: T2925

Synonym: gamma-Schisandrin,Schizandrin B,五味子素B,五味子乙素,Schisandrin B (Sch B),Wuweizisu-B

Target: ATM/ATR, Reactive Oxygen Species, Autophagy

Cat.No: T5543

Synonym: 四甲基哌啶酮,Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone

Target: Others

Cat.No: T1694

Synonym: Oxipurinol,羟基嘌呤

Target: ROS, Xanthine Oxidase, Endogenous Metabolite

Kaempferol-7-O-β-D-glucopyranoside

Cat.No: T4073

Synonym: 山奈酚-7-O-葡萄糖苷,Kaempferol-7-O-D-glucopyranoside

Target: Others

Cat.No: T7938

Synonym: 奎尼丁,奎宁树

Target: Parasite

Ginsenoside Rk3

Cat.No: T6S1495

Synonym: 人参皂苷Rk3,人参皂甙 Rk3

Target: Others, NF-κB

Pseudoginsenoside RT1

Cat.No: T4S1518

Synonym: 拟人参皂苷 RT1,假人参皂苷RT1

Target: Others

Cat.No: T6S1930

Synonym: 五味子酚,Schizanhenol,Gomisin-K3

Target: Antioxidant

Cat.No: T5645

Synonym: Cis-Geraniol,橙花醇,Neryl alcohol

Target: Apoptosis, Reactive Oxygen Species, Mitochondrial Metabolism, Endogenous Metabolite, Antifungal

Cat.No: T1670

Synonym: Cedilanid,Ceglunate,Isolanid,毛花甙丙,毛花苷C

Target: ATPase, Virus Protease, Autophagy

Cat.No: T3765

Synonym: 細辛素,(-)-Episesamin

Target: Others

Cat.No: T2S1778

Synonym: DL-甲状腺肿素,板蓝根,Goitrin,(R,S)-告依春

Target: Others

Pseudoginsenoside F11

Cat.No: T3920

Synonym: Ginsenoside A1,拟人参皂苷 F11,拟人参皂苷F11

Target: Others, Endogenous Metabolite

Luteolinidin chloride

Cat.No: TN1895

Target: CD38

Cat.No: T2939

Synonym: 毛喉素,Coleonol,Colforsin

Target: FXR, Adenylyl cyclase, AChR, Autophagy

Cat.No: T5S0890

Synonym: Neriostene,Folinerin,Foliandrin,欧夹竹桃苷

Target: Apoptosis, ATPase, Potassium Channel, Sodium Channel

Cat.No: T0962

Synonym: Daturine,Hyoscyamine,L-莨菪碱,L-天仙子胺

Target: AChR

Cat.No: T3243

Synonym: Abromine,glycine betaine,oxyneurine,trimethylglycine,lycine,甜菜碱

Target: Others, Endogenous Metabolite

L-Hyoscyamine sulfate

Cat.No: T4S1619

Synonym: Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate,硫酸天仙子胺水合物,L-莨菪碱硫酸盐

Target: AChR

Protosappanin A

Cat.No: TJS1779

Synonym: 原苏木素A,PTA

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

Cat.No: T4776

Synonym: Glycerin,甘油

Target: Endogenous Metabolite

2,7-Dihydrohomoerysotrine

Cat.No: TN2743

Target: Others

Methyl 3,4,5-trimethoxycinnamate

Cat.No: TMA0763

Target: Potassium Channel, Calcium Channel

Acetyldigitoxin

Cat.No: T29599

Synonym: Acylanide

Cat.No: T13933

Target: Others

Cat.No: T10913

Target: Others

6''-O-Acetylastragalin

Cat.No: TN3181

Target: Others

Cat.No: TN1367

Synonym: 泽泻醇

Target: Potassium Channel, Calcium Channel, PI3K

Cat.No: TN1412

Synonym: trans-Astringin,白皮杉醇葡萄糖苷

Target: IL Receptor, Others

L-Carnitine hydrochloride

Cat.No: T20123

Synonym: L-Carnitine chloride,LC 80,Levocarnitine chloride,(R)-Carnitine hydrochloride,LC-80,LC80

DL-Homocysteine

Cat.No: T4863

Synonym: DL-高半胱氨酸,2-Amino-4-mercaptobutyric acid

Target: Endogenous Metabolite

Cat.No: TN4860

Target: COX, PPAR

Cat.No: T80016

Target: Antibiotic

Lysophosphatidylcholine 18:2

Cat.No: T36791

Cat.No: T2O2683

Synonym: L-(-)-Proline,proline,脯氨酸,L-脯氨酸

Target: Endogenous Metabolite

N-Methyltaxol C

Cat.No: TN4616

Target: Others

Napyradiomycin A1

Cat.No: T35667

Synonym: Napyradiomycin A1

Cat.No: T37714

Cat.No: T4883

Synonym: Methylguanidoacetic acid,肌酸

Target: Endogenous Metabolite

Lyso-Globotriaosylceramide (d18:1)

Cat.No: T37291

Synonym: Lyso-Globotriaosylceramide (d18:1)

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