Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Indacaterol maleate (QAB149) 是一种超长效的 β-肾上腺素受体激动剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 248 | 现货 | ||
10 mg | ¥ 348 | 现货 | ||
25 mg | ¥ 563 | 现货 | ||
50 mg | ¥ 878 | 现货 | ||
100 mg | ¥ 1,470 | 现货 | ||
200 mg | ¥ 2,250 | 现货 | ||
500 mg | ¥ 3,830 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 312 | 现货 |
产品描述 | Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist. |
靶点活性 | β2-adrenoceptor:5.48(pKi), β1-adrenoceptor:7.36(pKi) |
体外活性 | Indacaterol inhibits cAMP production in Chinese hamster ovary cells stably transfected with human β2 adrenoceptors with pEC50 of 8.06. Indacaterol inhibits electrically induced contraction on the electrically stimulated guinea pig trachea in a concentration-dependent manner with pEC50 of 8.23. Indacaterol induces a concentration-dependent inotropic effect with maximal efficacy of 75% in the isolated guinea pig left atrium. [1] Indacaterol reverses the carbachol-induced contraction in a concentration-dependent manner with IC50 of 37 nM in human small airways. Indacaterol concentration dependently reverses the serotonin-induced contraction with IC50 of 10.5 nM in rat small airways. Indacaterol has the highest intrinsic efficacy of 53% in rat small airways and 73% in human small airways. [2] Indacaterol (10 μM) induces close to full inhibition of the EFS-induced contraction of isolated human bronchi and the effect lasts 12 hours. [3] Indacaterol inhibits the IgE-dependent release of histamine from mast cells with the intrinsic activity (Emax of a long-acting Indacaterol/Emax of Isoprenaline) of 1.03. [4] Indacaterol inihbits cAMP release from human airway smooth muscle with pEC50 of 8.53 and Emax of 48%. Indacaterol appears to have a reduced efficacy compared with the CHO-K1 data in the primary ASM cells. [5] |
体内活性 | Indacaterol (6.7 μg/kg) inhibits 5-HT-induced bronchoconstriction with a maximal effect of 85% in the conscious guinea pig. Indacaterol (12.5 μg/kg) dose-dependently inhibits methacholine-induced bronchoconstriction with a maximal effect of 85% in the anesthetized rhesus monkey. [1] |
别名 | 马来酸茚达特罗, QAB149 |
分子量 | 508.56 |
分子式 | C28H32N2O7 |
CAS No. | 753498-25-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 94 mg/mL (184.8 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9663 mL | 9.8317 mL | 19.6634 mL | 49.1584 mL |
5 mM | 0.3933 mL | 1.9663 mL | 3.9327 mL | 9.8317 mL | |
10 mM | 0.1966 mL | 0.9832 mL | 1.9663 mL | 4.9158 mL | |
20 mM | 0.0983 mL | 0.4916 mL | 0.9832 mL | 2.4579 mL | |
50 mM | 0.0393 mL | 0.1966 mL | 0.3933 mL | 0.9832 mL | |
100 mM | 0.0197 mL | 0.0983 mL | 0.1966 mL | 0.4916 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Indacaterol maleate 753498-25-8 GPCR/G Protein Neuroscience Adrenergic Receptor Inhibitor NF-κB heart failure 马来酸茚达特罗 myocardial infarction Indacaterol Maleate asthma QAB-149 HT1080 cells QAB 149 inhibit QAB149 Indacaterol COPD β-arrestin2 Beta Receptor inhibitor