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507

抑制剂 & 化合物

59

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36298	Tyrocidine Complex
	Tyrocidine complex is a mixture of cyclic decapeptides originally isolated from B. brevis. It is active against Gram-positive and Gram-negative bacteria. It forms a complex with single- and double-stranded DNA to inhibit RNA synthesis.
T37550	Bacitracin Complex
	Bacitracin complex is a bacitracin antibiotic complex composed of cyclic dipeptides that has been found inBacillus.1It is metal-dependent and is complexed to a divalent metal cation, such as Cu2+, Ni2+, Co2+, Zn2+, or Mn2+, for its activity.1,2Bacitracin complex is a mixture of bacitracin polypeptides in complex with copper. 1.Piacham, T., Isarankura-Na-Ayudhya, C., Nantasenamat, C., et al.Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutaseBiochem. Biophys. Res. ...
T38314	Parvodicin Complex
	Parvodicin complex is a mixture of closely related lipophilic glycopeptides originally isolated from A. parvosata. The parvodicin complex has activity against Gram-positive bacteria (MICs = 0.8-12.5 μg/ml) including methicillin-resistant strains of S. aureus (MRSA), S. hemolyticus, and E. faecalis (MICs = 0.1-25 μg/ml). Glycopeptide antibiotics act by preventing cell wall synthesis by binding and sequestering a cell wall precursor with a D-alanine-containing peptide.
T1338	Sucralfate 硫糖铝,Sucrose octasulfate–aluminum complex	FGFR; Others; Antibacterial; Prostaglandin Receptor	Angiogenesis; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Others; Tyrosine Kinase/Adaptors
	Sucralfate (Sucrose octasulfate–aluminum complex) 是一种口服活性胃保护剂。它抑制消化性活性，并与黏膜损伤时暴露的带负电荷的上皮下蛋白结合，形成一层粘性层，保护血管床和增殖区。它可用于预防和治疗胃肠道疾病。
T19332	Gadopentetic acid gadolinium complex,钆喷酸,Gd-DTPA	Others	Others
	Gadopentetic acid (gadolinium complex) 是一种顺磁性造影剂，通常通过静脉内注射 (i.v.) 的方式用于 DCE-MRI 研究。
TP2285	Quinupristin-Dalfopristin Complex (mesylate)	Others	Others
	Quinupristin-Dalfopristin Complex is a mixture of two streptogramin antibiotics. Quinupristin-dalfopristin complex is a mixture of two streptogramin antibiotics, dalfopristin, and quinupristin. Streptogramin antibiotics are divided into types A and B, whi
T19245	Cobalt phthalocyanine Cobaltous phthalocyanine,酞菁钴,Phthalocyanine cobalt complex,Cobalt(II) phthalocyanine	Others	Others
	Cobalt phthalocyanine (Phthalocyanine cobalt complex) 是氧化还原反应的催化剂，已经成功催化醛和酮从醛肟和酮肟中的有氧再生。
T1254	Chlorophyllin sodium copper salt Chlorophyllin copper sodium complex,Chlorophyllin,叶绿素铜钠盐,Chlorophyllin coppered trisodium salt,Sodium-copper chlorin e6	Others	Others
	Chlorophyllin sodium copper salt (Chlorophyllin coppered trisodium salt) 是一种由 Chlorophyll 衍生的铜钠盐的半合成混合物，常用作食品添加剂。
TP1781	Nuclear pore complex protein Nup98 315-360
	Nuclear pore complex protein Nup98 (315-360) is the 315-360 fragment part of the nuclear pore complex (NPC) protein.
T61009	Complex III-IN-1
	Complex III-IN-1 (Compd 4c-2) 是 complex III 的抑制剂，具有抗真菌活性。Complex III-IN-1 对核盘菌的EC50值为 18.53 mg/L。
T60949	Complex III-IN-2
	Complex III-IN-2 (Compd 4d-2) 是complex III 的抑制剂，具有抗真菌活性，其对植物病菌立枯病菌和核盘菌的EC50值分别为29.31 mg/L 和 29.98 mg/L。
T33934	Perhydroantamanide Lithium perhydroantamanide complex
	Perhydroantamanide is a bioactive chemical.
T25611	Lanatoside Lantoside,ABC lanatoside complex
	Lanatoside 是一种 FDA 批准的强心苷，已被确定为候选的抗登革热化合物。它也被发现可以促进脉粥样硬化，还具有抗肿瘤活性，可抑制结直肠癌细胞、肝癌细胞的生长。
T5860	CK-869	Microtubule Associated	Cytoskeletal Signaling
	CK-869 是一种肌动蛋白相关蛋白 2/3 复合体抑制剂，其 IC50值为 7 μM。
T32054	Heme arginate Hemearginat,Heme arginate complex,Normosang
	Heme arginine (or heme arginine) is a compound of heme and arginine used to treat acute porphyria by reducing the excessive production of δ-aminolevulinic acid, which causes acute symptoms during the onset of acute porphyria.
T8561	Apcin	APC	Cell Cycle/Checkpoint
	Apcin 是后期促进复合物/环体 (APC/C(Cdc20)) E3 连接酶活性的有效竞争性抑制剂，可通过与 Cdc20 结合并阻止底物识别竞争性地抑制 APC/C 依赖性泛素化。它占据 WD40 结构域侧面的 D-box 结合口袋，并可以延长有丝分裂。它通过阻断有丝分裂退出并通过共同添加 Ts-Arg-OMe 协同放大而起作用。
T2164	Wiskostatin	Others	Others
	Wiskostatin 是神经元 Wiskott-Aldrich 综合征蛋白介导的肌动蛋白聚合的选择性抑制剂，能够不可逆的使细胞 ATP 水平快速下降。
T32981	Lutenurine Alkaloid complex of nuphar luteum,Liutenurin
	Lutenurine is an alkaloid from yellow water lily; in treatment of skin and mucosal diseases.
T10826	CK-666	HIV Protease; Microtubule Associated	Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome
	CK-666 是一种肌动蛋白相关蛋白 Arp2/3 复合物的细胞渗透性抑制剂。它与 Arp2/3 复合物结合，稳定复合物的非活性状态，阻止 Arp2 和 Arp3 亚基进入活化的丝状短节距构象。
T1820	CK-636 CK-0944636,CK 636	Microtubule Associated	Cytoskeletal Signaling
	CK-636 (CK-0944636)是一种具有细胞渗透性的Arp2/3复合体抑制剂，能抑制肌动蛋白的聚合，对人，裂殖酵母和牛的IC50值分别为4、24 和 32 μM。
T5007	Benproperine phosphate 磷酸苯丙哌林,Blascorid,Pirexyl phosphate	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	Benproperine phosphate (Pirexyl phosphate) 是一种具有口服活性的，肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。它通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。它可抑制癌细胞迁移和肿瘤转移，有用于治疗止咳的潜力。
T9169	MPP+ iodide	Mitochondrial Metabolism; Autophagy	Autophagy; Metabolism
	MPP+ iodide 是一种 5-羟色胺转运体的高亲和力底物，也是一种神经毒素 MPTP 的有毒代谢物，通过选择性破坏黑质多巴胺能神经元，在动物模型中引起帕金森病症状。它被多巴胺转运体吸收进入多巴胺能神经元，通过影响呼吸链复合体 I 对线粒体发挥神经毒性作用。
T11541	HCV-IN-30	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	HCV-IN-30 是 HCV NS5A 复制复合物的抑制剂（基因型 1a 和 1b 复制子的 IC50 = 901 和 102 nM）。
T6904	Necrosulfonamide (E)-Necrosulfonamide	MLK	MAPK
	Necrosulfonamide ((E)-Necrosulfonamide) 是一种坏死性凋亡抑制剂，通过选择性靶向(MLKL)，可阻止 MLKL-RIP1-RIP3 坏死小体复合体与其下游效应子相互作用。MLKL 是诱导坏死过程中 RIP3 的重要底物。
T40732	TMPD dihydrochloride
	TMPD dihydrochloride 是酶促转化氧化还原的活性底物和用于还原血红素过氧化物酶的电子供体。
T9805	BAY 2666605	PDE	Metabolism
	BAY 2666605 是一种具有口服活性的 PDE3A 和 PDE3B 抑制剂，IC50 分别为 87 nM 和 50 nM。 BAY 2666605 具有抗癌作用。
T22884	JW 67	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	JW 67 是典型 Wnt 信号通路的抑制剂，IC50为 1.17 μM。它影响由 β- 连环蛋白/GSK-3β/AXIN/APC/CK1 组成的多蛋白复合物，快速降低活性 β- 连环蛋白，随后下调Wnt 靶基因。它也抑制结直肠癌细胞生长。
T9915	Eculizumab	Complement System	Immunology/Inflammation
	Eculizumab 是针对补体 C5 的长效人源化单克隆抗体。它对 C5 裂解为 C5a 和 C5b 具有抑制作用，并抑制了末端补体系统的部署，其中包括膜攻击复合物的形成。它可用于溶血的研究。
T9744	MP07-66	Phosphatase	Metabolism
	MP07-66 是 FTY720 的一种类似物，没有免疫抑制作用。MP07-66通过破坏 SET-PP2A 复合物导致PP2A 重新激活。MP07-66在慢性淋巴细胞白血病中显示出良好的抗肿瘤作用。
T4527	Seclidemstat SP-2577	Histone Demethylase	Chromatin/Epigenetic
	Seclidemstat (SP-2577) 是非竞争性可逆KDM1A (LSD1)抑制剂，可用于尤文肉瘤的研究。它促进 SWI/SNF 复合物突变卵巢癌的抗肿瘤免疫，并抑制病毒产生、病毒 DNA 复制和晚期基因表达。
T9714	Atpenin A5	Potassium Channel	Membrane transporter/Ion channel
	Atpenin A5 是高度特异性的complex II 抑制剂，IC50为 ~10 nM。Dolastatin 10也是有效的mKATP 通道激动剂，具有心脏保活的作用。
T1631	Sulbactam CP45899,舒巴坦,舒巴坦酸	Antibacterial; Antibiotic	Microbiology/Virology
	Sulbactam (CP45899) 是一种竞争性、不可逆的 β-内酰胺酶抑制剂，抑制耐多药不动杆菌-鲍曼不动杆菌复合物。它具有抗菌活性。
T6685	Sulbactam sodium 舒巴坦钠,CP-45899-2	Antibacterial; Antibiotic	Microbiology/Virology
	Sulbactam sodium (CP-45899-2) 是一种竞争性、不可逆的 β-内酰胺酶抑制剂。它具有抗菌活性，抑制耐多药不动杆菌-鲍曼不动杆菌复合物。
T5337	IACS-010759 IACS-10759,IACS 10759,IACS10759	Apoptosis; Others; Mitochondrial Metabolism	Apoptosis; Metabolism; Others
	IACS-010759 是一种口服有效的线粒体氧化磷酸化复合物 I 抑制剂。它在依赖 OXPHOS 的脑癌和急性髓性白血病模型中抑制增殖并诱导细胞凋亡，有研究复发/难治性 AML 和实体瘤潜力。
T22698	TLR3-IN-1 CU CPT 4a	TLR	Immunology/Inflammation
	TLR3-IN-1 (CU CPT 4a) 是一种选择性的TLR3信号抑制剂，在 RAW 264.7 细胞中 IC50 为 3.44 μM。它可以抑制 TLR3/dsRNA 复合物介导的下游信号通路，并抑制全细胞中 TNF-α 和 IL-1β 的产生。
T2504	Pritelivir 普瑞利韦,BAY 57-1293,AIC316	DNA/RNA Synthesis; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Pritelivir (BAY 57-1293) 是一种病毒解旋酶-引物酶复合物抑制剂，有抗病毒活性。它对 HSV-1 和 HSV-2 具有活性，IC50值为 20 nM。
T0239	Lonidamine AF1890,氯尼达明,DICA,Diclondazolic Acid	Apoptosis; Hexokinase; Mitochondrial Metabolism	Apoptosis; Metabolism
	Lonidamine (Diclondazolic Acid) 是一种抗肿瘤药物，是己糖激酶、线粒体丙酮酸载体和质膜单羧酸转运蛋白抑制剂，同时也抑制线粒体复合物 II。
T2154	MG-132 Z-LLL-al,Z-Leu-Leu-Leu-CHO	Apoptosis; Proteasome; Autophagy	Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination
	MG-132 (Z-Leu-Leu-Leu-al) 是一种 26S 蛋白酶体抑制剂 (IC50=100 nM)，具有细胞渗透性、可逆性。MG-132 可作为自噬激活剂，可诱导凋亡。
T71386	GW-597901 cinnamate
	GW-597901 cinnamate is a long-acting beta(2)-agonist.
T1731	TAME hydrochloride NA-P-甲苯磺酰-L-精氨酸甲酯盐酸盐,Tos-Arg-OMe HCl,TOS-ARG-OME hydrochloride	Amino Acids and Derivatives; APC	Cell Cycle/Checkpoint; Metabolism
	TAME hydrochloride (Tos-Arg-OMe HCl) 是后期促进复合体(APC/C 或 APC)的抑制剂，可与 APC/C 结合并阻止其通过 Cdc20 和 Cdh1 活化，产生有丝分裂阻滞。它是一种 od 氨基酸衍生物。
T64624	RuPhos Pd G1 Methyl t-Butyl Ether Adduct
	Chloro(2-dicyclohexylphosphino-2',6'-diisopropoxy-1,1-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) 2-methoxy-2-methylpropane complex 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64624。
T6693	TAME N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯,Tosylarginine methyl ester,N-4-Tosyl-L-arginine methyl ester	APC	Cell Cycle/Checkpoint
	TAME (N-4-Tosyl-L-arginine methyl ester) 是后期促进复合体(APC/C 或 APC)的抑制剂，可与 APC/C 结合并阻止其通过 Cdc20 和 Cdh1 活化，产生有丝分裂阻滞。
T9241	o-Cresolphthalein Complexone	Others	Others
	o-Cresolphthalein Complexone 是一种金属络合指示剂和酸碱指示剂。
T19963	Alizarin Complexone Alizarin Fluorine Blue,Alizarin-3-methyliminodiacetic acid,茜素络合指示剂	Reverse Transcriptase	Microbiology/Virology
	Alizarin Complexone (Alizarin-3-methyliminodiacetic acid) 是 Rous 相关病毒 2 逆转录酶的抑制剂。 Alizarin Complexone 可用作生物研究的钙示踪剂和螯合剂。
T63136	DX3-213B	OXPHOS	Apoptosis
	DX3-213B 是一种高效的、口服具有活力的氧化磷酸化 (OXPHOS) 复合物 I 抑制剂，其 IC50 值为 3.6 nM。DX3-213B 能够阻断 ATP 的生成 (IC50: 11 nM)，抑制 MIA PaCa-2 细胞生长 (GI50: 11 nM)。DX3-213B 能够用于研究胰腺癌。
T8727	TH1020	TLR; Antibacterial	Immunology/Inflammation; Microbiology/Virology
	TH1020 是一种选择性 Toll 样受体 5 /鞭毛蛋白复合拮抗剂，IC50为 0.85 μM。它抑制鞭毛蛋白诱导的TLR5信号传导。
T1838	Sapanisertib 沙帕色替,TAK-228,MLN0128,INK 128	PI3K; mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	Sapanisertib (INK 128) 是一种口服有效的 ATP 依赖性的mTOR1/2抑制剂，抑制 mTOR 激酶的IC50值为 1 nM，具有潜在抗肿瘤活性。
T10205	A-395	Histone Methyltransferase	Chromatin/Epigenetic
	A-395 是一种多梳抑制复合物 2 (PRC2) 蛋白质-蛋白质相互作用的拮抗剂，可有效抑制三聚体 PRC2 复合物 (EZH2-EED-SUZ12)，IC50为 18 nM。
T35300	Zeniplatin Zeniplatinum	Others	Others
	Zeniplatin (Zeniplatinum) 是一种新顺铂复合物，具有抗癌活性，可用于治疗转移性黑色素瘤和肾癌。
T19714	Fenpyroximate	Others	Others
	Fenpyroximate 是一种有效的杀螨剂。

化合物

Tyrocidine Complex

Cat.No: T36298

Bacitracin Complex

Cat.No: T37550

Parvodicin Complex

Cat.No: T38314

Cat.No: T1338

Synonym: 硫糖铝,Sucrose octasulfate–aluminum complex

Target: FGFR, Others, Antibacterial, Prostaglandin Receptor

Gadopentetic acid

Cat.No: T19332

Synonym: gadolinium complex,钆喷酸,Gd-DTPA

Target: Others

Quinupristin-Dalfopristin Complex (mesylate)

Cat.No: TP2285

Target: Others

Cobalt phthalocyanine

Cat.No: T19245

Synonym: Cobaltous phthalocyanine,酞菁钴,Phthalocyanine cobalt complex,Cobalt(II) phthalocyanine

Target: Others

Chlorophyllin sodium copper salt

Cat.No: T1254

Synonym: Chlorophyllin copper sodium complex,Chlorophyllin,叶绿素铜钠盐,Chlorophyllin coppered trisodium salt,Sodium-copper chlorin e6

Target: Others

Nuclear pore complex protein Nup98 315-360

Cat.No: TP1781

Complex III-IN-1

Cat.No: T61009

Complex III-IN-2

Cat.No: T60949

Perhydroantamanide

Cat.No: T33934

Synonym: Lithium perhydroantamanide complex

Cat.No: T25611

Synonym: Lantoside,ABC lanatoside complex

Cat.No: T5860

Target: Microtubule Associated

Cat.No: T32054

Synonym: Hemearginat,Heme arginate complex,Normosang

Cat.No: T8561

Target: APC

Cat.No: T2164

Target: Others

Cat.No: T32981

Synonym: Alkaloid complex of nuphar luteum,Liutenurin

Cat.No: T10826

Target: HIV Protease, Microtubule Associated

Cat.No: T1820

Synonym: CK-0944636,CK 636

Target: Microtubule Associated

Benproperine phosphate

Cat.No: T5007

Synonym: 磷酸苯丙哌林,Blascorid,Pirexyl phosphate

Target: Others, Microtubule Associated

Cat.No: T9169

Target: Mitochondrial Metabolism, Autophagy

Cat.No: T11541

Target: Others, HCV Protease

Necrosulfonamide

Cat.No: T6904

Synonym: (E)-Necrosulfonamide

Target: MLK

TMPD dihydrochloride

Cat.No: T40732

Cat.No: T9805

Target: PDE

Cat.No: T22884

Target: Wnt/beta-catenin

Cat.No: T9915

Target: Complement System

Cat.No: T9744

Target: Phosphatase

Cat.No: T4527

Synonym: SP-2577

Target: Histone Demethylase

Cat.No: T9714

Target: Potassium Channel

Cat.No: T1631

Synonym: CP45899,舒巴坦,舒巴坦酸

Target: Antibacterial, Antibiotic

Sulbactam sodium

Cat.No: T6685

Synonym: 舒巴坦钠,CP-45899-2

Target: Antibacterial, Antibiotic

Cat.No: T5337

Synonym: IACS-10759,IACS 10759,IACS10759

Target: Apoptosis, Others, Mitochondrial Metabolism

Cat.No: T22698

Synonym: CU CPT 4a

Target: TLR

Cat.No: T2504

Synonym: 普瑞利韦,BAY 57-1293,AIC316

Target: DNA/RNA Synthesis, HSV

Cat.No: T0239

Synonym: AF1890,氯尼达明,DICA,Diclondazolic Acid

Target: Apoptosis, Hexokinase, Mitochondrial Metabolism

Cat.No: T2154

Synonym: Z-LLL-al,Z-Leu-Leu-Leu-CHO

Target: Apoptosis, Proteasome, Autophagy

GW-597901 cinnamate

Cat.No: T71386

TAME hydrochloride

Cat.No: T1731

Synonym: NA-P-甲苯磺酰-L-精氨酸甲酯盐酸盐,Tos-Arg-OMe HCl,TOS-ARG-OME hydrochloride

Target: Amino Acids and Derivatives, APC

RuPhos Pd G1 Methyl t-Butyl Ether Adduct

Cat.No: T64624

Cat.No: T6693

Synonym: N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯,Tosylarginine methyl ester,N-4-Tosyl-L-arginine methyl ester

Target: APC

o-Cresolphthalein Complexone

Cat.No: T9241

Target: Others

Alizarin Complexone

Cat.No: T19963

Synonym: Alizarin Fluorine Blue,Alizarin-3-methyliminodiacetic acid,茜素络合指示剂

Target: Reverse Transcriptase

Cat.No: T63136

Target: OXPHOS

Cat.No: T8727

Target: TLR, Antibacterial

Cat.No: T1838

Synonym: 沙帕色替,TAK-228,MLN0128,INK 128

Target: PI3K, mTOR, Autophagy

Cat.No: T10205

Target: Histone Methyltransferase

Cat.No: T35300

Synonym: Zeniplatinum

Target: Others

Cat.No: T19714

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T11287	Filipin complex	Antifungal	Microbiology/Virology
	Filipin complex 是一种 28 元环戊烯大环内酯类抗真菌抗生素，由 S. filipinensis、S. avermitilis 和 S. miharaensis 产生的混合物，抑制 PRRSV 病毒进入细胞，通过与膜固醇相互作用发挥作用。
T36990	Moenomycin Complex
	Moenomycin complex is a mixture of moenomycins A, A12, C1, C3 and C4, which are antibiotics isolated from several strains of Streptomyces that directly inhibit bacterial peptidoglycan glycosyltransferases. [1] The minimal inhibitory concentration of moenomycin A against various Gram-positive bacteria ranges from 1-100 nM.[1]
T11202	Enniatin complex	Others	Others
	Enniatin complex, a mixture of cyclohexadepsipeptides predominantly derived from various Fusarium species of fungi, exhibits inhibitory effects on enzymes such as acyl-CoA: cholesterol acyl transferase. Furthermore, it has demonstrated the ability to induce apoptosis in multiple cancer cell lines. In addition to these activities, the Enniatin complex possesses ionophoric, antibiotic, and in vitro hypolipidemic properties.
T4860	5-Hydroxytryptamine creatinine sulfate monohydrate Serotonin creatinine sulfate monohydrate,5-Hydroxytryptamine creatinine sulfate complex,5-五羟色胺肌酸酐	Others; Endogenous Metabolite	Metabolism; Others
	5-Hydroxytryptamine creatinine sulfate monohydrate (Serotonin creatinine sulfate monohydrate) 是内源性代谢产物的一种。
T21494	Oligomycin	HIF	Angiogenesis; Chromatin/Epigenetic
	Oligomycin 是一种抗真菌抗生素，是 H+-ATP 合成酶的抑制剂。Oligomycin 能够阻断氧化磷酸化和电子传递链。Oligomycin 对缺氧性肿瘤细胞 HIF-1alpha 表达具有抑制作用。
T23927	Cylindrin Hollow cylinder protein complex
	Cylindrin is a six-stranded antiparallel beta-barrel that induces cell toxicity through an unknown mechanism.
T41044	Naringinase	Glucosidase	Metabolism
	Naringinase 是一种在自然界中广泛存在的水解酶复合物，具有 α-L-鼠李糖苷酶和 β-D-葡萄糖苷酶的活性，主要用于糖苷的水解。
T8433	HQNO	Mitochondrial Metabolism	Metabolism
	HQNO 是一种电子传递链抑制剂，对 complex III 的Kd 值为 64 nM，由P. aeruginosa 产生的。它是许多物种的线粒体NDH-2的有效抑制剂。
T19137	4'-Methylacetophenone	Others	Others
	4′-methylacetophenone 是一种香料，普遍存在于食品中的挥发性化合物和某些天然复合物中。
T4857	Pteridine-2,4(1H,3H)-dione 2,4-Dihydroxypteridine,2,4-二羟基蝶啶,Lumazine	Others; Endogenous Metabolite	Metabolism; Others
	Pteridine-2,4(1H,3H)-dione (Lumazine) 是内源性代谢产物的一种。
TQ0205	Procyanidin B1 原花青素B1,原花青素 B1	TLR	Immunology/Inflammation
	Procyanidin B1 是水果中常见的多酚类黄酮，能够与TLR4/MD-2复合体结合，具有抗炎活性。
T2144	Tacrolimus 他克莫司,Fujimycin,FK506,FR900506	Phosphatase; Others; Antibacterial; Antibiotic; mTOR; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling
	Tacrolimus (Fujimycin) 可与 FKBP12 结合形成高亲和力复合物 (Ki: 0.2 nM)，抑制钙/钙调蛋白依赖性蛋白磷酸酶的活性。
TQ0208	SAH SAH (S-Adenosylhomocysteine),S-(5'-腺苷)-L-高半胱氨酸	Others; Endogenous Metabolite	Metabolism; Others
	SAH (SAH (S-Adenosylhomocysteine)) 是氨基酸衍生物，是几种代谢途径中的调节剂。SAH 是腺苷和半胱氨酸合成的中间体。SAH 是 METTL3-METTL14 异二聚体复合物的抑制剂，IC50=0.9 µM。
T19355	Heparan Sulfate 硫酸乙酰肝素,硫酸类肝素	FGFR; Wnt/beta-catenin; Endogenous Metabolite	Angiogenesis; Cytoskeletal Signaling; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors
	Heparan sulfate 是一种复杂的线性多糖。Heparan sulfate 作为硫酸乙酰肝素蛋白聚糖的一部分出现，在细胞外基质和细胞表面表达丰富。
T4S0181	Hinokiflavone 日本扁柏黄酮,扁柏双黄酮	MMP; BCL; E1/E2/E3 Enzyme	Apoptosis; Proteases/Proteasome; Ubiquitination
	Hinokiflavone 是pre-mRNA 剪接活性的新型调节剂，通过抑制剪接体装配来阻止pre-mRNA 底物的剪接，特别是阻止 B complex 的形成。它是SUMO protease 蛋白酶抑制剂，能够抑制前哨蛋白特异性蛋白酶 1 的活性。
T14193	α-Galactosylceramide KRN7000,α-GalCer	Others	Others
	α-Galactosylceramide (KRN7000) 是一种具有抗肿瘤和免疫刺激作用的合成糖脂。它是一种高效的 NKT 细胞激动剂，可与 CD1d 有效结合。它与 CD1d 的复合物可与 NKT 细胞的 T 细胞抗原受体结合。
T2983	3,4,5-Trimethoxycinnamic acid 3-(3,4,5-Trimethoxyphenyl)acrylic Acid,O-Methylsinapic acid,3,4,5-三甲氧基肉桂酸	GABA Receptor; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) 是从远志中分离得到的苯丙素类天然产物，可延长动物的睡眠时间，增强 GAD65 和 GABAA 受体 γ 亚基，具有抗应激作用。
T21430	Oxytetracycline Hydrochloride Biosolvomycin,盐酸土霉素,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin	Antiviral; Endogenous Metabolite; Antibacterial; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology
	Oxytetracycline Hydrochloride (Dalimycin) 是由 Streptomyces rimosus 生产的，一种具有抗菌活性的四环素衍生物。它干扰氨酰-tRNA 与 mRNA-核糖体复合物的结合，从而阻止肽延伸并抑制蛋白质合成。
T0132	Etoposide VP-16,依托泊苷,依托泊甙,VP-16-213	Apoptosis; Mitophagy; Topoisomerase; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Microbiology/Virology
	Etoposide (VP-16-213) 是一种拓扑异构酶 II 的抑制剂，通过与拓扑异构酶 II 和 DNA 形成复合物来抑制 DNA 合成 (IC50=60.3 μM)。Etoposide 具有抗肿瘤活性，可以诱导细胞凋亡、自噬。
T2970	Rotenone Rotenon,鱼藤酮,Paraderil,Barbasco,Rotocide,Dactinol	Apoptosis; Dehydrogenase; Mitochondrial Metabolism; p53; Autophagy	Apoptosis; Autophagy; Metabolism
	Rotenone (Rotocide) 属于天然产物，是一种植物杀虫剂。Rotenone 是一种线粒体电子传递复合物 I 抑制剂，可以促进线粒体产生活性氧，并诱导细胞凋亡。
T11849	Lignin 木质素,脱碱的,木质素,Lignine	Others	Others
	Lignin (Lignine) 是一种具有生物可降解性和生物相容性的天然复合生物聚合物。它是植物细胞壁的主要成分，是一种可再生的芳香族聚合物，具有显著的抗氧化作用。
T1301	Guaiacol O-methylcatechol,2-hydroxyanisole,o-methoxyphenol,2-Methoxyphenol,愈创木酚	NF-κB; COX; Endogenous Metabolite	Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Guaiacol (2-Methoxyphenol) 是从小叶栲中提取的一种酚类，可抑制 LPS 刺激的COX-2表达和NF-κB 激活，具有抗炎活性。
TP2167	β-CGRP, human acetate β-CGRP, human acetate (101462-82-2 free),CGRP-II (Human) (acetate),Human β-CGRP acetate	CGRP Receptor	GPCR/G Protein; Neuroscience
	β-CGRP, human acetate 是降钙素肽之一，通过受体活性修饰蛋白 (RAMP) 和降钙素受体样受体 (CRLR) 的复合物发挥作用（对于 CRLR/RAMP1 和 CRLR，IC50：1 nM 和 300 nM /RAMP2 在单元格中）。
T6228	Irinotecan CPT-11,Topotecin,伊立替康,(+)-Irinotecan	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan (CPT-11) 是喜树碱的衍生物，是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂。Irinotecan 通过与 Topo I 复合物结合来阻止 DNA 链的重新连接，并导致双链 DNA 断裂和细胞死亡，具有抗肿瘤活性。
T0200	α-Lipoic Acid Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid,α-硫辛酸,硫辛酸	Apoptosis; NF-κB; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite	Apoptosis; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	α-Lipoic Acid (DL-α-Lipoic acid) 是线粒体酶复合物的重要辅助因子，是一种抗氧化剂，可抑制NF-κB 依赖性的HIV-1LTR 活化。它还可诱导内质网应激介导的肝癌细胞凋亡。
T4916	D-Glucaric acid potassium D-Saccharic acid potassium salt,Glucosaccharic acid,D-葡萄糖二酸单钾盐,Glucaric Acid	Others; Endogenous Metabolite	Metabolism; Others
	D-Glucaric acid potassium (D-Saccharic acid potassium salt) 是内源性代谢产物的一种。
T0912	Tetracycline hydrochloride NCI-c55561,盐酸四环素,Tetracycline HCl	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Tetracycline hydrochloride (NCI-c55561) 是一种广谱抗生素，抑制多种革兰氏阳性和革兰氏阴性细菌。
T5291	Malonic acid Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid	Others	Others
	Malonic acid (propanedioic acid) 是竞争性抑制剂的典型例子：它作用于呼吸电子传递链中的琥珀酸脱氢酶(复合物 II)。发现丙二酸与丙二酰辅酶A 脱羧酶缺乏有关，这是一种先天性代谢错误。
T0034	Cortisone acetate 醋酸可的松,Cortisone 21-acetate,NSC 49420	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Cortisone acetate (NSC-49420) 是 Cortisol(一种糖皮质激素)的氧化代谢产物。它在高浓度下能够部分干预 Glucocorticoid 与Glucocorticoid-receptor 的结合。它具有免疫抑制和消炎的作用。
T20879	Tacrolimus monohydrate FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506	Phosphatase; Others; Antibacterial; Antibiotic; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others
	Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物，它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。
T6480	D-Pantothenic acid vitamin B5,pantothenate,D-泛酸	Others	Others
	D-Pantothenic acid (vitamin B5) 是必需的微量营养素，是辅酶 A 的前体，在很多生物过程中发挥关键作用，如调节碳水化合物，脂质，蛋白和核酸代谢。
T1040	Vitamin B12 Cyanocobalamin,Cobalamin,维生素B12	Endogenous Metabolite	Metabolism
	Vitamin B12 (Cobalamin) 是一种维生素，在维持血流形成和脑、神经系统正常功能等方面发挥关键作用。
T5S0055	Chelidonine Helidonine,Khelidonin,白屈菜碱,Stylophorin	Apoptosis; Others; Influenza Virus	Apoptosis; Microbiology/Virology; Others
	Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱，有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞，诱导 caspase 依赖和非依赖性的细胞凋亡。
T0486L	Irinotecan Hydrochloride 盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan Hydrochloride (CPT-11 hydrochloride) 是喜树碱半合成衍生物的盐酸盐，是一种拓扑异构酶 I 抑制剂，可研究结肠癌和直肠癌。
T1168	Desonide Tridesilon,地索奈德,Locapred,Prednacinolone	Glucocorticoid Receptor	Endocrinology/Hormones
	Desonide (Prednacinolone) 是一种非氟化皮质类固醇抗炎剂，能够作用于糖皮质激素受体。
T3S0013	Ethyl trans-caffeate 咖啡酸乙酯,Ethyl caffeate,Caffeic Acid Ethyl Ester	Others	Others
	Ethyl trans-caffeate (Caffeic Acid Ethyl Ester) 具有抗炎作用。它是一种有前途的天然化合物，未来在慢性肝病中的应用。它是一种有效的化学预防化合物，可防止因太阳紫外线照射引起的皮肤癌变。它是与人胰腺α-淀粉酶复合的代表性抑制剂的高分辨率结构。它强烈抑制 JB6 Cl41细胞的肿瘤转化，无毒性。 PI3K、ERK1/2 和 p38 激酶活性在体外通过与 HOEC 直接结合而受到抑制。
T0798	Triamcinolone Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone	Glucocorticoid Receptor; COX	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
	Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂，也是一种合成的长效糖皮质激素，具有抗炎活性。
T3824	Jaceosidin	Apoptosis; BCL; COX; UGT	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
	Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物，可激活Bax，下调 Mcl-1 和 c-FLIP 的表达，诱导癌细胞凋亡。它能够降低炎性因子水平，激活 NF-κB，抑制COX-2的表达，具有抗癌和抗炎作用。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
T4947	3-Hydroxybutyric acid Butanoic acid,3-羟基丁酸	Endogenous Metabolite	Metabolism
	3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物，在 I 型糖尿病中升高。它能够调节膜脂的性质。
T25204	Carbomycin B Magnamycin B
	Carbomycin B is an intermediate in the synthesis of Carbomycin. Carbomycin is a macrolite antibiotic complex produced by Stroptomyces halstedii, that is similar to Leucomycin and Erythromycin.
T36029	Desertomycin A
	Desertomycin A is fungal metabolite and the major component of the desertomycin antibiotic complex that has been found in S. flavofungini.
T21438	Physostigmine Physostol,Antilirium,Eserine,毒扁豆碱,Esromiotin,Ezerin
	Physostigmine is a potent and reversible inhibitor of cholinesterase. It is also reported to form a slowly degrading carbamylated enzyme complex with acetylcholinesterase (AChE).
T11513	Gum arabic Arabic gum,阿拉伯胶	Others	Others
	Gum Arabic, a branched-chain, complex polysaccharide derived from A. Senegal, exhibits antioxidant properties and offers protection against experimental hepatic, renal, and cardiac toxicities. Additionally, it finds application in immunohistochemistry.
T0879L	Niacin hydrochloride
	Niacin hydrochloride is a water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is needed by the body for the formation of coenzymes NAD and NADP. It possesses PELLAGRA-curative, vasodilating, and antilipemic properties.
T14293	Annonacin	Others	Others
	Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex and it is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pu
T35667	Napyradiomycin A1 Napyradiomycin A1
	Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg/ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 μM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM...
T73954	Leucinostatin (mixture of A&B)
	Leucinostatin (mixture of A&B) 是来自Paecilomyces lilacinus 的九肽类复合物，具有抗生素活性。
TN5235	Vinorine	Others	Others
	Vinorine is a direct biosynthetic precursor along the complex pathway to the monoterpenoid indole alkaloid ajmaline, an antiarrhythmic drug from the Indian medicinal plant Rauvolfia serpentina.
T4110	Perivine Perivin,派利文碱	Others	Others
	Perivine (Perivin) 以视网膜母细胞瘤相关蛋白 (RbAp48) 为靶点，能够解决 RbAp48-FOG-1 复合物的不稳定性。Perivine 可用于研究阿尔茨海默病。
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天然产物

Filipin complex

Cat.No: T11287

Target: Antifungal

Moenomycin Complex

Cat.No: T36990

Enniatin complex

Cat.No: T11202

Target: Others

5-Hydroxytryptamine creatinine sulfate monohydrate

Cat.No: T4860

Synonym: Serotonin creatinine sulfate monohydrate,5-Hydroxytryptamine creatinine sulfate complex,5-五羟色胺肌酸酐

Target: Others, Endogenous Metabolite

Cat.No: T21494

Target: HIF

Cat.No: T23927

Synonym: Hollow cylinder protein complex

Cat.No: T41044

Target: Glucosidase

Cat.No: T8433

Target: Mitochondrial Metabolism

4'-Methylacetophenone

Cat.No: T19137

Target: Others

Pteridine-2,4(1H,3H)-dione

Cat.No: T4857

Synonym: 2,4-Dihydroxypteridine,2,4-二羟基蝶啶,Lumazine

Target: Others, Endogenous Metabolite

Cat.No: TQ0205

Synonym: 原花青素B1,原花青素 B1

Target: TLR

Cat.No: T2144

Synonym: 他克莫司,Fujimycin,FK506,FR900506

Target: Phosphatase, Others, Antibacterial, Antibiotic, mTOR, Autophagy

Cat.No: TQ0208

Synonym: SAH (S-Adenosylhomocysteine),S-(5'-腺苷)-L-高半胱氨酸

Target: Others, Endogenous Metabolite

Heparan Sulfate

Cat.No: T19355

Synonym: 硫酸乙酰肝素,硫酸类肝素

Target: FGFR, Wnt/beta-catenin, Endogenous Metabolite

Cat.No: T4S0181

Synonym: 日本扁柏黄酮,扁柏双黄酮

Target: MMP, BCL, E1/E2/E3 Enzyme

α-Galactosylceramide

Cat.No: T14193

Synonym: KRN7000,α-GalCer

Target: Others

3,4,5-Trimethoxycinnamic acid

Cat.No: T2983

Synonym: 3-(3,4,5-Trimethoxyphenyl)acrylic Acid,O-Methylsinapic acid,3,4,5-三甲氧基肉桂酸

Target: GABA Receptor, Endogenous Metabolite

Oxytetracycline Hydrochloride

Cat.No: T21430

Synonym: Biosolvomycin,盐酸土霉素,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin

Target: Antiviral, Endogenous Metabolite, Antibacterial, HSV

Cat.No: T0132

Synonym: VP-16,依托泊苷,依托泊甙,VP-16-213

Target: Apoptosis, Mitophagy, Topoisomerase, Antibacterial, Antibiotic, Autophagy

Cat.No: T2970

Synonym: Rotenon,鱼藤酮,Paraderil,Barbasco,Rotocide,Dactinol

Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism, p53, Autophagy

Cat.No: T11849

Synonym: 木质素,脱碱的,木质素,Lignine

Target: Others

Cat.No: T1301

Synonym: O-methylcatechol,2-hydroxyanisole,o-methoxyphenol,2-Methoxyphenol,愈创木酚

Target: NF-κB, COX, Endogenous Metabolite

β-CGRP, human acetate

Cat.No: TP2167

Synonym: β-CGRP, human acetate (101462-82-2 free),CGRP-II (Human) (acetate),Human β-CGRP acetate

Target: CGRP Receptor

Cat.No: T6228

Synonym: CPT-11,Topotecin,伊立替康,(+)-Irinotecan

Target: Topoisomerase, Autophagy

Cat.No: T0200

Synonym: Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid,α-硫辛酸,硫辛酸

Target: Apoptosis, NF-κB, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite

D-Glucaric acid potassium

Cat.No: T4916

Synonym: D-Saccharic acid potassium salt,Glucosaccharic acid,D-葡萄糖二酸单钾盐,Glucaric Acid

Target: Others, Endogenous Metabolite

Tetracycline hydrochloride

Cat.No: T0912

Synonym: NCI-c55561,盐酸四环素,Tetracycline HCl

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T5291

Synonym: Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid

Target: Others

Cortisone acetate

Cat.No: T0034

Synonym: 醋酸可的松,Cortisone 21-acetate,NSC 49420

Target: Glucocorticoid Receptor, Endogenous Metabolite

Tacrolimus monohydrate

Cat.No: T20879

Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506

Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy

D-Pantothenic acid

Cat.No: T6480

Synonym: vitamin B5,pantothenate,D-泛酸

Target: Others

Cat.No: T1040

Synonym: Cyanocobalamin,Cobalamin,维生素B12

Target: Endogenous Metabolite

Cat.No: T5S0055

Synonym: Helidonine,Khelidonin,白屈菜碱,Stylophorin

Target: Apoptosis, Others, Influenza Virus

Irinotecan Hydrochloride

Cat.No: T0486L

Synonym: 盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride

Target: Topoisomerase, Autophagy

Cat.No: T1168

Synonym: Tridesilon,地索奈德,Locapred,Prednacinolone

Target: Glucocorticoid Receptor

Ethyl trans-caffeate

Cat.No: T3S0013

Synonym: 咖啡酸乙酯,Ethyl caffeate,Caffeic Acid Ethyl Ester

Target: Others

Cat.No: T0798

Synonym: Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone

Target: Glucocorticoid Receptor, COX

Cat.No: T3824

Target: Apoptosis, BCL, COX, UGT

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

3-Hydroxybutyric acid

Cat.No: T4947

Synonym: Butanoic acid,3-羟基丁酸

Target: Endogenous Metabolite

Cat.No: T25204

Synonym: Magnamycin B

Cat.No: T36029

Cat.No: T21438

Synonym: Physostol,Antilirium,Eserine,毒扁豆碱,Esromiotin,Ezerin

Cat.No: T11513

Synonym: Arabic gum,阿拉伯胶

Target: Others

Niacin hydrochloride

Cat.No: T0879L

Cat.No: T14293

Target: Others

Napyradiomycin A1

Cat.No: T35667

Synonym: Napyradiomycin A1

Leucinostatin (mixture of A&B)

Cat.No: T73954

Cat.No: TN5235

Target: Others

Cat.No: T4110

Synonym: Perivin,派利文碱

Target: Others

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