Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MP07-66 是 FTY720 的一种类似物,没有免疫抑制作用。MP07-66通过破坏 SET-PP2A 复合物导致PP2A 重新激活。MP07-66在慢性淋巴细胞白血病中显示出良好的抗肿瘤作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 828 | 现货 | ||
5 mg | ¥ 1,830 | 现货 | ||
10 mg | ¥ 2,920 | 现货 | ||
25 mg | ¥ 4,890 | 现货 | ||
50 mg | ¥ 6,860 | 现货 | ||
100 mg | ¥ 9,430 | 现货 | ||
500 mg | ¥ 18,900 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,970 | 现货 |
产品描述 | MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells. |
体外活性 | CLL cells were incubated with increasing concentrations of MP07-66 (0-16 μM) for 24 and 48 hours and then subject to annexin V–PI flow cytometry. The level of apoptosis reached 50% and 80%, at 24 hours and 48 hours, respectively, at a MP07-66 concentration as high as 16 μM, which paralleled PARP cleavage, a marker of caspase-dependent apoptosis. In addition, the phosphorylation status of PP2A targets, namely Akt, GSK-3, and SHP-1, was negatively affected by the treatment with MP07-66, triggering known downstream events promoting apoptosis, such as Mcl-1 degradation and caspase-3 activation[1]. |
分子量 | 323.47 |
分子式 | C19H33NO3 |
CAS No. | 1938056-90-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (772.87 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0915 mL | 15.4574 mL | 30.9148 mL | 77.2869 mL |
5 mM | 0.6183 mL | 3.0915 mL | 6.183 mL | 15.4574 mL | |
10 mM | 0.3091 mL | 1.5457 mL | 3.0915 mL | 7.7287 mL | |
20 mM | 0.1546 mL | 0.7729 mL | 1.5457 mL | 3.8643 mL | |
50 mM | 0.0618 mL | 0.3091 mL | 0.6183 mL | 1.5457 mL | |
100 mM | 0.0309 mL | 0.1546 mL | 0.3091 mL | 0.7729 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MP07-66 1938056-90-6 Metabolism Phosphatase MP0766 chronic lymphocytic leukemia FTY720 analogue Inhibitor SET-PP2A complex inhibit immunosuppressive effects MP-07-66 MP07 66 antitumor effects inhibitor