store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物,在 I 型糖尿病中升高。它能够调节膜脂的性质。
产品描述 | 3-Hydroxybutyric acid (Butanoic acid) (or beta-hydroxybutyrate) is a ketone body. Like the other ketone bodies (acetoacetate and acetone), levels of 3-hydroxybutyrate in blood and urine are raised in ketosis. In humans, 3-hydroxybutyrate is synthesized in the liver from acetyl-CoA and can be used as an energy source by the brain when blood glucose is low. Blood levels of 3-hydroxybutyric acid levels may be monitored in diabetic patients to look for diabetic ketoacidosis. Persistent mild hyperketonemia is a common finding in newborns. Ketone bodies serve as an indispensable source of energy for extrahepatic tissues, especially the brain and lung of developing mammals. Another important function of ketone bodies is to provide acetoacetyl-CoA and acetyl-CoA for the synthesis of cholesterol, fatty acids, and complex lipids. During the early postnatal period, acetoacetate (AcAc) and beta-hydroxybutyrate are preferred over glucose as substrates for synthesis of phospholipids and sphingolipids in accord with requirements for brain growth and myelination. Thus, during the first 2 weeks of postnatal development, when the accumulation of cholesterol and phospholipids accelerates, the proportion of ketone bodies incorporated into these lipids increases. On the other hand, an increased proportion of ketone bodies is utilized for cerebroside synthesis during the period of active myelination. In the lung, AcAc serves better than glucose as a precursor for the synthesis of lung phospholipids. The synthesized lipids, particularly dipalmitoylphosphatidylcholine, are incorporated into surfactant, and thus have a potential role in supplying adequate surfactant lipids to maintain lung function during the early days of life (PMID: 3884391 ). 3-Hydroxybutyric acid is found to be associated with fumarase deficiency and medium-chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism. |
别名 | Butanoic acid, 3-羟基丁酸 |
分子量 | 104.1 |
分子式 | C4H8O3 |
CAS No. | 300-85-6 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 200mg/mL(1.92 M)
DMSO: 55 mg/mL (528.34 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 9.6061 mL | 48.0307 mL | 96.0615 mL | 240.1537 mL |
5 mM | 1.9212 mL | 9.6061 mL | 19.2123 mL | 48.0307 mL | |
10 mM | 0.9606 mL | 4.8031 mL | 9.6061 mL | 24.0154 mL | |
20 mM | 0.4803 mL | 2.4015 mL | 4.8031 mL | 12.0077 mL | |
50 mM | 0.1921 mL | 0.9606 mL | 1.9212 mL | 4.8031 mL | |
100 mM | 0.0961 mL | 0.4803 mL | 0.9606 mL | 2.4015 mL |
中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
龙芽草/仙鹤草 | Agrimonia pilosa Ldb. | 平 | 苦, 涩 | 心, 肝 |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
3-Hydroxybutyric acid 300-85-6 Metabolism Endogenous Metabolite inhibit Inhibitor Butanoic acid 3-羟基丁酸 diabetes β-Hydroxybutyric acid 3Hydroxybutyric acid membrane metabolite lipids 3 Hydroxybutyric acid type inhibitor