Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CK-869 是一种肌动蛋白相关蛋白 2/3 复合体抑制剂,其 IC50值为 7 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 219 | 现货 | ||
2 mg | ¥ 318 | 现货 | ||
5 mg | ¥ 578 | 现货 | ||
10 mg | ¥ 913 | 现货 | ||
25 mg | ¥ 1,830 | 现货 | ||
50 mg | ¥ 2,890 | 现货 | ||
100 mg | ¥ 4,360 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 638 | 现货 |
产品描述 | CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor(IC50 of 7 μM),and is useful tools for the investigation of the Arp2/3 complex. |
靶点活性 | ARP2:7 μM, ARP3:7 μM |
体外活性 | CK-869 inhibits comet tail formation by L. monocytogenes with an IC50 value of 7 μM.It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells[1]. |
细胞实验 | Cells were treated in suspension with different concentrations of the compounds, allowed to adhere to the surface of a tissue culture dish for one hour, washed and the number of adherent cells counted and presented as a fraction of untreated cells (10X lens, 10 fields/condition).?For cell spreading assays, cells were treated with CK-869 in suspension, plated on coverslips coated with 5 μg/ml fibronectin for imaging[1]. |
分子量 | 394.28 |
分子式 | C17H16BrNO3S |
CAS No. | 388592-44-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 75 mg/mL (190.22 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5363 mL | 12.6813 mL | 25.3627 mL | 63.4067 mL |
5 mM | 0.5073 mL | 2.5363 mL | 5.0725 mL | 12.6813 mL | |
10 mM | 0.2536 mL | 1.2681 mL | 2.5363 mL | 6.3407 mL | |
20 mM | 0.1268 mL | 0.6341 mL | 1.2681 mL | 3.1703 mL | |
50 mM | 0.0507 mL | 0.2536 mL | 0.5073 mL | 1.2681 mL | |
100 mM | 0.0254 mL | 0.1268 mL | 0.2536 mL | 0.6341 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CK-869 388592-44-7 Cytoskeletal Signaling Microtubule Associated Arp2/3 Complex inhibit Inhibitor CK869 Actin-related protein 2/3 complex CK 869 inhibitor