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Search Results for " apoptosis induction "

156

抑制剂 & 化合物

35

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2051	SKLB4771 FLT3-IN-1,FLT3-IN-1	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	SKLB4771 (FLT3-IN-1) 是一种新型的、高效的 Flt3 抑制剂 (IC50:10nM)。
T11209	EOAI3402143	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	EOAI3402143 是一种去泛素化酶抑制剂，以剂量依赖性抑制 Usp9x/Usp24和 Usp5，增加肿瘤细胞凋亡。
T21017	5'-Amino-5'-deoxyadenosine 5' Amino 5' deoxyadenosine,5'Amino5'deoxyadenosine,Nsc 238990,NH2dAdo	Apoptosis; Adenosine Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	5'-Amino-5'-deoxyadenosine (NH2dAdo) 是一种针对惰性淋巴系统恶性肿瘤的腺苷激酶抑制剂，具有抗肿瘤和抗癌作用。5'-Amino-5'-deoxyadenosine 的抗癌机制通过抑制 DNA 合成，诱导细胞凋亡 (apoptosis) 等来实现。
T1535	Sodium 4-phenylbutyrate 苯丁酸钠,Sodium Phenylbutyrate,Buphenyl,4-苯基丁酸钠盐,TriButyrate	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Sodium 4-phenylbutyrate (TriButyrate) 是一种组蛋白去乙酰化酶和内质网应激抑制剂，可研究癌症和感染等疾病。
T6017	Linsitinib OSI-906,林西替尼	IGF-1R	Tyrosine Kinase/Adaptors
	Linsitinib (OSI-906) 是选择性的、有效的、具有口服活性的IGF-1和胰岛素受体(IR)的双重抑制剂，IC50分别为 35 和 75 nM。
T6891	MK-4101	Apoptosis; Hedgehog/Smoothened; Smo	Apoptosis; GPCR/G Protein; Stem Cells
	MK-4101 是一种 SMO 拮抗剂，对 293 细胞的 IC50为 1.1 µM。它也是一种 hedgehog 信号通路的有效抑制剂，对小鼠细胞和KYSE180 食管癌细胞的IC50分别为 1.5 µM 和 1 µM。它能抗肿瘤，抑制肿瘤细胞增殖并诱导细胞凋亡。
T8969	API-1 NSC177223	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	API-1 (NSC-177223) 是Akt/PKB 抑制剂，可同 PH 结构域相结合并抑制 Akt 膜易位，有效降低 Akt 的磷酸化水平。它可选择性的抑制PKB，对 PKC 和 PKA 的激活无抑制作用。它可以和 TNF 相关的凋亡诱导配体协同作用从而诱导细胞凋亡。
T1608	ADH-1 trifluoroacetate Exherin trifluoroacetate	Dehydrogenase	Metabolism
	ADH-1 trifluoroacetate (Exherin trifluoroacetate) 是一种选择性的、竞争性N-钙粘蛋白拮抗剂，具有潜在抗肿瘤和抗血管生成作用。
T10352	APTO-253 LOR-253,LT-253	Apoptosis; c-Myc; KLF	Apoptosis; Cell Cycle/Checkpoint; MAPK
	APTO-253 (LOR-253) 抑制 c-Myc 表达，稳定 G-四链体 DNA，并诱导急性髓细胞白血病细胞的细胞周期停滞和凋亡。它通过诱导 KLF4 肿瘤抑制因子介导抗癌活性，具有抗关节炎活性。
T35528L	TD52 dihydrochloride TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl	Others	Others
	TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signaling pathway, resulting in the induction of apoptosis in triple-negative breast cancer (TNBC) cells. Mechanistically, TD52 dihydrochloride disrupts the binding of Elk1 to the CIP2A promoter, effectively reducing CIP2A levels. Notably, TD52 dihydrochloride demonstrates powerful anti...
T3351	Onatasertib CC223,CC 223,CC-223	Apoptosis; c-Fms; DNA-PK; FLT; PI3K; mTOR	Angiogenesis; Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Onatasertib (CC223) 是一种口服有效的mTOR 激酶抑制剂，抑制mTOR 激酶，IC50为 16 nM。它抑制mTORC1和mTORC2。
TNU0630	2'-O-Methyl-5-iodouridine 5-Iodo-2'-O-methyluridine
	2'-O-Methyl-5-iodouridine (5-Iodo-2'-O-methyluridine) 是一种靶向惰性淋巴系统恶性肿瘤的嘌呤核苷类似物，具有广泛的抗肿瘤活性。2'-O-Methyl-5-iodouridine 的抗癌机制依赖于抑制 DNA 合成，诱导细胞凋亡 (apoptosis) 。
T1849	Momelotinib CYT11387,CYT387,LM-1149	Apoptosis; JAK; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Momelotinib (LM-1149) 是一种 ATP 竞争性的 JAK1/JAK2抑制剂，IC50值分别为 11 nM/18 nM。
T3124	Carbendazim Bavistin,Carbendazole,多菌灵,Mercarzole	Antifungal	Microbiology/Virology
	Carbendazim (Mercarzole) 是一种具有抗肿瘤活性的苯并咪唑衍生物，可用于癌症研究。它是一种口服广谱苯并咪唑杀菌剂，可作为真菌疾病研究的杀虫剂。
T19965	Dacomitinib hydrate PF 299804,:达克替尼一水合物,PF00299804,PF 00299804,PF-00299804,PF299804,PF-299804	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Dacomitinib hydrate (PF 299804) 是泛表皮生长因子受体家族酪氨酸激酶的高选择性第二代小分子抑制剂。 Dacomitinib 特异性且不可逆地结合并抑制人 EGFR 亚型，从而抑制表达 EGFR 的肿瘤细胞的增殖和诱导细胞凋亡。
T3637	Pifithrin-β hydrobromide Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)	Ferroptosis; p53	Apoptosis
	Pifithrin-β hydrobromide (Cyclic PFT-α) 是一种 p53 的抑制剂，可逆地阻断 p53 依赖性转录激活和细胞凋亡。IC50值为23 μM。
T3352	XL413	cholecystokinin; Casein Kinase; Pim; CDK	Cell Cycle/Checkpoint; Chromatin/Epigenetic; GPCR/G Protein; JAK/STAT signaling; Metabolism; Stem Cells
	XL413 是一种口服生物可利用的细胞分裂周期 7 同源物 (CDC7) 激酶抑制剂，具有潜在的抗肿瘤活性，IC50值为 3.4 nM。它对 pMCM 的 EC50值为 118 nM，对 CK2 和 PIM1 的 IC50值分别为 215 和 42 nM。
T68405	KW-2450 free base	IGF-1R	Tyrosine Kinase/Adaptors
	KW-2450 free base 是一种 IGF-1R/IR和酪氨酸激酶多重抑制剂具有抗肿瘤活性。KW-2450 free base 在小鼠 HT-29/GFP 结肠癌异种移植模型中显示出适度的生长抑制活性并抑制 IGF-1 诱导的信号转导。
T41285	N-Acetyl-L-cysteine ethyl ester NACET,N-Acetylcysteine ethyl ester	Antioxidant	oxidation-reduction
	N-Acetyl-L-cysteine ethyl ester (NACET) 是氨基酸-l-半胱氨酸的衍生物。N-Acetyl-L-cysteine ethyl ester 已被证明具有广泛的生化和生理作用，包括抑制蛋白质合成、抑制DNA 复制和诱导细胞凋亡。它还被证明具有抗炎、抗氧化和抗癌活性
T33701	NM-3 NM-3,isocoumarin,NM 3,Isocoumarin NM-3,NM3	Apoptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	NM-3 是一种可口服的抗血管生成的抑制剂，具有抗肿瘤活性。NM-3在体外和体内可当作辐射调节剂使用。NM-3抑制血管内皮生长因子（VEGF），从而抑制内皮细胞的增殖。NM-3与活性氧的机制诱导细胞凋亡有关。
T3661	Citarinostat ACY241,HDAC-IN-2	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Citarinostat (ACY241) 是一种强效、选择性和口服组蛋白脱乙酰酶 (HDAC) 抑制剂，具有抗肿瘤活性，对 HDAC1、HDAC2、HDAC3、HDAC6 和 HDAC8 的 IC50分别为 35、45、46、2.6 和 137 nM。
T16328	Nitroaspirin 2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016	Apoptosis; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	Nitroaspirin (NCX 4016) 是一氧化氮供体和阿司匹林的硝基衍生物，与 Aspirin 结合可抑制环氧合酶=，可作为 COX-1 的直接和不可逆抑制剂。它通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白，显着诱导顺铂耐药人卵巢癌细胞的细胞周期停滞和凋亡，具有抗血栓和抗血小板特性。
T3157	COH29 RNR Inhibitor COH29	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	COH29 (RNR Inhibitor COH29) 是一种口服可用的芳香族取代噻唑，是人类核糖核苷酸还原酶 (RNR) 的抑制剂，具有潜在的抗肿瘤活性。它抑制核糖核苷酸还原酶的IC50为 16 μM。
T36674	DMU-212	Apoptosis; ERK	Apoptosis; MAPK
	DMU-212 是具有口服活性的白藜芦醇的甲基化衍生物，表现出抗分裂、抗增殖、抗氧化和促进细胞凋亡的活性。它通过诱导凋亡和激活ERK1/2蛋白阻止有丝分裂。
T25275	Crambene NSC 321802,NSC-321802,NSC321802
	Crambene results in the induction of apoptosis by protects mice against acute pancreatitis via anti-inflammatory pathways.
TQ0016	NKP-1339 IT-139,KP-1339	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.
T36083	DS-7423	PI3K; mTOR	PI3K/Akt/mTOR signaling
	DS-7423 是PI3K 和mTOR 的有效抑制剂，抑制PI3Kα 和 mTOR 的IC50分别为15.6 nM 和 34.9 nM。DS-7423表现出抗癌活性。
T19779	SL-01 Z L Phe chloromethyl ketone,NSC-251810,ZLPhe chloromethyl ketone,Z-Phe-chloromethylketone
	SL-01 is an oral derivative of gemcitabine. SL-01 inhibited human breast cancer growth through the induction of apoptosis. SL-01 inhibited human cancer growth more potently than gemcitabine.
T40723	Bromoiodoacetamide
	Bromoiodoacetamide, an iodinated haloacetamide (I-HAcAm) compound, exhibits cytotoxic properties. Its mechanism of action involves the accumulation of reactive oxygen species (ROS) and induction of apoptosis in HepG-2 cells.
T71231	VMY-1-101
	VMY-1-101 is a synthesized fluorescent CDK inhibitor. VMY-1-101 demonstrates potent CDK inhibitory activity, enhanced induction of G2/M arrest and modest apoptosis as compared to purvalanol B.
T21321	MK-0731
	MK-0731, a synthetic small molecule with potential antineoplastic activity, selectively inhibits kinesin spindle protein (KSP), leading to the inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase and apoptosis in
T14554	BI-0252	Others	Others
	BI-0252 is an inhibitor of MDM2-p53 (IC50:4 nM). BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft. And it concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis.
T61137	VEGFR-2-IN-19
	VEGFR-2-IN-19 (Compound 15b) is a highly efficacious inhibitor of VEGFR2, a receptor involved in angiogenesis. Its mechanism of action involves the induction of cellular apoptosis and elevation of intracellular reactive oxygen species. Due to these properties, VEGFR-2-IN-19 holds promise as an effective anticancer agent [1].
T71034	Bizelesin
	Bizelesin is a synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis.
T70152	Miransertib mesylate
	Miransertib mesylate is a selective AKT inhibitor that binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may result in reduction in tumor cell proliferation and the induction of tumor cell apoptosis.
T36399	PAO-Nap
	PAO-Nap is a chemically modified version of PAO, in which a naphthalimide fluorophore is attached to the compound using a linker called aminocaproic acid. This modified compound, PAO-Nap, exhibits a selective targeting of thioredoxin reductase, leading to the induction of apoptosis in HL-60 cells through oxidative stress mechanisms[1].
T75212	Confiden
	Confiden 为一种嘌呤核苷类似物，广泛抗肿瘤活性，针对惰性淋巴系统恶性肿瘤。其抗癌机制通过抑制DNA合成及诱导细胞凋亡(apoptosis)实现。
T75066	N1-Methylxylo-guanosine
	N1-Methylxylo-guanosine 为一种具备广泛抗肿瘤活性的嘌呤核苷类似物，主要针对惰性淋巴系统恶性肿瘤。其抗癌机制涉及抑制 DNA 合成与诱导细胞凋亡(apoptosis)。
T75036	N1-(2-Methyl)propyl pseudouridine
	N1-(2-Methyl)propyl pseudouridine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物，主要用于靶向惰性淋巴系统恶性肿瘤。其抗癌机制包括抑制 DNA 合成和诱导细胞凋亡（apoptosis）。
T68536	WP-1034
	WP-1034 is a novel Jak-Stat inhibitor, which is active against AML blasts. WP-1034 effectively inhibited proliferation of OCIM2 cells and fresh AML samples. WP-1034 caused cell cycle arrest of OCIM2 cells in sub-Go phase. WP-1034 induced apoptosis of OCIM2 cells and that induction of apoptosis involved cleavage of caspase 3 and the DNA repair enzyme poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP).
T75033	Adenosine-2-carboxy methyl amide
	Adenosine-2-carboxy methyl amide为一种嘌呤核苷类似物，其抗肿瘤活性广泛，尤其针对惰性淋巴系统恶性肿瘤。其作用机制主要通过抑制DNA合成及诱导细胞凋亡（apoptosis）实现。
T75211	Confidential-2
	Confidential-2 为嘌呤核苷类似物，具广泛抗肿瘤活性，靶向惰性淋巴系统恶性肿瘤。其抗癌机制通过抑制 DNA 合成及诱导细胞凋亡（apoptosis）实现。
T61584	ASK1-IN-3
	ASK1-IN-3 is a highly potent and selective inhibitor of ASK1 kinase, demonstrating an IC 50 of 33.8 nM. This compound also exhibits inhibitory effects on various cell cycle regulating kinases. ASK1-IN-3 showcases remarkable induction of apoptosis in HepG2 cancer cells and displays potent activity in arresting the cell cycle [1].
T75087	Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester
	Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester 为一种嘌呤核苷类似物，广泛显示出抗肿瘤活性，并针对惰性淋巴系统恶性肿瘤。其抗癌机制主要通过抑制DNA合成和诱导细胞凋亡(apoptosis)实现。
T75053	3’-β-C-Methyl-2-thiouridine
	3’-β-C-Methyl-2-thiouridine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物，主要通过抑制DNA合成及诱导细胞凋亡（apoptosis）等机制，靶向惰性淋巴系统恶性肿瘤。
T35542	LLP-3
	Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 μM). It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.
T75034	N1-Methylsulfonyl pseudouridine
	N1-Methylsulfonyl pseudouridine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物，主要针对惰性淋巴系统恶性肿瘤。其抗癌机制涉及抑制 DNA 合成和诱导细胞凋亡（apoptosis）。
T12003	Mensacarcin	Others	Others
	Mensacarcin, a highly complex polyketide compound, exhibits multifaceted effects on cellular processes. Specifically, it targets mitochondria, perturbs energy metabolism within these organelles, and activates caspase-dependent apoptotic pathways. Functionally, Mensacarcin can serve as a cytotoxic constituent in antibody-drug conjugates (ADCs). Furthermore, this antibiotic compound displays broad-spectrum inhibition of cell growth across various cancer cell lines and demonstrates potent induction...
T26817	Bim-BLK-A Bim Blocker A,Compound A,Bim BLK A,BimBLKA
	Bim-BLK-A efficiently blocks Bim-induced apoptosis after Bax is activated on the mitochondria. The cellular target of Bim-BLK-A was identified to be the succinate dehydrogenase subunit B (SDHB) protein of complex II of the mitochondrial electron transfer
T75038	N1-Benzoyl pseudouridine
	N1-Benzoyl pseudouridine 是嘌呤核苷类似物，广泛应用于靶向惰性淋巴系统恶性肿瘤的抗肿瘤活性中。其抗癌机制主要通过抑制DNA合成和诱导细胞凋亡(apoptosis)实现。

化合物

Cat.No: T2051

Synonym: FLT3-IN-1,FLT3-IN-1

Target: FLT

Cat.No: T11209

Target: DUB

5'-Amino-5'-deoxyadenosine

Cat.No: T21017

Synonym: 5' Amino 5' deoxyadenosine,5'Amino5'deoxyadenosine,Nsc 238990,NH2dAdo

Target: Apoptosis, Adenosine Receptor

Sodium 4-phenylbutyrate

Cat.No: T1535

Synonym: 苯丁酸钠,Sodium Phenylbutyrate,Buphenyl,4-苯基丁酸钠盐,TriButyrate

Target: Apoptosis, HDAC, Autophagy

Cat.No: T6017

Synonym: OSI-906,林西替尼

Target: IGF-1R

Cat.No: T6891

Target: Apoptosis, Hedgehog/Smoothened, Smo

Cat.No: T8969

Synonym: NSC177223

Target: Akt

ADH-1 trifluoroacetate

Cat.No: T1608

Synonym: Exherin trifluoroacetate

Target: Dehydrogenase

Cat.No: T10352

Synonym: LOR-253,LT-253

Target: Apoptosis, c-Myc, KLF

TD52 dihydrochloride

Cat.No: T35528L

Synonym: TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl

Target: Others

Cat.No: T3351

Synonym: CC223,CC 223,CC-223

Target: Apoptosis, c-Fms, DNA-PK, FLT, PI3K, mTOR

2'-O-Methyl-5-iodouridine

Cat.No: TNU0630

Synonym: 5-Iodo-2'-O-methyluridine

Cat.No: T1849

Synonym: CYT11387,CYT387,LM-1149

Target: Apoptosis, JAK, Autophagy

Cat.No: T3124

Synonym: Bavistin,Carbendazole,多菌灵,Mercarzole

Target: Antifungal

Dacomitinib hydrate

Cat.No: T19965

Synonym: PF 299804,:达克替尼一水合物,PF00299804,PF 00299804,PF-00299804,PF299804,PF-299804

Target: EGFR

Pifithrin-β hydrobromide

Cat.No: T3637

Synonym: Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)

Target: Ferroptosis, p53

Cat.No: T3352

Target: cholecystokinin, Casein Kinase, Pim, CDK

KW-2450 free base

Cat.No: T68405

Target: IGF-1R

N-Acetyl-L-cysteine ethyl ester

Cat.No: T41285

Synonym: NACET,N-Acetylcysteine ethyl ester

Target: Antioxidant

Cat.No: T33701

Synonym: NM-3,isocoumarin,NM 3,Isocoumarin NM-3,NM3

Target: Apoptosis, Reactive Oxygen Species

Cat.No: T3661

Synonym: ACY241,HDAC-IN-2

Target: HDAC

Cat.No: T16328

Synonym: 2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016

Target: Apoptosis, COX

Cat.No: T3157

Synonym: RNR Inhibitor COH29

Target: DNA/RNA Synthesis

Cat.No: T36674

Target: Apoptosis, ERK

Cat.No: T25275

Synonym: NSC 321802,NSC-321802,NSC321802

Cat.No: TQ0016

Synonym: IT-139,KP-1339

Target: DNA/RNA Synthesis

Cat.No: T36083

Target: PI3K, mTOR

Cat.No: T19779

Synonym: Z L Phe chloromethyl ketone,NSC-251810,ZLPhe chloromethyl ketone,Z-Phe-chloromethylketone

Bromoiodoacetamide

Cat.No: T40723

Cat.No: T71231

Cat.No: T21321

Cat.No: T14554

Target: Others

Cat.No: T61137

Cat.No: T71034

Miransertib mesylate

Cat.No: T70152

Cat.No: T36399

Cat.No: T75212

N1-Methylxylo-guanosine

Cat.No: T75066

N1-(2-Methyl)propyl pseudouridine

Cat.No: T75036

Cat.No: T68536

Adenosine-2-carboxy methyl amide

Cat.No: T75033

Cat.No: T75211

Cat.No: T61584

Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester

Cat.No: T75087

3’-β-C-Methyl-2-thiouridine

Cat.No: T75053

Cat.No: T35542

N1-Methylsulfonyl pseudouridine

Cat.No: T75034

Cat.No: T12003

Target: Others

Cat.No: T26817

Synonym: Bim Blocker A,Compound A,Bim BLK A,BimBLKA

N1-Benzoyl pseudouridine

Cat.No: T75038

Cat. No.	Product Name	Target	Signaling Pathways
T6S0234	Toosendanin	Others	Others
	Toosendanin 是一种从杜鹃花果实皮中提取的三萜，具有杀虫和抗炎活性，可用于研究缓解疼痛。
TMS0484	Episyringaresinol 4'-O-β-D-glncopyranoside (-)-丁香树脂酚-4-O-β-D-葡萄糖苷,(-)-Syringaresinol 4-O-β-D-glucopyranosi	Others	Others
	Episyringaresinol 4'-O-β-D-glncopyranoside ((-)-Syringaresinol 4-O-β-D-glucopyranosi) 是一种天然的潜在神经炎症抑制剂，分离自鼠尾草 (Alhagi sparsifoliaShap) 。
TJS0487	(-)-Syringaresinol DL-Syringaresinol,Lirioresinol b,(-)-丁香脂素	Others	Others
	(-)-Syringaresinol (DL-Syringaresinol) 来源于番荔枝 Annona Montana 的茎。 (-)-Syringaresinol 通过 G1 期阻滞和诱导细胞凋亡来抑制人早幼粒细胞 HL-60 细胞的增殖，并具有抗癌活性。
TN1461	(-)-Butin Butin,漆黄素 ( 紫铆素)	Akt; PI3K; Nrf2	Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling
	(-)-Butin (Butin) 是 Butin 的 S 对映体。其中 Butin 是一种分离自黄檀的心材中的生物活性黄酮类化合物，具有显著的抗血小板、抗氧化、抗炎作用。
T2S0886	Terrestrosin D	Apoptosis; Others	Apoptosis; Others
	Terrestrosin D 是从刺蒺藜中提取得到一种的甾体皂苷，可诱导细胞周期阻滞和癌细胞凋亡，具有抗血管生成的活性。
T5S1607	Morusin Mulberrochromene,桑辛素	NF-κB; Antibacterial; STAT	JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells
	Morusin (Mulberrochromene) 是从M. australis 分离的去乙烯基化黄酮，可抑制NF-κB 和STAT3的活性，具有抗菌、抗肿瘤、抗氧化等各种生物活性。
T5S1285	(+)-(3R,8S)-Falcarindiol Falcarindiol,镰叶芹二醇	Others	Others
	(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔，有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用，对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。
T3S1227	Aristolactam I Aristolactam,Aristololactam I,马兜铃内酰胺I,Aristololactum	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Aristolactam I (Aristololactum) 是马兜铃酸 I (AA-I) 的主要代谢产物，参与导致肾损伤的过程。它具有细胞毒性，通过诱导半胱天冬酶 3 依赖性途径中的细胞凋亡介导。
TN1804	Isosilybin A 异水飞蓟素 A,异水飞蓟宾A,水飞蓟素 B2	Apoptosis; Tyrosinase; PPAR; ABC	Apoptosis; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome
	Isosilybin A 是从水飞蓟中分离出来的一种黄酮木脂素，可抑制癌细胞增殖并诱导 G1 期停滞和凋亡，通过靶向 Akt-NF-κB-雄激素受体轴激活前列腺癌细胞的凋亡机制，具有抗前列腺癌活性。
T3S0081	Oxypeucedanin (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin	Potassium Channel	Membrane transporter/Ion channel
	Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物，分离自Angelica dahurica。它是选择性开放通道阻滞剂，可抑制hKv1.5通道电流，IC50值为 76 nM。它延长心脏动作电位持续时间，是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。
TWS2045	Bruceine D 鸦胆子素D,鸦胆子苦素D	Apoptosis; Antiviral; Gamma-secretase; Parasite	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Bruceine D 是Notch 抑制剂，有抗癌活性，诱导几种人癌细胞调亡。它是一种有效的植物性昆虫拒食剂，有显著的系统特性和抑制害虫生长的作用。它具有较强的驱虫活性，抑制D. intermedius 的 EC50值为 0.57 mg/L。
T6S2391	L-Chicoric Acid (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	L-Chicoric Acid (trans-Caffeoyltartaric acid) 是一种二咖啡酰酒石酸，是一种选择性可逆的 HIV-1 整合酶抑制剂，IC50约为 100 nM。它还可抑制 HIV-1 复制。
T4S2126	Ginkgetin 银杏双黄酮,银杏素	Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Ginkgetin 是从银杏叶中分离得到的一种双黄酮，具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂，IC50值为 5.92 μM。
T3229	Cytochalasin D	ATPase; p38 MAPK; Calcium Channel; Akt; PI3K	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit
T6S0525	Farrerol	ERK; p38 MAPK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Farrerol 是一种杜鹃花的生物活性成分，具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。
T3877	Esculentoside A	NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Esculentoside A 是一种三萜皂苷，从商陆根部分离得到。它在具有抗炎活性，对环氧合酶-2 具有选择性抑制活性。它通过抑制NF-κB 和丝裂原活化蛋白激酶信号通路抑制 LPS 诱导的急性肺损伤中的炎症反应。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
T3S0027	Picropodophyllotoxin AXL 1717,Picropodophyllin,苦鬼臼毒素	IGF-1R	Tyrosine Kinase/Adaptors
	Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱，存在于五月树(Podophyllum peltatum) 中，是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达，而不干扰其他生长因子受体的活性，例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) ）。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶，在多种癌细胞的生长和存活中起关键作用。
TN3937	ent-16alpha,17-Dihydroxyatisan-3-one	P-gp	Membrane transporter/Ion channel; Neuroscience
	ent-16alpha,17-Dihydroxyatisan-3-one and ent-16alpha,17-dihydroxykauran-3-one have apoptosis induction activities on L5178 human MDR1 gene-transfected mouse lymphoma cells.
T13764	Lycopodine	Lipoxygenase; Caspase	Apoptosis; Metabolism; Proteases/Proteasome
	Lycopodine, a bioactive compound derived from Lycopodium clavatum spores, effectively inhibits the proliferation of HeLa cells through the induction of apoptosis. This process is mediated by caspase-3 activation. In refractory prostate cancer cells, Lycopodine triggers apoptosis by modulating 5-lipoxygenase and depolarizing the mitochondrial membrane potential, without altering p53 activity.
TN2400	alpha-Terthienylmethanol	Others	Others
	Alpha-terthienylmethanol possesses potent cytotoxic activity against human endometrial cancer cells; it inhibits growth mediated by the induction of apoptosis, as shown by the accumulation of sub-G1 and apoptotic cells.
TN1572	Desacetylcinobufotalin	Others	Others
	Desacetylcinobufotalin has significant antitumor activity through induction apoptosis via mitochondria pathway, it also shows potent cytotoxic activities against HL-60 cell lines.
TN1442	Betulinic acid methyl ester	Antifection	Microbiology/Virology
	Betulinic acid methyl ester showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro.It also inhibited B16 2F2 cell proliferation by induction of apoptosis.
TN4132	Germanicol
	Germanicol induces selective growth inhibitory effects in human colon HCT-116 and HT29 cancer cells through induction of apoptosis, cell cycle arrest and inhibition of cell migration. Germanicol may have anti-inflammatory effects .
TN1211	2-Hydroxy-3-methylanthraquinone	ERK; p38 MAPK; Caspase	Apoptosis; MAPK; Proteases/Proteasome
	2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activation mediated apoptotic induction.
T11201	Enniatin A1 恩镰孢菌素 A1	ERK	MAPK
	Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes. Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids.
T75704	Isoharringtonine
	Isoharringtonine，一种从Cephalotaxus koreanaNakai 纯化得到的天然生物碱，具有抑制癌细胞增殖和迁移的能力，同时能诱导癌细胞(apoptosis)。该化合物在癌症研究中应用。
TN2529	1-Decarboxy-3-oxo-ceanothic acid	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	1-Decarboxy-3-oxo-ceanothic acid shows in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, the cytotoxic effect is mediated, at least in part, by the induction of apoptosis. It shows cytotoxic against OVCAR-3 and HeLa cancer cell line
T72802	Spongionellol A
	Spongionellol A 是一种 MDR1(p-糖蛋白) 抑制剂。Spongionellol A 通过诱导 caspase 依赖性的凋亡 (apoptosis) 而对前列腺癌细胞具有较强的细胞毒活性和选择性。Spongionellol A 可用于癌症的研究，如前列腺癌。
TN5050	Sprengerinin C	NADPH-oxidase; VEGFR; p38 MAPK; ROS; Akt; PI3K; mTOR; p53	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein endothelial cells, it blocks vascul
T75424	(±)-Evodiamine
	(±)-Evodiamine，一种天然生物碱，作为Top1的抑制剂，展现了抗炎、抗肥胖及抗肿瘤特性。(±)-Evodiamine能够通过诱导细胞凋亡来抑制多种肿瘤细胞的增殖。
T72737	Ganoderic acid R
	Ganoderic acid R为一种高效的抗癌化合物，通过促进肿瘤细胞系的凋亡(apoptosis)机制来抑制其生长。它对多药耐药(MDR)肿瘤细胞系(KB-A-1/Dox)及敏感肿瘤细胞系(KB-A-1)展现出显著的细胞毒性效应。
TN4277	Isocupressic acid	cAMP; P450; PKA	GPCR/G Protein; Metabolism; Tyrosine Kinase/Adaptors
	Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reproductive system, the decrease in blood flow and apoptosis of corpus luteum-derived endothelial ce
TN5414	Wallichinine
	Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significa
TN3364	Agrimonolide	Apoptosis; Dehydrogenase; p38 MAPK; ROS; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; MAPK; Metabolism; Stem Cells
	Agrimonolide 是一种来自异香豆素的化合物，主要存在于草药Agrimonia pilosa Ledeb 中，具有显著的生物活性。Agrimonolide 通过抑制脂多糖（LPS）诱导的JAK-STATs 和p38 MAPKs 信号通路的激活而发挥抗炎作用。Agrimonolide 及其衍生物去甲阿戈莫内德已显示出能够有效提高肝细胞中胰岛素介导的糖原水平，可能在调节胰岛素抵抗的HepG2细胞中发挥关键作用。Agrimonolide 通过靶向卵巢癌细胞中的SCD1，对癌症的进展和诱导细胞死亡和凋亡表现出抑制作用。特别是，Agrimonolide 对A2780和SKOV-3细胞的增殖、迁移和侵袭表现出剂量依赖性的抑制，同时促进细胞凋亡。该化合物还被发现能诱导铁介导的细胞死亡，同时增加活性氧（ROS）和总铁的水平。Agrimonolide 很容易穿过血脑屏障，表明其在神经系统疾病的治疗应用方面具有潜力。

天然产物

Cat.No: T6S0234

Target: Others

Episyringaresinol 4'-O-β-D-glncopyranoside

Cat.No: TMS0484

Synonym: (-)-丁香树脂酚-4-O-β-D-葡萄糖苷,(-)-Syringaresinol 4-O-β-D-glucopyranosi

Target: Others

(-)-Syringaresinol

Cat.No: TJS0487

Synonym: DL-Syringaresinol,Lirioresinol b,(-)-丁香脂素

Target: Others

Cat.No: TN1461

Synonym: Butin,漆黄素 ( 紫铆素)

Target: Akt, PI3K, Nrf2

Cat.No: T2S0886

Target: Apoptosis, Others

Cat.No: T5S1607

Synonym: Mulberrochromene,桑辛素

Target: NF-κB, Antibacterial, STAT

(+)-(3R,8S)-Falcarindiol

Cat.No: T5S1285

Synonym: Falcarindiol,镰叶芹二醇

Target: Others

Cat.No: T3S1227

Synonym: Aristolactam,Aristololactam I,马兜铃内酰胺I,Aristololactum

Target: Apoptosis, Caspase

Cat.No: TN1804

Synonym: 异水飞蓟素 A,异水飞蓟宾A,水飞蓟素 B2

Target: Apoptosis, Tyrosinase, PPAR, ABC

Cat.No: T3S0081

Synonym: (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin

Target: Potassium Channel

Cat.No: TWS2045

Synonym: 鸦胆子素D,鸦胆子苦素D

Target: Apoptosis, Antiviral, Gamma-secretase, Parasite

L-Chicoric Acid

Cat.No: T6S2391

Synonym: (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸

Target: Others, HIV Protease

Cat.No: T4S2126

Synonym: 银杏双黄酮,银杏素

Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy

Cat.No: T3229

Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K

Cat.No: T6S0525

Target: ERK, p38 MAPK, Akt

Esculentoside A

Cat.No: T3877

Target: NF-κB, COX

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

Picropodophyllotoxin

Cat.No: T3S0027

Synonym: AXL 1717,Picropodophyllin,苦鬼臼毒素

Target: IGF-1R

ent-16alpha,17-Dihydroxyatisan-3-one

Cat.No: TN3937

Target: P-gp

Cat.No: T13764

Target: Lipoxygenase, Caspase

alpha-Terthienylmethanol

Cat.No: TN2400

Target: Others

Desacetylcinobufotalin

Cat.No: TN1572

Target: Others

Betulinic acid methyl ester

Cat.No: TN1442

Target: Antifection

Cat.No: TN4132

2-Hydroxy-3-methylanthraquinone

Cat.No: TN1211

Target: ERK, p38 MAPK, Caspase

Cat.No: T11201

Synonym: 恩镰孢菌素 A1

Target: ERK

Isoharringtonine

Cat.No: T75704

1-Decarboxy-3-oxo-ceanothic acid

Cat.No: TN2529

Target: DNA/RNA Synthesis

Spongionellol A

Cat.No: T72802

Cat.No: TN5050

Target: NADPH-oxidase, VEGFR, p38 MAPK, ROS, Akt, PI3K, mTOR, p53

(±)-Evodiamine

Cat.No: T75424

Ganoderic acid R

Cat.No: T72737

Isocupressic acid

Cat.No: TN4277

Target: cAMP, P450, PKA

Cat.No: TN5414

Cat.No: TN3364

Target: Apoptosis, Dehydrogenase, p38 MAPK, ROS, JAK

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