449
59
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T23291 |
(S)-3-Hydroxyphenylglycine
|
GluR | Neuroscience |
(S)-3-Hydroxyphenylglycine 是 I 组代谢型谷氨酸受体 (mGluRs) 的激动剂。 | |||
T38311 |
(S)-3-Thienylglycine
|
Others | Others |
(S)-3-Thienylglycine 是一种噻吩衍生物,可用于研究与噻吩衍生物相似结构的遗传毒性。 | |||
T83646 |
(S)-OSMI 3
Ent-OSMI-3 |
Others | Others |
(S)-OSMI 3 (Ent-OSMI-3) 具有抗炎抗肿瘤活性,可用以研究糖尿病和神经退行性疾病。 | |||
T7401 |
(S)-3-AMino-2-Methylpropanoic acid-HCl
|
Others | Others |
(S)-3-AMino-2-Methylpropanoic acid-HCl 是一种氨基酸衍生物,是兴奋性神经递质谷氨酸的激动剂,影响神经系统。 | |||
T67926 |
(S)-(+)-N-3-Benzylnirvanol
ZSN-76403 |
P450; HIV Protease | Metabolism; Microbiology/Virology; Proteases/Proteasome |
(S)-(+)-N-3-Benzylnirvanol (ZSN-76403) 是一种细胞色素P450 CYP2C19抑制剂,IC50值为0.179 µM,可用于研究艾滋病毒感染。 | |||
T9281 |
(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide
|
Others | Others |
(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide 是一种大麻素受体拮抗剂/反向激动剂。 | |||
T60035 |
(S)-5-chloro-N-(1-((4-chlorophenyl)amino)-1-oxo-3-phenylpropan-2-yl)-2-hydroxybenzamide
|
Antibiotic; Antifungal | Microbiology/Virology |
(S)-5-chloro-N-(1-((4-chlorophenyl)amino)-1-oxo-3-phenylpropan-2-yl)-2-hydroxybenzamide 具有抗真菌和抗结核活性。 | |||
T60186 |
(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide
|
Discoidin Domain Receptor (DDR) | Tyrosine Kinase/Adaptors |
MitoBloCK-6 是一种有效的 Erv1/ALR 抑制剂,IC50 分别为 900 nM 和 700 nM。MitoBloCK-6 还抑制 Erv2 (IC50=1.4 μM)。MitoBloCK-6 可通过细胞色素 c 的释放诱导 hESCs 细胞凋亡。 | |||
T20789 |
S-23
(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide,S23 |
Androgen Receptor | Endocrinology/Hormones |
S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) 是口服选择性雄激素受体调节剂(Ki:1.7 nM)。它能够诱导 CV-1 细胞雄激素受体介导的转录激活,提高去势大鼠前列腺、精囊和肛提肌重量。 | |||
T15076 |
DBCO-S-S-PEG3-biotin
生物素-PEG3-二硫-DBCO |
Others; PROTAC Linker | Others; PROTAC |
DBCO-S-S-PEG3-biotin 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T77597 |
SXC 2023
(S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid |
Others | Others |
SXC 2023 ((S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid) 是一种可治疗中枢神经疾病和神经认知障碍的N-乙酰-L-半胱氨酸的前药,可用于治疗谷氨酸能功能障碍和氧化应激起关键作用的精神疾病。 | |||
T18656 |
S-acetyl-PEG2-Boc
Tert-Butyl 3-[2-(2-Acetylsulfanylethoxy)Ethoxy]Propanoate,S-Acetyl-PEG2-T-Butyl Ester |
Others; PROTAC Linker | Others; PROTAC |
S-acetyl-PEG2-Boc (S-Acetyl-PEG2-T-Butyl Ester) 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T12791 |
(S)-3-Hydroxy Midostaurin
(S)-CGP52421 |
Others | Others |
(S)-3-Hydroxy Midostaurin is a potent inhibitor of kinases(IC50 of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et)). | |||
T9280 |
CS-0047390
(S)-Di-tert-butyl 2-(3-((S)-6-amino-1-(tert-butoxy)-1-oxohexan-2-yl)ureido)pentanedioate |
Others | Others |
CS-0047390 ((S)-Di-tert-butyl 2-(3-((S)-6-amino-1-(tert-butoxy)-1-oxohexan-2-yl)ureido)pentanedioate)又称 tert-Butyl-DCL,PSMA 抑制剂,是一种放射显影多肽试剂。 | |||
T22487 | (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 | Others | Others |
somatostatin sst2 receptor agonist | |||
T17920 |
(S,R,S)-AHPC-PEG1-N3
VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3 |
Others; Ligand for E3 Ligase | Others; PROTAC |
(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) 是 E3 连接酶配体和linker 连接得到的 偶联物,包含基于 (S,R,S)-AHPC 的 VHL 配体和 1 个单元 PEG linker。 | |||
T34471 |
S-(3-Carboxypropyl)-L-cysteine
|
||
S-(3-Carboxypropyl)-L-cysteine is a thioether derivative of L-cysteine. | |||
T39494 |
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH,(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH |
||
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH, also known as VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH, is a conjugate compound comprising a ligand-linker that targets E3 ligase and, on one end, features a VHL ligand. It is employed in PROTAC technology applications. | |||
T27503L |
GV-150013X
(S)-1-(1-(adamantan-1-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-3-phenylurea |
cholecystokinin | GPCR/G Protein |
GV-150013X ((S)-1-(1-(adamantan-1-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-3-phenylurea) 是一种有效的CCKB 拮抗剂,pKi= 9.02。 | |||
T23290 | (S)-3-Carboxy-4-hydroxyphenylglycine | Others | Others |
group I metabotropic glutamate receptor antagonist and group II mGlu agonist | |||
T6156 |
Ruxolitinib (S enantiomer)
S-Ruxolitinib,环丙基[4-[3-(1H-咪唑-5-基)丙氧基]苯,Ruxolitinib S enantiomer,INCB018424,INCB18424 |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Ruxolitinib S enantiomer (INCB18424) 是 Ruxolitinib 的 S 型对映体,是一种JAK 抑制剂。 | |||
T12961 |
Sofosbuvir impurity F
索非布韦杂质 F,Sofosbuvir 3',5'-Bis-(S)-phosphate |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Sofosbuvir impurity F (Sofosbuvir 3',5'-Bis-(S)-phosphate) 既是 Sofosbuvir 的非对映异构体,也是 Sofosbuvir 的杂质,Sofosbuvir 是 HCV RNA 复制的抑制剂。 | |||
T77706 |
4-Borono-L-phenylalanine
(s)-2-amino-3-(4-boronophenyl)propanoic acid,L-p-Boronophenylalanine |
Others | Others |
4-Borono-L-phenylalanine 具有抗肿瘤活性,可用于硼中子俘获疗法治疗黑色素瘤和多形性胶质母细胞瘤的临床试验。 | |||
T17924 |
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
VH032-PEG2-NH2 hydrochloride,VHL Ligand-Linker Conjugates 3 hydrochloride,E3 ligase Ligand-Linker Conjugates 6 |
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
(S,R,S)-AHPC-PEG2-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 6) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物,可用于 PROTAC 的合成分子。 | |||
T1689 |
Enalapril IMpurity B
(+)-N-[1-(S)-Ethoxycarbonxyl-3-phenylpropyl]-L-alanine,依那普利杂质B |
Others | Others |
Enalapril IMpurity B ((+)-N-[1-(S)-Ethoxycarbonxyl-3-phenylpropyl]-L-alanine) 是 Moexipril 中间体,是 Imidapril 的主要代谢物。 | |||
T16834 |
S26131
N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide |
MT Receptor | Neuroscience |
S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) 是一种选择性的褪黑激素配体 MT1 和 MT2 拮抗剂,对 MT1 和 MT2 的 Ki 值分别为 0.5 和 112 nM。 | |||
T23321 |
SB 328437
(S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate,ZINC29222893 |
CCR | Immunology/Inflammation; Microbiology/Virology |
SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate)是一种有效和选择性的CCR3拮抗剂(IC50 = 4.5 nM)。 | |||
T11284 |
FIDAS-3
|
Others; Wnt/beta-catenin; Methionine Adenosyltransferase (MAT) | Chromatin/Epigenetic; Cytoskeletal Signaling; Others; Stem Cells |
FIDAS-3 是一种强效Wnt 抑制剂,也是一种二苯乙烯衍生物,对甲硫氨酸腺苷转移酶 2A (MAT2A) 的IC50为 4.9 μM。它能够与 S-腺苷甲硫氨酸有效竞争MAT2A 结合,并具有抗癌作用。 | |||
T29522L |
(S)-ABT 102
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
N-[(1S)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea 是一种有效的TRPV1拮抗剂,其IC50为123 nM,可阻断capsaicin 对TRPV1的激活。 | |||
T60002 |
DC-S239
|
Histone Methyltransferase | Chromatin/Epigenetic |
DC-S239 (DC-S239) 是一种选择性的组蛋白甲基转移酶 SETD7 抑制剂 (IC50 = 4.59 μM),具有抗癌活性。 | |||
T17909 |
(S,R,S)-AHPC-PEG3-N3
VHL Ligand-Linker Conjugates 8,VH032-PEG3-N3,E3 ligase Ligand-Linker Conjugates 12 |
Others; E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase | Others; PROTAC |
(S,R,S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 3 个单元 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T40376 |
L-Phenylalanine-15N
L-苯丙氨酸 15N,(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) 是 15N 标记的 L-Phenylalanine。L-Phenylalanine 是从大肠杆菌中分离出来的一种必需氨基酸。 L-Phenylalanine 广泛用于食品香精和药物的生产。 | |||
T7353 |
RSV604
(S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea |
RSV | Microbiology/Virology |
RSV604 ((S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea) 是一种呼吸道合胞病毒抑制剂,可与 RSV 核蛋白结合,靶向核衣壳蛋白的 Kd 值为 1.6 μM。它对 RSV A 和 B 亚型的众多临床分离株有亚微摩尔活性,EC50平均值为 0.8 μM。 | |||
T1484L |
Perindopril erbumine
培哚普利叔丁胺,培哚普利叔丁胺盐,S9490-3,Perindopril tert-butylamine salt |
Apoptosis; RAAS; MRP | Apoptosis; Endocrinology/Hormones; Immunology/Inflammation |
Perindopril erbumine (S9490-3) 是一种长效血管紧张素转换酶抑制剂。 | |||
T19647 |
PNU-105368
PNU105368,(S)-5-(氨基甲基)-3-(3-氟-4-吗啉基苯基)-2-唑烷酮 |
Others | Others |
PNU-105368是一种生物活性化学物质,可用于生命科学领域相关研究。 | |||
T37485 |
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC
|
||
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC by 15-lipoxygenase (15-LO). | |||
T37284 |
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE
|
||
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. It is formed in human peripheral monocytes activated by the calcium ionophore A23187 by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-LO. Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes. | |||
T7716 |
TNCA
(S)-2,3,4,9-四氢-1H-吡啶[3,4-B]吲哚-3-羧酸,Lycoperodine-1 |
Others | Others |
TNCA (Lycoperodine-1) 是一种具有共激动剂活性的高亲和力 CaSR 配体 (CaSRL)。 | |||
T37486 |
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC
|
||
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is toxic to human umbilical vein endothelial cells (HUVECs) when used at a concentration of 100 μM. | |||
T37487 |
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
|
||
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3. | |||
T12808 |
S-Nitroso-N-acetyl-DL-penicillamine
N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸,SNAP |
NO Synthase | Immunology/Inflammation |
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) 是一种稳定的血小板聚集抑制剂,是一氧化氮的供体。 | |||
T8651 |
CAL-101
(S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one,GS-1101,Idelalisib |
PI3K | PI3K/Akt/mTOR signaling |
CAL-101 (Idelalisib) 是 p110δ 的选择性抑制剂(IC50:2.5 nM;在无细胞试验中);显示对 p110δ 的选择性比 p110α/β/γ 高 40 到 300 倍,对 p110δ 的选择性比 C2β、hVPS34、DNA-PK 和 mTOR 高 400 到 4000 倍。 | |||
T17922 |
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
VHL Ligand-Linker Conjugates 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 5,VH032-PEG3-NH2 hydrochloride,VHL Ligand-Linker Conjugates 1 HCl |
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) 是一种 E3 ligase ligand-linker conjugate,包含了 (S,R,S)-AHPC-based VHL ligand 和 3-unit PEG linker。 | |||
T21544 |
AZD-5597
(S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone |
CDK | Cell Cycle/Checkpoint |
AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) 是一种有效的咪唑嘧啶酰胺 CDK 抑制剂。 | |||
T12628 |
(R)-MG-132
(S,R,S)-(-)-MG-132,N-[(苯基甲氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲酰基-3-甲基丁基]-D-亮氨酰胺,Z-Leu-D-leu-leu-al |
Proteasome | Proteases/Proteasome; Ubiquitination |
(R)-MG-132 (Z-Leu-D-leu-leu-al) 是一种 MG-132 的对映异构体,是一种蛋白酶体 (proteasome) 抑制剂,细胞毒性比 MG-132 弱,是一种比 MG-132 更有效的proteasome 抑制剂。 | |||
T11122 |
DUPA(OtBu)-OH
(S)-5-叔丁氧基-4-(3-((S)-1,5-二-叔丁氧基-1,5-二氧代-2-戊基)脲啶)-5-氧代戊酸 |
Others | Others |
DUPA(OtBu)-OH 是DUPA 前体。其中 DUPA 是传递 Docetaxel (DTX) 的靶向基序,可用于表达前列腺特异性膜抗原的前列腺肿瘤的研究。 | |||
T66645 |
Fmoc-His-OH
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanoic acid,(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-histidine,FMOC-L-Histidine |
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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanoic acid 是一种组氨酸衍生物。 | |||
T9304 |
(S)-Sunvozertinib
N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008 |
EGFR; HER | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
(S)-Sunvozertinib (DZD9008) 是 Sunvozertinib 的 S-对映体,能够抑制EGFR 外显子 20 NPH 和 ASV 插入、EGFR L858R/T790M 突变及 Her2 外显子 20 YVMA 插入,也能够抑制BTK。 | |||
T21357 |
Ibrutinib Interm 0441
(S)-1-Boc-3-hydroxypiperidine,(S)-1-Boc-3-piperidinol |
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Ibrutinib Interm 0441 is a piperidine derivative with an amine protecting group and may be used in the preparation of biologically active compounds. | |||
T23294 |
(S)-4C3HPG
|
Others | Others |
group I mGlu1a/1a receptor antagonist and mGluR2 agonist |
Cat. No. | Product Name | Target | Signaling Pathways |
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T13979 |
(S)-3-Hydroxybutanoic acid
L-β-Hydroxybutyric acid,(S)-β-Hydroxybutanoic acid,L-(+)-3-Hydroxybutyric acid,(S)-3-羟基丁酸 |
Endogenous Metabolite | Metabolism |
(S)-3-Hydroxybutanoic acid (L-(+)-3-Hydroxybutyric acid) 是一种正常的人体代谢产物,在患有抑郁症的老年患者中升高。它在人类的肝脏中由乙酰-CoA 合成,当血糖低时能够被脑用作能量来源。 | |||
T39887 |
(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid
(S)-3-(4-羟苯基)乳酸,(S)-3-(4-Hydroxyphenyl)lactic acid,(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid |
Others | Others |
(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid ((S)-3-(4-Hydroxyphenyl)lactic acid) 是分离自间肠隐球菌培养基的代谢物,具有高的 DPPH 清除自由基活性和抗氧化活性。 | |||
T5290 |
(S)-2-Hydroxy-3-phenylpropanoic acid
L-(−)-3-Phenyllactic acid,L-3-苯乳酸 |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) 是苯丙氨酸的代谢产物。苯丙酮尿症患者体液中苯丙氨酸的水平升高。 | |||
T2760 |
(S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate
Iodogorgoic acid,apothyrin,jodgorgon,3,5-Diiodotyrosine Dihydrate,双碘酪氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate (jodgorgon) 是内源性代谢产物的一种。 | |||
T5764 |
Alliin
蒜氨酸,(S)-3-(Allylsulphinyl)-L-alanine |
NF-κB; PPAR | DNA Damage/DNA Repair; Metabolism; NF-κB |
Alliin ((S)-3-(Allylsulphinyl)-L-alanine) 是一种从大蒜中提取的亚砜化合物,具有口服活性,表现出降血糖、抗氧化和抗炎特性。 | |||
TN2245 |
Sunset Yellow FCF
Food Yellow 3,Orange Yellow S,Sunset yellow,CI 15985 |
Androgen Receptor | Endocrinology/Hormones |
Sunset Yellow FCF (Sunset yellow) 是一种橙色偶氮染料,吸光度具有pH 依赖性。Sunset Yellow FCF 可在食品,化妆品和药品中使用,在许多食品中用作着色剂食品添加剂,它们可能具有细胞毒性和遗传毒性,因此在使用这些材料作为食品添加剂时必须小心。 | |||
T12796 |
S-Dihydrodaidzein
S-二氢大豆苷元,(3S)-7-hydroxy-3-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one |
Others | Others |
S-Dihydrodaidzein ((3S)-7-hydroxy-3-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one) 是一种 dihydrodaidzein 的 (S) 型对映体。其中 dihydrodaidzein 是一种可食用性植物雌激素。 | |||
T2O2730 |
L-Serine
(S)-Serine,L-丝氨酸,丝氨酸,serine,(-)-Serine,(S)-2-Amino-3-hydroxypropanoic acid |
Endogenous Metabolite | Metabolism |
L-Serine (serine) 是一种人体非必需氨基酸,它存在于许多蛋白质中,并且在功能上很重要。L-Serine 也存在于丝氨酸蛋白酶类的活性位点,包括胰蛋白酶和凝乳胰蛋白酶。 | |||
T0710 |
L-Cycloserine
Levcycloserine,Levcicloserina,(-)-Cycloserine,(S)-Cycloserine,Levcycloserinum,环丝氨酸,(S)-4-Amino-3-isoxazolidone |
HIV Protease; GABA Receptor | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
L-Cycloserine ((-)-Cycloserine) 不可逆地抑制大肠杆菌以及各种动物大脑中的 GABA 吡哆醛 5'-磷酸依赖性转氨酶,导致体内抑制性神经递质 γ-氨基丁酸水平升高。 | |||
T2S1682 |
Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside
Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose,pinocembrin-7-o-3-o-galloyl-4-6-hexahydroxydiphenoyl-beta-d-glucoside |
Amylase | Metabolism |
Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside 可抑制 α-淀粉酶活性,IC50值为0.03 umol/ml。 | |||
T3377 |
L-Phenylalanine
L-苯丙氨酸,(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine |
Calcium Channel; Endogenous Metabolite; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
L-Phenylalanine (3-Phenyl-L-alanine) 是分离自大肠杆菌的必需氨基酸,是 NMDARs(KB573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂,用于食品香料和药品的生产中。它是一种电压依赖性 α2δ 亚基 Ca2+通道拮抗剂,Ki 为 980 nM。 | |||
T5740 |
25(R,S)-Ruscogenin
(25RS)鲁斯可皂苷元,(25RS)-Ruscogenin |
Others; HIF | Angiogenesis; Chromatin/Epigenetic; Others |
25(R,S)-Ruscogenin 能够调节 PI3K/Akt/mTOR 信号通路,抑制 MMP-2、MMP-9、uPA、VEGF 和 HIF-1α 的表达,阻碍肝癌转移。 它能够抑制 TLR4信号通路,减轻 LPS 诱导的肺内皮细胞凋亡。 | |||
T4929 |
L-2-Phosphoglyceric acid
L-GLYCERATE 3-PHOSPHATE 二钠盐,L-2-Phosphoglyceric acid disodium salt h |
Others; Endogenous Metabolite | Metabolism; Others |
L-2-Phosphoglyceric acid (L-2-Phosphoglyceric acid disodium salt) 是内源性代谢产物的一种。 | |||
T5S1285 |
(+)-(3R,8S)-Falcarindiol
Falcarindiol,镰叶芹二醇 |
Others | Others |
(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔,有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用,对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。 | |||
T19619 |
3-Hydroxyisobutyric acid
(S)-3-Hydroxyisobutyric acid |
Others | Others |
(S)-3-Hydroxyisobutyric acid is an important interorgan metabolite. | |||
TN1446 |
Bisabolol oxide A
甜没药萜醇氧化物A,[S-(R*,R*)]-α’-4-二甲基-α’-(4-甲基-3-戊烯基)-3-环己烯-1-甲醇 |
Others | Others |
Bisabololoxide A induces apoptosis in rat thymocytes. | |||
TN1201 |
25(S)-Ruscogenin-1-O-α-L-rhamnopyranosyl (1→2)-β-D-xylopyranoside
25(S)-鲁斯可皂苷元-1-O-Α-L-吡喃鼠李糖基-(1→2)-Β-D-吡喃木糖苷,山麦冬皂苷C,(1beta,3beta,25S)-3-Hydroxyspirost-5-en-1-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-xylopyranoside |
Others | Others |
(1beta,3beta,25S)-3-Hydroxyspirost-5-en-1-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-xylopyranoside is a natural product | |||
T83521 |
(S)-7-O-Methylpeucedanol 3′-O-β-D-glucopyranoside
|
||
(S)-7-O-Methylpeucedanol 3'-O-β-D-glucopyranoside 为一种香豆素糖苷[sup][1]。 | |||
TN6776 |
β-D-glucopyranosyl-[α-L-rhamnopyranosyl-(1→3)-βD-glucuronopyranosyl-(1→3)]-3β-hydroxyolean-12-ene28-oate
Cyaonoside B,川牛膝皂苷B |
Others | Others |
Cyaonoside B 是一种皂苷,有一个葡萄糖醛酸连接到碳 C-3,能够从单胞菌中分离。 | |||
TN7156 |
ochracin
8-hydroxy-3-methylisochroman-1-one,8-hydroxy-3-methyl-3,4-dihydroisochromen-1-one,3,4-Dihydro-8-hydroxy-3-methylisocoumarin,Ochracin |
Others | Others |
Ochracin (8-hydroxy-3-methyl-3,4-dihydroisochromen-1-one) 是一种海洋来源的天然产物,存在于Helicascus kanaloanus。 | |||
T4447 |
S-(5'-Adenosyl)-L-methionine tosylate
S-腺苷蛋氨酸对甲苯磺酸盐,SAMe,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt |
Others | Others |
S-(5'-Adenosyl)-L-methionine tosylate (SAMe) 是一种普遍存在的甲基供体,参与多种生物反应,包括由 DNA 和蛋白质甲基转移酶介导的反应。它可改善抑郁、与骨关节炎和纤维肌痛相关的疼痛以及肝毒性。 | |||
T5767 |
Isovanillic acid
3-羟基-4-甲氧基苯甲酸,3-Hydroxy-4-methoxybenzoic acid |
Others | Others |
Isovanillic acid (3-Hydroxy-4-methoxybenzoic acid) 是一种酚醛酸化合物,从 S. frutescens 中分离得到,具有抗炎作用。 | |||
T3S0218 |
Thonningianin A
|
Apoptosis; Others | Apoptosis; Others |
Thonningianin A 是从非洲草药通宁宁的甲醇提取物中,分离得到的一种鞣花素,具有抗癌和抗氧化性,涉及自由基清除、抗超氧化物形成和金属螯合。 | |||
T3S1967 |
(S)-Indoximod
N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine |
Others; Indoleamine 2,3-Dioxygenase (IDO) | Metabolism; Others |
(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂,可用于研究癌症。 | |||
TCO2745 |
Cyclic AMP
Adenosine 3',5'-cyclophosphate,cAMP,腺苷环磷酸酯,环磷腺苷,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate |
Others; Endogenous Metabolite | Metabolism; Others |
Cyclic AMP (cAMP)(Adenosine 3',5'-cyclophosphate) 是有丝分裂信使,可以促进 G1期到 S 期的细胞周期进程。 | |||
T4A2462 |
Telocinobufagin
Telobufotoxin,远华蟾蜍精,Telocinobufogenin |
Others | Others |
Telocinobufagin (Telobufotoxin) 是一种从蟾酥中分离提取获得的组份。 | |||
T4839 |
Ac-Ala-OH
N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。 | |||
T6S0071 |
Fraxinellone
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HIF/HIF Prolyl-Hydroxylase; STAT; PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Metabolism; Stem Cells |
Fraxinellone 是从白鲜的根皮中分离出来的一种天然产物,是PD-L1抑制剂,可抑制HIF-1α蛋白质合成。它通过靶向 PD-L1,有用于癌症免疫的潜力。 | |||
T6S0525 |
Farrerol
|
ERK; p38 MAPK; Akt | Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Farrerol 是一种杜鹃花的生物活性成分,具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。 | |||
T5S1981 |
alpha-Cyperone
(+)-α-Cyperone,α-香附酮,α-Cyperone |
Others; Endogenous Metabolite | Metabolism; Others |
alpha-Cyperone (α-Cyperone) 与 IL-6, Cox-2, Cdc42, Nck-2, Rac1 的表达下调相关,从而能够抑制炎症反应。 | |||
T6S1487 |
Ginsenoside Rg5
人参皂苷Rg5,人参皂甙 Rg5 |
NF-κB; COX; IGF-1R | Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors |
Ginsenoside Rg5 是红参的主要成分,可阻断IGF-1与其受体的结合,IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压,具有抗炎和治疗阿尔茨海默病的潜力。 | |||
T6S0221 |
Eriocitrin
eriodictyol 7-rutinoside,圣草次甙,Eriodictyol-7-O-Rutinoside,Eriodictioside,圣草次甙;圣草次苷,Eriodictyol glycoside |
Apoptosis; Carbonic Anhydrase | Apoptosis; Metabolism |
Eriocitrin (Eriodictyol-7-O-Rutinoside) 是从柠檬中分离出来的一种黄酮类天然产物,是强效的抗氧化剂。它通过激活线粒体涉及的内在信号传导途径来触发细胞凋亡。它通过上调 p53、cyclin A、cyclin D3 和 CDK6 使 S 期细胞周期停滞,从而抑制肝癌细胞的增殖。 | |||
T81768 |
Molluscicidal agent-1
|
||
Molluscicidal agent-1 (Compound 3)为从S. vesicaria分离得到的皂苷类化合物。 | |||
TN5820 |
Senkyunolide S
|
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Senkyunolide S 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5820,CAS号为 172723-28-3。 | |||
T78494 |
Rebaudioside O
|
||
Rebaudioside O是从选育的S.rebaudiana Bertoni中分离出的一种甜菊糖苷,通常在S.rebaudiana Morita中发现,常作为甜味剂使用。 | |||
TN2849 |
3-(2-Glucosyloxy-4-methoxyphenyl)propanoic acid
|
Antifection | Microbiology/Virology |
2-O-beta-d-Glucosyloxy-4-methoxybenzenepropanoic acid[3-(2-Glucosyloxy-4-methoxyphenyl)propanoic acid] exhibits glutathione S-transferase (GST) inhibitory and antifungal activities. | |||
T71784 |
Asukamycin
|
||
Asukamycin is polyketide isolated from the S. nodosus subspecies asukaensis that demonstrates a broad range of antibiotic functions. It has been shown to inhibit growth of various tumor cell lines by activating caspases 8 and 3. | |||
T35754 |
Aszonapyrone A
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||
Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, and 10.2 μM, respectively).1 Aszonapyrone A is active against multidrug-resistant isolates of S. aureus, E. faecalis, and E. faecium (MICs = 8, 16, and 16 μg/ml, respectively) and inhibits S. aureus biofilm formation.2 It is also active against P. falciparum in vitro (IC50 = 1.34... | |||
T37272 |
9(S),12(S),13(S)-TriHOME
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9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME... | |||
T73207 |
Laburnetin
|
||
Laburnetin 是一种异黄酮类抗菌剂 (antibacterial agent)。Laburnetin 对真菌、S. vesicarium 具有抗菌活性。Laburnetin 增强了耐甲氧西林 (Methicillin) 金黄色葡萄球菌 (MRSA) 菌株对甲氧西林的敏感性。Laburnetin 可用于控制栽培物种的虫害。 | |||
T36417 |
Nargenicin
Antibiotic 47444 |
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Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (... | |||
T35409 |
(+)-δ-Cadinene
|
Apoptosis; Antibacterial | Apoptosis; Microbiology/Virology |
(+)-δ-Cadinene 是一种从G. hirsutum 中发现的倍半萜,具有抗菌、杀虫、抗癌和抗增殖活性。 它对肺炎双球菌的MIC 值为31.25 μg/ml,对 A. stephensi、A. aegypti 和 C. quinquefasciatust 三龄幼虫的LC50s 值分别8.23、9. 2和3。(+)-δ-Cadinene(10、50 和 100 μM)可诱导 OVCAR-3 人类卵巢癌细胞凋亡并抑制其增殖。 | |||
T5066 |
Nε,Nε,Nε-Trimethyllysine chloride
Lys(Me)3-OH Chloride,Nε,Nε,Nε-Trimethyllysine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
Nε,Nε,Nε-Trimethyllysine chloride (Lys(Me)3-OH Chloride) 是肠道菌群依赖性形成 N,N,N-trimethyl-5-aminovaleric acid (TMAVA) 的前体。 | |||
T36438 |
Sporogen-AO 1
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Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3 1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(... | |||
T36329 |
Terpendole I
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Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 |1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter... | |||
T36226 |
Beauveriolide I
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Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.78 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 6 μM).2 1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific i... | |||
T36000 |
3-Hydroxyterphenyllin
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3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi... | |||
T35758 | Butyrolactone V | ||
Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amazonensis promastigotes (IC50 = 23.7 μM).2,1 Butyrolactone V (227 and 454.1 μM) is also active against adult S. mansoni worms.1 It scavenges 2,2-diphenyl-1-picrylhydrazyl and ABTS radicals with IC50 values of 20.7 and 3.7 μM, respectively, in cell-free assays.3 Butyrolactone V also... | |||
T37609 |
(rel)-Asperparaline A
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Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces... | |||
T37451 |
Stachybotrysin B
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Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).2 |1. Zhao, J., Feng, J., Tan, Z., et al. Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. J. Nat. Prod. 80(6), 1819-1826 (2017).|2. Ma, X.-h., Zhen... | |||
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