Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RSV604 ((S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea) 是一种呼吸道合胞病毒抑制剂,可与 RSV 核蛋白结合,靶向核衣壳蛋白的 Kd 值为 1.6 μM。它对 RSV A 和 B 亚型的众多临床分离株有亚微摩尔活性,EC50平均值为 0.8 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 218 | 现货 | ||
2 mg | ¥ 297 | 现货 | ||
5 mg | ¥ 496 | 现货 | ||
10 mg | ¥ 818 | 现货 | ||
25 mg | ¥ 1,590 | 现货 | ||
50 mg | ¥ 2,720 | 现货 | ||
100 mg | ¥ 4,350 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 546 | 现货 |
产品描述 | RSV604 ((S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea) is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 μM) |
靶点活性 | nucleocapsid protein:1.6 μM (Kd) |
体外活性 | RSV-604 increases viability of RSV-infected HEp-2 cells (EC50 = 0.86 μM) and inhibits RSV replication in human airway epithelial (HAE) cell monolayers following mucosal inoculation[1]. |
体内活性 | RSV604 resistance mutations in the N protein. RSV604 engaged in two different MoAs in HeLa cells, inhibiting both RSV RNA synthesis and the infectivity of released virus. RSV604 did not inhibit viral RNA synthesis in the RSV subgenomic replicon cells or in the cell-free RNP assay, suggesting that it might act prior to viral replication complex formation. RSV604 did not alter N protein localization in the infected cells[2]. |
别名 | (S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea |
分子量 | 388.39 |
分子式 | C22H17FN4O2 |
CAS No. | 676128-63-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 195 mg/mL (502.07 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5747 mL | 12.8737 mL | 25.7473 mL | 64.3683 mL |
5 mM | 0.5149 mL | 2.5747 mL | 5.1495 mL | 12.8737 mL | |
10 mM | 0.2575 mL | 1.2874 mL | 2.5747 mL | 6.4368 mL | |
20 mM | 0.1287 mL | 0.6437 mL | 1.2874 mL | 3.2184 mL | |
50 mM | 0.0515 mL | 0.2575 mL | 0.5149 mL | 1.2874 mL | |
100 mM | 0.0257 mL | 0.1287 mL | 0.2575 mL | 0.6437 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
RSV604 676128-63-5 Microbiology/Virology RSV virus (S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea Respiratory syncytial virus A 60444 respiratory protein inhibit RSV 604 syncytial A-60444 RSV-604 Inhibitor A60444 nucleocapsid inhibitor