6843
1000+
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T28036 |
MI-2-2
MI22,MI 2 2 |
Histone Methyltransferase | Chromatin/Epigenetic |
MI-2-2 是一种抑制 menin 和 MLL 之间二价蛋白质-蛋白质相互作用的抑制剂,IC50 为 46 nM。 MI-2-2 与 menin 结合,Kd 为 22 nM。 | |||
T2649 |
Menin-MLL inhibitor MI-2
Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2 |
Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase | Apoptosis; Chromatin/Epigenetic |
Menin-MLL inhibitor MI-2 (MI2) 抑制Menin-MLL 相互作用,IC50为 446±28 nM。 | |||
T2643 |
MI-3
Menin-MLL Inhibitor,Menin-MLL inhibitor 3,MI 3 |
Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase | Apoptosis; Chromatin/Epigenetic |
MI-3 (Menin-MLL Inhibitor)是一种有高亲和力的 menin-MLL 抑制剂,IC50值为 648 nM,Kd 值为 201 nM。 | |||
T2350 |
MALT1 inhibitor MI-2
MALT1 inhibitor,MI 2,MI 2 (MALT1 inhibitor) |
MALT | Immunology/Inflammation |
MI 2 (MALT1 inhibitor) 是一种MALT1抑制剂 (IC50=5.84 μM),对动物无毒性。它能够直接与 MALT1 结合,不可逆地抑制蛋白酶功能,并伴有 NF-κB 报告子活性抑制、c-REL 核定位抑制和 NF-κB 靶基因下调。 | |||
T39584 |
MI-3454
|
||
MI-3454 is a highly potent, orally active, and selective inhibitor of the interaction between menin and MLL1, with an IC50 of 0.51 nM. This compound effectively inhibits the proliferation of leukemic cells and promotes their differentiation, leading to the regression or complete remission of leukemia in mouse models featuring MLL1 rearrangements or NPM1 mutations. This remarkable therapeutic effect is achieved through the downregulation of key genes involved in the development of leukemia. | |||
TQ0069 |
MI-503
|
Epigenetic Reader Domain; Histone Methyltransferase | Chromatin/Epigenetic |
MI-503 是一种高效且可口服的 menin-mLL 相互作用抑制剂。 | |||
TQ0058 |
MI-463
|
Epigenetic Reader Domain; Histone Methyltransferase | Chromatin/Epigenetic |
MI-463 是一种有口服活性的menin-mLL 相互作用的高效小分子抑制剂,IC50为15.3 nM。 | |||
T6889 |
MI-136
|
Apoptosis; Epigenetic Reader Domain; Androgen Receptor | Apoptosis; Chromatin/Epigenetic; Endocrinology/Hormones |
MI136 是 menin-MLL(PPI) 蛋白互作的抑制剂,其 IC50值为31 nM,Kd 值为23.6 nM。它可抑制 DHT 诱导的雄激素受体 (AR) 靶基因的表达,有用于去势抵抗性肿瘤的潜能。 | |||
T16072 |
MI-538
|
Epigenetic Reader Domain; Histone Methyltransferase | Chromatin/Epigenetic |
MI-538是一种menin 和MLL 融合蛋白相互作用的抑制剂,IC50值为 21 nM。 | |||
T6585 |
SAR405838
MI773,MI 773,MI-77301,MI-773 |
Mdm2; E1/E2/E3 Enzyme | Apoptosis; Ubiquitination |
SAR405838 (MI 773) 是 MI-773 的类似物,具有抗肿瘤活性。它是一种高效、选择性的MDM2-p53相互作用抑制剂,与 MDM2 结合的Ki 值为 0.88 nM。 | |||
T24463 |
MI-1481
MI 1481 |
||
MI-1481 is an effective MML1 inhibitor (IC50: 3.6 nM). MI-1481 showed very potent inhibition of the menin-MLL1 interaction (IC50: 3.6 nM). MI-1481 also demonstrates pronounced activity in MLL leukemia cells and in vivo in MLL leukemia models. | |||
T33379 |
MI 658
MI658,MI-658 |
||
MI 658 interferes with the development and induces increased synthesis of myo-inositol synthetase in Neurospora crassa. | |||
T25808 |
MI 1544
Attcpl-LHRH,AttcplLHRH,MI-1544,MI1544,Attcpl LHRH |
||
MI 1544 is a LHRH antagonist. | |||
T68395 | MI-63 | ||
MI-63 is a potent, specific, non-peptide inhibitor of the MDM2-p53 interaction. | |||
T69524 |
MI-09
|
||
MI-09 is a SARS-CoV-2 Protease inhibitor (IC50 = 15.2 nM). In a transgenic mouse model of SARS-CoV-2 infection, oral or intraperitoneal treatment with MI-09 significantly reduced lung viral loads and lung lesions. | |||
T69540 |
MI-30
|
||
MI-30 is a SARS-CoV-2 Protease inhibitor (IC50 = 17.2 nM). In a transgenic mouse model of SARS-CoV-2 infection, oral or intraperitoneal treatment, MI-30 significantly reduced lung viral loads and lung lesions. | |||
T69541 |
MI-23
|
||
MI-23 is a SARS-CoV-2 Protease inhibitor (IC50 = 7.6 nM). | |||
T68394 |
MI-219
|
||
MI-219 is a human double minute 2 (HDM2) inhibitor. | |||
T69640 |
MI-1851
|
||
MI-1851 is a potent peptidomimetic inhibitor. MI-1851could prevent proteolytic processing of the S protein from SARSCoV-2 by endogenous furin in HEK293 cells. | |||
T25809 |
MI-14
MI14 |
||
MI-14 is a potent and selective inhibitor of PI 4-K IIIß. | |||
T12031 | MI-1061 | Mdm2 | Apoptosis |
MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM). | |||
T33380 |
MI-389
|
PROTACs | PROTAC |
MI-389 is a protein degrader, targeting the translation termination factor G1 to S phase transition 1 (GSPT1). | |||
T68398 |
MI-223
|
||
MI-223 is an inhibitor of Mcl-1-stimulated homologous recombination (HR) DNA repair, which leads to sensitization of cancer cells to hydroxyurea- or olaparib-induced DNA replication stress. | |||
T21898 |
MI-192
|
||
MI-192 是一种选择性 HDAC2和 HDAC3抑制剂,IC50分别为 30 nM 和 16 nM。MI-192 比其他 HDAC 异构体对 HDAC2/3 具有更高选择性。MI-192 诱导髓系白血病细胞凋亡 (apoptosis)。抗癌和神经保护活性。 | |||
T71023 |
MI-888 free base
|
||
MI-888 is a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. MI-888 is capable of achieving rapid, complete, and durable tumor regression in two types of xenograft models of human cancer with oral administration and represents the most potent and efficacious MDM2 inhibitor reported to date. | |||
T19774 |
Methylisothiazolinone
KB-838,MI,N-Methylisothiazolin-3-one,甲基异噻唑啉酮,Methylisothiazolinone free base |
Antibacterial | Microbiology/Virology |
Methylisothiazolinone (MI) 是合成的杀菌剂和防腐剂,可广泛用于工业和消费产品。它作为化妆品和盥洗用品中的防腐剂。 | |||
T22978 |
MI-2 (hydrochloride)
|
Others | Others |
MI-2 (Menin-MLL Inhibitor) is an effective menin-MLL interaction inhibitor (IC50: 446 ± 28 nM). | |||
T74247 |
TPE-MI
|
||
TPE-MI(Tetraphenylethene maleimide)在与马来酰亚胺与硫醇反应前不具荧光性。在与游离的半胱氨酸硫醇标记时,其荧光被激活,后者多在球形蛋白质的核心,仅在展开时显露。TPE-MI适用于测量细胞中未折叠蛋白质的负荷,并能在亨廷顿病诱导的多能干细胞模型中监测蛋白质平衡失衡,以及在形成可见聚合体之前,监测转染突变亨廷顿外显子1的细胞的状况。此外,TPE-MI用于检测双氢青蒿素处理后疟疾寄生虫的蛋白质损伤。应暗处储存。 | |||
T63974 | MI-773 | ||
MI-773 是 MDM2-p53 蛋白质相互作用 (PPI) 的有效抑制剂,能够高度亲和 MDM2,其 Kd 值为 8.2 nM。MI-773 表现出抗肿瘤作用。 | |||
T61735 |
MI-1
|
||
MI-1 抑制 Menin-MLL 相互作用,IC50为 1.9 μM。 | |||
T23747 |
Apazone dihydrate
Rheumox,MI 85,Tolyprin,Prolixan |
||
Apazone dihydrate is a nonsteroidal anti-inflammatory agent. | |||
T73895 | MI-1061 TFA | ||
MI-1061 TFA 是一种有效、口服生物可用、化学稳定性高的MDM2(MDM2-p53 互作) 抑制剂,具有低纳摩尔级别的抑制活性(IC50=4.4 nM;Ki=0.16 nM)。它能在小鼠SJSA-1 异种移植瘤组织中激活p53并诱导凋亡,展现出抗肿瘤活性。 | |||
T124683 | Mi-Saponin B | ||
Mi-Saponin B 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124683,CAS号为 54328-43-7。 | |||
T32136 |
ICT2700
de OH CPI MI,deOHCPIMI,de-OH-CPI-MI,ICT 2700,ICT-2700 |
||
ICT2700 is a potent cytotoxin selectively by CYP1A1 as a tumor-selective treatment for human bladder cancers. | |||
T124684 |
Mi-Saponin A
|
||
Mi-Saponin A 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124684,CAS号为 54328-42-6。 | |||
T26710 |
Azapropazone
DuP-141,NSC-102824,AHR-3018,AHR 3018,MI-85 |
||
Azapropazone is anti-inflammatory agent. Azapropazone has uricosuric properties used to treat rheumatoid arthritis and ankylosing spondylitis. Azapropazone lowered plasma uric acid but exerted only a modest and variable uricosuric effect without altering | |||
T83043 |
Anti-MI/R injury agent 1
|
||
Anti-MI/R injury agent 1 (compound 18) 是一种口服有效的人参三醇衍生物,专用于抗心肌缺血/再灌注 (MI/R) 损伤。该化合物能增强经氧-葡萄糖剥夺和再灌注 (OGD/R) 诱导心肌细胞损伤模型中的细胞活力,显着缩小大鼠心肌梗死面积,减少循环心肌肌钙蛋白 I (cTnI) 的释放,并减轻心脏组织损害。 | |||
T28029 |
Methylisothiazolinone hydrochloride
N-Methylisothiazolin-3-one,MI,2-甲基-4-异噻唑啉-3-酮盐酸盐,KB-838,Methylisothiazolinone HCl |
||
Methylisothiazolinone is a powerful synthetic biocide and preservative. | |||
T21919 |
UCF 101
|
Apoptosis | Apoptosis |
UCF 101 是竞争性的促凋亡蛋白酶Omi/HtrA2选择性抑制剂。它对 MI/R 损伤具有明显的心脏保护作用,还具有一定的神经保护作用。它在 543 nm 处具有天然的红色荧光,可用于监视其进入哺乳动物细胞的能力。 | |||
T69639 |
Sevasemten
|
||
Sevasemten为骨骼肌肌球蛋白(Myosin)的变构抑制剂,具有选择性抑制作用,其IC50值对骨骼肌球蛋白 ≤ 10 μM,而对心脏肌球蛋白则 >100 μM。 | |||
T71021 |
Fendiline
|
||
Fendiline is a coronary vasodilator that inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as an antiarrhythmic and antianginal agent. | |||
T7755 |
Thalidomide 4-fluoride
E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮 |
IRAK; Ligand for E3 Ligase | Immunology/Inflammation; NF-κB; PROTAC |
Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接,得到 PROTAC IRAK4 degrader-1。 | |||
T16705 |
Quinfamide
喹法米特,WIN-40014 |
Others; Parasite | Microbiology/Virology; Others |
Quinfamide 是一种具有治疗热带寄生虫感染(如阿米巴病和蠕虫病)的潜力的化合物。 | |||
T19507 |
Perfluamine
FTPA,Tris(perfluoropropyl)amine,Perfluorotripropylamine |
Others | Others |
Perfluamine (FTPA) 是一种疏水性载液,可用作血液替代品。 | |||
T0503 |
Meglumine
Meglumin,Methylglucamin,葡甲胺,葡萄糖甲胺,Methylglucamine |
Others | Others |
Meglumine (Meglumin) 是一种氨基糖,来源于山梨糖醇。其中常在药物中用作赋形剂,并与碘代化合物葡甲胺和碘帕胺葡甲胺等造影剂中的碘化化合物一起使用。 | |||
T22520 |
5-Carboxamidotryptamine maleate
5-CT maleate |
5-HT Receptor | GPCR/G Protein; Neuroscience |
5-Carboxamidotryptamine maleate (5-CT maleate) (5-CT maleate) 是一种 受体激动剂,具有降压和升血糖的作用。 | |||
T15390 |
Glufosfamide
D 19575,Glucosylifosfamide mustard |
Others | Others |
Glufosfamide 是一种新型噁唑磷胺化合物,具有抗癌活性,可用于研究晚期非小细胞肺癌。 | |||
T1515 |
Bromindione
溴茚二酮,溴茚二酮(INN),Fluidane,Halinone |
Others | Others |
Bromindione (Fluidane) 是强效且长效的 Inandione 衍生口服抗凝化合物。 | |||
T9838 |
2-Amino-3-(2-chlorophenyl)propanoic acid
2-Chloro-DL-Phenylalanine |
Amino Acids and Derivatives | Metabolism |
2-Amino-3-(2-chlorophenyl)propanoic acid (2-Chloro-DL-Phenylalanine) 是一种苯丙氨酸衍生物,参与生物代谢。 | |||
T12632 |
(R)-Mirtazapine
(R)-Org3770,(R)-6-Azamianserin |
5-HT Receptor | GPCR/G Protein; Neuroscience |
(R)-Mirtazapine ((R)-Org3770) 是 Mirtazapine 的 R(-)-对映体,在急性热痛觉动物模型中具有抗伤害感受的特性。(R)-Mirtazapine 是 5-HT3 受体的拮抗剂,是一种潜在的镇痛剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
THS1455 |
DihydroarteMisinic acid
双氢青蒿酸,Dihydro-Artmisinic Acid,二氢青蒿酸 |
Ferroptosis; Parasite | Apoptosis; Microbiology/Virology |
DihydroarteMisinic acid (Dihydro-Artmisinic Acid) 是青蒿的天然产物,是青蒿素的主要直接前体,青蒿素是一种广泛用于治疗疟疾的药草。 | |||
T4820 |
Maleimide
马来酰亚胺,2,5-Pyrroledione |
Others | Others |
Maleimide (2,5-Pyrroledione) 可用于制备荧光探针,主要用于硫醇分析物的特异性检测。它也可用于制备用于癌症研究的抗体-药物偶联物 (ADC)。 | |||
T22911 |
β-N-methylamino-L-alanine hydrochloride
L-BMAA hydrochloride |
Others | Others |
β-N-methylamino-L-alanine hydrochloride (L-BMAA hydrochloride) 是由蓝细菌产生的一种神经毒素,既有导致肌萎缩性侧索硬化症 (ALS) 以及其他可能的神经退行性疾病可能性。 | |||
T4940 |
3-Methylhistamine dihydrochloride
|
Others; Endogenous Metabolite | Metabolism; Others |
3-Methylhistamine dihydrochloride 是一种组胺的降解产物,与免疫反应有关,并在接种过疫苗的小鼠中表现出上调作用。 | |||
T7026 |
KukoaMine B
|
Antioxidant | oxidation-reduction |
Kukoamine B, as a constituent of Lycii Cortex, exhibits anti-acute inflammatory, anti-oxidant, and anti-diabetic characteristics. | |||
T0361 |
Isovaleramide
异戊酰胺,3-Methylbutanamide |
Dehydrogenase | Metabolism |
Isovaleramide (3-Methylbutanamide) 是抗惊厥剂,能够调节中枢神经系统的活性。 | |||
TQ0298 |
Fagomine
D-Fagomine |
ROS; glycosidase | Immunology/Inflammation; Metabolism |
Fagomine (D-Fagomine) 是一种温和的糖苷酶 (glycosidase) 抑制剂,是1-脱氧野尻霉素 (DNJ) 的类似物,具有降血糖活性,Fagomine 降低了细胞内活性氧(ROS)的产生和丙二醛(MDA)水平。 | |||
T8120 |
N-Benzyloctadecanamide
N-苄基硬脂酰胺,N-Benzylstearamide |
Others | Others |
N-Benzyloctadecanamide 是一种 Macamide,Macamides 是Lepidium meyeniiWalp (玛咖)中的一类独特的次级代谢产物。 | |||
T4824 |
5,6-Dimethyl-1H-benzo[d]imidazole
5,6-Dimethylbenzimidazole,5,6-二甲基苯并咪唑 |
Others; Endogenous Metabolite | Metabolism; Others |
5,6-Dimethyl-1H-benzo[d]imidazole (5,6-Dimethylbenzimidazole) 是内源性代谢产物的一种。 | |||
T7730 |
Aminopterin
APGA,氨基蝶呤,4-Aminofolic acid |
Antifolate | Cell Cycle/Checkpoint |
Aminopterin (4-Aminofolic acid) 是叶酸的 4-氨基衍生物,是叶酸拮抗剂,具有抗癌和免疫抑制活性,用于研究儿童白血病。它催化叶酸还原为四氢叶酸,竞争性抑制二氢叶酸还原酶,Ki 值为 3.7 pM。 | |||
TN2554 |
1-Monopalmitin
Glyceryl palmitate |
Apoptosis | Apoptosis |
1-Monopalmitin (Glyceryl palmitate) 是一种从Mougeotia nummuloides 和 Spirulina major 提取出来的小分子化合物,具有潜在的抗肿瘤活性,抑制A549和SPC-A1细胞增殖,诱导G2/M阻滞和半胱天冬酶依赖性细胞凋亡。 | |||
TN1353 |
N-Benzyllinoleamide
(9Z,12Z)-N-Benzyloctadeca-9,12-dienamide,N-苄基-(9Z,12Z)-十八碳二烯酰胺 |
Others | Others |
N-Benzyllinoleamide ((9Z,12Z)-N-Benzyloctadeca-9,12-dienamide) 是一种分离自 Lepidium meyeniiWalp,能够抗运动性疲劳的药物。 | |||
TN7035 |
N-benzylpentadecanamide
N-(Phenylmethyl)pentadecanamide,N-苄基十五碳酰胺 |
Others | Others |
N-benzylpentadecanamide (N-(Phenylmethyl)pentadecanamide) 是一种天然产物。 | |||
T5680 |
Aloin(mixture of A&B)
芦荟素,葡糖基蒽酮,芦荟大黄素甙,芦荟苷 |
MMP; IL Receptor; Antibacterial; Antifungal | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Aloin (mixture of A&B) 是一种从芦荟中分离出来的蒽醌衍生物。它是刺激性粒细胞基质金属蛋白酶的有效抑制剂。它具有多种生物活性,如抗炎、抗菌、抗真菌、抗氧化、抗肿瘤、抗糖尿病和免疫活性。 | |||
T2P2898 |
Neodiosmin
新地奥斯明,Diosmetin-7-neohesperidoside,新地奥司明,Diosmetin-7-O-neohesperidoside |
Antioxidant | oxidation-reduction |
Neodiosmin (Diosmetin-7-O-neohesperidoside) 是一种黄酮苷,分离自柑桔叶中。 | |||
T6S1683 |
Demethoxycurcumin
Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin |
Apoptosis; Antioxidant; Antibacterial; Autophagy | Apoptosis; Autophagy; Microbiology/Virology; oxidation-reduction |
Demethoxycurcumin (Desmethoxycurcumin) 是姜黄素的主要活性成分,有抗炎和抗癌作用。 | |||
T5S0661 |
Koumine
|
Others | Others |
Koumine 是一种从钩吻中得到的生物碱,具有高效抗肿瘤活性,在肿瘤细胞中能够提高 Bax/Bcl-2 的蛋白比例和 caspase-3 的表达。在类风湿性关节炎动物模型中,它能够预防关节炎的发展。它具有抗焦虑、抗应激、抗银屑病作用,也可用于缓解疼痛的研究。 | |||
T5688 |
Micheliolide
|
NOS; NF-κB; COX | Immunology/Inflammation; Neuroscience; NF-κB |
Micheliolide 是一种倍半萜内酯,能够抑制各种炎症反应。它能减弱高糖刺激的NF-κB 活化,IκBα的降解,和MCP-1,TGF-β1,FN 在鼠系膜细胞的表达。 | |||
T4753 |
Imidazoleacetic acid hydrochloride
I4AA,(4-Imidazolyl)acetic acid hydrochloride,4-咪唑乙酸盐酸盐,4-Imidazoleacetic acid hydrochloride |
Endogenous Metabolite; Antibiotic | Metabolism; Microbiology/Virology |
Imidazoleacetic acid hydrochloride (I4AA) 是咪唑衍生物,具有潜在的抗结核性能。它还用于制备β-分泌酶的酰基胍抑制剂。 | |||
T8790 |
1-Methylhistamine dihydrochloride
|
Endogenous Metabolite | Metabolism |
1-Methylhistamine dihydrochloride 是组胺代谢物。 | |||
T3805 |
Prim-O-glucosylcimifugin
升麻苷,Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside |
TNF; COX; JAK; NO Synthase | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells |
Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) 具有强效的抗炎作用。通过调节 JAK2/STAT3 信号传导可抑制iNOS 和COX-2表达。 | |||
T6942 |
Picolinamide
2-Pyridinecarboxamide,2-Carbamoylpyridine,2-吡啶甲酰胺,2-Picolinamide,Picolinoylamide |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Picolinamide (Picolinoylamide) 被发现是大鼠胰岛细胞核聚 (ADP-核糖) 合成酶的强抑制剂。 | |||
TWO2724 |
N,N-Bis(2-hydroxyethyl)-p-phenylenediami
|
Others | Others |
N,N-Bis(2-hydroxyethyl)-p-phenylenediami 是中间体。 | |||
TN7142 |
N-methyl-1H-indole-2-carboxamide
1H-indole-2-carboxylic acid methylamide,ZINC35137534,N-甲基-1H-吲哚-2-酰胺 |
Others | Others |
N-methyl-1H-indole-2-carboxamide (ZINC35137534) 是一种海洋来源的天然产物,存在于 Neosartorya pseudofischeri。 | |||
T2336 |
Vitamin K2
Menatetrenone,四烯甲萘醌 |
Endogenous Metabolite | Metabolism |
Vitamin K2 (Menatetrenone) 是内源性代谢产物的一种。 | |||
T19281L |
Dihydroxyacetone phosphate hemimagnesium salt hydrate
Dihydroxyacetone phosphate hemimagnesium salt hydrate(57-04-5 free base) |
Others | Others |
Dihydroxyacetone phosphate hemimagnesium salt hydrate 也称为磷酸二羟基丙酮或 3-羟基-2-氧代丙基磷酸。 Dihydroxyacetone phosphate hemimagnesium salt hydrate 存在于从细菌到人类的所有生物中。在人类体内, Dihydroxyacetone phosphate hemimagnesium salt hydrate参与许多酶促反应。 Dihydroxyacetone phosphate hemimagnesium salt hydrate 已被研究用于治疗淋巴瘤、大细胞淋巴瘤、弥漫性淋巴瘤。 | |||
TN1016 |
Kukoamine A
|
NF-κB; Lipoxygenase; DNA/RNA Synthesis; Parasite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB |
Kukoamine A 是一种天然的精胺衍生物,具有抗癌、抗高血压、细胞保护、抗氧化和抗炎活性。它是锥虫硫磷还原酶抑制剂,Ki 值为 1.8 μM。 | |||
T4767 |
Formamide
甲酰胺,Carbamaldehyde,Methanamide,NSC 748,Formimidic acid |
Others; Endogenous Metabolite | Metabolism; Others |
Formamide (NSC-748) 是甲酸的酰胺衍生物,被用作许多离子化合物的溶剂。 | |||
T3232 |
Higenamine hydrochloride
Higenamine HCl,Demethylcoclaurine hydrochloride,盐酸去甲乌头碱,norcoclaurine HCl,(+-)-Demethylcoclaurine hydrochloride,Higenamine Hydrochloride |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Higenamine hydrochloride (norcoclaurine HCl) 是一种 β2-AR 激动剂,是用于心力衰竭相关研究的中药乌头的关键成分,具有抗凋亡活性。 | |||
T1286 |
Vincamine
Angiopac,Oxybral,Devincan,Novicet,Equipur,长春胺,Perval |
GPR; Others | Endocrinology/Hormones; GPCR/G Protein; Others |
Vincamine (Perval) 是从长春花中提取的单萜类吲哚生物碱,可作为外周血管扩张剂,对脑微血管循环有选择性的血管调节作用。它可改善体内葡萄糖稳态,对 2 型糖尿病具有研究潜力。它是GPR40激动剂,通过改善 β 细胞功能障碍和促进葡萄糖刺激型胰岛素分泌发挥 β 细胞保护作用。 | |||
T2S0271 |
Voacamine
老刺木胺,Voacanginine |
Cannabinoid Receptor; P-gp | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Voacamine (Voacanginine) 是非洲马铃果中的一种吲哚生物碱,可抑制多药耐药肿瘤细胞中的 P-糖蛋白作用,具有强效的大麻素 CB1受体拮抗活性。 | |||
T5721 |
Dehydroevodiamine hydrochloride
|
AChE | Neuroscience |
Dehydroevodiamine hydrochloride 是分离自吴茱萸叶中,能够抑制 AChE。 它能够调节一氧化氮的产生,具有降压和神经保护作用。 | |||
T4S1725 |
Galanthamine
Galantamine,加兰他敏 |
Apoptosis; AChE | Apoptosis; Neuroscience |
Galanthamine (Galantamine) 是一种乙酰胆碱酯酶抑制剂,IC50为 500 nM。 | |||
T1505 |
Imipenem monohydrate
N-Formimidoyl thienamycin monohydrate,亚胺培南,Imipenem,亚胺培南一水物 |
Antibacterial; Antibiotic | Microbiology/Virology |
Imipenem monohydrate (Imipenem) 是从微生物 Streptomyces cattleya 分离得到的碳青霉烯类抗生素,是一种用于静脉注射的β 内酰胺类抗生素,作用于细菌细胞壁,能广泛有效抑制多种革兰氏阳性和阴性菌。 | |||
T0965 |
Histamine
Ergamine,组胺 |
5-HT Receptor; Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Histamine (Ergamine) 是通过组胺的酶促脱羧衍生的胺。它是一种强大的胃分泌兴奋剂、支气管平滑肌的收缩剂、血管扩张剂以及中枢作用的神经递质。 | |||
T3413 |
5-O-Methylvisammioside
5-O-Methylvisamminol glucoside,4'-O-β-D-Glucosyl-5-O-methylvisamminol,5-O-甲基维斯阿米醇苷 |
Others | Others |
5-O-Methylvisammioside (4'-O-β-D-Glucosyl-5-O-methylvisamminol) 是一种天然产物,分离自防风。 | |||
T13475 |
β-Aminopropionitrile
3-氨基丙腈,3-Aminopropionitrile,BAPN |
Others; Endogenous Metabolite | Metabolism; Others |
β-Aminopropionitrile (3-Aminopropionitrile) 是赖氨酰氧化酶的特异性抑制剂。 | |||
T2868 |
Evodiamine
d-Evodiamine,Isoevodiamine,(+)-Evodiamine,吴茱萸碱 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Evodiamine (d-Evodiamine) 是一种生物碱,从萱草的果实中分离得到,具有多种生物活性,包括抗炎,抗肥胖和抗肿瘤。 | |||
T2198 |
Arecoline hydrobromide
Arecoline HBr,氢溴酸槟榔碱,Arecoline bromide |
AChR | Neuroscience |
Arecoline hydrobromide (Arecoline HBr) 是从槟榔中得到的一种生物碱,具有刺激、警觉、抗焦虑和抗寄生虫作用。它是烟碱和毒蕈碱乙酰胆碱受体的部分激动剂,可诱导氧化应激。 | |||
T0881 |
6-Aminocaproic acid
氨基己酸,EACA,6-氨基己酸,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid |
Others | Others |
6-Aminocaproic acid (EACA) 是一种单氨基羧酸,是一种有效的、具有口服活性的纤溶酶和纤溶酶原的抑制剂。它是一种有效的抗纤维蛋白溶解剂,能够竞争性结合纤溶酶原上的赖氨酸残基,防止血块溶解,并抑制纤溶酶的形成,减少纤维蛋白溶解。它可用于出血性疾病的研究。 | |||
T4893 |
Spermidine
N-(3-Aminopropyl)-1,4-diaminobutane,亚精胺,N-(4-Aminobutyl)-1,3-diaminopropane |
Endogenous Metabolite | Metabolism |
Spermidine (N-(3-Aminopropyl)-1,4-diaminobutane) 能够维持细胞膜稳定性,提高抗氧化酶活性,改善光系统 II 以及相关基因表达。它结合并激活 NMDA,并已显示以浓度依赖性方式增强 NMDA 诱导的电流。 | |||
T4809 |
Pyrimidine
嘧啶,Metadiazine |
Others; Endogenous Metabolite | Metabolism; Others |
Pyrimidine (Metadiazine) 是内源性代谢产物的一种。 | |||
T1426 |
Pyrazinamide
Pyrazinoic acid amide,Pyrazinecarboxamide,吡嗪酰胺 |
Antibacterial; Antibiotic; Autophagy; Fatty Acid Synthase | Autophagy; Metabolism; Microbiology/Virology |
Pyrazinamide (Pyrazinecarboxamide) 是一种口服抗结核类抗生素。它是一种前药,通过结核分枝杆菌pncA 基因编码的 PZase/烟酰胺酶转化为活性吡嗪酸形式。 | |||
T0617 |
Nicotinamide N-oxide
Nicotinamide-N-oxide,Nicotinamide 1-oxide,N-氧代烟酰胺,烟酰胺-N-氧化物,1-oxynicotinamide |
c-Myc; Endogenous Metabolite; CXCR; Drug Metabolite | Autophagy; Cell Cycle/Checkpoint; GPCR/G Protein; Immunology/Inflammation; Metabolism |
Nicotinamide N-oxide (Nicotinamide 1-oxide) 是生物体内烟酰胺分解代谢物,是高效选择性CXCR2受体拮抗剂。 | |||
T13923 |
Thiamine nitrate
硝酸硫胺,Vitamin B1 nitrate |
Others | Others |
Thiamine nitrate (Vitamin B1 nitrate) 是必不能够少的维生素,能够提高正常的神经元活性。 | |||
T0130 |
Physostigmine Salicylate
水杨酸依色林,水杨酸毒扁豆碱 |
AChR; AChE | Neuroscience |
Physostigmine salicylate 是一种可逆的乙酰胆碱酯酶抑制剂,也一种是抗胆碱能中毒的解毒剂。它可透过血脑屏障并刺激中枢胆碱能神经传递。它能逆转阿尔茨海默病转基因小鼠的记忆缺陷。 | |||
T5267 |
N-Acetyl-L-glutamic acid
Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid |
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) 是一种 N-Acyl-L-氨基酸,是动物细胞培养基的组成成分,是一种酿酒酵母和人类的代谢物。 | |||
T2983 |
3,4,5-Trimethoxycinnamic acid
3-(3,4,5-Trimethoxyphenyl)acrylic Acid,O-Methylsinapic acid,3,4,5-三甲氧基肉桂酸 |
GABA Receptor; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Neuroscience |
3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) 是从远志中分离得到的苯丙素类天然产物,可延长动物的睡眠时间,增强 GAD65 和 GABAA 受体 γ 亚基,具有抗应激作用。 | |||
T12039 |
Miglustat
N-Butyldeoxynojirimycin,OGT918,美格鲁特,NB-DNJ,N-丙基脱氧野尻霉素 |
Others | Others |
Miglustat (NB-DNJ) 是一种葡萄糖神经酰胺合成酶抑制剂,可用于I 型戈谢病。 | |||
T12296 |
Oleoylethanolamide
油酰单乙醇胺,N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide |
Endogenous Metabolite; PPAR | DNA Damage/DNA Repair; Metabolism |
Oleoylethanolamide (N-Oleoylethanolamide) 是一种PPAR-α 的高亲和力内源性激动剂,可用于肥胖和动脉硬化的相关研究。 | |||
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