Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MI-538是一种menin 和MLL 融合蛋白相互作用的抑制剂,IC50值为 21 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 790 | 现货 | ||
5 mg | ¥ 1,590 | 现货 | ||
10 mg | ¥ 2,780 | 现货 | ||
25 mg | ¥ 4,910 | 现货 | ||
50 mg | ¥ 7,520 | 现货 | ||
100 mg | ¥ 9,870 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,980 | 现货 |
产品描述 | MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM). |
靶点活性 | Menin:6.5 nM(Kd), Menin-MLL:21 nM |
体外活性 | Treatment with MI-538 results in strong down regulation of expression of Hoxa9 and Meis1 genes. About 100 nM 27 was sufficient to reduce by ~50% Hoxa9 expression in MLL-AF9 cells, and even more pronounced effect was seen on Meis1 expression. |
体内活性 | Treatment with MI-538 results in a pronounced, about 80%, reduction in the MV4;11 tumor volume, without causing substantial signs of toxicity reflected by less than 10% reduction of the body weight. |
分子量 | 566.6 |
分子式 | C27H25F3N8OS |
CAS No. | 1857417-10-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (167.67 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7649 mL | 8.8246 mL | 17.6491 mL | 44.1228 mL |
5 mM | 0.353 mL | 1.7649 mL | 3.5298 mL | 8.8246 mL | |
10 mM | 0.1765 mL | 0.8825 mL | 1.7649 mL | 4.4123 mL | |
20 mM | 0.0882 mL | 0.4412 mL | 0.8825 mL | 2.2061 mL | |
50 mM | 0.0353 mL | 0.1765 mL | 0.353 mL | 0.8825 mL | |
100 mM | 0.0176 mL | 0.0882 mL | 0.1765 mL | 0.4412 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MI-538 1857417-10-7 Chromatin/Epigenetic Epigenetic Reader Domain Histone Methyltransferase inhibit Inhibitor MI538 MI 538 inhibitor