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Search Results for " dihydrochloride "

547

抑制剂 & 化合物

20

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T15374	Ipatasertib dihydrochloride GDC-0068 dihydrochloride,RG-7440 dihydrochloride	Akt; PKA	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) 是ATP 竞争性的pan-Akt 选择性抑制剂，抑制Akt1，Akt2，Akt3，IC50分别为 5，18，8 nM。
T7821	DG172 dihydrochloride DG172 (dihydrochloride),DG-172 dihydrochloride	PPAR	DNA Damage/DNA Repair; Metabolism
	DG172 dihydrochloride (DG-172 dihydrochloride) 是一种 PPARβ/δ拮抗剂，IC50值为 27 nM。
T11345L	Lerociclib dihydrochloride G1T38 dihydrochloride	CDK	Cell Cycle/Checkpoint
	Lerociclib dihydrochloride (G1T38 dihydrochloride) 是一种有效的选择性CDK4/CDK6抑制剂，抑制CDK6/CyclinD3和CDK4/CyclinD1，IC50值分别为 2 nM 和 1 nM。
T9012	Preq1-Dihydrochloride pre-queuosine1 Dihydrochloride	Others	Others
	Preq1-Dihydrochloride (pre-queuosine1 Dihydrochloride) 是 queuosine 途径的中间体，它以高亲和力结合 PreQ1 核糖开关的适体，从而减弱蛋白质表达。
T9172	Simufilam dihydrochloride PTI-125 dihydrochloride	Others	Others
	Simufilam dihydrochloride (PTI-125 dihydrochloride) 是口服具有活力的、毒性低的 filamin A 激活剂。它可优先结合改变的 FLNA，并恢复其天然构象，恢复受体和突触活性，并减少其与 a7nAChR/TLR4 的关联和下游病理作用。它可用于研究阿尔茨海默症。
T10358	Netarsudil Dihydrochloride AR-13324 Dihydrochloride	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) 是 Rho 相关蛋白激酶 (ROCK) 和去甲肾上腺素转运蛋白 (NET) 的抑制剂，可有效降低眼压 (IOP)。
T12374	PAβN dihydrochloride MC-207,110 dihydrochloride,Phe-Arg-β-naphthylamide dihydrochloride	Others; Antibacterial	Microbiology/Virology; Others
	PAβN dihydrochloride (MC-207,110 dihydrochloride) 是一种外排泵抑制剂。
T13675	Elacestrant dihydrochloride RAD1901 dihydrochloride	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Elacestrant dihydrochloride (DA-DKRAD1901 dihydrochloride) 是一种具有口服活性的的选择性雌激素受体 (ER) 降解剂 (SERD)，能够作用于 ERα (IC50:48 nM) 和 ERβ (IC50:870 nM)。
T22354	Levocetirizine Dihydrochloride Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria.
T4467	UAMC00039 dihydrochloride UAMC 00039 dihydrochloride	Proteasome	Proteases/Proteasome; Ubiquitination
	UAMC00039 dihydrochloride 是可逆、竞争性的 dipeptidyl peptidase II 高效抑制剂，IC50=为0.48 nM。
T11727	JPH203 dihydrochloride KYT-0353 dihydrochloride	Others	Others
	JPH203 dihydrochloride (KYT-0353 dihydrochloride) 是一种酪氨酸类似物，可作为 L 型氨基酸转运蛋白 1 (LAT1) 的选择性抑制剂，用于癌症研究。
T12241	Norbinaltorphimine dihydrochloride nor-BNI dihydrochloride,Nor-BNI dihydrochloride,nor-Binaltorphimine dihydrochloride,Nor-Binaltorphimine dihydrochloride	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Norbinaltorphimine dihydrochloride是一种具有选择性和有效性的κ阿片受体 (κ opioid receptor) 拮抗剂，可在小鼠中诱导瘙痒相关反应。
T4676	Sardomozide dihydrochloride CGP 48664 dihydrochloride,Sardomozide dihydrochloride	Others	Others
	Sardomozide dihydrochloride (CGP 48664 dihydrochloride) 是 S-腺苷甲硫氨酸脱羧酶 (SAMDC) 的抑制剂 (IC50 = 5 nM)。
T21648	CP-31398 dihydrochloride CP 31398 dihydrochloride	p53	Apoptosis
	CP-31398 dihydrochloride 是一种 p53 稳定剂，可稳定 p53 的活性构象并促进具有突变型或野生型 p53 的癌细胞系中的 p53 活性。
T10459	Banoxantrone dihydrochloride AQ4N dihydrochloride,AZD1689 2HCl	NOS	Immunology/Inflammation
	Banoxantrone dihydrochloride (AQ4N dihydrochloride) 是一种新型缺氧细胞毒素，通过 iNOS 依赖机制选择性地杀死缺氧细胞。
T3597	Cutamesine dihydrochloride AGY94806 dihydrochloride,库他美新二盐酸盐,SA4503 (dihydrochloride),SA4503 dihydrochloride	Sigma receptor	GPCR/G Protein
	Cutamesine dihydrochloride (SA4503 dihydrochloride) 是一种选择性 σ1 受体激动剂，IC50值为 17.4 nM。
T6720	Vatalanib dihydrochloride CGP-797870 dihydrochloride,ZK-222584 dihydrochloride,Vatalanib 2HCl,PTK787 dihydrochloride,Vatalanib (PTK787) 2HCl,CGP-79787 dihydrochloride,瓦他拉尼	Apoptosis; VEGFR; PDGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Vatalanib dihydrochloride (PTK787 dihydrochloride) 是一种VEGFR2/KDR 的抑制剂，其IC50值为37nM。
T5135	Flupentixol dihydrochloride 盐酸氟哌噻吨,Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Flupentixol dihydrochloride 是噻克西酮类试剂，能够用于研究精神分裂症以及抗焦虑和抑郁障碍。
T26240	Surfen dihydrochloride Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl	FGFR; Antiviral; Antibiotic	Angiogenesis; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Surfen dihydrochloride (Aminoquinuride dihydrochloride) 是一种有效的硫酸肝素小分子拮抗剂，具有抗菌和抗病毒活性，抑制炭疽致死因子、凝血因子 X 和致死因子。Surfen dihydrochloride 可抑制普通肝素和低分子量肝素的抗凝活性，抑制肝素的硫酸化和肝素裂解酶的降解。Surfen dihydrochloridn 抑制阻断硫酸乙酰肝素介导的 FGF2 结合和信号转导。Surfen 抑制 SEVI 和精液介导的 HIV 1 型感染增强。
T4327	Prexasertib dihydrochloride LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368	Apoptosis; Chk; S6 Kinase	Apoptosis; Cell Cycle/Checkpoint; MAPK; PI3K/Akt/mTOR signaling
	Prexasertib dihydrochloride (LY2606368) 是一种选择性的，ATP 竞争性的细胞周期检测点激酶 1 抑制剂，Ki 为 0.9 nM，IC50为 <1 nM。它抑制 CHK2(IC50=8 nM) 和 RSK1 (IC50=9 nM)。它引起双链 DNA 断裂和复制突变，导致细胞凋亡，有抗肿瘤活性。
T22288	(1E)-CFI-400437 dihydrochloride CFI-400437 dihydrochloride	PLK	Cell Cycle/Checkpoint
	(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) 是一种选择性和有效的 polo 样激酶 4 (PLK4) 抑制剂，IC50为 0.6 nM。它还抑制 Aurora A、 Aurora B、 KDR 和 FLT-3，IC50分别为 0.37、0.21、0.48 和 0.18 μM，具有抗增殖活性。
T11500L	GSK3368715 dihydrochloride EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl	Histone Methyltransferase	Chromatin/Epigenetic
	GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) 是一种具有口服活性和高效性的 I 型蛋白精氨酸甲基转移酶 (PRMTs) 抑制剂，具有抗癌和抗肿瘤活性，抑制PRMT1，PRMT3，PRMT4，PRMT6，PRMT8的活性，可用于研究晚期实体肿瘤。
T7153	Vanoxerine dihydrochloride GBR-12909 dihydrochloride,伐诺司林二盐酸盐,I893 dihydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) 是一种竞争性的、有效的、选择性的多巴胺再摄取抑制剂，能够与多巴胺转运体 (DAT) 上的靶点结合。
T11227L	Eravacycline dihydrochloride TP-434-046,TP-434 dihydrochloride	Antibacterial	Microbiology/Virology
	Eravacycline dihydrochloride (TP-434-046) 是一种有效的广谱抗菌剂，可对抗六种大肠杆菌(MIC：0.125-0.25 mg/L)。
T2501	Canertinib dihydrochloride CI-1033 dihydrochloride,PD-183805 dihydrochloride,Canertinib,卡奈替尼二盐酸盐	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Canertinib dihydrochloride (PD-183805 dihydrochloride) 是一种可口服的喹唑啉盐酸盐，具有潜在的抗肿瘤和放射增敏活性，抑制细胞 EGFR 和 ErbB2自身磷酸化的 IC50值分别为 7.4 和 9 nM。
T19069	TMB dihydrochloride 3,3',5,5'-四甲基联苯胺盐酸盐,BM blue dihydrochloride,Sure Blue TMB dihydrochloride,3,3',5,5'-Tetramethylbenzidine dihydrochloride	Others	Others
	TMB dihydrochloride (Sure Blue TMB dihydrochloride) 是一种免疫组化和 ELISA 的显色底物。
T11011	Dexpramipexole dihydrochloride 普拉克索杂质D,KNS-760704 dihydrochloride,R-(+)-Pramipexole dihydrochloride,右旋普拉克索二盐酸盐,(R)-Pramipexole dihydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Dexpramipexole dihydrochloride (KNS-760704 dihydrochloride) 是一种神经保护剂，是一种弱的非麦角类多巴胺受体激动剂。
T60248	4-Aminobenzamidine dihydrochloride p-Aminobenzamidine dihydrochloride	Serine Protease	Proteases/Proteasome
	4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) 是一种强胰蛋白酶 (trypsin)抑制剂，也是一种相对较弱的尿激酶型纤溶酶原激活剂 (uPA) 抑制剂 (Ki=82 μM)。4-Aminobenzamidine 可抑制 SCID 小鼠体内前列腺肿瘤的生长。
T2663	GTS-21 dihydrochloride GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine	5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	GTS-21 dihydrochloride (DMBX-anabaseine) 是一种选择性 α7 烟碱乙酰胆碱受体激动剂，具有抗炎和增强认知的活性。它也是一种拮抗剂，对人α4β2的 Ki 为20 nM，对5-HT3A 受体的 IC50为3.1 μM。
T7505	Azimilide Dihydrochloride NE-10064 Dihydrochloride,盐酸阿齐利特	Potassium Channel	Membrane transporter/Ion channel
	Azimilide Dihydrochloride (NE-10064 Dihydrochloride) 是 I(Ks) 和 I(Kr) 抑制剂，具有抗心律失常活性。
T5495	Decloxizine dihydrochloride 盐酸去氯羟嗪,UCB 1402 dihydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Decloxizine dihydrochloride (UCB 1402 dihydrochloride) 是组胺 1 受体拮抗剂。
T35528L	TD52 dihydrochloride TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl	Others	Others
	TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signaling pathway, resulting in the induction of apoptosis in triple-negative breast cancer (TNBC) cells. Mechanistically, TD52 dihydrochloride disrupts the binding of Elk1 to the CIP2A promoter, effectively reducing CIP2A levels. Notably, TD52 dihydrochloride demonstrates powerful anti...
T6562	Latrepirdine dihydrochloride Dimebolin dihydrochloride,Latrepirdine,Latrepirdine 2HCl,Dimebolin	Beta Amyloid; 5-HT Receptor; Adrenergic Receptor; GluR; Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Latrepirdine dihydrochloride (Dimebolin dihydrochloride) 是一种具有口服活性和神经活性的多种药物靶点的拮抗剂，可刺激淀粉样前体蛋白分解代谢和 β-淀粉样蛋白分泌。
T35328	H-1152 dihydrochloride H-1152 2HCl,H-1152 dihydrochloride	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	H-1152 dihydrochloride (H-1152 2HCl) 是 Rho 相关蛋白激酶 (ROCK) 的特异性抑制剂，IC50 为 12 nM，Ki 为 1.6 nM。 H-1152 dihydrochloride 抑制 PKA、PKC、PKG、Aurora A 和 CaMKII，IC50 值分别为 3.03 μM、5.68 μM、0.360 μM、0.745 μM 和 0.180 μM。
T38034	MAO-IN-M30 dihydrochloride M 30 dihydrochloride	Monoamine Oxidase	Neuroscience
	MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) 是一种口服活性，可通过血脑屏障的，脑选择性不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。
T4167	Raf inhibitor 1 dihydrochloride B-Raf inhibitor 1 dihydrochloride	Raf	MAPK
	Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) 是 Raf 激酶抑制剂，对 B-RafWT、B-RafV600E 和 C-Raf 的Ki 分别为 1、1 和 0.3 nM。
T25268L	Coblopasvir dihydrochloride Coblopasvir dihydrochloride(1312608-46-0 Free base)	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Coblopasvir dihydrochloride 是一种泛基因型非结构蛋白 5A(NS5A)抑制剂。本品可用于慢性丙型肝炎病毒感染的研究。
T1786	Daclatasvir dihydrochloride BMS-790052 dihydrochloride,盐酸达拉他韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) 是有机阴离子转运多肽 1B(OATP1B) 和 OATP1B3抑制剂，IC50分别为 1.5 µM 和 3.27 µM。它也具有口服活性的 HCV NS5A 蛋白抑制剂，多种 HCV 复制子基因型的 EC50范围为 9-146 pM。
T23132	Pentamidine dihydrochloride 喷他脒二盐酸盐,MP-601205 dihydrochloride	Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology
	Pentamidine dihydrochloride (MP-601205 dihydrochloride) 是一种抗微生物剂，会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究，有抗肿瘤活性，抗菌活性。
T6146	Dorsomorphin dihydrochloride BML-275 2HCl,Compound C dihydrochloride,6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride	AMPK; Autophagy; TGF-beta/Smad	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Stem Cells
	Dorsomorphin dihydrochloride (BML-275 2HCl) 是一种选择性和 ATP 竞争性的AMPK 抑制剂，Ki 为 109 nM。它诱导自噬，通过靶向抑制 I 型受体ALK2，ALK3和ALK6来抑制 BMP 途径。
T7309	TAS-103 dihydrochloride 6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐,TAS-103 (dihydrochloride),BMS-247615 dihydrochloride	Topoisomerase	DNA Damage/DNA Repair
	TAS-103 dihydrochloride (BMS-247615 dihydrochloride) 是可用于癌症研究的一种 DNA 拓扑异构酶 I/II 双重抑制剂。
T16524	Philanthotoxin 74 dihydrochloride PhTx-74 HCl,PhTx 74 dihydrochloride	GluR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Philanthotoxin 74 dihydrochloride 是一种 AMPAR 拮抗剂，对 GluR3 和 GluR1 的 IC50 分别为 263 和 296 nM。
T12383	PD 168568 dihydrochloride PD 168568 (dihydrochloride),二盐酸PD168568	Dopamine Receptor	GPCR/G Protein; Neuroscience
	PD 168568 dihydrochloride (PD 168568 (dihydrochloride)) 是一种口服有效的，选择性的 D4 受体拮抗剂，其 Ki 值为 8.8 nM。
T14490	Talipexole dihydrochloride Domnin,盐酸他利克索,B-HT 920 dihydrochloride	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Talipexole dihydrochloride (Domnin) 是一种多巴胺 D2 受体激动剂、α2-肾上腺素受体激动剂和 5-HT3 受体拮抗剂，有抗帕金森病活性。
T2105	Veliparib dihydrochloride 维利帕尼二盐酸盐,ABT-888 dihydrochloride	PARP; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Veliparib dihydrochloride (ABT-888 dihydrochloride) 是一种PARP1和PARP2抑制剂，Ki 分别为5.2 nM 和2.9 nM。
T3213	Hematoporphyrin dihydrochloride 血卟啉二盐酸盐,Hematoporphyrin IX dihydrochloride	Apoptosis; Others; Endogenous Metabolite	Apoptosis; Metabolism; Others
	Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride) 是一种光敏剂，是血红素结合蛋白亲和色谱底物。它暴露在红光下时，可诱导 U87 胶质瘤细胞凋亡，并降低体内肿瘤的生长。
T61156	L-Lysyl-L-lysine dihydrochloride Lysyllysine dihydrochloride	Others	Others
	L-Lysyl-L-lysine dihydrochloride (Lysyllysine dihydrochloride) 是一种酶可裂解的接头。L-Lysyl-L-lysine dihydrochloride 可用作递送多种生物活性肽的简单接头。
T1791L	Ceritinib dihydrochloride LDK378 dihydrochloride,双盐酸盐色瑞替尼	IGF-1R; ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	Ceritinib dihydrochloride (LDK378 dihydrochloride) 是一种选择性的、口服具有活性的、ATP 竞争性的ALK 酪氨酸激酶抑制剂 (IC50:200 pM)。它还抑制IGF-1R (IC50:8 nM)，InsR (IC50:7 nM) 和 STK22D (IC50:23 nM)。它显示出良好的抗肿瘤作用。
T40711	H-D-Phe-Pip-Arg-pNA dihydrochloride S-2238 dihydrochloride,H-D-Phe-Pip-Arg-pNA dihydrochloride	Others	Others
	H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, H-D-Phe-Pip-Arg-pNA dihydrochloride is employed for the quantification of antithrombin-heparin cofactor (AT-III). The AT-III assay utilizing this substrate is characterized by its sensitivity, accuracy, and ease of implementation.
T1856	TPT-260 Dihydrochloride TPT-260,TPT 260,NSC55712,TPT260,TPU-260 Dihydrochloride	Others	Others
	TPT-260 Dihydrochloride (NSC55712) 是一种噻吩硫脲衍生物。

化合物

Ipatasertib dihydrochloride

Cat.No: T15374

Synonym: GDC-0068 dihydrochloride,RG-7440 dihydrochloride

Target: Akt, PKA

DG172 dihydrochloride

Cat.No: T7821

Synonym: DG172 (dihydrochloride),DG-172 dihydrochloride

Target: PPAR

Lerociclib dihydrochloride

Cat.No: T11345L

Synonym: G1T38 dihydrochloride

Target: CDK

Preq1-Dihydrochloride

Cat.No: T9012

Synonym: pre-queuosine1 Dihydrochloride

Target: Others

Simufilam dihydrochloride

Cat.No: T9172

Synonym: PTI-125 dihydrochloride

Target: Others

Netarsudil Dihydrochloride

Cat.No: T10358

Synonym: AR-13324 Dihydrochloride

Target: ROCK

PAβN dihydrochloride

Cat.No: T12374

Synonym: MC-207,110 dihydrochloride,Phe-Arg-β-naphthylamide dihydrochloride

Target: Others, Antibacterial

Elacestrant dihydrochloride

Cat.No: T13675

Synonym: RAD1901 dihydrochloride

Target: Estrogen/progestogen Receptor

Levocetirizine Dihydrochloride

Cat.No: T22354

Synonym: Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride

Target: Histamine Receptor

UAMC00039 dihydrochloride

Cat.No: T4467

Synonym: UAMC 00039 dihydrochloride

Target: Proteasome

JPH203 dihydrochloride

Cat.No: T11727

Synonym: KYT-0353 dihydrochloride

Target: Others

Norbinaltorphimine dihydrochloride

Cat.No: T12241

Synonym: nor-BNI dihydrochloride,Nor-BNI dihydrochloride,nor-Binaltorphimine dihydrochloride,Nor-Binaltorphimine dihydrochloride

Target: Opioid Receptor

Sardomozide dihydrochloride

Cat.No: T4676

Synonym: CGP 48664 dihydrochloride,Sardomozide dihydrochloride

Target: Others

CP-31398 dihydrochloride

Cat.No: T21648

Synonym: CP 31398 dihydrochloride

Target: p53

Banoxantrone dihydrochloride

Cat.No: T10459

Synonym: AQ4N dihydrochloride,AZD1689 2HCl

Target: NOS

Cutamesine dihydrochloride

Cat.No: T3597

Synonym: AGY94806 dihydrochloride,库他美新二盐酸盐,SA4503 (dihydrochloride),SA4503 dihydrochloride

Target: Sigma receptor

Vatalanib dihydrochloride

Cat.No: T6720

Synonym: CGP-797870 dihydrochloride,ZK-222584 dihydrochloride,Vatalanib 2HCl,PTK787 dihydrochloride,Vatalanib (PTK787) 2HCl,CGP-79787 dihydrochloride,瓦他拉尼

Target: Apoptosis, VEGFR, PDGFR

Flupentixol dihydrochloride

Cat.No: T5135

Synonym: 盐酸氟哌噻吨,Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride

Target: Dopamine Receptor

Surfen dihydrochloride

Cat.No: T26240

Synonym: Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl

Target: FGFR, Antiviral, Antibiotic

Prexasertib dihydrochloride

Cat.No: T4327

Synonym: LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368

Target: Apoptosis, Chk, S6 Kinase

(1E)-CFI-400437 dihydrochloride

Cat.No: T22288

Synonym: CFI-400437 dihydrochloride

Target: PLK

GSK3368715 dihydrochloride

Cat.No: T11500L

Synonym: EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl

Target: Histone Methyltransferase

Vanoxerine dihydrochloride

Cat.No: T7153

Synonym: GBR-12909 dihydrochloride,伐诺司林二盐酸盐,I893 dihydrochloride

Target: Dopamine Receptor

Eravacycline dihydrochloride

Cat.No: T11227L

Synonym: TP-434-046,TP-434 dihydrochloride

Target: Antibacterial

Canertinib dihydrochloride

Cat.No: T2501

Synonym: CI-1033 dihydrochloride,PD-183805 dihydrochloride,Canertinib,卡奈替尼二盐酸盐

Target: EGFR

TMB dihydrochloride

Cat.No: T19069

Synonym: 3,3',5,5'-四甲基联苯胺盐酸盐,BM blue dihydrochloride,Sure Blue TMB dihydrochloride,3,3',5,5'-Tetramethylbenzidine dihydrochloride

Target: Others

Dexpramipexole dihydrochloride

Cat.No: T11011

Synonym: 普拉克索杂质D,KNS-760704 dihydrochloride,R-(+)-Pramipexole dihydrochloride,右旋普拉克索二盐酸盐,(R)-Pramipexole dihydrochloride

Target: Dopamine Receptor

4-Aminobenzamidine dihydrochloride

Cat.No: T60248

Synonym: p-Aminobenzamidine dihydrochloride

Target: Serine Protease

GTS-21 dihydrochloride

Cat.No: T2663

Synonym: GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine

Target: 5-HT Receptor, AChR

Azimilide Dihydrochloride

Cat.No: T7505

Synonym: NE-10064 Dihydrochloride,盐酸阿齐利特

Target: Potassium Channel

Decloxizine dihydrochloride

Cat.No: T5495

Synonym: 盐酸去氯羟嗪,UCB 1402 dihydrochloride

Target: Histamine Receptor

TD52 dihydrochloride

Cat.No: T35528L

Synonym: TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl

Target: Others

Latrepirdine dihydrochloride

Cat.No: T6562

Synonym: Dimebolin dihydrochloride,Latrepirdine,Latrepirdine 2HCl,Dimebolin

Target: Beta Amyloid, 5-HT Receptor, Adrenergic Receptor, GluR, Autophagy, Histamine Receptor

H-1152 dihydrochloride

Cat.No: T35328

Synonym: H-1152 2HCl,H-1152 dihydrochloride

Target: ROCK

MAO-IN-M30 dihydrochloride

Cat.No: T38034

Synonym: M 30 dihydrochloride

Target: Monoamine Oxidase

Raf inhibitor 1 dihydrochloride

Cat.No: T4167

Synonym: B-Raf inhibitor 1 dihydrochloride

Target: Raf

Coblopasvir dihydrochloride

Cat.No: T25268L

Synonym: Coblopasvir dihydrochloride(1312608-46-0 Free base)

Target: HCV Protease

Daclatasvir dihydrochloride

Cat.No: T1786

Synonym: BMS-790052 dihydrochloride,盐酸达拉他韦

Target: HCV Protease

Pentamidine dihydrochloride

Cat.No: T23132

Synonym: 喷他脒二盐酸盐,MP-601205 dihydrochloride

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Dorsomorphin dihydrochloride

Cat.No: T6146

Synonym: BML-275 2HCl,Compound C dihydrochloride,6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride

Target: AMPK, Autophagy, TGF-beta/Smad

TAS-103 dihydrochloride

Cat.No: T7309

Synonym: 6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐,TAS-103 (dihydrochloride),BMS-247615 dihydrochloride

Target: Topoisomerase

Philanthotoxin 74 dihydrochloride

Cat.No: T16524

Synonym: PhTx-74 HCl,PhTx 74 dihydrochloride

Target: GluR, iGluR

PD 168568 dihydrochloride

Cat.No: T12383

Synonym: PD 168568 (dihydrochloride),二盐酸PD168568

Target: Dopamine Receptor

Talipexole dihydrochloride

Cat.No: T14490

Synonym: Domnin,盐酸他利克索,B-HT 920 dihydrochloride

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Veliparib dihydrochloride

Cat.No: T2105

Synonym: 维利帕尼二盐酸盐,ABT-888 dihydrochloride

Target: PARP, Autophagy

Hematoporphyrin dihydrochloride

Cat.No: T3213

Synonym: 血卟啉二盐酸盐,Hematoporphyrin IX dihydrochloride

Target: Apoptosis, Others, Endogenous Metabolite

L-Lysyl-L-lysine dihydrochloride

Cat.No: T61156

Synonym: Lysyllysine dihydrochloride

Target: Others

Ceritinib dihydrochloride

Cat.No: T1791L

Synonym: LDK378 dihydrochloride,双盐酸盐色瑞替尼

Target: IGF-1R, ALK

H-D-Phe-Pip-Arg-pNA dihydrochloride

Cat.No: T40711

Synonym: S-2238 dihydrochloride,H-D-Phe-Pip-Arg-pNA dihydrochloride

Target: Others

TPT-260 Dihydrochloride

Cat.No: T1856

Synonym: TPT-260,TPT 260,NSC55712,TPT260,TPU-260 Dihydrochloride

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2920	Berbamine dihydrochloride Berbamine,盐酸小檗胺,dihydrochloride	Apoptosis; NF-κB; Bcr-Abl; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; NF-κB; Tyrosine Kinase/Adaptors
	Berbamine dihydrochloride (Berbamine) 是源自小檗植物的天然产物，是一种NF-κB 抑制剂，具有显著的抗骨髓瘤疗效。
TN1012L	Febrifugine dihydrochloride ISF-2123,Propyldazine hydrochloride,Atensil,(+)-Febrifugine dihydrochloride,常山乙素二盐酸盐,Pildralazine dihydrochloride	Parasite	Microbiology/Virology
	Febrifugine dihydrochloride (Propyldazine hydrochloride) 是存在于常山的根和叶中的一种喹唑啉酮类生物碱，具有治疗疟疾、癌症、纤维化和炎症性疾病的活性。
T4754	Pyridoxylamine dihydrochloride 盐酸吡多胺,Pyridorin,Pyridoxamine dihydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Pyridoxylamine dihydrochloride (Pyridorin) 是一种糖基化终产物和脂质化终产物抑制剂，能够防止糖尿病引起的视网膜血管病变。
T0810	Ethambutol dihydrochloride Ethambutol 2HCl,盐酸乙胺丁醇,Emb dihydrochloride,CL40881	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Ethambutol dihydrochloride (CL40881) 能抗分枝杆菌，可抑制阿拉伯糖基转移酶活性来阻止细胞壁形成。
T7117	Sapropterin dihydrochloride Sapropterin Hydrochloride,6R-Tetrahydro-L-biopterin dihydrochloride,(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐,6R-BH4 dihydrochloride,盐酸沙丙蝶呤	Hydroxylase	Metabolism
	Sapropterin dihydrochloride (6R-BH4 dihydrochloride) 是一种合成的 BH4 形式，已经被批准用于 BH4 反应的 PKU 研究。
T4895	Pentane-1,5-diamine dihydrochloride 5-diamine dihydrochloride,Cadaverine dihydrochloride,1,5-戊二胺盐酸盐,Pentane-1	Endogenous Metabolite	Metabolism
	Pentane-1,5-diamine dihydrochloride (Cadaverine dihydrochloride) 是内源性代谢产物的一种。
T2219	Puromycin dihydrochloride CL13900 dihydrochloride,Puromycin 2HCl,嘌呤霉素二盐酸盐水合物,嘌呤霉素二盐酸盐	ribosome; DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Puromycin dihydrochloride (CL13900 dihydrochloride) 属于肉桂酰胺腺苷抗生素，是一种蛋白质合成的抑制剂。Puromycin dihydrochloride 通过与 RNA 结合来抑制蛋白质合成，具有抗肿瘤和抗锥虫活性。
T8790	1-Methylhistamine dihydrochloride	Endogenous Metabolite	Metabolism
	1-Methylhistamine dihydrochloride 是组胺代谢物。
T4333	Quinine dihydrochloride 盐酸奎宁,Quinine bimuriate	Others	Others
	Quinine dihydrochloride (Quinine bimuriate) 是Cinchona(Rubiaceae) 各种物种的主要生物碱。它也是一种抗疟药和肌肉松弛剂（骨骼）。
T4940	3-Methylhistamine dihydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	3-Methylhistamine dihydrochloride 是一种组胺的降解产物，与免疫反应有关，并在接种过疫苗的小鼠中表现出上调作用。
T4899	L-Histidinol dihydrochloride	Endogenous Metabolite	Metabolism
	L-Histidinol dihydrochloride 是内源性代谢产物的一种。
T19466	N8-Acetylspermidine dihydrochloride N8-乙酰基亚精胺二盐酸盐	Endogenous Metabolite	Metabolism
	N8-Acetylspermidine dihydrochloride 是一种多胺物质。
T6534	Histamine dihydrochloride 组胺二盐酸盐,peremin,Ceplene,Histamine 2HCl	Endogenous Metabolite; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Histamine dihydrochloride (Ceplene) 是 Histamine 的二盐酸形式。Histamine 是一种有机氮化合物，是一种强效的胃分泌兴奋剂，支气管平滑肌收缩剂，血管舒张剂，也是一种中枢作用的神经递质。
T0788	Spectinomycin dihydrochloride 淋必治,Spectinomycin 2HCl,盐酸奇霉素,Actinospectacin	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Spectinomycin dihydrochloride (Actinospectacin) 是一种能与细菌核糖体的30S 亚基结合，干扰蛋白质合成的抗生素。
T19394	L-hydroxylysine dihydrochloride (2S,5R)-5-Hydroxylysine dihydrochloride	Others	Others
	L-hydroxylysine dihydrochloride , is formed by posttranslational hydroxylation of some lysine residues. It is an amino acid, is exclusive to collagen protein.
TQ0109	Cephaeline dihydrochloride (-)-Cephaeline dihydrochloride,盐酸吐根酚碱,NSC 32944	P450	Metabolism
	(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).
T38541	Chitobiose dihydrochloride
	Chitobiose dihydrochloride is a chitosan oligosaccharide consisting of β-1,4-linked glucosamine units.
T22213	1,4-Diaminobutane Dihydrochloride	Others	Others
	1,4-Diaminobutane dihydrochloride, an endogenous metabolite, acts as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). In addition, 1,4-Diaminobutane dihydrochloride is an important source of GABA.
T60789	L-Cystine dihydrochloride
	L-Cystine dihydrochloride 是合成谷胱甘肽 (GSH) 的含硫前体。L-Cystine dihydrochloride 的稳态对谷胱甘肽的功能很重要。L-Cystine dihydrochloride 可用作细胞培养组分。
TN7229	Baihuaqianhuoside Praeroside	Others	Others
	Baihuaqianhuoside (Praeroside) 是一种香豆素苷。Baihuaqianhuoside 可以从西番莲和 Hindenia solanacea 的根部分离出来，是首次从 P. japonicum 身上分离出来的。Baihuaqianhuoside 在体外具有抗炎活性，可以用于炎症的研究。Baihuaqianhuoside 对1,1-二苯基-2-丙烯酰肼自由基的清除作用，以及对2,2'-偶氮双（2-脒基丙烷）二盐酸盐诱导的脂质体氧化的抑制作用。

天然产物

Berbamine dihydrochloride

Cat.No: T2920

Synonym: Berbamine,盐酸小檗胺,dihydrochloride

Target: Apoptosis, NF-κB, Bcr-Abl, Autophagy

Febrifugine dihydrochloride

Cat.No: TN1012L

Synonym: ISF-2123,Propyldazine hydrochloride,Atensil,(+)-Febrifugine dihydrochloride,常山乙素二盐酸盐,Pildralazine dihydrochloride

Target: Parasite

Pyridoxylamine dihydrochloride

Cat.No: T4754

Synonym: 盐酸吡多胺,Pyridorin,Pyridoxamine dihydrochloride

Target: Others, Endogenous Metabolite

Ethambutol dihydrochloride

Cat.No: T0810

Synonym: Ethambutol 2HCl,盐酸乙胺丁醇,Emb dihydrochloride,CL40881

Target: Antibacterial, Antibiotic, Antifungal

Sapropterin dihydrochloride

Cat.No: T7117

Synonym: Sapropterin Hydrochloride,6R-Tetrahydro-L-biopterin dihydrochloride,(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐,6R-BH4 dihydrochloride,盐酸沙丙蝶呤

Target: Hydroxylase

Pentane-1,5-diamine dihydrochloride

Cat.No: T4895

Synonym: 5-diamine dihydrochloride,Cadaverine dihydrochloride,1,5-戊二胺盐酸盐,Pentane-1

Target: Endogenous Metabolite

Puromycin dihydrochloride

Cat.No: T2219

Synonym: CL13900 dihydrochloride,Puromycin 2HCl,嘌呤霉素二盐酸盐水合物,嘌呤霉素二盐酸盐

Target: ribosome, DNA/RNA Synthesis, Antibacterial, Antibiotic

1-Methylhistamine dihydrochloride

Cat.No: T8790

Target: Endogenous Metabolite

Quinine dihydrochloride

Cat.No: T4333

Synonym: 盐酸奎宁,Quinine bimuriate

Target: Others

3-Methylhistamine dihydrochloride

Cat.No: T4940

Target: Others, Endogenous Metabolite

L-Histidinol dihydrochloride

Cat.No: T4899

Target: Endogenous Metabolite

N8-Acetylspermidine dihydrochloride

Cat.No: T19466

Synonym: N8-乙酰基亚精胺二盐酸盐

Target: Endogenous Metabolite

Histamine dihydrochloride

Cat.No: T6534

Synonym: 组胺二盐酸盐,peremin,Ceplene,Histamine 2HCl

Target: Endogenous Metabolite, Histamine Receptor

Spectinomycin dihydrochloride

Cat.No: T0788

Synonym: 淋必治,Spectinomycin 2HCl,盐酸奇霉素,Actinospectacin

Target: ribosome, Antibacterial, Antibiotic

L-hydroxylysine dihydrochloride

Cat.No: T19394

Synonym: (2S,5R)-5-Hydroxylysine dihydrochloride

Target: Others

Cephaeline dihydrochloride

Cat.No: TQ0109

Synonym: (-)-Cephaeline dihydrochloride,盐酸吐根酚碱,NSC 32944

Target: P450

Chitobiose dihydrochloride

Cat.No: T38541

1,4-Diaminobutane Dihydrochloride

Cat.No: T22213

Target: Others

L-Cystine dihydrochloride

Cat.No: T60789

Baihuaqianhuoside

Cat.No: TN7229

Synonym: Praeroside

Target: Others

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