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112

抑制剂 & 化合物

39

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22414	RBN012759	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	RBN012759 是选择性和具有口服活性的 PARP14抑制剂，IC50值小于3 nM，可降低促肿瘤巨噬细胞功能并在肿瘤外植体中引发炎症反应，比对 monoPARPs 的选择性高 300 倍，比对 polyPARPs 的选择性高 1000 倍。
T2057	BVT 2733	Dehydrogenase	Metabolism
	BVT 2733 是具有口服活性的、强效的、非甾体类11β-HSD1选择性抑制剂。它对小鼠 11β-HSD1 酶的作用 (IC50:96 nM) 比对人 11β-HSD1 酶 (IC50:3341 nM) 的作用强。它对关节炎和肥胖相关疾病具有潜在的研究价值。
T8732	CTPI-2	Others; Mitochondrial Metabolism	Metabolism; Others
	CTPI-2 是一种特异性线粒体柠檬酸盐载体SLC25A1抑制剂，KD=3.5 μM，具有抗肿瘤作用。它能够抑制糖酵解、PPARγ 及其下游靶点葡萄糖转运蛋白 GLUT4。它阻断非酒精性脂肪性肝炎逆转脂肪变性的显著改变，防止演变为脂肪性肝炎，减少肝脏和脂肪组织中炎性巨噬细胞的浸润，并显著减轻由高脂肪饮食引起的肥胖。
T11344	G150	DNA; cGAS	DNA Damage/DNA Repair; Immunology/Inflammation
	G150 是高选择性h-cGAS 抑制剂，IC50值为 10.2 nM，用于抑制 dsDNA 引发的干扰素表达。
T39789	BMS-986235 BMS-986235,LAR-1219	Others	Others
	BMS-986235 (LAR-1219) 是一种特异性和口服活性的甲酰肽受体 2 (FPR2) 激动剂，对 hFPR2 和 mFPR2 的 EC50 分别为 0.41 nM 和 3.4 nM。 BMS-986235 可用于预防心力衰竭的研究。
T27730	KGP94 KGP-94,KGP 94	Cysteine Protease	Proteases/Proteasome
	KGP94 是一种有效的、选择性的和竞争性的溶酶体内肽酶抑制剂。
T23146	PHA 568487 free base PHA 568487	AChR	Neuroscience
	PHA 568487 free base 是一种选择性的 α7 烟碱乙酰胆碱受体激动剂，可用于减缓神经炎症。
T2319	Acotiamide monohydrochloride trihydrate Acotiamide hydrochloride,YM-443 HCl,盐酸阿考替胺,Z-338 HCl	AChE	Neuroscience
	Acotiamide monohydrochloride trihydrate (Z-338 HCl) 是一种首创的、具有口服活性的胃肠动力药。它通过促毒蕈碱受体拮抗作用和乙酰胆碱酯酶(AChE)抑制作用增强肠神经元释放的乙酰胆碱，从而增强胃排空和胃部适应性，有潜力用于功能性消化不良的研究。
T4583	PFI-2 hydrochloride (R)-PFI-2 hydrochloride,PFI-2 HCl	Histone Methyltransferase	Chromatin/Epigenetic
	PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) 是一种有效的、高度选择性的、具有细胞活性的 SETD7 甲基转移酶抑制剂，IC50值为2nM，活性是 (S)-PFI-2 的 500 倍。
T2036	6-OAU GTPL5846	GPR	Endocrinology/Hormones; GPCR/G Protein
	6-OAU (GTPL5846) 是 GPR84 的替代激动剂，在 Gqi5 嵌合体存在的情况下，在 HEK293 细胞中激活人 GPR84，在 PI 测定中 EC50 为 105 nM。
T36573	NHWD-870	Apoptosis; Epigenetic Reader Domain	Apoptosis; Chromatin/Epigenetic
	NHWD-870 是一种有效且特异性的 BET 家族溴结构域抑制剂，仅与 BRD2、BRD3、BRD4 (IC50 = 2.7 nM) 和 BRDT 结合。 NHWD-870 具有强大的抗肿瘤功效，并通过增加肿瘤细胞凋亡和抑制肿瘤增殖来抑制癌细胞-巨噬细胞相互作用。
T1987	PFI-2 PFI2,PFI 2,(R)-PFI-2	Histone Methyltransferase	Chromatin/Epigenetic
	PFI-2 是一种有效、特异性和细胞活性的赖氨酸甲基转移酶 SETD7 抑制剂，Ki 和 IC50值分别为 0.33 和 2 nM。
T40863	Bisdionin C	Antibacterial	Microbiology/Virology
	Bisdionin C 是一种有效的 GH18 chitinase 抑制剂，对 A. fumigatus ChiB1 的 IC50 为 0.2 μM。 Bisdionin C 抑制人巨噬细胞壳三糖苷酶 (HCHT, IC50 = 8.3 μM) 和酸性哺乳动物几丁质酶 (AMCase, IC50 = 3.4 μM)。
T8811	Tuftsin 3TFA	Endogenous Metabolite	Metabolism
	Tuftsin 3TFA 是一种四肽。它是一种巨噬细胞/小胶质细胞激活剂。
T77674	3-Cyano-7-hydroxycoumarin 3-Cyanoumbelliferone
	3-Cyano-7-hydroxycoumarin (3-Cyanoumbelliferone) 是一种巨噬细胞游走抑制因子 (MIF) 互变异构酶抑制剂，Ki 为 2.9 μM。3-Cyano-7-hydroxycoumarin 属于香豆素衍生物，可被用作分子探针和荧光染料。
T77493	Murlentamab 3C23K,GM102	Others	Others
	Murlentamab (GM102) 是一种人源化抗 AMHRII 抗体。Murlentama 具有潜在的抗肿瘤活性，可诱导巨噬细胞介导的抗体依赖的细胞介导的细胞毒性作用 (ADCC)。Murl可通过募，集、活化T细胞激发促炎和抗肿瘤内环境。Murlentama 通过促进幼稚的巨噬细胞定向，促进肿瘤相关巨噬细胞 (TAM) 重编程来发挥抗肿瘤活性。
T11449L	Golotimod SCV 07,Gamma-D-glutamyl-L-tryptophan	STAT	JAK/STAT signaling; Stem Cells
	Golotimod is an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function.
T7844	4-IPP 4-Iodo-6-phenylpyrimidine	Others	Others
	4-IPP (4-Iodo-6-phenylpyrimidine) 是一种巨噬细胞迁移抑制因子 (MIF) 的特异性自杀底物，也是 MIF 的不可逆抑制剂。
T25859	Necrostatin-7 Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7	Apoptosis	Apoptosis
	Necrostatin-7 (Necrostatin 7) 是一种坏死性凋亡抑制剂，具有心脏保护作用，可抑制 RANK-NFATc1 信号传导并减弱巨噬细胞向破骨细胞的分化。
T4412	Roquinimex Linomide,罗喹美克,LS2616,FCF89,ABR212616	TNF	Apoptosis
	Roquinimex (FCF89) 是一种喹啉衍生物免疫刺激剂，可增加 NK 细胞活性和巨噬细胞的细胞毒性，抑制血管生成并减少 TNF α 的分泌。
T17157	TRAF-STOP inhibitor 6877002 CD40-TRAF6 inhibitor	NF-κB	NF-κB
	TRAF-STOP inhibitor 6877002 (CD40-TRAF6 inhibitor)是一种 CD40-TRAF6 相互作用的选择性抑制剂，可以抑制 RAW 细胞中 NF-κB 活化。TRAF-STOP 6877002 可阻止小鼠动脉粥样硬化的恶化，减少白细胞募集和巨噬细胞的活化，减少动脉粥样硬化斑块中的巨噬细胞增殖。
T5641	RP-54745	Interleukin	Immunology/Inflammation
	RP-54745 是一种能抑制噬细胞刺激和的白介素-1 的产生的化合物，对风湿病的治疗具有潜在的研究价值。
T11765	KPLH1130	Dehydrogenase; PDK	Metabolism; PI3K/Akt/mTOR signaling
	KPLH1130，一种选择性丙酮酸脱氢酶激酶(PDK)抑制剂，在高脂饮食(HFD)喂养的小鼠中提高了糖耐量。KPLH1130 抑制巨噬细胞极化并减轻了炎症反应。
T77362	Vorsetuzumab SGN-70	Immunology/Inflammation related	Immunology/Inflammation
	Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) 是靶向 CD70 抗体的单克隆抗体。Vorsetuzumab 具有抗癌活性，能够加强肾癌细胞巨噬相关吞噬作用，抑制 Burkitt 淋巴瘤。
T7397	GSK547 GSK'547	RIP kinase	Apoptosis; NF-κB
	GSK547 (GSK'547) 是一种高选择性、强效的 RIP1激酶抑制剂，可抑制巨噬细胞介导的胰腺癌适应性免疫耐受。
T60388	MIF098	Others	Others
	MIF098 是一种巨噬细胞迁移抑制因子 (MIF) 拮抗剂。MIF098，抑制与 SLE 相关的肺动脉高压，抑制肺平滑肌细胞(PASMC)增殖和迁移。MIF098 可用于研究特发性肺动脉高压。
T83972	NOX-6-18 GPR132 antagonist 1,GPR132-B-160	GPR	Endocrinology/Hormones; GPCR/G Protein
	NOX-6-18 (GPR132-B-160) 是一种具有高效性和选择性的 GPR132 拮抗剂，具有促进胰岛素分泌活性，可以调节胰岛内的巨噬细胞重编程，减少体重增加。
T70277	Cynandione A	Others	Others
	Cynandione A 是从 Cynanchum wilfordii 中提取的苯乙酮，具有抗炎活性，可通过巨噬细胞 α7 nAChR 激活和随后的 IL-10 表达来显着减少促炎细胞因子的过表达。
T60850	MIF-IN-2	Others	Others
	MIF-IN-2 是一种杂环巨噬细胞迁移抑制因子 (MIF) 抑制剂，具有抗癌活性，可用于研究癌症和自身免疫性疾病。
T17315	(±)-CPSI-1306 cpsi-1306,2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one	Others	Others
	(±)-CPSI-1306 (2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one) 是一种巨噬细胞迁移抑制因子 (MIF) 拮抗剂，可用于关于非胰岛素依赖型糖尿病 (NIDDM) 的研究以及预防急性和慢性 UVB 暴露对皮肤的有害影响。
T27371	FR-167356 FR167356,FR 167356	ATPase	Membrane transporter/Ion channel
	FR-167356 是 a3 异构体液泡型 H+-ATPase 的特异性抑制剂，对破骨细胞质膜、肾刷状缘膜和巨噬细胞微粒体的 IC50 分别为 170 nM、370 nM 和 220 nM。 FR-167356 减少 B16-F10 细胞的骨转移。
T77616	VU533 Nape-Pld activator	Phospholipase	Metabolism
	VU533 (Nape-Pld activator) 是一种NAPE-PLD 激活剂，其 EC50 值为0.30 µM。VU533 可以提高 NAPE-PLD 活性，增加巨噬细胞的胞葬作用。VU533 可用于与心脏代谢相关的疾病。
T77379	Bexmarilimab FP-1305	Others	Others
	Bexmarilimab (FP-1305) 是一种高效的人源化抗 CLEVER-1 IgG4 抗体，其 IC50 值为 4.51 nM。Bexmarilimab 能够促使肿瘤相关巨噬细胞表型 M2 到 M1 的免疫转换。Bexmarilimab 可用于研究癌症。
T5032	Iguratimod 艾拉莫德,T614	Others; COX	Immunology/Inflammation; Neuroscience; Others
	Iguratimod (T614) 是一种抗风湿药，作为 COX-2 的抑制剂，IC50 为 20 μM (7.7 μg/mL)。它还抑制巨噬细胞迁移抑制因子 (MIF)，IC50值为 6.81 μM。
T11139	(E/Z)-BCI NSC 150117	Apoptosis; Phosphatase	Apoptosis; Metabolism
	(E/Z)-BCI (NSC-150117) 是一种DUSP6抑制剂，可通过激活 Nrf2 信号和抑制 NF-κB 通路，减弱 LPS 诱导的巨噬细胞炎症和 ROS 生成，具有抗炎活性。
T77125	Otilimab GSK 3196165,MOR103	CSF-1R	Tyrosine Kinase/Adaptors
	Otilimab (GSK 3196165) 是一种人源化抗粒细胞-巨噬细胞集落刺激因子 (GM-CSF) 单克隆抗体。Otilimab 具有抗炎活性，通过阻断 GM-CSF 与其细胞表面受体的相互作用来调节 GM-CSF 的生物学功能，可用于研究治疗重症 COVID-19 肺炎。
T4535L	Etomoxir (R)-(+)-Etomoxir	Antioxidant; CPT	Metabolism; oxidation-reduction
	Etomoxir 是肉碱棕榈酰转移酶 1a （CPT-1a）抑制剂，通过抑制 CPT-1a 来抑制脂肪酸氧化，且抑制人、大鼠和豚鼠中棕榈酸酯的氧化。Etomoxir 对腺嘌呤核苷酸转位酶有抑制作用，可通过破坏CoA稳态来抑制巨噬细胞极化。
T17028	Tefinostat CHR-2845	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Tefinostat (CHR-2845) 是一种有效的单核细胞/巨噬细胞靶向组蛋白脱乙酰酶 (HDAC) 抑制剂。 Tefinostat 可被胞内酯酶人羧酸酯酶-1 (hCE-1) 裂解成活性酸 CHR-2847。Tefinostat 具有抗肿瘤活性，可用于研究白血病和晚期血液系统恶性肿瘤。
T60336	CCR4 antagonist 3-1	CCR	Immunology/Inflammation; Microbiology/Virology
	CCR4 antagonist 3-1 是一种具有较低活性的趋化因子受体 4 (CCR4) 拮抗剂，对 [125I]TARC (胸腺和活化调节趋化因子) 具有抑制作用，IC50 值为 1.7 μM。CCR4 antagonist 3-1 对放射标记的[125I]TARC和巨噬细胞来源的趋化因子(MDC) 与 CEM 细胞表面的CCR4 受体的结合有抑制作用，并对 TARC 介导的 CEM 细胞的体外迁移有抑制作用，IC50 值为 6.4 μM。
T0944	Levamisole hydrochloride (-)-Tetramisole hydrochloride,盐酸左旋咪唑	Phospholipase; AChR; Parasite; HSV	Metabolism; Microbiology/Virology; Neuroscience
	Levamisole hydrochloride ((-)-Tetramisole hydrochloride) 是驱虫剂和免疫调节剂。它对HSV 病毒有明显抗病毒作用。
T38293	4-CPPC	Others	Others
	4-CPPC 是一种巨噬细胞迁移抑制因子 2 (MIF-2; IC50= 27 μM) 的抑制剂。它对 MIF-2 的选择性高于 MIF-1 (IC50= 450 μM)。当以 10 μM 浓度使用时，它在体外抑制 MIF-2，但不抑制 MIF-1，与 CD74 结合。 4-CPPC（5、10 和 25 μM）抑制原代人皮肤成纤维细胞中 MIF-2 诱导的 ERK1/2 磷酸化。
T3614	Inosine pranobex Groprinosin,Isoprinosine,异丙肌苷,Immunovir,Delimmun	IL Receptor; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Inosine pranobex (Delimmun) 是一种免疫增强剂，它是一种广谱抗病毒剂，用于 HIV 感染。
T76690	Mavrilimumab CAM 3001	Virus Protease; CSF-1R	Microbiology/Virology; Tyrosine Kinase/Adaptors
	Mavrilimumab (CAM 3001) 是一种单克隆抗体，具有抗病毒活性，对粒细胞-巨噬细胞集落刺激因子 (GM-CSF) 受体的 α 亚基有亲和力，并阻止 GM-CSF 下游细胞内信号传导。GM-CSF 可能与呼吸衰竭和死亡相关的过度活跃炎症反应有关，可用于研究类风湿性关节炎。
T13647	Dextran sulfate sodium salt (MW 4500-5500) DSS,Dextran sulfate sodium salt (MW 4500-5500),硫酸葡聚糖钠盐	Apoptosis; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Dextran sulfate sodium salt (MW 4500-5500) 是一种脱水葡萄糖的聚合物，分子量范围是4500-5500。Dextran sulfate sodium salt (MW 4500-5500) 通过阻止病毒吸附到宿主细胞中来抑制人免疫缺陷病毒的复制。Dextran sulfate sodium salt (MW 4500-5500) 是常用的炎症性肠病造模药物，可通过硫酸基团引起的高负电荷破坏肠黏膜屏障完整性，从而导致肠屏障受损，巨噬细胞功能失调以及菌群紊乱等现象。
TP2336	Tripalmitoyl pentapeptide P3C-Ssna,Bpppcssaa,Bppp cssaa,Bppp-cssaa,P3C Ssna P3CSsna
	Tripalmitoyl pentapeptide is a Mitogen from E Coli lipoprotein. It also is a potent macrophage B lymphocyte activator.
T26548	Acaterin
	Acaterin, an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), inhibits synthesis of cholesteryl ester in macrophage J774.
T27957	LY-465608 LY 465608
	LY-465608, a PPAR Agonist, inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice.
T70983	Zoledronate disodium
	Zoledronate disodium is an inhibitor of osteoclastogenesis and macrophage recruitment, decreasing bone turnover and stabilizing the bone matrix, exhibiting diverse anti-tumor effects in osteosarcoma.
TP2332	Mifamurtide sodium hydrate L-MTP-PE,Mifamurtide,Muramyl tripeptide
	Mifamurtide protects mice against herpes simplex virus type 2. It also is a macrophage activator.
T63322	MIF-IN-4 hydrochloride
	MIF-IN-4 hydrochloride 是一种巨噬细胞移动抑制因子(MIF)的有效抑制剂，其pIC50值在5.01-6之间。其中 MIF 是发现于抑制巨噬细胞迁移过程中的一种细胞因子。

化合物

Cat.No: T22414

Target: PARP

Cat.No: T2057

Target: Dehydrogenase

Cat.No: T8732

Target: Others, Mitochondrial Metabolism

Cat.No: T11344

Target: DNA, cGAS

Cat.No: T39789

Synonym: BMS-986235,LAR-1219

Target: Others

Cat.No: T27730

Synonym: KGP-94,KGP 94

Target: Cysteine Protease

PHA 568487 free base

Cat.No: T23146

Synonym: PHA 568487

Target: AChR

Acotiamide monohydrochloride trihydrate

Cat.No: T2319

Synonym: Acotiamide hydrochloride,YM-443 HCl,盐酸阿考替胺,Z-338 HCl

Target: AChE

PFI-2 hydrochloride

Cat.No: T4583

Synonym: (R)-PFI-2 hydrochloride,PFI-2 HCl

Target: Histone Methyltransferase

Cat.No: T2036

Synonym: GTPL5846

Target: GPR

Cat.No: T36573

Target: Apoptosis, Epigenetic Reader Domain

Cat.No: T1987

Synonym: PFI2,PFI 2,(R)-PFI-2

Target: Histone Methyltransferase

Cat.No: T40863

Target: Antibacterial

Cat.No: T8811

Target: Endogenous Metabolite

3-Cyano-7-hydroxycoumarin

Cat.No: T77674

Synonym: 3-Cyanoumbelliferone

Cat.No: T77493

Synonym: 3C23K,GM102

Target: Others

Cat.No: T11449L

Synonym: SCV 07,Gamma-D-glutamyl-L-tryptophan

Target: STAT

Cat.No: T7844

Synonym: 4-Iodo-6-phenylpyrimidine

Target: Others

Cat.No: T25859

Synonym: Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7

Target: Apoptosis

Cat.No: T4412

Synonym: Linomide,罗喹美克,LS2616,FCF89,ABR212616

Target: TNF

TRAF-STOP inhibitor 6877002

Cat.No: T17157

Synonym: CD40-TRAF6 inhibitor

Target: NF-κB

Cat.No: T5641

Target: Interleukin

Cat.No: T11765

Target: Dehydrogenase, PDK

Cat.No: T77362

Synonym: SGN-70

Target: Immunology/Inflammation related

Cat.No: T7397

Synonym: GSK'547

Target: RIP kinase

Cat.No: T60388

Target: Others

Cat.No: T83972

Synonym: GPR132 antagonist 1,GPR132-B-160

Target: GPR

Cat.No: T70277

Target: Others

Cat.No: T60850

Target: Others

Cat.No: T17315

Synonym: cpsi-1306,2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one

Target: Others

Cat.No: T27371

Synonym: FR167356,FR 167356

Target: ATPase

Cat.No: T77616

Synonym: Nape-Pld activator

Target: Phospholipase

Cat.No: T77379

Synonym: FP-1305

Target: Others

Cat.No: T5032

Synonym: 艾拉莫德,T614

Target: Others, COX

Cat.No: T11139

Synonym: NSC 150117

Target: Apoptosis, Phosphatase

Cat.No: T77125

Synonym: GSK 3196165,MOR103

Target: CSF-1R

Cat.No: T4535L

Synonym: (R)-(+)-Etomoxir

Target: Antioxidant, CPT

Cat.No: T17028

Synonym: CHR-2845

Target: HDAC

CCR4 antagonist 3-1

Cat.No: T60336

Target: CCR

Levamisole hydrochloride

Cat.No: T0944

Synonym: (-)-Tetramisole hydrochloride,盐酸左旋咪唑

Target: Phospholipase, AChR, Parasite, HSV

Cat.No: T38293

Target: Others

Inosine pranobex

Cat.No: T3614

Synonym: Groprinosin,Isoprinosine,异丙肌苷,Immunovir,Delimmun

Target: IL Receptor, HIV Protease

Cat.No: T76690

Synonym: CAM 3001

Target: Virus Protease, CSF-1R

Dextran sulfate sodium salt (MW 4500-5500)

Cat.No: T13647

Synonym: DSS,Dextran sulfate sodium salt (MW 4500-5500),硫酸葡聚糖钠盐

Target: Apoptosis, HIV Protease

Tripalmitoyl pentapeptide

Cat.No: TP2336

Synonym: P3C-Ssna,Bpppcssaa,Bppp cssaa,Bppp-cssaa,P3C Ssna P3CSsna

Cat.No: T26548

Cat.No: T27957

Synonym: LY 465608

Zoledronate disodium

Cat.No: T70983

Mifamurtide sodium hydrate

Cat.No: TP2332

Synonym: L-MTP-PE,Mifamurtide,Muramyl tripeptide

MIF-IN-4 hydrochloride

Cat.No: T63322

Cat. No.	Product Name	Target	Signaling Pathways
TN2167	Rutaevin	Reactive Oxygen Species; NO Synthase	Immunology/Inflammation; Metabolism; NF-κB
	Rutaevin 从Euodia rutaecarpa 中分离。它对 Raw 264.7 巨噬细胞中 LPS 诱导的NO 产生具有抑制作用。
TN1546	Dactylorhin A	NO Synthase	Immunology/Inflammation
	Dactylorhin A 是一种琥珀酸衍生物酯，分离自 Gymnadenia conopsea 根茎中。它对 RAW 264.7 巨噬细胞产生 NO 有中等程度的抑制作用。
T4837	Itaconic acid methylene-butanedioicaci,衣康酸	Others; Endogenous Metabolite	Metabolism; Others
	Itaconic acid (methylene-butanedioicaci) 是聚合物，化学物质和燃料的合成前体。Itaconic acid 可由真菌合成。它也是巨噬细胞特异性代谢产物。它介导巨噬细胞代谢和腹膜肿瘤之间的串扰。
T2893	Muscone 3-Methylcyclopentadecanone,Methylexaltone,麝香酮	MMP; TNF; NF-κB; NOD-like Receptor (NLR); P-gp; Interleukin	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; NF-κB; Proteases/Proteasome
	Muscone (3-Methylcyclopentadecanone) 是中药麝香的一种主要活性单体。它抑制NF-κB 和NLRP3炎性小体的活化，显著降低炎性细胞因子水平，并最终改善心脏功能和存活率。
T2758	Madecassic acid 6-Deoxy-L-Galactose,羟基积雪草酸,L-Fucose,Brahmic acid,L-fucopyranose	Others; TNF; COX; NO Synthase; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience; Others
	Madecassic acid (L-fucopyranose) 是分离自积雪草的一种天然产物，抑制iNOS、COX-2、TNF-α、IL-1beta 和IL-6，可通过在 RAW 264.7 巨噬细胞中下调NF-κB 激活而具有抗炎作用。
TN1291	7,3',4'-Tri-O-methylluteolin 5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚	TNF; COX; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience
	7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) 是来自草药马鞭草科的一种类黄酮，具有抗炎，解热，镇咳，抗糖尿病、抗癌和抗黑素生成特性。它以浓度依赖方式明显抑制促炎细胞因子，可显著降低在转录水平的诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。
T19711	Desmosterol Desmesterol,24-Dehydrocholesterol	Endogenous Metabolite	Metabolism
	Desmosterol(24-Dehydrocholesterol) 是一种胆固醇生物合成中间体，抑制巨噬细胞炎症小体活化，防止血管炎症和动脉粥样硬化。
TN2010	Ombuin 商陆黄素,商陆素	Antibacterial	Microbiology/Virology
	Ombuin 是一种从花椒中分离出的广谱抗菌剂，MIC 为 125 至 500 μg/mL。
TN1786	Isomerazin Isomeranzin,异橙皮内酯	ERK; NF-κB; AChE	MAPK; Neuroscience; NF-κB
	Isomerazin (Isomeranzin) 是一种香豆素类化合物，分离于 Poncirus trifoliateRaf 中，具有胆碱酯酶抑制作用。
T13864	Resolvin D1 RvD1	Apoptosis	Apoptosis
	Resolvin D1 (RvD1) 是一种内源性促进炎症消解介质，可通过调节肌动蛋白聚合阻断促进炎症的中性粒细胞迁移，减少 TNF-α 介导的炎症在巨噬细胞中的作用，并增强巨噬细胞对凋亡细胞的吞噬作用。
T3383	Cimifugin 升麻素,Cimitin	Others	Others
	Cimifugin (Cimitin) 是中草药Saposhnikovia divaricate 的一种生物活性成分。它能够调节紧密连接减少上皮衍生的主动关键因子，对过敏性炎症产生抑制作用。
T19397	L-Methionine sulfoxide L-蛋氨酸亚砜,H-Met(O)-OH	Endogenous Metabolite	Metabolism
	L-Methionine sulfoxide (H-Met(O)-OH) 是一种甲硫氨酸的代谢产物，能够诱导 M1/classical 巨噬细胞极化，并调节氧化应激和嘌呤能的信号传递参数。
TN2359	Iristectorigenin B Iristectrigenin B	Liver X Receptor	Metabolism
	Iristectorigenin B (Iristectrigenin B) 是一种有效的肝脏 X 受体 (LXR) 调节剂，是从 Belamcanda chinensis 中分离的小分子化合物。Iristectrigenin B 可促进巨噬细胞 RAW 1.1 细胞中 ABCA264 和 ABCG7 的表达。
T5S1895	Norisoboldine Laurelliptine,去甲异波尔定,(+)-Laurelliptine	MAPK; Adenosine Receptor	GPCR/G Protein; MAPK; Neuroscience
	Norisoboldine ((+)-Laurelliptine) 是一种可口服的芳基烃受体激动剂，是乌药中主要的异喹啉类生物碱，可用于类风湿性关节炎和溃疡性结肠炎的研究。
TL0007	Bisdemethoxycurcumin 双去甲氧基姜黄素,Curcumin III,Didemethoxycurcumin	Epigenetic Reader Domain; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells
	Bisdemethoxycurcumin (Curcumin III) 是一种具有抗炎及抗氧化作用的姜黄素。
T1257	Bestatin Ubenimex,乌苯美司	Others; Aminopeptidase; Antibacterial; Antibiotic; LTR	Immunology/Inflammation; Metabolism; Microbiology/Virology; Others
	Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，可用于癌症研究。
T16165	Myriocin ISP-I,Thermozymocidin	HCV Protease; Antifungal	Microbiology/Virology; Proteases/Proteasome
	Myriocin (Thermozymocidin) 是一种从 Myriococcum albomyces 中得到的代谢产物，是一种丝氨酸-棕榈酰转移酶 (SPT) 抑制剂,具有潜在的抗肿瘤抗癌和抗寄生虫活性，通过 PI3K/Akt/mTOR 通路调节巨噬细胞极化和功能来抑制肿瘤生长。Myriocin 抑制 HCV 感染，可用于研究神经病变和真菌感染。
T3926	Echinatin 刺甘草查尔酮,Retrochalcone	Free radical scavengers	oxidation-reduction
	Echinatin (Retrochalcone) 是分离自中草药甘草中，具有保肝和抗炎活性。在大鼠中，它可以被快速吸收和消除，并广泛分布，绝对生物利用度约为 6.81％。
TN5302	Withaperuvin C
	Withaperuvin C may have anti-inflammatory activity with lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells.
TN4047	Excisanin B	Others	Others
	Excisanin B shows inhibitory effects on LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells.
T19127	3-Phosphoglyceric acid	Others	Others
	3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. It is involved in alveolar macrophage epigenetic regulation.
T60256	2,4,5-Trimethoxybenzoic acid
	2,4,5-Trimethoxybenzoic acid 是一种紫苏提取物中发现的化合物，可抑制 M1 巨噬细胞表型介导的糖尿病炎症反应。
TN1462	Cajanin 2',4',5-三羟基-7-甲氧基异黄酮,木豆异黄酮	ERK; MEK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol efflux and RCT, it can significantly improve basal glucose uptake in HepG2 cells, its improving effect is concentration dependent, it exhibits effects stronger than that of rosiglitazone, which has been used as an antidiabetic drug.
TN4146	Glutinol acetate	TNF	Apoptosis
	Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29), with GI(50) in the range of 11.1-17.9microM; it also has anti-inflammatory effect, exhibits moderate inhibitory activity of TNF-alpha secretion in the lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cell line.
T35614	D-Trimannuronic acid
	D-Trimannuronic acid is an alginate oligomer that originates from seaweed. It can induce TNF-α secretion by mouse macrophage cell lines, making it valuable in pain and vascular dementia research [1][2][3].
T7732	Carbenoxolone Biogastrone,甘珀酸,Carbenoxolona,Carbenoxolone,Bioral	Dehydrogenase; Gap Junction Protein	Cytoskeletal Signaling; Metabolism
	Carbenoxolone (Carbenoxolona) 是 11β-HSD 和 gap junction connexin 通道的抑制剂。 Carbenoxolone 抑制巨噬细胞迁移到心房并防止脂肪肝的发展。
T69446	Cochlioquinone A
	Cochlioquinone A is an inhibitor of diacylglycerol kinase (DGK) and diacylglycerol acyltransferase (DGAT). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma and has also been shown to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors.
TN4050	Fargesone A	NOS	Immunology/Inflammation
	Fargesone A shows inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774.1.
TN4089	Futokadsurin C	Others	Others
	Futokadsurin C can inhibit nitric oxide production by a murine macrophage-like cell line (RAW 264.7), which is activated by lipopolysaccharide and interferon-gamma.
T82141	Hyperectumine
	Hyperectumine 在RAW 264.7 巨噬细胞中对LPS诱导的炎症反应具有调节作用，通过抑制炎性介质的活化表现出适度的抗炎效应。
T82572	D-Glucosyl-β-1,1′-N-palmitoylsphingosine C16 Glucosyl(β) Ceramide (d18:1/16:0)
	D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) 是内源性Mincle配体，具免疫刺激活性。
TN3869	Dimeric coniferyl acetate	Others	Others
	Dimeric coniferyl acetate has anti-inflammary activity, it shows strong NO inhibition with IC50 values of 27.1 uM in lipopolysacchalide (LPS)-activated murine macrophage-like J774.1 cells. It exhibits significant inhibitory effects on the nitric oxide pro
T38097	Antibiotic PF 1052
	Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also in...
T36226	Beauveriolide I
	Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.78 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 6 μM).2 1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific i...
TN6062	1,3,9-Trimethyluric acid
	1,3,9-Trimethyluric acid exhibits in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 uM. 1,3,9-Trimethyluric a
T37714	Fuscin
	Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 μM in a radioligand binding assay. Fuscin (20 μM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-...
T36227	Beauveriolide III
	Beauveriolide III is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.41 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 5.5 μM).2Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic ...
TN4580	Morachalcone A	Tyrosinase	Proteases/Proteasome
	Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. Morachalcone A exhibits neuroprotective effects on HT22-immortalized hippocampal cells agai
T83916	Cytogenin
	Cytogenin（一种源自S. eurocidicum的香豆素衍生物）具有多种生物活性。在每日给药25 mg/kg剂量下，能减轻Ehrlich鼠自发性腺癌模型的肿瘤重量。在体内，Cytogenin（每日30和100 mg/kg）可减少链脲佐菌素诱导的体重下降和血浆葡萄糖水平上升，以及小鼠糖尿病模型中巨噬细胞胰腺浸润。同时，在每日100 mg/kg的剂量下，能降低小鼠巨噬细胞中zymosan和LPS诱导的一氧化氮产生，及LPS诱导的Il-6水平增加。

天然产物

Cat.No: TN2167

Target: Reactive Oxygen Species, NO Synthase

Cat.No: TN1546

Target: NO Synthase

Cat.No: T4837

Synonym: methylene-butanedioicaci,衣康酸

Target: Others, Endogenous Metabolite

Cat.No: T2893

Synonym: 3-Methylcyclopentadecanone,Methylexaltone,麝香酮

Target: MMP, TNF, NF-κB, NOD-like Receptor (NLR), P-gp, Interleukin

Madecassic acid

Cat.No: T2758

Synonym: 6-Deoxy-L-Galactose,羟基积雪草酸,L-Fucose,Brahmic acid,L-fucopyranose

Target: Others, TNF, COX, NO Synthase, Interleukin

7,3',4'-Tri-O-methylluteolin

Cat.No: TN1291

Synonym: 5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚

Target: TNF, COX, Interleukin

Cat.No: T19711

Synonym: Desmesterol,24-Dehydrocholesterol

Target: Endogenous Metabolite

Cat.No: TN2010

Synonym: 商陆黄素,商陆素

Target: Antibacterial

Cat.No: TN1786

Synonym: Isomeranzin,异橙皮内酯

Target: ERK, NF-κB, AChE

Cat.No: T13864

Synonym: RvD1

Target: Apoptosis

Cat.No: T3383

Synonym: 升麻素,Cimitin

Target: Others

L-Methionine sulfoxide

Cat.No: T19397

Synonym: L-蛋氨酸亚砜,H-Met(O)-OH

Target: Endogenous Metabolite

Iristectorigenin B

Cat.No: TN2359

Synonym: Iristectrigenin B

Target: Liver X Receptor

Cat.No: T5S1895

Synonym: Laurelliptine,去甲异波尔定,(+)-Laurelliptine

Target: MAPK, Adenosine Receptor

Bisdemethoxycurcumin

Cat.No: TL0007

Synonym: 双去甲氧基姜黄素,Curcumin III,Didemethoxycurcumin

Target: Epigenetic Reader Domain, Wnt/beta-catenin

Cat.No: T1257

Synonym: Ubenimex,乌苯美司

Target: Others, Aminopeptidase, Antibacterial, Antibiotic, LTR

Cat.No: T16165

Synonym: ISP-I,Thermozymocidin

Target: HCV Protease, Antifungal

Cat.No: T3926

Synonym: 刺甘草查尔酮,Retrochalcone

Target: Free radical scavengers

Cat.No: TN5302

Cat.No: TN4047

Target: Others

3-Phosphoglyceric acid

Cat.No: T19127

Target: Others

2,4,5-Trimethoxybenzoic acid

Cat.No: T60256

Cat.No: TN1462

Synonym: 2',4',5-三羟基-7-甲氧基异黄酮,木豆异黄酮

Target: ERK, MEK, Akt

Glutinol acetate

Cat.No: TN4146

Target: TNF

D-Trimannuronic acid

Cat.No: T35614

Cat.No: T7732

Synonym: Biogastrone,甘珀酸,Carbenoxolona,Carbenoxolone,Bioral

Target: Dehydrogenase, Gap Junction Protein

Cochlioquinone A

Cat.No: T69446

Cat.No: TN4050

Target: NOS

Cat.No: TN4089

Target: Others

Cat.No: T82141

D-Glucosyl-β-1,1′-N-palmitoylsphingosine

Cat.No: T82572

Synonym: C16 Glucosyl(β) Ceramide (d18:1/16:0)

Dimeric coniferyl acetate

Cat.No: TN3869

Target: Others

Antibiotic PF 1052

Cat.No: T38097

Beauveriolide I

Cat.No: T36226

1,3,9-Trimethyluric acid

Cat.No: TN6062

Cat.No: T37714

Beauveriolide III

Cat.No: T36227

Cat.No: TN4580

Target: Tyrosinase

Cat.No: T83916

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