Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Levamisole hydrochloride ((-)-Tetramisole hydrochloride) 是驱虫剂和免疫调节剂。它对HSV 病毒有明显抗病毒作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 326 | 现货 | ||
5 g | ¥ 395 | 现货 | ||
10 g | ¥ 662 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 395 | 现货 |
产品描述 | Levamisole hydrochloride ((-)-Tetramisole hydrochloride) is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. |
体外活性 | L-tetramisole (250 and 500 mg/mL) suppresses IFN synthesis in the cells from BALB/c and NZB mice. L-tetramisole (125 mg/mL) inhibits the IFN production only partially and this effect is observed when the IFN production is high. L-tetramisole affects the production of the physiological IFN, but not the production of IFN induced by Newcastle disease virus (NDV) in the peritoneal cells of mice or in L929 cells. [1] |
体内活性 | Tetramisole leads to the mean faecal egg count rose from 3 weeks after treatment and remain continuously higher than those Closantel or Albendazole treated group up to 12 weeks after treatment. [2] Tetramisole reduces neuronal response amplitude in a dose-dependent manner in mouse cortex. Tetramisole also decreases axonal conduction velocity in mouse cortex. [3] Tetramisole significantly increases the stereotyped behavior (grooming, sniffing, biting and licking and head bobbing) of the mice when compared to the control group. Tetramisole significantly increases stereotyped behavior of the mice on days 3, 5 and 8 in comparison with respective control values. Tetramisole treatments (0.5 and 1 mg/kg) also significantly decreases the time needed to complete the negative geotaxis task and reduces landing foot splay. [4] |
别名 | (-)-Tetramisole hydrochloride, 盐酸左旋咪唑 |
分子量 | 240.75 |
分子式 | C11H12N2S·HCl |
CAS No. | 16595-80-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15.5 mg/mL (64.38 mM), sonification/heating is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.1537 mL | 20.7684 mL | 41.5369 mL | 103.8422 mL |
5 mM | 0.8307 mL | 4.1537 mL | 8.3074 mL | 20.7684 mL | |
10 mM | 0.4154 mL | 2.0768 mL | 4.1537 mL | 10.3842 mL | |
20 mM | 0.2077 mL | 1.0384 mL | 2.0768 mL | 5.1921 mL | |
50 mM | 0.0831 mL | 0.4154 mL | 0.8307 mL | 2.0768 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Levamisole hydrochloride 16595-80-5 Metabolism Microbiology/Virology Neuroscience Phospholipase Parasite AChR HSV Inhibitor Levamisole Levamisole Hydrochloride (-)-Tetramisole hydrochloride 盐酸左旋咪唑 inhibit Tetramisole Hydrochloride Herpes simplex virus inhibitor