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Levamisole hydrochloride

Levamisole hydrochloride

产品编号 T0944   CAS 16595-80-5
别名: (-)-Tetramisole hydrochloride, 盐酸左旋咪唑

Levamisole hydrochloride ((-)-Tetramisole hydrochloride) 是驱虫剂和免疫调节剂。它对HSV 病毒有明显抗病毒作用。

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Levamisole hydrochloride Chemical Structure
Levamisole hydrochloride, CAS 16595-80-5
规格 价格/CNY 货期 数量
500 mg ¥ 326 现货
5 g ¥ 395 现货
10 g ¥ 662 现货
1 mL * 10 mM (in DMSO) ¥ 395 现货
其他形式的 Levamisole hydrochloride:
产品目录号及名称: Levamisole hydrochloride (T0944)
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纯度: 99.89%
纯度: 99.57%
纯度: 98%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Levamisole hydrochloride ((-)-Tetramisole hydrochloride) is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects.
体外活性 L-tetramisole (250 and 500 mg/mL) suppresses IFN synthesis in the cells from BALB/c and NZB mice. L-tetramisole (125 mg/mL) inhibits the IFN production only partially and this effect is observed when the IFN production is high. L-tetramisole affects the production of the physiological IFN, but not the production of IFN induced by Newcastle disease virus (NDV) in the peritoneal cells of mice or in L929 cells. [1]
体内活性 Tetramisole leads to the mean faecal egg count rose from 3 weeks after treatment and remain continuously higher than those Closantel or Albendazole treated group up to 12 weeks after treatment. [2] Tetramisole reduces neuronal response amplitude in a dose-dependent manner in mouse cortex. Tetramisole also decreases axonal conduction velocity in mouse cortex. [3] Tetramisole significantly increases the stereotyped behavior (grooming, sniffing, biting and licking and head bobbing) of the mice when compared to the control group. Tetramisole significantly increases stereotyped behavior of the mice on days 3, 5 and 8 in comparison with respective control values. Tetramisole treatments (0.5 and 1 mg/kg) also significantly decreases the time needed to complete the negative geotaxis task and reduces landing foot splay. [4]
别名 (-)-Tetramisole hydrochloride, 盐酸左旋咪唑
分子量 240.75
分子式 C11H12N2S·HCl
CAS No. 16595-80-5

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 15.5 mg/mL (64.38 mM), sonification/heating is recommended.

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1537 mL 20.7684 mL 41.5369 mL 103.8422 mL
5 mM 0.8307 mL 4.1537 mL 8.3074 mL 20.7684 mL
10 mM 0.4154 mL 2.0768 mL 4.1537 mL 10.3842 mL
20 mM 0.2077 mL 1.0384 mL 2.0768 mL 5.1921 mL
50 mM 0.0831 mL 0.4154 mL 0.8307 mL 2.0768 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Błach-Olszewska Z, et al. Arch Immunol Ther Exp (Warsz), 19 2. Khan FA, et al. Trop Anim Health Prod,1999, 31(4), 193-204. 3. Nowak LG, et al. Subcell Biochem,2015, 76, 239-281. 4. Mohammad FK, et al. Neurotoxicology,2006, 27(2), 153-157.
L-Hyoscyamine Ethidium bromide Propoxur SEN12333 Desformylflustrabromine hydrochloride Phenserine Zamifenacin fumarate (-)-Coclaurine hydrochloride

相关化合物库

该产品包含在如下化合物库中:
神经退行性疾病化合物库 神经信号分子库 抗阿尔茨海默症化合物库 药物片段库 经典已知活性库 FDA上市及药典收录分子库 FDA 上市药物库 免疫/炎症分子化合物库 抗寄生虫库 口服活性化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Levamisole hydrochloride 16595-80-5 Metabolism Microbiology/Virology Neuroscience Phospholipase Parasite AChR HSV Inhibitor Levamisole Levamisole Hydrochloride (-)-Tetramisole hydrochloride 盐酸左旋咪唑 inhibit Tetramisole Hydrochloride Herpes simplex virus inhibitor

 

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