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215

抑制剂 & 化合物

18

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13273	UT-34	Androgen Receptor	Endocrinology/Hormones
	UT-34 是选择性的、具有口服活性的泛雄激素受体拮抗剂和降解剂，能够作用于野生型 AR (IC50:211.7 nM)、F876L-AR (IC50:262.4 nM)、W741L-AR (IC50:215.7 nM)。它与配体结合结构域和功能 1结构域结合，并需要泛素蛋白酶体途径来降解AR。它有抗前列腺癌的能力。
T14676	BMS-688521	Integrin	Cytoskeletal Signaling
	BMS-688521 是一种具有口服活性和高效性的 LFA-1/ICAM 相互作用抑制剂，是白细胞功能相关抗原-1 （LFA-1）的小分子拮抗剂，具有潜在的抗炎活性。
T3977	Lifitegrast SHP-606,SAR 1118,立他司特,利非司特	Integrin	Cytoskeletal Signaling
	Lifitegrast (SAR 1118) 是一种整合素淋巴细胞功能相关抗原 1 拮抗剂，抑制 Jurkat T 细胞附着于ICAM-1的IC50为 2.98 nM。
T27084	Crisdesalazine AAD2004,AAD 2004,AAD-2004	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Crisdesalazine (AAD 2004) 是微粒体前列腺素 E2 合酶 1 (mPGES-1) 的抑制剂。 Crisdesalazine 可减少自噬体形成、轴索病变和运动神经元变性，改善运动功能并延长寿命。
T21781	A-286982	Integrin	Cytoskeletal Signaling
	A 286982是高效的LFA-1/ICAM-1相互作用变构抑制剂，在LFA-1/ICAM-1结合和LFA-1介导的细胞粘附实验中，其IC50分别为44和35 nM。
T14969	CINPA1 CINPA-1,CINPA 1	Others	Others
	CINPA1 (CINPA 1) 是组成型雄甾烷受体 (CAR) 的特异性抑制剂，对 CAR 介导的转录的 IC50 为 70 nM。 CINPA1 可用于研究 CAR 功能。
T12783	RWJ 50271	Integrin	Cytoskeletal Signaling
	RWJ 50271 是具有口服活性的选择性LFA-1/ICAM-1相互作用抑制剂，抑制 LFA-1/ICAM-1 介导的细胞粘附，在细胞HL60中的IC50值为 5.0 μM。
T8870	1-(4-methansulfinylphenyl)ethanone	Ras	GPCR/G Protein; MAPK
	1-(4-methansulfinylphenyl)ethanone 抑制 Ras 功能，因此抑制细胞的异常生长。
T9179	CLP-3094 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE	Androgen Receptor	Endocrinology/Hormones
	CLP-3094 (2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE) 是一种雄激素受体 BF3(binding function 3) 抑制剂，是一种选择性GPR142拮抗剂。BF3-IN-1 抑制 AR 转录活性 (IC50:4 μM)。
T0038	Doxapram hydrochloride hydrate 多沙普仑盐酸一水合物,盐酸多沙普仑,Doxapram hydrochloride monohydrate,Doxapram HCl	Potassium Channel	Membrane transporter/Ion channel
	Doxapram hydrochloride hydrate (Doxapram HCl) 是 TASK-1，TASK-3和 TASK-1/TASK-3异二聚体通道的抑制剂，EC50分别为410 nM，37 μM 和9 μM。
T50047	1-(3,4-dihydroxyphenyl)-2-(dimethylamino)ethan-1-one hydrochloride	Others	Others
	1-(3,4-dihydroxyphenyl)-2-(dimethylamino)ethan-1-one hydrochloride 是一种胆碱能制剂，抑制胆碱代谢，从而导致大脑中乙酰胆碱水平的增加，进而增强认知功能和记忆。
T2650	MK-8245	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	MK8245 是肝靶向的硬脂酰 -CoA 去饱和酶(SCD)抑制剂，对人 SCD1 和鼠 SCD1 的IC50值分别为 1 nM 和 3 nM，具有抗糖尿病和抗血脂异常的作用。
T22980	MIRA-1 p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor	DNA/RNA Synthesis; p53	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	MIRA-1 (WRN Helicase Inhibitor) 是马来酰亚胺类似物。它可以恢复p53依赖的转录转激活诱导 p53 突变细胞凋亡，具有抗肿瘤作用。
T27710	K6PC-5 K6PC5,K6PC 5	S1P Receptor	GPCR/G Protein
	K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and virus infection, K6PC-5 presents a promising compound for research purposes.
T37042	SCH529074 SCH 529074	p53	Apoptosis
	SCH529074 是 p53 的选择性激活剂 (Ki = 1 μM)，可用于非小细胞肺癌的研究。 SCH529074 恢复突变 p53 功能并中断 HDM2 介导的野生型 p53 泛素化。
T4414	Eprenetapopt APR-246,PRIMA-1Met	Apoptosis; Others; Ferroptosis; p53; Autophagy	Apoptosis; Autophagy; Others
	Eprenetapopt (PRIMA-1Met) 是一种在 TP53突变细胞中恢复野生型 p53功能的小分子，可引发肿瘤细胞凋亡，还抑制硒蛋白硫氧还蛋白还原酶 1。
T76687	Ibalizumab TNX-355,TMB-355	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Ibalizumab(TMB-355) 是一种人源化 IgG4 单克隆抗体，可作为 CD4 受体抑制，通过与 CD4 受体结合来阻止 HIV-1进入细胞。Ibalizumab 具有抗HIV-1感染活性，可用于维持机体正常免疫功能。
T29968	AMG-0347 UNII-CD7L9290QR	TRP/TRPV Channel	Membrane transporter/Ion channel
	AMG-0347 (UNII-CD7L9290QR)是一种靶向TRPA1(瞬时受体电位锚蛋白1)离子通道的小分子抑制剂，是一种在感觉神经元中发现的受体，参与疼痛和环境刺激物的检测。AMG-0347通过阻断TRPA1的功能起作用，具有镇痛作用。
T10366L	Arg-Gly-Asp-Ser acetate Arg-Gly-Asp-Ser acetate(91037-65-9 free base)	Integrin	Cytoskeletal Signaling
	Arg-Gly-Asp-Ser acetate 是一种整合素结合序列，可直接特异性结合 pro-caspase-8、pro-caspase-9 和 pro-caspase-3，但不结合 pro-caspase-1。它抑制整合素受体功能。
T3045	Salubrinal	Apoptosis; Phosphatase; PERK; Autophagy; HSV	Apoptosis; Autophagy; Metabolism; Microbiology/Virology
	Salubrinal 是一种磷酸酶抑制剂，对真核翻译起始因子 2 亚基 (eIF2α) 发挥作用。它作为双特异性磷酸酶 2 抑制剂，抑制抗胶原蛋白抗体诱导的关节炎。它具有抗HSV-1病毒的活性，并抑制由HSV-1蛋白 ICP34.5 介导的eIF2α的去磷酸化。
T21650	IWP-3
	IWP-3 是高效的Wnt 产生抑制剂(IC50= 40 nM)。IWP-3 抑制 Porcupine (Porcn) 功能，从而阻断 Wnt 蛋白的棕榈酰化。IWP-3 适度抑制 CK1γ3 和 CK1ε，不抑制 CK1α。
T38905	FATP1-IN-1 FATP1-IN-1	Others	Others
	FATP1-IN-1 是一种强效的脂肪酸转运蛋白1（FATP1）抑制剂。它能有效抑制对FATP1功能至关重要的重组人类或小鼠的酰辅酶A合成酶活性。其抑制特征通过IC50值体现，分别为人类FATP1的0.046 μM 和小鼠FATP1的0.60 μM。
T36569	KR-32568	Sodium Channel	Membrane transporter/Ion channel
	KR-32568是一种钠/氢交换器1（NHE-1）抑制剂（IC50：230 nM）。KR-32568具有强大的心脏保护作用。当使用浓度为10μM 时，它能在离体的缺血大鼠心脏模型中恢复心脏收缩功能。KR-32568（0.3mg/kg）在缺血和再灌注损伤的大鼠模型中减少了心肌梗死的大小。
TP1937L1	RFRP-1 (human) acetate(311309-25-8 free base)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	RFRP-1 (human) acetate(311309-25-8 free base) 是一种有效的内源性 NPFF 受体激动剂（NPFF2 和 NPFF1 的 EC50 值分别为 0.0011 和 29 nM）。它减弱离体大鼠和兔心肌细胞的收缩功能。降低心率、每搏输出量、射血分数和心输出量，并增加大鼠的血浆催乳素水平。 GnIH 同系物。
T9033	BTYNB MDK6620,BTYNB IMP1 Inhibitor	Others; c-Myc; NF-κB	Cell Cycle/Checkpoint; NF-κB; Others
	BTYNB (MDK6620) 是IMP1结合 c-Myc mRNA 的有效选择性抑制剂，IC50为 5 μM。它下调 β-TrCP1 mRNA 并减少NF-κB 的激活。它通过损害 IGF2 mRNA 结合蛋白 1 结合来破坏这种增强子功能，可用于癌症研究。
T6778	BDA-366	BCL	Apoptosis
	BDA-366 是一种有效的 Bcl2 拮抗剂，以高亲和力和选择性 (Ki = 3.3 nM) 结合 Bcl2-BH4 结构域。 BDA-366 诱导 Bcl2 的构象变化，从而消除其抗凋亡功能，将其从存活分子转变为细胞死亡诱导剂。 BDA-366 抑制肺癌细胞的生长。
T13330	WAY-213613 hydrochloride WAY-213613 hydrochloride (868359-05-1 free base)	transporter	Metabolism
	WAY-213613 hydrochloride 是一个有效，选择性的，非底物再摄取 GLT-1/EAAT2抑制剂，具有有效的 EAAT2 抑制活性，IC50值为 85 nM，它是阐明 EAAT2 功能的潜在工具,可用于中枢神经系统的研究。
T12818	S119-8	Influenza Virus	Microbiology/Virology
	S119-8 是一种广谱甲型和乙型流感病毒抑制剂，抑制多种乙型流感病毒和耐奥司他韦的甲型流感病毒。
T3627	IQ-1S free acid IQ-1,IQ-1S,IQ-1S (free acid)	NF-κB; JNK	MAPK; NF-κB
	IQ-1S free acid (IQ-1S) 是 NF-κB/激活蛋白1 (AP-1) 抑制剂(IC50:2.3±0.41 μM)。它对 JNK1(Kd:240 nM)、JNK2(Kd:360 nM) 和 JNK3(Kd:100 nM)的都具有高的结合亲和力。
T4978	Sarpogrelate hydrochloride 盐酸沙格雷酯,MCI-9042	5-HT Receptor	GPCR/G Protein; Neuroscience
	Sarpogrelate hydrochloride (MCI-9042) 是一种选择性5-HT2R 拮抗剂，可用于研究与血栓形成有关的血管疾病，对 5-HT2A、5-HT2B 和 5-HT2C 受体的pKi 值分别为 8.52、6.57 和 7.43。
T35689	MTP 131 acetate	Others	Others
	MTP 131 acetate 是一种小的线粒体靶向四肽。
T14529	Bentiromide	Others	Others
	Bentiromide 是一种可被胰腺分泌的胰凝乳蛋白酶分解的多肽。Bentiromide 通过胰凝乳蛋白酶功能的体外试验确认胰腺外分泌功能。
T24017	DQBS
	DQBS is an HIV-1 Nef function antagonist.
T14558	BI-1950	Integrin	Cytoskeletal Signaling
	BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component in normal immune system function and a target for drug discovery[1].
T23865	CCT-271850 MPS1-IN-77,MPS1IN77,CCT271850,CCT 271850,MPS1 IN 77
	CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.
T10121	Substance P Receptor Antagonist 1	Others	Others
	Substance P Receptor Antagonist 1 has the potential function in gastrointestinal disorders, inflammatory diseases, respiratory, and central nervous system disorders.
T39685	PCSK9 degrader 1
	PCSK9 degrader 1 is a selective proprotein convertase substilisin-like/kexin type 9 (PCSK9) degrader. PCSK9 degrader 1 does not affect PCSK9 function.
T83156	AGL-0182-30
	AGL-0182-30为专有微管破坏剂。
T40808	Glucocorticoids receptor agonist 1
	Glucocorticoids receptor agonist 1 (GRA-1) is a highly effective arylpyrazole-based compound that acts as an agonist for the glucocorticoid receptor. GRA-1 exhibits strong anti-inflammatory properties while maintaining insulin secretion function.
T68666	Benfluron Hydrochloride
	Benfluron Hydrochloride is an inhibitor of HIV-1 Rev function which also acts as a cytostatic agent with substantial antiretroviral activity.
T14187	ALLM Calpain inhibitor II	Others	Others
	ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].
T68408	AMG-1
	AMG-1 is a specific CRAC channel inhibitor. AMG-1 blocks the function of effector T cells, but not regulatory T cells in vitro and it attenuates the progression and severity of EAE in vivo.
T38226	TSHR antagonist S37b
	TSHR antagonist S37b, the less potent enantiomer of TSHR antagonist S37a, exhibits minimal efficacy in inhibiting the thyrotropin receptor (TSHR). It is utilized in thyroid function research[1].
T19579	Thiamine diphosphate analog 1	Others	Others
	Thiamine diphosphate analog 1, an analog of Thiamine diphosphate (the active form of vitamin B1 and a universal cofactor in key cellular pathways), mirrors the structure and potentially the function of its prototype.
T40399	ZnAF-1
	ZnAF-1, a zinc sensor compound, utilizes a fluorescein-based structure incorporating the N,N-bis(2-pyridylmethyl)ethylenediamine chelating unit. Its primary function lies in the detection of Zn2+ ions. Through its binding capability, ZnAF-1 achieves a 1:1 stoichiometry with Zn(II).
T13524	9-cis-β-Carotene	Others	Others
	9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. It inhibits photoreceptor degeneration and restores retinal function in vivo.
T25256	Pitstop1 Clathrin inhibitor 1,Clathrin-inhibitor-1,Clathrin IN 1
	Clathrin-IN-1 is a selective clathrin inhibitor that acts by addressing clathrin function in cell physiology with potential applications as an inhibitor of virus and pathogen entry and as a modulator of cell signaling.
T3977L	Lifitegrast sodium SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra
	Lifitegrast sodium (SAR-1118) is an LFA-1 antagonist for the therapy of vascular complications of the eye. It inhibits T cell-mediated inflammation by blocking the binding of two cell surface proteins (lymphocyte function-associated antigen 1 and intercel
T76329	[Asn18] Endothelin-1, human
	[Asn18] Endothelin-1, human 为一种多肽，属于内皮素家族中的主要亚型，关键于血管功能调节。
T39139	PARP1-IN-6 PARP1-IN-6
	PARP1-IN-6 is a dual tubulin/PARP-1 inhibitor with IC 50 values of 0.94 and 0.48 μM, respectively.

化合物

Cat.No: T13273

Target: Androgen Receptor

Cat.No: T14676

Target: Integrin

Cat.No: T3977

Synonym: SHP-606,SAR 1118,立他司特,利非司特

Target: Integrin

Cat.No: T27084

Synonym: AAD2004,AAD 2004,AAD-2004

Target: Prostaglandin Receptor

Cat.No: T21781

Target: Integrin

Cat.No: T14969

Synonym: CINPA-1,CINPA 1

Target: Others

Cat.No: T12783

Target: Integrin

1-(4-methansulfinylphenyl)ethanone

Cat.No: T8870

Target: Ras

Cat.No: T9179

Synonym: 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE

Target: Androgen Receptor

Doxapram hydrochloride hydrate

Cat.No: T0038

Synonym: 多沙普仑盐酸一水合物,盐酸多沙普仑,Doxapram hydrochloride monohydrate,Doxapram HCl

Target: Potassium Channel

1-(3,4-dihydroxyphenyl)-2-(dimethylamino)ethan-1-one hydrochloride

Cat.No: T50047

Target: Others

Cat.No: T2650

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T22980

Synonym: p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor

Target: DNA/RNA Synthesis, p53

Cat.No: T27710

Synonym: K6PC5,K6PC 5

Target: S1P Receptor

Cat.No: T37042

Synonym: SCH 529074

Target: p53

Cat.No: T4414

Synonym: APR-246,PRIMA-1Met

Target: Apoptosis, Others, Ferroptosis, p53, Autophagy

Cat.No: T76687

Synonym: TNX-355,TMB-355

Target: HIV Protease

Cat.No: T29968

Synonym: UNII-CD7L9290QR

Target: TRP/TRPV Channel

Arg-Gly-Asp-Ser acetate

Cat.No: T10366L

Synonym: Arg-Gly-Asp-Ser acetate(91037-65-9 free base)

Target: Integrin

Cat.No: T3045

Target: Apoptosis, Phosphatase, PERK, Autophagy, HSV

Cat.No: T21650

Cat.No: T38905

Synonym: FATP1-IN-1

Target: Others

Cat.No: T36569

Target: Sodium Channel

RFRP-1 (human) acetate(311309-25-8 free base)

Cat.No: TP1937L1

Target: Neuropeptide Y Receptor

Cat.No: T9033

Synonym: MDK6620,BTYNB IMP1 Inhibitor

Target: Others, c-Myc, NF-κB

Cat.No: T6778

Target: BCL

WAY-213613 hydrochloride

Cat.No: T13330

Synonym: WAY-213613 hydrochloride (868359-05-1 free base)

Target: transporter

Cat.No: T12818

Target: Influenza Virus

IQ-1S free acid

Cat.No: T3627

Synonym: IQ-1,IQ-1S,IQ-1S (free acid)

Target: NF-κB, JNK

Sarpogrelate hydrochloride

Cat.No: T4978

Synonym: 盐酸沙格雷酯,MCI-9042

Target: 5-HT Receptor

MTP 131 acetate

Cat.No: T35689

Target: Others

Cat.No: T14529

Target: Others

Cat.No: T24017

Cat.No: T14558

Target: Integrin

Cat.No: T23865

Synonym: MPS1-IN-77,MPS1IN77,CCT271850,CCT 271850,MPS1 IN 77

Substance P Receptor Antagonist 1

Cat.No: T10121

Target: Others

PCSK9 degrader 1

Cat.No: T39685

Cat.No: T83156

Glucocorticoids receptor agonist 1

Cat.No: T40808

Benfluron Hydrochloride

Cat.No: T68666

Cat.No: T14187

Synonym: Calpain inhibitor II

Target: Others

Cat.No: T68408

TSHR antagonist S37b

Cat.No: T38226

Thiamine diphosphate analog 1

Cat.No: T19579

Target: Others

Cat.No: T40399

9-cis-β-Carotene

Cat.No: T13524

Target: Others

Cat.No: T25256

Synonym: Clathrin inhibitor 1,Clathrin-inhibitor-1,Clathrin IN 1

Lifitegrast sodium

Cat.No: T3977L

Synonym: SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra

[Asn18] Endothelin-1, human

Cat.No: T76329

Cat.No: T39139

Synonym: PARP1-IN-6

Cat. No.	Product Name	Target	Signaling Pathways
T17143	Toyocamycin 丰加霉素,Vengicide	Apoptosis; Others; IRE1; Antibiotic; Antifungal	Apoptosis; Cell Cycle/Checkpoint; Microbiology/Virology; Others
	Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物，为 X 盒结合蛋白 1 (XBP1) 抑制剂，抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂，IC50值为 80 nM。它还诱导凋亡。
TN4661	Nodosin	IL Receptor; Autophagy	Autophagy; Immunology/Inflammation
	Nodosin 是一种二萜化合物，从Isodon trichocarpusKudo 和I. JaponicusHARA 中提取得到。
T6981	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid 1-甲基-6-氧代-1,6-二氢吡啶-3-羧酸,Nudifloric Acid	Others	Others
	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (Nudifloric Acid) 是来源于冬虫夏草，能够靶向阻断 AP-1 介导的荧光素酶活性，具有抗炎活性。其中冬虫夏草具有抗氧化，抗癌，抗炎，抗糖尿病，抗肥胖，抗血管生成和抗伤害感受活动。
T5S0285	Cistanoside A 肉苁蓉苷 A,肉苁蓉苷A	Others	Others
	Cistanoside A 是一种肉苁蓉中的苯丙素类化合物，能够抑制 NO 的聚集，但不影响诱导型一氧化氮合酶 iNOS 的 mRNA 和蛋白水平及其活性。它具有抗炎作用。
TCS1704	Artemitin 艾黄素,Artemetin,Artemisetin,Erianthin	Antioxidant	oxidation-reduction
	Artemitin (Erianthin) 是一种存在于翼齿六棱菊中的天然黄酮，具有抗氧化、抗炎、抗病毒活性。
T6S1027	Tussilagone	Others	Others
	Tussilagone 是Tussilago farfara 的主要活性成分，具有抗炎作用。它抑制盲肠结扎和穿刺导致脓毒症的小鼠的炎症反应，提高其生存率。它改善葡聚糖硫酸钠诱导的小鼠结肠炎的炎症反应。
T5S2357	Acetylcorynoline (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵	Antifungal	Microbiology/Virology
	Acetylcorynoline (O-Acetylcorynoline) 是提取自 Corydalis bungeana 中的一种主要生物碱成分，具有抗炎活性。
T4S1615	Sanggenon C 桑根酮C,桑根酮 C,Sanggenone C	NF-κB	NF-κB
	Sanggenon C (Sanggenone C) 是一种从桑属的根皮中分离得到的黄烷酮 Diels-Alder 加合物化合物。它可抑制NF-κB 活性，抑制 RAW264.7 细胞中诱导型一氧化氮合酶的表达，以及肿瘤坏死因子-α 刺激的细胞粘附和血管细胞粘附分子-1 的表达。它具有抗氧化和抗炎作用，也有抑制胰脂肪酶作用。
T2732	(-)-Epicatechin gallate 表儿茶素没食子酸酯,(−)-Epicatechin 3-gallate,Epicatechin gallate,(-)-Epicatechin 3-gallate,(-)-Epicatechin 3-O-gallate,ECG	Virus Protease; COX; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	(-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) 抑制环加氧酶-1 的IC50值为 7.5 μM。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T3S1553	trans-Cinnamaldehyde Cinnamaldehyde,Cinnamic aldehyde,桂皮醛,反式肉桂醛,Cinnamal,Phenylacrolein	COX; Endogenous Metabolite	Immunology/Inflammation; Metabolism; Neuroscience
	trans-Cinnamaldehyde (Phenylacrolein) 是一种能够用于合成反式肉桂醛-β-环糊精复合物，一种能够食用的抗菌涂层，能够延长鲜切水果的保质期。它是一种能够通过烷基异氰化物与乙炔二羧酸二烷基酯的反应来合成高度多官能的呋喃环。
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。
T6S1684	8-Gingerol	Antioxidant; Antibacterial; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction
	8-Gingerol 分离自姜的根状茎，是口服有效的 TRPV1激活剂，EC50值为5.0 µM。8-Gingerol 抑制 COX-2，还能抑制体外 H. pylori 的生长。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶，具有抗肿瘤特性。
T82806	Bupleuroside XIII
	Bupleuroside XIII为具有肝脏保护作用的天然皂苷。
T21101	1-Decanol 1-Hydroxydecane,Caprinic alcohol,Decyl alcohol,Decanol,n-Decanol,Alcohol C-10
	1-Decanol is used in the production of lubricants, surfactants, plasticizers, and solvents. It is also used to study the thermal properties of polymer-monolithic stationary phases and is used to enhance the homomeric glycine receptor function. It is used
T81629	OAT1/3-IN-2
	OAT1/3-IN-2（化合物8）是一种针对OAT1和OAT3的双重抑制剂。该化合物能够以10 μM的浓度逆转Cys-Hg对HEK-OAT1细胞的毒害作用，并可能对肾脏具有保护效应。OAT1/3-IN-2适用于研究汞导致的肾脏损伤。
T81072	Suffruticosol A
	Suffruticosol A是一种从P. lactiflora种子中分离得到的神经保护剂，能够逆转由Scopolamine诱导的细胞神经退行性损伤。该化合物还能改善海马体胆碱能缺陷并部分增强BDNF信号传导，从而在Scopolamine诱导模型中显示出改善神经功能的作用，可恢复小鼠记忆与认知行为。

天然产物

Cat.No: T17143

Synonym: 丰加霉素,Vengicide

Target: Apoptosis, Others, IRE1, Antibiotic, Antifungal

Cat.No: TN4661

Target: IL Receptor, Autophagy

1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Cat.No: T6981

Synonym: 1-甲基-6-氧代-1,6-二氢吡啶-3-羧酸,Nudifloric Acid

Target: Others

Cat.No: T5S0285

Synonym: 肉苁蓉苷 A,肉苁蓉苷A

Target: Others

Cat.No: TCS1704

Synonym: 艾黄素,Artemetin,Artemisetin,Erianthin

Target: Antioxidant

Cat.No: T6S1027

Target: Others

Acetylcorynoline

Cat.No: T5S2357

Synonym: (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵

Target: Antifungal

Cat.No: T4S1615

Synonym: 桑根酮C,桑根酮 C,Sanggenone C

Target: NF-κB

(-)-Epicatechin gallate

Cat.No: T2732

Synonym: 表儿茶素没食子酸酯,(−)-Epicatechin 3-gallate,Epicatechin gallate,(-)-Epicatechin 3-gallate,(-)-Epicatechin 3-O-gallate,ECG

Target: Virus Protease, COX, Autophagy

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

trans-Cinnamaldehyde

Cat.No: T3S1553

Synonym: Cinnamaldehyde,Cinnamic aldehyde,桂皮醛,反式肉桂醛,Cinnamal,Phenylacrolein

Target: COX, Endogenous Metabolite

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Cat.No: T6S1684

Target: Antioxidant, Antibacterial, TRP/TRPV Channel

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Bupleuroside XIII

Cat.No: T82806

Cat.No: T21101

Synonym: 1-Hydroxydecane,Caprinic alcohol,Decyl alcohol,Decanol,n-Decanol,Alcohol C-10

Cat.No: T81629

Suffruticosol A

Cat.No: T81072

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