Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lifitegrast (SAR 1118) 是一种整合素淋巴细胞功能相关抗原 1 拮抗剂, 抑制 Jurkat T 细胞附着于ICAM-1的IC50为 2.98 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 251 | 现货 | ||
5 mg | ¥ 557 | 现货 | ||
10 mg | ¥ 867 | 现货 | ||
25 mg | ¥ 1,620 | 现货 | ||
50 mg | ¥ 2,810 | 现货 | ||
100 mg | ¥ 4,170 | 现货 | ||
500 mg | ¥ 8,880 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 616 | 现货 |
产品描述 | Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist. |
靶点活性 | LFA-1:2.98 nM. |
体外活性 | Lifitegrast is a novel small molecule integrin antagonist that inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses. Lifitegrast strongly inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM[1]. |
体内活性 | Lifitegrast, has potent anti-inflammatory activity on corneal inflammation induced by antibiotic-killed P. aeruginosa and S. aureus in the presence of a silicone hydrogel lens with the optimal application being a 1% solution applied either 2 or 3 times prior. Topical application of lifitegrast to the corneal surface of healthy adults is safe and well tolerated[2]. SAR 1118 ophthalmic drops administered thrice daily deliver therapeutic levels of SAR 1118 in the retina and can alleviate the retinal complications associated with diabetes[3]. |
别名 | SHP-606, SAR 1118, 立他司特, 利非司特 |
分子量 | 615.48 |
分子式 | C29H24Cl2N2O7S |
CAS No. | 1025967-78-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 29 mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Lifitegrast 1025967-78-5 Cytoskeletal Signaling Integrin ICAM-1 T cell SHP-606 inhibit SAR 1118 SHP606 立他司特 SHP 606 利非司特 dry eye disease SAR-1118 Jurkat T LFA-1 SAR1118 inflammatory cycle Inhibitor inhibitor