keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MTP 131 acetate 是一种小的线粒体靶向四肽。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 479 | 现货 | ||
2 mg | ¥ 693 | 现货 | ||
5 mg | ¥ 992 | 现货 | ||
10 mg | ¥ 1,480 | 现货 | ||
25 mg | ¥ 3,030 | 现货 | ||
50 mg | ¥ 4,470 | 现货 | ||
100 mg | ¥ 6,370 | 现货 | ||
500 mg | ¥ 12,900 | 待询 |
产品描述 | MTP 131 (acetate) is a small mitochondrially-targeted tetrapeptide. |
体外活性 | Pretreatment of cells with MTP 131 (acetate) inhibited H2O2?induced cytotoxicity and reduced LDH release in a dose?dependent manner, compared with cells treated with H2O2 alone. Mitochondrial depolarization and ROS generation were also prevented by MTP 131 (acetate) pretreatment. In addition, MTP 131 (acetate) pretreatment inhibited cytochrome c release from mitochondria to cytoplasm, and significantly reduced apoptosis in RGC?5 cells, compared with cells treated with H2O2 alone[1]. |
体内活性 | 18-week-old db/db mice have reduced renal and cardiac superoxide levels, as measured by dihydroethidium oxidation, and increased levels of albuminuria, mesangial matrix accumulation, and urinary H2O2 Administration of MTP 131 (acetate) significantly inhibited increases in albuminuria, urinary H2O2, and mesangial matrix accumulation in db/db mice and fully preserved levels of renal superoxide production in these mice. MTP 131 (acetate) also reduced total renal lysocardiolipin and major lysocardiolipin subspecies and preserved lysocardiolipin acyltransferase 1 expression in db/db mice[1]. |
分子量 | 699.84 |
分子式 | C34H53N9O7 |
CAS No. | 1334953-95-5 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PBS (pH 7.2): 10 mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MTP 131 acetate 1334953-95-5 Others MTP131 Acetate MTP 131 Acetate MTP-131 Acetate Inhibitor inhibitor inhibit