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Targets Recommended: VEGFR

84

抑制剂 & 化合物

14

天然产物

3

化合物库

175

重组蛋白

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Cat. No. Product Name
L2192 抗胰腺癌化合物库

2238 compounds
2238 种与胰腺癌相关的化合物,可以用于高通量和高内涵筛选;
L4800 血管生成库

1353 compounds
1353 个高潜力的抑制或促进血管生成的小分子集合,可用于药物靶点开发、血管生成机理研究的高通量筛选,高内涵筛选;
L2191 抗乳腺癌化合物库

1939 compounds
1939 种与乳腺癌相关的化合物,可以用于抗乳腺癌药物研发和药理研究;

化合物库

抗胰腺癌化合物库
Cat.No: L2192
Compounds: 2238
血管生成库
Cat.No: L4800
Compounds: 1353
抗乳腺癌化合物库
Cat.No: L2191
Compounds: 1939
Cat. No. Product Name Target Signaling Pathways
T4288 hVEGF-IN-1

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
hVEGF-IN-1 是一种喹唑啉衍生物,可以特异性结合内部核糖体进入位点 A 中富含 G 的序列,并会使 G-四链体结构不稳定。在 SPR 实验中,它与 IRES-A (WT) 结合的Kd 值为 0.928 μM。它能够抑制VEGF-A 蛋白表达,阻止肿瘤细胞迁移,抑制肿瘤生长。
T11153 EG00229

Others Others
EG00229 selectively inhibits VEGF-A binding to NRP1 b1 domain with an IC50 of 3 μM, but has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. EG00229 is a neuropilin 1 (NRP1) receptor antagonist.
T9929 Ramucirumab

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
Ramucirumab 是一种人 VEGFR-2 拮抗剂,具有抗实体瘤活性。它是人源化单克隆抗体,能够与 VEGFR-2 结合,阻碍 VEGFR 配体 VEGF-AVEGF-C 和 VEGF-D 结合。
T4554 AG 1406

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
AG 1406 是受体酪氨酸激酶 VEGF 受体 2 的选择性抑制剂。
T9928 Ranibizumab

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
Ranibizumab 是一种人源化单克隆抗体片段,旨在靶向和抑制血管内皮生长因子 (VEGF),包括 VEGF110、VEGF121 和 VEGF165。 Ranibizumab 选择性靶向和中和 VEGF-A 同工型的能力使其成为湿性年龄相关性黄斑变性 (AMD) 研究和治疗策略的重要组成部分。
T61349 HIF-1α-IN-2

HIF Angiogenesis; Chromatin/Epigenetic
HIF-1α-IN-2 是一种新型高效的 HIF-1α 抑制剂,具有抗癌抗肿瘤活性,以剂量依赖的方式抑制 HIF-1α 和 VEGF 的表达,抑制细胞迁移。
T37424 CAY10781

CAY10781

Others Others
CAY10781 是一种神经纤毛蛋白-1 (NRP-1) 和 VEGF-A.1 之间蛋白质-蛋白质相互作用的抑制剂。当使用浓度为 12.5 μM 时,它可抑制 43% 的相互作用。 当以相同浓度使用时,CAY10781 还抑制 VEGF-A 诱导的儿茶酚胺 A 分化 (CAD) 细胞中 VEGFR2 的磷酸化。
T3567 SU 4942

Others Others
SU-4942 是酪氨酸激酶信号传导调节剂。SU-4942 对 VEGF 和内皮细胞生长因子 (ECGF) 诱导的内皮细胞有丝分裂具有抑制作用。
T19832 Acriflavine Hydrochloride

盐酸吖啶黄,Acriflavine HCl

HIF Angiogenesis; Chromatin/Epigenetic
Acriflavine Hydrochloride (Acriflavine HCl) 是一种 HIF-1α 抑制剂。它通过靶向 HIF-1α 介导的途径并在体外和体内降低 PGK1、VEGF 和 HIF-1α 的水平发挥作用。
T8496 MAZ51

Apoptosis; VEGFR Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
MAZ51 是一种 VEGFR-3酪氨酸激酶的选择性抑制剂。它抑制 VEGF-C 诱导的 VEGFR-3 激活,而没有阻断 VEGF-C 介导的 VEGFR2 刺激。它阻止增殖并诱导多种肿瘤细胞凋亡,具有抗肿瘤活性。
T7836 ML228

HIF Angiogenesis; Chromatin/Epigenetic
ML228 是一种有效的 HIF 信号通路激活剂,EC50 为 1 μM。ML228 可激活 HIF 以及下游 EGFR。
T12574 PTC299

Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate

VEGFR; Dehydrogenase Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) 是一种口服活性的 VEGFA mRNA 翻译抑制剂,可选择性地抑制转录后水平的 VEGF 蛋白合成。它还是二氢乳酸脱氢酶 (DHODH) 的有效抑制剂,可研究血液系统恶性肿瘤。
T9904 Bevacizumab

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
Bevacizumab 是一种人源化单克隆抗体,能以高亲和力与所有血管内皮生长因子-A 异构体特异性结合。
T8973 HS-1793

Others Others
HS-1793 是 resveratrol 类似物,可以诱导细胞凋亡,在多种癌细胞中有抗肿瘤的能力。
T3560 Desmethylanethol trithione

ADT-OH

VEGFR; Akt Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
Desmethylanethol trithione (ADT-OH) 是合成硫化氢的供体。它利用上调 FADD 诱导细胞凋亡,并对体内黑色素瘤的形成具有一定的抑制作用,可用于研究癌症疾病。
T3599 BFH772

BFH-722

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
BFH772 是 VEGFR2抑制剂(IC50:3 nM),具有口服活性。
T33701 NM-3

NM-3,isocoumarin,NM 3,Isocoumarin NM-3,NM3

Apoptosis; Reactive Oxygen Species Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
NM-3 是一种可口服的抗血管生成的抑制剂,具有抗肿瘤活性。NM-3在体外和体内可当作辐射调节剂使用。NM-3抑制血管内皮生长因子(VEGF),从而抑制内皮细胞的增殖。NM-3与活性氧的机制诱导细胞凋亡有关。
T76756 Parsatuzumab

RG 7414,Anti-EGFL7,MEGF0444A,MEGF-0444A,RO-5490248,M0444A

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
Parsatuzumab (RG 7414) 是一种人源化靶向 EGFL7 的单克隆抗体,也可作为一种免疫调节剂使用。Parsatuzumab 选择性抑制 EGFL7 与内皮细胞之间的相互作用,对内皮生长因子 (VEGF) 有抑制作用。Parsatuzumab 长期其他化合物联合联合使用来研究直肠癌
TP1886L1 NoxA1ds acetate(1435893-78-9 free base)

NADPH-oxidase Immunology/Inflammation
NoxA1ds acetate(1435893-78-9 free base) 是一种有效的选择性 NADPH 氧化酶 1 (NOX1) 抑制剂 (IC50 : 20 nM)。对 NOX1 的选择性优于对 NOX2、NOX4、NOX5 和黄嘌呤氧化酶的选择性。它抑制 HT-29 人结肠癌细胞中 NOX1 衍生的 O2 产生。在体外缺氧条件下减弱 VEGF 诱导的人肺动脉内皮细胞迁移。
T67836 AT-533

HSP; HSV Cytoskeletal Signaling; Metabolism; Microbiology/Virology
AT-533 是有效的 HSV 和 Hsp90 抑制剂。AT-533 可以阻断 HIF-1α/VEGF/VEGFR-2 信号通路,从而抑制血管生成和肿瘤生长。AT-533 也抑制下游通路的激活,包括 Erk1/2, FAK, Akt/mTOR/p70S6K。AT-533 抑制人脐静脉内皮细胞 (HUVEC) 的细胞迁移、侵袭和管形成。
T2064 Semaxinib

司马沙尼,SU5416

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
Semaxinib (SU5416) 是一种选择性的 VEGFR(Flk-1/KDR) 抑制剂,其 IC50=1.23 μM。
T72924 VEGFR-3-IN-1

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
VEGFR-3-IN-1 是一种新型有效且具有选择性的 VEGFR3 抑制剂,其 IC50 为 110.4 nM。VEGFR-3-IN-1 具有抗肿瘤活性,可使 VEGFR3 信号通路失活,可抑制 VEGF-C 诱导人真皮淋巴管内皮细胞 (HDLEC)、MDA-MB-231 和 MDA-MB-436 细胞的增殖和迁移,并且能有效抑制乳腺癌的生长。
T3980 Su1498

Tyrphostin SU 1498,AG 1498

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
Su1498 (Tyrphostin SU 1498) 是一种选择性的 VEGFR2 抑制剂,能够抑制 Flk-1 (IC50:700 nM)。
T2283 PX-12

2-[(1-甲基丙基)二硫代]-1H-咪唑,IV-2,PX12

Thioredoxin Metabolism
PX-12 (PX12) 是一种可逆的硫氧还蛋白-1(Trx-1)抑制剂,能够抑制 MCF-7 细胞(IC50:1.9 μM)和HT-29 细胞(IC50:2.9 μM)的生长。
T2160 Suramin Sodium Salt

苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060

Apoptosis; Phosphatase; SARS-CoV; Sirtuin; Reverse Transcriptase; Topoisomerase; Parasite Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
Suramin Sodium Salt (BAY-205) 是可逆的竞争性蛋白酪氨酸磷酸酶抑制剂。它抑制 IP5K,是抗寄生虫,抗肿瘤和抗血管生成剂。它是sirtuins 的有效抑制剂,也是 SARS-CoV-2 RNA 依赖性 RNA 聚合酶抑制剂。
T4425 JK-P3

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
JK-P3 是广谱 VEGFR2抑制剂。它能够抑制 VEGF-A 刺激的 VEGFR2 激活和细胞内信号转导,也可阻碍内皮单层细胞迁移和血管生成,影响成纤维细胞生长因子受体激酶在体外的活性。它具有抗血管生成的作用。
T2500L Cediranib maleate

AZD-2171,Recentin,西地尼布马来酸盐,AZD2171,AZD2171 maleate,AZD 2171

Cediranib is a potent and selective inhibitor of VEGF with antineoplastic activities. It inhibits all three vascular endothelial growth factor receptor (VEGF-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth.
T71944 FGF/PDGF/VEGF RTK Inhibitor

FGF/PDGF/VEGF RTK Inhibitor is a potent, reversible, atp-competitive inhibitor against pdgfrβ, fgfr-1, and vegfr-2 (ic50 = 20, 90, and 240 nm, respectively) and effectively suppresses vegf-stimulated proliferation of hmvecs (ec50 = 420 nm).
T68039 cep-5214

CEP-5214是一种有效的、低纳摩尔的人 VEGF-R 酪氨酸激酶泛抑制剂,对 VEGF-R1/FLT-1、VEGF-R2/KDR 和VEGF-R3/FLT-4的IC50分别为16、8和4 nM,细胞活性与分离的酶活性相当。
T28760 Setafrastat

Setafrastat is a vascular endothelial growth factor (VEGF) promotor and rotamase inhibitor.
T40037 Timtraxanib

AVI-3207

Timtraxanib (AVI-3207) is a potent and specific inhibitor of VEGF-2, offering great potential for investigating senile macular degeneration.
T27622 IPS-05002

IPS-05002 is an integrin a5β1 antagonist. IPS-05002 inhibited VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation, adhesion, and migration in a dose-dependent manner. IPS-05002 is a potent inhibitor for VEGF-mediated angiogenesis.
T75156L Bevasiranib sodium

Bevasiranib sodium 是一种siRNA,可沉默产生血管内皮生长因子(VEGF)的基因。VEGF 在脉络膜新生血管形成(choroidal neo-vascularization, CNV)的发病机制中起着关键作用,而CNV 是湿性年龄相关性黄斑变性(wet age-related macular degeneration, wet AMD)的前兆。
T80287 KLTWQELYQLKYKGI

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
KLTWQELYQLKYKGI (QK) 是一种与VEGF受体结合并同VEGF竞争的VEGF模拟肽。在口服或全身给药时,该化合物对啮齿类动物胃溃疡的愈合展现了活性。此外,KLTWQELYQLKYKGI 在体外具有诱导毛细血管形成和组织的能力。
T78009 ATWLPPR Peptide

ATWLPPR Peptide 是一种具有特异性 VEGFR2/KDR 七肽拮抗剂,能够结合VEGFR2(KDR/flk),有效阻断VEGF与KDR的结合,并抑制VEGF诱导的体内血管生成。在体外,该肽特异性地抑制人内皮细胞的增殖;在体内,则能彻底消除VEGF诱导的血管形成。
T22259 AMG-Tie2-1

AMG-Tie2,4-甲基-3-[[3-[2-(甲基氨基)-4-嘧啶基]-2-吡啶基]氧基]-N-[3-(三氟甲基)苯基]苯甲酰胺

Others Others
AMG-Tie2-1 is a dual inhibitor of VEGF receptor 2 (VEGFR2) and tunica interna endothelial cell kinase 2 (Tie2).
T77046 Ivonescimab

Ivonescimab (AK112) 是一种PD-1/VEGF 双特异性抗体。Ivonescimab 可用于癌症研究。
T78253 Faricimab

RG7716

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
Faricimab是一种双特异性抗体,针对angiopoietin-2和血管内皮生长因子-A (VEGF-A)。该化合物可应用于糖尿病黄斑水肿(DME)的研究。
T30107 Apratyramide

Apratyramide is a marine-derived peptidic stimulator of VEGF-A and other growth factors with potential application in wound healing.
T77157 Dilpacimab

Dilpacimab (ABT165) 是一种有效的双可变结构域免疫球蛋白,靶向 delta 样配体 4 (DLL4) 和VEGF 通路。Dilpacimab 可用于癌症研究。
T21387 Nafoxidine HCl(1845-11-0 Free base)

PNU-0011100,PNU0011100,CP5600,CP 5600,CP-5600,PNU 0011100,Nafoxidine HCl

Nafoxidine is a partial estrogen antagonist. It inhibits angiogenesis in some tissues by blocking the effects of VEGF and FGF; paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces calcium signaling, oxidative stress, and p
T76837 Vanucizumab

Vanucizumab 是一种首创的双特异性 IgG1单克隆抗体,可同时阻断 VEGF-A 和血管生成素-2 (Ang-2) 与其受体相互作用。 Vanucizumab 具有抗血管生成和抗癌作用。
T28960 Thaspine HCl

Thaspine,Thaspine HCl, NSC 135784,NSC-135784,NSC135784

Thaspine is a potent topoisomerase IB inhibitor. Taspine downregulates VEGF expression and inhibits proliferation of vascular endothelial cells through PI3 kinase and MAP kinase signaling pathways.
T80593 Brolucizumab

DLX1008,ESBA 1008,RTH258

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
Brolucizumab(DLX1008)是一种具有高亲和力(KD=1.05 pM)的单链抗VEGF-A抗体片段,适用于癌症研究。
T80152 Protein LMWP

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
Protein LMWP为具有血管内皮生长因子(VEGF)抑制活性的细胞穿透肽,能够抑制肿瘤生长,适用于癌症研究领域。
T76574 Arginyl-Glutamine

Arginyl-Glutamine 是一种二肽,可以降低VEGF 水平,并抑制氧诱导视网膜病变小鼠模型中的视网膜新生血管。
T10273 AhR modulator-1

Others Others
AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrogenic properties in rat uterus.
T21795 CRT5

CRT5 是一种吡嗪苯甲酰胺,对经 VEGF 处理的内皮细胞中的所有三种 PKD 亚型 (对 PKD1、PKD2 和 PKD3 的 IC50s 分别为 1、2 和 1.5 nM) 都是一种有效的选择性抑制剂,并且 CRT5 减少 VEGF 诱导的内皮细胞迁移、增殖和微管生成。
T28788 SK-216

SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor

SK-216 is a specific PAI-1 inhibitor. SK-216 reduced the extent of angiogenesis in the tumors and inhibited VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro. SK-216 reduced the degree of bleomycin-induced pulmon
T78937 HIF-2α-IN-9

HIF/HIF Prolyl-Hydroxylase Chromatin/Epigenetic; Metabolism
HIF-2α-IN-9(compound 35r)为HIF-2α抑制剂,能够抑制VEGF-A(IC50=305 nM),影响肿瘤细胞生长基因表达并促进巨噬细胞介导的肿瘤免疫反应。

化合物

hVEGF-IN-1
Cat.No: T4288
Synonym:
Target: VEGFR
EG00229
Cat.No: T11153
Synonym:
Target: Others
Ramucirumab
Cat.No: T9929
Synonym:
Target: VEGFR
AG 1406
Cat.No: T4554
Synonym:
Target: VEGFR
Ranibizumab
Cat.No: T9928
Synonym:
Target: VEGFR
HIF-1α-IN-2
Cat.No: T61349
Synonym:
Target: HIF
CAY10781
Cat.No: T37424
Synonym: CAY10781
Target: Others
SU 4942
Cat.No: T3567
Synonym:
Target: Others
Acriflavine Hydrochloride
Cat.No: T19832
Synonym: 盐酸吖啶黄,Acriflavine HCl
Target: HIF
MAZ51
Cat.No: T8496
Synonym:
Target: Apoptosis, VEGFR
ML228
Cat.No: T7836
Synonym:
Target: HIF
PTC299
Cat.No: T12574
Synonym: Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
Target: VEGFR, Dehydrogenase
Bevacizumab
Cat.No: T9904
Synonym:
Target: VEGFR
HS-1793
Cat.No: T8973
Synonym:
Target: Others
Desmethylanethol trithione
Cat.No: T3560
Synonym: ADT-OH
Target: VEGFR, Akt
BFH772
Cat.No: T3599
Synonym: BFH-722
Target: VEGFR
NM-3
Cat.No: T33701
Synonym: NM-3,isocoumarin,NM 3,Isocoumarin NM-3,NM3
Target: Apoptosis, Reactive Oxygen Species
Parsatuzumab
Cat.No: T76756
Synonym: RG 7414,Anti-EGFL7,MEGF0444A,MEGF-0444A,RO-5490248,M0444A
Target: VEGFR
NoxA1ds acetate(1435893-78-9 free base)
Cat.No: TP1886L1
Synonym:
Target: NADPH-oxidase
AT-533
Cat.No: T67836
Synonym:
Target: HSP, HSV
Semaxinib
Cat.No: T2064
Synonym: 司马沙尼,SU5416
Target: VEGFR
VEGFR-3-IN-1
Cat.No: T72924
Synonym:
Target: VEGFR
Su1498
Cat.No: T3980
Synonym: Tyrphostin SU 1498,AG 1498
Target: VEGFR
PX-12
Cat.No: T2283
Synonym: 2-[(1-甲基丙基)二硫代]-1H-咪唑,IV-2,PX12
Target: Thioredoxin
Suramin Sodium Salt
Cat.No: T2160
Synonym: 苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060
Target: Apoptosis, Phosphatase, SARS-CoV, Sirtuin, Reverse Transcriptase, Topoisomerase, Parasite
JK-P3
Cat.No: T4425
Synonym:
Target: VEGFR
Cediranib maleate
Cat.No: T2500L
Synonym: AZD-2171,Recentin,西地尼布马来酸盐,AZD2171,AZD2171 maleate,AZD 2171
Target:
FGF/PDGF/VEGF RTK Inhibitor
Cat.No: T71944
Synonym:
Target:
cep-5214
Cat.No: T68039
Synonym:
Target:
Setafrastat
Cat.No: T28760
Synonym:
Target:
Timtraxanib
Cat.No: T40037
Synonym: AVI-3207
Target:
IPS-05002
Cat.No: T27622
Synonym:
Target:
Bevasiranib sodium
Cat.No: T75156L
Synonym:
Target:
KLTWQELYQLKYKGI
Cat.No: T80287
Synonym:
Target: VEGFR
ATWLPPR Peptide
Cat.No: T78009
Synonym:
Target:
AMG-Tie2-1
Cat.No: T22259
Synonym: AMG-Tie2,4-甲基-3-[[3-[2-(甲基氨基)-4-嘧啶基]-2-吡啶基]氧基]-N-[3-(三氟甲基)苯基]苯甲酰胺
Target: Others
Ivonescimab
Cat.No: T77046
Synonym:
Target:
Faricimab
Cat.No: T78253
Synonym: RG7716
Target: VEGFR
Apratyramide
Cat.No: T30107
Synonym:
Target:
Dilpacimab
Cat.No: T77157
Synonym:
Target:
Nafoxidine HCl(1845-11-0 Free base)
Cat.No: T21387
Synonym: PNU-0011100,PNU0011100,CP5600,CP 5600,CP-5600,PNU 0011100,Nafoxidine HCl
Target:
Vanucizumab
Cat.No: T76837
Synonym:
Target:
Thaspine HCl
Cat.No: T28960
Synonym: Thaspine,Thaspine HCl, NSC 135784,NSC-135784,NSC135784
Target:
Brolucizumab
Cat.No: T80593
Synonym: DLX1008,ESBA 1008,RTH258
Target: VEGFR
Protein LMWP
Cat.No: T80152
Synonym:
Target: VEGFR
Arginyl-Glutamine
Cat.No: T76574
Synonym:
Target:
AhR modulator-1
Cat.No: T10273
Synonym:
Target: Others
CRT5
Cat.No: T21795
Synonym:
Target:
SK-216
Cat.No: T28788
Synonym: SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor
Target:
HIF-2α-IN-9
Cat.No: T78937
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
Cat. No. Product Name Target Signaling Pathways
TWA2417 Sodium taurocholate

牛黄胆酸钠(牛胆酸钠,牛胆酸钠盐,牛磺膽酸鈉,牛磺胆酸钠,牛磺胆酸钠盐,牛胆酸钠水合物,水合牛磺胆酸钠,牛胆酸钠(混合物),牛黄胆酸钠(水合),牛磺胆酸钠(标准品)),Taurocholate Sodium

Others Others
Sodium taurocholate (Taurocholate Sodium) hydrate 具有显著的生物学效应,例如通过上调 VEGF-A 的表达抑制肝动脉结扎所致的胆道损伤。对免疫系统具有一定的调节作用。
TC0036 Compound Lup-20(29)-en-3-yl acetate

IL Receptor; VEGFR; Others; TNF; COX Angiogenesis; Apoptosis; Immunology/Inflammation; Neuroscience; Others; Tyrosine Kinase/Adaptors
Lup-20(29)-en-3-yl acetate 是 Lupeol 的衍生物,通过下调 TNF-α、IL-1β、MCP-1、COX-2、VEGF 和颗粒酶 B 来抑制类风湿性关节炎的进展。
T7203 Oglufanide

奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH

VEGFR; HCV Protease; Endogenous Metabolite Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂,可抑制血管内皮生长因子,可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。
T3890 Verbenalin

Verbenalol β-D-glucopyranoside,马鞭草苷,Verbenaloside,Verbenalol glucoside,Cornin

Others Others
Verbenalin (Verbenaloside) 是马鞭草苷,具有抗炎、抗真菌、抗病毒等活性。它能减轻脑缺血再灌注损伤。它可用于前列腺炎的研究。
T5429 Theaflavin 3,3'-digallate

茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG

Virus Protease; Antioxidant; HIV Protease; HSV Microbiology/Virology; oxidation-reduction; Proteases/Proteasome
Theaflavin 3,3'-digallate (8-Gingerol) 是一种寨卡病毒蛋白酶抑制剂,IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制,可抑制 gp41 和 NS2B-3 蛋白酶的活性,并具有抗 HSV 和 HIV-1病毒活性。它是红茶中的主要多酚,有抗肿瘤作用。
T5740 25(R,S)-Ruscogenin

(25RS)鲁斯可皂苷元,(25RS)-Ruscogenin

Others; HIF Angiogenesis; Chromatin/Epigenetic; Others
25(R,S)-Ruscogenin 能够调节 PI3K/Akt/mTOR 信号通路,抑制 MMP-2、MMP-9、uPAVEGF 和 HIF-1α 的表达,阻碍肝癌转移。 它能够抑制 TLR4信号通路,减轻 LPS 诱导的肺内皮细胞凋亡。
T4S1551 Cinnamaldehyde

Cinnamic Aldehyde,肉桂醛

HIF Angiogenesis; Chromatin/Epigenetic
Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。 它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生,发挥血管扩张和抗癌作用。 它似乎是一种有希望的候选药物,可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。 它在抑制黑色素瘤的发生和发展方面具有一定的作用,其作用机制可能表现为抑制VEGF 和HIF-α的表达,从而使血管模拟和黑色素瘤细胞新生血管的形成,促进肿瘤的生长。
T3S2344 β,β-Dimethylacrylshikonin

β,β-二甲基丙烯酰紫草素,Dimethylacrylshikonin,β, β-Dimethylacrylshikonin

ERK; HIF/HIF Prolyl-Hydroxylase Chromatin/Epigenetic; MAPK; Metabolism
β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) 是一种萘醌衍生物,从 Arnebia nobilis 中提取得到。它利用 PI3K 通路诱导 eNOS、VEGF 和 HIF-1α 的表达,促进血管生成,具有抗肿瘤活性。
TN3139 5α-Hydroxycostic acid

5alpha-Hydroxycostic acid

ERK; FAK; Phospholipase; NOS; Akt; Src Angiogenesis; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
T14055 5Z-7-Oxozeaenol

FR148083,L783279,LL-Z 1640-2

VEGFR; FLT; MEK; MAPK; PDGFR; Antibiotic; Src Angiogenesis; MAPK; Microbiology/Virology; Tyrosine Kinase/Adaptors
5Z-7-Oxozeaenol (FR148083) 是一种天然抗原生动物抑制剂,不可逆的选择性抑制 TAK1和 VEGF-R2,IC50值分别为 8 nM 和 52 nM。
TN4356 Jolkinolide A

Akt; STAT; mTOR Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem Cells
Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly inhibited the proliferation and migration of HUVECs.
TN5942 Dammarenediol II

达玛烯二醇II,Dammar-24-ene-3,20-diol

Dammarenediol II may have the ability to prevent diabetic microvascular complications, including diabetic retinopathy, it can inhibit vascular endothelial growth factor (VEGF)-induced intracellular reactive oxygen species generation and stress fiber forma
T75487 7-Hydroxyneolamellarin A

7-Hydroxyneolamellarin A,一种从海绵Dendrilla nigra 提取的天然产物,是高效的缺氧诱导因子 1α (HIF-1α) 抑制剂。该化合物能够减弱HIF-1α蛋白的积累,并抑制血管表皮生长因子 (VEGF) 的转录活性,因而在癌症研究中有应用价值。
T36749 Herboxidiene

Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.3 Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.[4] Herbo...

天然产物

Sodium taurocholate
Cat.No: TWA2417
Synonym: 牛黄胆酸钠(牛胆酸钠,牛胆酸钠盐,牛磺膽酸鈉,牛磺胆酸钠,牛磺胆酸钠盐,牛胆酸钠水合物,水合牛磺胆酸钠,牛胆酸钠(混合物),牛黄胆酸钠(水合),牛磺胆酸钠(标准品)),Taurocholate Sodium
Target: Others
Compound Lup-20(29)-en-3-yl acetate
Cat.No: TC0036
Synonym:
Target: IL Receptor, VEGFR, Others, TNF, COX
Oglufanide
Cat.No: T7203
Synonym: 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH
Target: VEGFR, HCV Protease, Endogenous Metabolite
Verbenalin
Cat.No: T3890
Synonym: Verbenalol β-D-glucopyranoside,马鞭草苷,Verbenaloside,Verbenalol glucoside,Cornin
Target: Others
Theaflavin 3,3'-digallate
Cat.No: T5429
Synonym: 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG
Target: Virus Protease, Antioxidant, HIV Protease, HSV
25(R,S)-Ruscogenin
Cat.No: T5740
Synonym: (25RS)鲁斯可皂苷元,(25RS)-Ruscogenin
Target: Others, HIF
Cinnamaldehyde
Cat.No: T4S1551
Synonym: Cinnamic Aldehyde,肉桂醛
Target: HIF
β,β-Dimethylacrylshikonin
Cat.No: T3S2344
Synonym: β,β-二甲基丙烯酰紫草素,Dimethylacrylshikonin,β, β-Dimethylacrylshikonin
Target: ERK, HIF/HIF Prolyl-Hydroxylase
5α-Hydroxycostic acid
Cat.No: TN3139
Synonym: 5alpha-Hydroxycostic acid
Target: ERK, FAK, Phospholipase, NOS, Akt, Src
5Z-7-Oxozeaenol
Cat.No: T14055
Synonym: FR148083,L783279,LL-Z 1640-2
Target: VEGFR, FLT, MEK, MAPK, PDGFR, Antibiotic, Src
Jolkinolide A
Cat.No: TN4356
Synonym:
Target: Akt, STAT, mTOR
Dammarenediol II
Cat.No: TN5942
Synonym: 达玛烯二醇II,Dammar-24-ene-3,20-diol
Target:
7-Hydroxyneolamellarin A
Cat.No: T75487
Synonym:
Target:
Herboxidiene
Cat.No: T36749
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPJ-00865 VEGF121 Protein, Human, Recombinant (His)

VEGFA,VEGF-A,Va...

Human HEK293 Cells
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel...
TMPY-01717 VEGF164 Protein, Mouse, Recombinant

vascular endothelial growth f...

Mouse Baculovirus Insect Cells
VEGF164 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.4 kDa and the accession number is Q00731-2.
TMPY-03698 VEGF121b Protein, Human, Recombinant

MVCD1,VEGF,VPF,vascular endotheli...

Human HEK293 Cells
VEGF121b Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.10 kDa and the accession number is P15692-9.
TMPY-01656 VEGF183 Protein, Human, Recombinant

血管内皮生长因子,VEGF165,VPF,VEGF,vascul<...

Human Baculovirus Insect Cells
VEGF183 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 21 kDa and the accession number is P15692-3.
TMPY-05798 VEGF145 Protein, Human, Recombinant

血管内皮生长因子,vascular endothelial gro...

Human HEK293 Cells
VEGF145 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16.92 kDa and the accession number is P15692-6.
TMPJ-00864 VEGF165 Protein, Human, Recombinant

Vascular Endothelial Growth F...

Human HEK293 Cells
Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimul...
TMPK-00823 VEGF165 Protein, Human, Recombinant (His & Avi)

血管内皮生长因子,RP1-261G23.1,MVCD1,MGC70609,VEGFA...

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4.
TMPJ-00562 PDGF-BB Protein, Mouse, Recombinant (His)

PDGFBB,PDGF-BB,血小板源生长因子

Mouse E. coli
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. As growth factor,it plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival...
TMPJ-00412 VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)

Vascular endothelial growth f...

Human HEK293 Cells
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas...
TMPJ-00735 PDGF-BB Protein, Human, Recombinant

PDGF-BB,血小板源生长因子,PDGFBB

Human E. coli
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In a...
TMPJ-00355 Neuropilin-1 Protein, Human, Recombinant (aa 22-644, Avi & His), Biotinylated

CD304,VEGF165R,NRP1,NRPNP1,BDCA4

Human HEK293 Cells
Neuropilin-1 (Npn-1, previously neuropilin; also CD304) is a 130 - 140 kDa type I transmembrane (TM) glycoprotein that regulates axon guidance and angiogenesis. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. Neuropilin-1 binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds ...
TMPK-00825 VEGF121 Protein, Human, Recombinant (His & Avi)

VPF,VEGF,VEGFA,VEGFMGC70...

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPY-02945 Prokineticin 1/EG-VEGF Protein, Human, Recombinant (His)

PK1,EGVEGF,PRK1,prokineticin 1

Human Baculovirus Insect Cells
EG-VEGF, also known as prokineticin-1, is a member of the AVIT (prokineticin) family. Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. EG-VEGF can be detected in the steroidogenic glands, ovary, testis, adrenal and placenta. EG-VEGF has little or no effect on a variety of other endothelial and non-endothelial cell types. It induces proliferation, migration and fenestration (the formation of membrane discontinuities) i...
TMPK-00826 VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated

VAS,VEGFMGC70609,RP1-261G23.1,血管内皮生长因子,

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPJ-00054 PLGF-2 Protein, Human, Recombinant (His)

PlGF-2,PlGF2,PlGF,PGF,PGFL

Human HEK293 Cells
Placental growth factor is a protein that in humans is encoded by the PGF gene. It is a secreted protein and belongs to the PDGF/VEGF growth factor family. Alternate splicing results in at least three human mature PlGF forms containing 131 (PlGF‑1), 152 (PlGF‑2), and 203 (PlGF‑3) amino acids (aa) respectively. PlGF is mainly found as a variably glycosylated, secreted, 55 ‑ 60 kDa disulfide linked homodimer.The protein is a member of the VEGF (vascular endothelial growth factor) sub-family-a key ...
TMPK-00822 VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled

RP1-261G23.1,VEGFA,MGC70609,VEGF,...

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4.
TMPJ-00987 PLGF/PGF Protein, Mouse, Recombinant (His)

Plgf,PlGF-2,PGFL,PGF,SHGC-10760,D12S1900,Placent

Mouse HEK293 Cells
Placental growth factor is a protein that in humans is encoded by the PGF gene. It is a secreted protein and belongs to the PDGF/VEGF growth factor family. The protein is a member of the VEGF (vascular endothelial growth factor) sub-family-a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast.
TMPK-00893 PGF Protein, Human, Recombinant (hFc)

PlGF,SHGC-10760,PGFL,PGF,D12S1900,PlGF-2

Human HEK293 Cells
Placental growth factor (PGF) is another member of the VEGF family of cytokines with pro-angiogenic and pro-inflammatory effects. Retinal inhibition of PGF in combination with VEGF-A prevents vascular leakage and CNV possibly via modulating their own expression in mononuclear phagocytes. PGF-related, optimized strategies to target inflammation-mediated angiogenesis may help to increase efficacy and reduce non-responders in the treatment of wet AMD patients.
TMPH-03240 Angiopoietin-2 Protein, Rat, Recombinant (His)

Angiopoietin-2,Angpt2,ANG-2

Rat Baculovirus Insect Cells
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Angiopoietin-2 Protein,...
TMPY-04327 VEGFB Protein, Human, Recombinant (hFc)

VRF,血管内皮生长因子,vascular endothelial...

Human HEK293 Cells
Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. In detail, VEGFB can positively prevent the Ang II-induced rising in the size of cardiomyocyte as well as reduce Ang II-induced mRNA and protein levels of β-MHC (β-myosin heavy chain), BNP (brain natriuretic peptide), and ANP (atrial natriuretic peptide). Moreover, VEGFB can regulate the decline of the Ang I...
TMPH-03241 Angiopoietin-2 Protein, Rat, Recombinant (E. coli, His)

Angpt2,Angiopoietin-2,ANG-2

Rat E. coli
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Angiopoietin-2 Protein,...
TMPH-01281 ELAVL3 Protein, Human, Recombinant (His)

PLE21,Hu-antigen C,ELAVL3,ELAV-li...

Human P. pastoris (Yeast)
RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Plays a role in the stabilization of GAP43 mRNA and in spatial learning.
TMPK-00293 Nectin-2 Protein, Human, Recombinant (His & Avi)

PRR2,CD112,Nectin2,MPH,PVRR2,PVRL2,HVEB

Human HEK293 Cells
Nectin-2 is an adhesion molecule that has been reported to play a role in tumor growth, metastasis and tumor angiogenesis. Nectin-2 expression in ovarian cancer may support tumor cell adhesion, leading to growth and lymph node metastasis. Effect of VEGF on Nectin-2 expression as well as permeability was investigated in HUVEC.
TMPK-00143 TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Flag)

TL1A,TL1,TNFSF15,VEGI,VEGI192A,VEGI-251

Human HEK293 Cells
TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2. TNFSF15 Trimer Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight...
TMPH-02572 TMEM2 Protein, Mouse, Recombinant (His)

Mouse E. coli
Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments. Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling. Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate.
TMPK-00489 TL1A/TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

TNFSF15,TNF superfamily member 15,TL1,VEGI192A<...

Cynomolgus,Rhesus HEK293 Cells
TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2. TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weigh...
TMPK-01153 PLVAP Protein, Human, Recombinant (His)

PV1,FELS

Human HEK293 Cells
Plasmalemma vesicle-associated protein (PLVAP, also called PV-1) is the only protein that forms endothelial diaphragms. PLVAP expression is very low in the normal blood-retinal barrier; however, pathological factors such as high glucose and vascular endothelial growth factor (VEGF) induce its expression, leading to the exacerbation of cellular permeability. Because the new blood vessels are fragile and leaky, PLVAP could possibly be considered a therapeutic target against retinovascular diseases...
TMPH-00343 Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His)

Angiopoietin-1,ANG-1,ANGPT1

Canine HEK293 Cells
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His) is expressed in HEK293 mammalian cells wi...
TMPJ-00802 THBS1 Protein, Human, Recombinant (His)

TSP,TSP1,Thrombospondin-1,THBS1

Human HEK293 Cells
Thrombospondin-1 (TSP-1) is a 150-180kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. TSP-1 regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 contains an N-terminal Laminin G-like globular domain, an extended central region with one vWFC domain, 3 TSP type 1domains, 2 EGF-like domains, and 8 TSP type3 domains, and a globular TSP C-terminal domain. Distinct regions of TSP-1 have...
TMPH-00479 Angiopoietin-1 Protein, Canine, Recombinant (His)

ANG-1,ANGPT1,Angiopoietin-1

Canine Baculovirus Insect Cells
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Canine, Recombinant (His) is expressed in Baculovirus insect cells with C-6...
TMPH-03239 Angiopoietin-1 Protein, Rat, Recombinant (His)

ANG-1,ANGPT1,Angiopoietin-1

Rat HEK293 Cells
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis ...
TMPK-00978 ECSCR Protein, Human, Recombinant (hFc)

ECSM2,ECSCR,ARIA

Human HEK293 Cells
Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angioblasts and in axial vessels during angioblast migration and vasculogenesis. Morpholino-directed ecscr knockdown resulted in defective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vascular endothelial-derived growth factor (VEGF). ECSC...
TMPK-00988 ECSCR Protein, Mouse, Recombinant (hFc)

ECSCR,ARIA,ECSM2

Mouse HEK293 Cells
Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angioblasts and in axial vessels during angioblast migration and vasculogenesis. Morpholino-directed ecscr knockdown resulted in defective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vascular endothelial-derived growth factor (VEGF). ECSC...
TMPJ-00968 NAMPT Protein, Human, Recombinant (His)

PBEF,PBEF1,Nicotinamide phosphoribosyltran...

Human E. coli
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular enzyme nicotinamide phosphoribosyltranferase (NAMPT) and the adipokine “visfatin”. PBEF is constitutively expressed in the fetal membranes where its greatest expression is in the amnion. It has intracellular and extracellular forms. Most of the intracellular functions of PBEF are ...
TMPH-01282 ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO)

PNEM,ELAVL4,HuD,Hu-antigen D,ELAV...

Human E. coli
RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA. Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function. By binding to th...
TMPK-01419 Peptide Ready HLA-A*03:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated

MHC,HLA-A*02:01,Peptide Ready

Human HEK293 Cells
Peptide Ready HLA-A*03:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*03:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01426 Peptide Ready HLA-A*11:01&B2M Monomer Protein, Human, MHC (His & Avi)

HLA-A*02:01,Peptide Ready,MHC

Human HEK293 Cells
Peptide Ready HLA-A*11:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*11:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01421 Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated

HLA-A*02:01,MHC,Peptide Ready

Human HEK293 Cells
HLA-A*02:01&B2M&Peptide ready Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01420 Peptide Ready HLA-A*03:01&B2M Monomer Protein, Human, MHC (His & Avi)

Peptide Ready,MHC,HLA-A*02:01

Human HEK293 Cells
Peptide Ready HLA-A*03:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*03:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01422 Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi)

Peptide Ready,MHC,HLA-A*02:01

Human HEK293 Cells
Peptide Ready HLA-A*02:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01425 Peptide Ready HLA-A*11:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated

MHC,HLA-A*02:01,Peptide Ready

Human HEK293 Cells
Peptide Ready HLA-A*11:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*11:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01410 Peptide Ready HLA-A*24:02&B2M Monomer Protein, Human, MHC (His & Avi)

HLA-A,MHC,Peptide Ready

Human HEK293 Cells
Peptide Ready HLA-G&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-G. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01409 Peptide Ready HLA-A*24:02&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated

Peptide Ready,MHC,HLA-A

Human HEK293 Cells
Peptide Ready HLA-G&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-G. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01415 APC-equivalent Peptide Ready HLA-A*02:01&B2M Tetramer Protein, Human, MHC (His)

Peptide Ready,HLA-A*02:01,MHC

Human HEK293 Cells
Peptide Ready HLA-A*02:01&B2M Tetramer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01403 HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi)

K-Ras 2,KI-RAS,CFC2,KRAS1,GTP...

Human E. coli
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01448 HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (E. coli, His & Avi)

MHC,LAGE-2,NY-ESO-1,ESO1CTAG,MY-ESO-1,CT

Human E. coli
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01427 HLA-A*11:01&B2M&KRAS G12D (VVGADGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated

C-K-RAS,K-RAS4B,GTPase Kra

Human E. coli
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01399 HLA-A*11:01&B2M&KRAS WT (VVGAGGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated

K-RAS2A,NS3,KRAS2,CFC2,K-RA

Human E. coli
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target.
TMPK-01404 HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi), Biotinylated

NS,KRAS,KRAS1,KRAS2,MHC,RA

Human E. coli
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01467 HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer Protein, Human, MHC (His & Avi)

HPV16,E6,Human papillomavirus typ...

Human HEK293 Cells
Human papillomavirus (HPV) 16 infection is a necessary condition for the pathogenesis and development of cervical cancer. The E6 protein is expressed by the HPV16 E6 gene and promotes malignant phenotype transformation, which is an important mechanism for the occurrence and development of cervical cancer.
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重组蛋白

VEGF121 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00865
Species: Human
Expression System: HEK293 Cells
VEGF164 Protein, Mouse, Recombinant
Cat.No: TMPY-01717
Species: Mouse
Expression System: Baculovirus Insect Cells
VEGF121b Protein, Human, Recombinant
Cat.No: TMPY-03698
Species: Human
Expression System: HEK293 Cells
VEGF183 Protein, Human, Recombinant
Cat.No: TMPY-01656
Species: Human
Expression System: Baculovirus Insect Cells
VEGF145 Protein, Human, Recombinant
Cat.No: TMPY-05798
Species: Human
Expression System: HEK293 Cells
VEGF165 Protein, Human, Recombinant
Cat.No: TMPJ-00864
Species: Human
Expression System: HEK293 Cells
VEGF165 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00823
Species: Human
Expression System: HEK293 Cells
PDGF-BB Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00562
Species: Mouse
Expression System: E. coli
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00412
Species: Human
Expression System: HEK293 Cells
PDGF-BB Protein, Human, Recombinant
Cat.No: TMPJ-00735
Species: Human
Expression System: E. coli
Neuropilin-1 Protein, Human, Recombinant (aa 22-644, Avi & His), Biotinylated
Cat.No: TMPJ-00355
Species: Human
Expression System: HEK293 Cells
VEGF121 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00825
Species: Human
Expression System: HEK293 Cells
Prokineticin 1/EG-VEGF Protein, Human, Recombinant (His)
Cat.No: TMPY-02945
Species: Human
Expression System: Baculovirus Insect Cells
VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00826
Species: Human
Expression System: HEK293 Cells
PLGF-2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00054
Species: Human
Expression System: HEK293 Cells
VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled
Cat.No: TMPK-00822
Species: Human
Expression System: HEK293 Cells
PLGF/PGF Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00987
Species: Mouse
Expression System: HEK293 Cells
PGF Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00893
Species: Human
Expression System: HEK293 Cells
Angiopoietin-2 Protein, Rat, Recombinant (His)
Cat.No: TMPH-03240
Species: Rat
Expression System: Baculovirus Insect Cells
VEGFB Protein, Human, Recombinant (hFc)
Cat.No: TMPY-04327
Species: Human
Expression System: HEK293 Cells
Angiopoietin-2 Protein, Rat, Recombinant (E. coli, His)
Cat.No: TMPH-03241
Species: Rat
Expression System: E. coli
ELAVL3 Protein, Human, Recombinant (His)
Cat.No: TMPH-01281
Species: Human
Expression System: P. pastoris (Yeast)
Nectin-2 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00293
Species: Human
Expression System: HEK293 Cells
TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Flag)
Cat.No: TMPK-00143
Species: Human
Expression System: HEK293 Cells
TMEM2 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02572
Species: Mouse
Expression System: E. coli
TL1A/TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
Cat.No: TMPK-00489
Species: Cynomolgus,Rhesus
Expression System: HEK293 Cells
PLVAP Protein, Human, Recombinant (His)
Cat.No: TMPK-01153
Species: Human
Expression System: HEK293 Cells
Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His)
Cat.No: TMPH-00343
Species: Canine
Expression System: HEK293 Cells
THBS1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00802
Species: Human
Expression System: HEK293 Cells
Angiopoietin-1 Protein, Canine, Recombinant (His)
Cat.No: TMPH-00479
Species: Canine
Expression System: Baculovirus Insect Cells
Angiopoietin-1 Protein, Rat, Recombinant (His)
Cat.No: TMPH-03239
Species: Rat
Expression System: HEK293 Cells
ECSCR Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00978
Species: Human
Expression System: HEK293 Cells
ECSCR Protein, Mouse, Recombinant (hFc)
Cat.No: TMPK-00988
Species: Mouse
Expression System: HEK293 Cells
NAMPT Protein, Human, Recombinant (His)
Cat.No: TMPJ-00968
Species: Human
Expression System: E. coli
ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO)
Cat.No: TMPH-01282
Species: Human
Expression System: E. coli
Peptide Ready HLA-A*03:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01419
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-A*11:01&B2M Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01426
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01421
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-A*03:01&B2M Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01420
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01422
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-A*11:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01425
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-A*24:02&B2M Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01410
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-A*24:02&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01409
Species: Human
Expression System: HEK293 Cells
APC-equivalent Peptide Ready HLA-A*02:01&B2M Tetramer Protein, Human, MHC (His)
Cat.No: TMPK-01415
Species: Human
Expression System: HEK293 Cells
HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi)
Cat.No: TMPK-01403
Species: Human
Expression System: E. coli
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (E. coli, His & Avi)
Cat.No: TMPK-01448
Species: Human
Expression System: E. coli
HLA-A*11:01&B2M&KRAS G12D (VVGADGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01427
Species: Human
Expression System: E. coli
HLA-A*11:01&B2M&KRAS WT (VVGAGGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01399
Species: Human
Expression System: E. coli
HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi), Biotinylated
Cat.No: TMPK-01404
Species: Human
Expression System: E. coli
HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01467
Species: Human
Expression System: HEK293 Cells
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