store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5Z-7-Oxozeaenol (FR148083) 是一种天然抗原生动物抑制剂,不可逆的选择性抑制 TAK1和 VEGF-R2,IC50值分别为 8 nM 和 52 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,250 | 待询 | ||
5 mg | 待询 | 待询 | ||
10 mg | 待询 | 待询 | ||
25 mg | 待询 | 待询 | ||
50 mg | 待询 | 待询 | ||
100 mg | 待询 | 待询 |
产品描述 | 5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is also an inhibitor of VEGF-R2 with IC50 of 52 nM. |
靶点活性 | Src:6600 nM, B-RAF VE:6300 nM, TAK1:8.1 nM, MEK1:411 nM, VEGFR-3:110 nM, PDGFR-β:340 nM, VEGFR-2:52 nM, FLT3:170 nM |
体外活性 | 5Z-7-Oxozeaenol is a natural anti-protozoan compound from the fungal origin with inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE, and SRC with IC50s of 110, 170, 340, 6300, and 6600 nM, respectively[1]. 5Z-7-Oxozaeenol inhibited PMA-induced AP-1 activity to almost basal levels in KT cells but had no effect on IL-1-induced NF-kB activity in KK cells[2]. 5Z-7-Oxozaeenol inhibits the JNK/p38 pathway, but it is not a direct inhibitor and is signal-specific. 5Z-7-Oxozaeenol prevents inflammation by inhibiting the catalytic activity of the TAK1 MAPK kinase[3]. |
别名 | FR148083, L783279, LL-Z 1640-2 |
分子量 | 362.37 |
分子式 | C19H22O7 |
CAS No. | 253863-19-3 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (110.38 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7596 mL | 13.7981 mL | 27.5961 mL | 68.9903 mL |
5 mM | 0.5519 mL | 2.7596 mL | 5.5192 mL | 13.7981 mL | |
10 mM | 0.276 mL | 1.3798 mL | 2.7596 mL | 6.899 mL | |
20 mM | 0.138 mL | 0.6899 mL | 1.3798 mL | 3.4495 mL | |
50 mM | 0.0552 mL | 0.276 mL | 0.5519 mL | 1.3798 mL | |
100 mM | 0.0276 mL | 0.138 mL | 0.276 mL | 0.6899 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
5Z-7-Oxozeaenol 253863-19-3 Angiogenesis MAPK Microbiology/Virology Tyrosine Kinase/Adaptors MEK FLT VEGFR PDGFR Antibiotic Src Vascular endothelial growth factor receptor L 783279 MAP kinase kinase kinase, MEKK, MAPKKK inhibit FR148083 5Z7Oxozeaenol L-783279 FR 148083 FR-148083 L783279 5Z 7 Oxozeaenol Inhibitor LL-Z 1640-2 MAP3K inhibitor