177
24
3
1
137
Cat. No. | Product Name | ||
---|---|---|---|
L2192 | 抗胰腺癌化合物库 | 2238 compounds | |
2238 种与胰腺癌相关的化合物,可以用于高通量和高内涵筛选; | |||
L4800 | 血管生成库 | 1353 compounds | |
1353 个高潜力的抑制或促进血管生成的小分子集合,可用于药物靶点开发、血管生成机理研究的高通量筛选,高内涵筛选; | |||
L2191 | 抗乳腺癌化合物库 | 1939 compounds | |
1939 种与乳腺癌相关的化合物,可以用于抗乳腺癌药物研发和药理研究; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
CL0068 |
VEGFR inhibitor kit
VEGFR inhibitor kit |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T71944 |
FGF/PDGF/VEGF RTK Inhibitor
|
||
FGF/PDGF/VEGF RTK Inhibitor is a potent, reversible, atp-competitive inhibitor against pdgfrβ, fgfr-1, and vegfr-2 (ic50 = 20, 90, and 240 nm, respectively) and effectively suppresses vegf-stimulated proliferation of hmvecs (ec50 = 420 nm). | |||
T8496 |
MAZ51
|
Apoptosis; VEGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
MAZ51 是一种 VEGFR-3酪氨酸激酶的选择性抑制剂。它抑制 VEGF-C 诱导的 VEGFR-3 激活,而没有阻断 VEGF-C 介导的 VEGFR2 刺激。它阻止增殖并诱导多种肿瘤细胞凋亡,具有抗肿瘤活性。 | |||
T4288 |
hVEGF-IN-1
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
hVEGF-IN-1 是一种喹唑啉衍生物,可以特异性结合内部核糖体进入位点 A 中富含 G 的序列,并会使 G-四链体结构不稳定。在 SPR 实验中,它与 IRES-A (WT) 结合的Kd 值为 0.928 μM。它能够抑制VEGF-A 蛋白表达,阻止肿瘤细胞迁移,抑制肿瘤生长。 | |||
T8574 |
SPHINX
|
Others | Others |
SPHINX 是新一代的 SPRK1抑制剂。 | |||
T15102 |
Dexamethasone palmitate
地塞米松棕榈酸酯,DXP |
Glucocorticoid Receptor | Endocrinology/Hormones |
Dexamethasone palmitate (DXP) (DXP) 是 Dexamethasone 的前药。Dexamethasone 是糖皮质激素受体激动剂。与Dexamethasone 相比, DXP 对糖皮质激素受体的亲和力低 47 倍。DXP 显示出抗炎活性。 | |||
T0463 |
Loxoprofen
Loxoprofene,洛索洛芬,Loxoprofeno,Koloxo |
COX | Immunology/Inflammation; Neuroscience |
Loxoprofen (Koloxo) 是一种非甾体类抗炎药,具有解热作用,可用于缓解疼痛的研究。它是非选择性COX 抑制剂,对 COX-1 和 COX-2 的IC50分别为 6.5 和 13.5 μM。 | |||
T9928 |
Ranibizumab
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Ranibizumab 是一种人源化单克隆抗体片段,旨在靶向和抑制血管内皮生长因子 (VEGF),包括 VEGF110、VEGF121 和 VEGF165。 Ranibizumab 选择性靶向和中和 VEGF-A 同工型的能力使其成为湿性年龄相关性黄斑变性 (AMD) 研究和治疗策略的重要组成部分。 | |||
T8973 |
HS-1793
|
Others | Others |
HS-1793 是 resveratrol 类似物,可以诱导细胞凋亡,在多种癌细胞中有抗肿瘤的能力。 | |||
T8657 |
KYP-2047
|
Others | Others |
KYP-2047 是一种非常有效的选择性脯氨酰寡肽酶 (POP) 抑制剂。 | |||
T6182 |
Tirofiban
L700462,Aggrastat,替罗非班,MK383 |
Integrin | Cytoskeletal Signaling |
Tirofiban (L700462) 是一种非肽类选择性 GPIIb/IIIa 拮抗剂,IC50 为 9 nM,可抑制血小板聚集。 | |||
T2537 |
Tirofiban hydrochloride monohydrate
Tirofiban Hydrochloride,盐酸替罗非班水合物,MK-383 Hydrochloride,盐酸替罗非班 |
ATPase; Integrin | Cytoskeletal Signaling; Membrane transporter/Ion channel |
Tirofiban hydrochloride monohydrate (MK-383 Hydrochloride) 是一种非肽类糖蛋白IIb/IIIa 的拮抗剂。 | |||
T72924 |
VEGFR-3-IN-1
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR-3-IN-1 是一种新型有效且具有选择性的 VEGFR3 抑制剂,其 IC50 为 110.4 nM。VEGFR-3-IN-1 具有抗肿瘤活性,可使 VEGFR3 信号通路失活,可抑制 VEGF-C 诱导人真皮淋巴管内皮细胞 (HDLEC)、MDA-MB-231 和 MDA-MB-436 细胞的增殖和迁移,并且能有效抑制乳腺癌的生长。 | |||
T37078 |
VEGFR-2-IN-6
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR-2-IN-6(WO 02/059110)是一种 VEGFR2 的强效抑制剂,这是一种在血管生成调控中起关键作用的受体[1]。 | |||
T2056 |
VEGFR-2-IN-5
2, 4-Pyrimidinediamine with linker,UNC0064-12,2,4-Pyrimidinediamine with linker |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR-2-IN-5 (UNC0064-12) 是 VEGFR2 抑制剂。 | |||
T79860 |
TIE-2/VEGFR-2 kinase-IN-5
|
VEGFR; Tie-2 | Angiogenesis; Tyrosine Kinase/Adaptors |
TIE-2/VEGFR-2 kinase-IN-5 是一种高效的 TIE-2 和 VEGFR-2 酪氨酸激酶受体抑制剂,具有的抗血管生成活性,常用于血管生成相关的生物医学研究领域。 | |||
T9724 |
VEGFR2-IN-2
|
Others | Others |
VEGFR2-IN-2 具有抗炎和镇痛活性。 | |||
T9979 |
VEGFR-2-IN-29
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR-2-IN-29是一种 VEGFR2抑制剂。 | |||
T61899 |
VEGFR2-IN-1
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR2-IN-1 是一种具有选择性和高效性的 VEGFR2 抑制剂,具有抗肿瘤活性,可抑制细胞的增殖和迁移,可用于研究乳腺癌。 | |||
T61038 | VEGFR-2-IN-10 | ||
VEGFR-2-IN-10 对 VEGF 诱导的VEGFR2磷酸化表现出增强的抗血管生成效力,IC50值为 0.7 μM,而无细胞毒性作用。 | |||
T37079 |
VEGFR2 Kinase Inhibitor II
|
||
Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor of VEGFR2's kinase activity (IC50 = 70 nM). It less potently inhibits the platelet-derived growth factor receptor β (PDGFRβ; IC50 = 920 nM) and related receptor and non-receptor tyrosine kinases. V... | |||
T80873 | VEGFR2/HDAC1-IN-1 | VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR2/HDAC1-IN-1(compound 13)是一款有效的VEGFR-2和HDAC双重抑制剂,其IC50值分别为57.83 nM 和9.82 nM 。该化合物能够阻滞细胞周期于S期及G2期,并能诱导HeLa细胞发生凋亡,同时具有抗血管生成的特性。 | |||
T63112 | VEGFR-IN-3 | ||
VEGFR-IN-3 (compound 3f) 是 VEGFR 抑制剂。VEGFR-IN-3 抑制 OVCAR-4 和 MDA-MB-468 癌细胞的生长,其 IC50值分别为 0.29 和 0.35 μM。VEGFR-IN-3 可用于癌症的研究。 | |||
T79540 |
hCA/VEGFR-2-IN-1
|
Carbonic Anhydrase | Metabolism |
hCA/VEGFR-2-IN-1 是一种高效的双靶点抑制剂,对 hCA IX 和 hCA XII 两种碳酸酐酶(CA)具有极低的Ki值,分别为8.3 nM和4.7 nM。同时,hCA/VEGFR-2-IN-1 也是一种有效的 VEGFR-2 抑制剂,其 IC50 值仅为26.3 nM,并且显示出抗癌活性。 | |||
T72713 |
PI3K/VEGFR2-IN-1
|
PI3K | PI3K/Akt/mTOR signaling |
PI3K/VEGFR2-IN-1是一种具有双重抑制效应的化合物,对PI3K和VEGFR2的IC50分别为2.21 μM和68 μM,能够诱导细胞凋亡(apoptosis),在癌症研究中应用。 | |||
T61631 |
VEGFR-2-IN-23
|
||
VEGFR-2-IN-23 (compound 11b) is a highly potent and selective inhibitor of VEGFR-2, with an impressive IC 50 value of 0.34 nM. This compound exhibits notable antitumor activity, capable of inducing apoptosis and cell cycle arrest specifically at the G1 phase [1]. | |||
T61943 | VEGFR-2-IN-5 hydrochloride | ||
VEGFR-2-IN-5 hydrochloride 是有效的VEGFR2抑制剂。 | |||
T62763 | VEGFR-2-IN-12 | ||
VEGFR-2-IN-12 (compound 6g) 是一种 2-oxoquinoxalinyl-1,2,4-triazole,是一种 VEGFR-2 的有效抑制剂 (IC50: 0.037 μM)。VEGFR-2-IN-12 能够高度抑制 MCF-7 细胞的生长 (GI50: 1.6 μM)。VEGFR-2-IN-12 具有抗肿瘤作用。 | |||
T62071 | VEGFR-2-IN-16 | ||
VEGFR-2-IN-16 (Compound 15b) 是一种 VEGFR-2 的有效抑制剂 (IC50: 86.36 nM),表现出抗肿瘤效果。 | |||
T61542 | VEGFR-2-IN-17 | ||
VEGFR-2-IN-17 (Compound 15a) is a highly potent inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2), with an IC50 value of 67.25 nM. This compound exhibits significant antitumor properties [1]. | |||
T72890 | VEGFR-2-IN-30 | ||
VEGFR-2-IN-30为一种针对VEGFR-2的抑制剂(IC50:66 nM),同时对PDGFR、EGFR及FGFR1亦有一定抑制作用,其IC50s分别为180、98、82 nM。此外,VEGFR-2-IN-30能够阻止癌细胞在S期的进展并诱导早期以及晚期的细胞凋亡(apoptosis)。 | |||
T79591 |
hCA/VEGFR-2-IN-4
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
hCA/VEGFR-2-IN-4 (化合物15b) 是一种具有癌症治疗潜力的吲哚酮基苯磺酰胺类双重抑制剂,旨在抑制与癌症相关的hCA IX/XII 和VEGFR-2。该化合物对VEGFR-2具有较强的抑制能力(IC50=0.811 μM),并对hCAs展现高亲和性,其Ki值分别为hCA XII的3.8 nM,hCA IX的6.2 nM,hCA II的19.8 nM,以及hCA I的35.5 nM。此外,hCA/VEGFR-2-IN-4 对于VEGFR-2过表达的乳腺癌细胞有抗增殖作用。 | |||
T79400 |
VEGFR-2-IN-35
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR-2-IN-35(compound 7)作为 VEGFR-2 抑制剂,展示出37 nM 的IC50值;同时,该化合物对MCF-7 和 HCT 116 癌细胞的抑制效果显著,IC50值分别为10.56 μM 和7.07 μM。 | |||
T78759 |
VEGFR2-IN-4
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR2-IN-4(化合物25)为一种针对VEGFR2激酶的有效且选择性抑制剂,其GI50为0.7 nM。该化合物表现出抗血管生成活性,可用于类风湿关节炎研究领域。 | |||
T78819 |
VEGFR-2-IN-33
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR-2-IN-33(Compound 4d)为一种有效的VEGFR抑制剂,其IC50值为61.04 nM。该化合物在抑制HepG2细胞增殖方面表现出更高的效力,IC50仅为4.31 nM,因此常用于肝细胞癌(HCC)研究领域。 | |||
T63722 |
VEGFR-2-IN-24
|
||
VEGFR-2-IN-24 是 VEGFR-2 的有效抑制剂 (IC50: 0.22 μM),能够用于研究肿瘤。 | |||
T8817 |
TIE-2/VEGFR-2 kinase-IN-1
|
||
TIE-2/VEGFR-2 kinase-IN-1 用于合成TIE-2或者VEGFR-2抑制剂,可用于研究不适当的血管生成的相关疾病。 | |||
T61861 |
VEGFR-2-IN-20
|
||
VEGFR-2-IN-20 (Compound 7) is a highly effective VEGFR inhibitor with significant potential for cancer research [1]. | |||
T63822 |
VEGFR-2-IN-22
|
||
VEGFR-2-IN-22 (Compound 25) 是 VEGFR-2 和 β-tubulin 聚合抑制剂,对 VEGFR-2 的 IC50=19.82 nM。VEGFR-2-IN-22 能够诱导细胞凋亡 (apoptosis)。 | |||
T63168 | VEGFR-2-IN-26 | ||
VEGFR-2-IN-26 (compound 5h) 是一种 VEGFR-2 的高效抑制剂 (IC50: 15.5 nM)。VEGFR-2-IN-26 对白血病、中枢神经系统、非小肺、卵巢、肾、前列腺和乳腺癌细胞表现出良好的抗增殖作用。 | |||
T80874 | VEGFR-2/c-Met-IN-1 | VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR-2/c-Met-IN-1为VEGFR-2及c-Met的双重抑制剂,IC50值为138 nM和74 nM,显示出抗肿瘤活性。 | |||
T23504 |
VEGFR-IN-1
VEGFR Tyrosine Kinase Inhibitor II |
Others | Others |
VEGFR inhibitor | |||
T61137 | VEGFR-2-IN-19 | ||
VEGFR-2-IN-19 (Compound 15b) is a highly efficacious inhibitor of VEGFR2, a receptor involved in angiogenesis. Its mechanism of action involves the induction of cellular apoptosis and elevation of intracellular reactive oxygen species. Due to these properties, VEGFR-2-IN-19 holds promise as an effective anticancer agent [1]. | |||
T61489 | VEGFR-2/DHFR-IN-1 | ||
VEGFR-2/DHFR-IN-1 (compound 8b) 是 VEGFR-2和DHFR 的抑制剂,其IC50值分别为 0.384 和 7.881 μM。VEGFR-2/DHFR-IN-1 对大肠埃希菌,粪链球菌,肠沙门氏菌,金黄色酿脓葡萄球菌,MSSA 和MRSA 显示了良好的抗菌活性,MIC 值分别为 16,16,16,8 和 16 μg/mL。VEGFR-2/DHFR-IN-1 对 C26,HepG2 和 CF7 癌细胞系具有良好的细胞毒性,IC50值为 2.97-7.12 μM。VEGFR-2/DHFR-IN-1 可用于癌症的研究。 | |||
T79859 |
TIE-2/VEGFR-2 kinase-IN-4
|
||
TIE-2/VEGFR-2 kinase-IN-4,一种苯并咪唑衍生物,作为有效的TIE-2和VEGFR-2酪氨酸激酶受体抑制剂,其IC50值分别为5.2 nM和5.1 nM,适用于血管生成相关研究。 | |||
T78845 |
FGFR1/VEGFR2-IN-1
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
FGFR1/VEGFR2-IN-1 (compound 2b) 为FGFR1/VEGFR2抑制剂,适用于癌症研究。 | |||
T62901 |
VEGFR-2-IN-27
|
||
VEGFR-2-IN-27 (compound 7a) 是一种 VEGFR-2 的高效抑制剂 (IC50: 14.8 nM),能够用于抗癌研究。 | |||
T72607 |
VEGFR-2/BRAF-IN-1
|
||
VEGFR-2/BRAF-IN-1 是一种 VEGFR-2和 BRAF 双重抑制剂,对 VEGFR-2、BRAFV600E 和BRAFWT 的IC50分别为 0.049、0.063 和 0.005 µM。VEGFR-2/BRAF-IN-1 诱导细胞凋亡,在 G1/S 期阻滞细胞周期。 | |||
T68526 |
VEGFR-IN-V
|
||
VEGFR-IN-V is a potent, vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor. | |||
T61229 |
VEGFR-2/DHFR-IN-2
|
||
VEGFR-2/DHFR-IN-2 (compound 5b) is a dual inhibitor targeting VEGFR-2 and DHFR, with respective IC50 values of 0.623 μM and 9.085 μM. It demonstrates potent cytotoxicity against C26, HepG2, and MCF7 cancer cell lines, with IC50 values ranging from 3.59 μM to 8.38 μM. VEGFR-2/DHFR-IN-2 holds promise for cancer research [1]. | |||
T61561 |
VEGFR-2-IN-18
|
||
VEGFR-2-IN-18 (Compound 15d) is a high-potency inhibitor of VEGFR-2, with an IC 50 value of 60 nM. This compound effectively initiates cell apoptosis and demonstrates significant antitumor properties [1]. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9715 |
Aplidine
|
SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Aplidine 是有效的eEF1A2(KD=80 nM) 靶向的抗癌药物。Aplidine 具有抗病毒活性,抑制SARS-CoV-2的 IC90为 0.88 nM。Aplidine 在多发性骨髓瘤,晚期癌症及 COVID-19 领域有研究的价值。 | |||
T1152 |
Albendazole
SKF-62979,阿苯达唑 |
HIF/HIF Prolyl-Hydroxylase; Microtubule Associated; Antibiotic; Parasite | Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Microbiology/Virology |
Albendazole (SKF-62979) 是一种广谱抗寄生虫剂,具有高效,低宿主毒性的特点。 它用于研究人类和动物的胃肠道寄生虫。 | |||
TWA2417 |
Sodium taurocholate
牛黄胆酸钠(牛胆酸钠,牛胆酸钠盐,牛磺膽酸鈉,牛磺胆酸钠,牛磺胆酸钠盐,牛胆酸钠水合物,水合牛磺胆酸钠,牛胆酸钠(混合物),牛黄胆酸钠(水合),牛磺胆酸钠(标准品)),Taurocholate Sodium |
Others | Others |
Sodium taurocholate (Taurocholate Sodium) hydrate 具有显著的生物学效应,例如通过上调 VEGF-A 的表达抑制肝动脉结扎所致的胆道损伤。对免疫系统具有一定的调节作用。 | |||
T17280 |
(Z)-Guggulsterone
|
Apoptosis; VEGFR; Akt | Angiogenesis; Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
(Z)-Guggulsterone 是印度阿育吠陀药用植物Commiphora mukul 的成分,可通过引起细胞凋亡来抑制人前列腺癌细胞的生长,还可通过抑制VEGF-VEGF-R2-Akt 信号传导轴来抑制血管生成。 | |||
TC0036 |
Compound Lup-20(29)-en-3-yl acetate
|
IL Receptor; VEGFR; Others; TNF; COX | Angiogenesis; Apoptosis; Immunology/Inflammation; Neuroscience; Others; Tyrosine Kinase/Adaptors |
Lup-20(29)-en-3-yl acetate 是 Lupeol 的衍生物,通过下调 TNF-α、IL-1β、MCP-1、COX-2、VEGF 和颗粒酶 B 来抑制类风湿性关节炎的进展。 | |||
TQ0169 |
Inulicin
1-O-Acetylbritannilactone,旋覆花内酯 |
FAK; NF-κB; COX; Src | Angiogenesis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors |
Inulicin (1-O-Acetylbritannilactone) 是从欧亚旋覆花中提取的一种天然产物,可抑制 VEGF 介导的Src 和FAK 活化,抑制NF-κB 活化和易位,以及抑制 LPS 诱导的PGE2产生和COX-2表达。 | |||
T3890 |
Verbenalin
Verbenalol β-D-glucopyranoside,马鞭草苷,Verbenaloside,Verbenalol glucoside,Cornin |
Others | Others |
Verbenalin (Verbenaloside) 是马鞭草苷,具有抗炎、抗真菌、抗病毒等活性。它能减轻脑缺血再灌注损伤。它可用于前列腺炎的研究。 | |||
T3250 |
Royal Jelly acid
10-羟基-2-癸烯酸(10-HAD),蜂王浆酸,王浆酸,10-Hydroxy-trans-2-decenoic acid,10-Hydroxy-2-decenoic acid,10H2DA,10-Hydroxy-2-decylenic acid,Queen Bee Acid,(E)-10-Hydroxy-2-decenoic acid |
VEGFR; Endogenous Metabolite | Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors |
Royal Jelly acid (Queen Bee Acid) 是一种蜂王浆中的主要脂肪酸,可促进神经元的生长和保护,减少焦虑。 | |||
T7203 |
Oglufanide
奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH |
VEGFR; HCV Protease; Endogenous Metabolite | Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂,可抑制血管内皮生长因子,可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。 | |||
T3S0335 |
Soyasaponin Bb
Soyasaponin I,大豆皂苷Bb |
NF-κB; Caspase | Apoptosis; NF-κB; Proteases/Proteasome |
Soyasaponin Bb (Soyasaponin I) 是一种分离自菜豆科中的大豆皂苷,可用作醛糖还原酶差异抑制剂。 | |||
T5429 |
Theaflavin 3,3'-digallate
茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG |
Virus Protease; Antioxidant; HIV Protease; HSV | Microbiology/Virology; oxidation-reduction; Proteases/Proteasome |
Theaflavin 3,3'-digallate (8-Gingerol) 是一种寨卡病毒蛋白酶抑制剂,IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制,可抑制 gp41 和 NS2B-3 蛋白酶的活性,并具有抗 HSV 和 HIV-1病毒活性。它是红茶中的主要多酚,有抗肿瘤作用。 | |||
TN1557 |
Decursinol angelate
|
ERK; VEGFR; PKC; JNK | Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Tyrosine Kinase/Adaptors |
Decursinol angelate 是从朝鲜当归根部分离得到的一种天然产物,是 PKC 激酶的激活剂,有细胞毒性,抗肿瘤和抗炎活性。 | |||
T5740 |
25(R,S)-Ruscogenin
(25RS)鲁斯可皂苷元,(25RS)-Ruscogenin |
Others; HIF | Angiogenesis; Chromatin/Epigenetic; Others |
25(R,S)-Ruscogenin 能够调节 PI3K/Akt/mTOR 信号通路,抑制 MMP-2、MMP-9、uPA、VEGF 和 HIF-1α 的表达,阻碍肝癌转移。 它能够抑制 TLR4信号通路,减轻 LPS 诱导的肺内皮细胞凋亡。 | |||
T2906 |
Tanshinone IIA
丹参酮IIA,Tanshinone B,Dan Shen ketone |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Tanshinone IIA (Tanshinone B) 是红根丹参根系中的一种主要组合物。它能够利用靶向 VEGF/VEGFR2的蛋白激酶结构域,抑制血管生成。 | |||
T3780 |
Oroxin B
Hypocretin-2,木蝴蝶苷B |
Apoptosis; PTEN; Antioxidant; PI3K; Autophagy | Apoptosis; Autophagy; oxidation-reduction; PI3K/Akt/mTOR signaling |
Oroxin B (Hypocretin-2) 是从传统中草药木蝴蝶中分离出来的黄酮类天然产物,在恶性淋巴瘤细胞中诱导肿瘤抑制性 ER 应激。它通过上调 PTEN,下调 COX-2,VEGF,PI3K 和 p-AKT,对肝癌细胞具有明显的抑制作用,诱导细胞早期凋亡。 | |||
T4S1551 |
Cinnamaldehyde
Cinnamic Aldehyde,肉桂醛 |
HIF | Angiogenesis; Chromatin/Epigenetic |
Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。 它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生,发挥血管扩张和抗癌作用。 它似乎是一种有希望的候选药物,可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。 它在抑制黑色素瘤的发生和发展方面具有一定的作用,其作用机制可能表现为抑制VEGF 和HIF-α的表达,从而使血管模拟和黑色素瘤细胞新生血管的形成,促进肿瘤的生长。 | |||
T3S2344 |
β,β-Dimethylacrylshikonin
β,β-二甲基丙烯酰紫草素,Dimethylacrylshikonin,β, β-Dimethylacrylshikonin |
ERK; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; MAPK; Metabolism |
β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) 是一种萘醌衍生物,从 Arnebia nobilis 中提取得到。它利用 PI3K 通路诱导 eNOS、VEGF 和 HIF-1α 的表达,促进血管生成,具有抗肿瘤活性。 | |||
TN3139 |
5α-Hydroxycostic acid
5alpha-Hydroxycostic acid |
ERK; FAK; Phospholipase; NOS; Akt; Src | Angiogenesis; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate. | |||
TN1874 |
Liriodendrin
鹅掌楸苦素 |
ATPase; Potassium Channel; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel |
Liriodendrin 调节肺部炎症、NF-kB (p65) 的磷酸化和血管内皮生长因子 (VEGF) 的表达。Liriodendrin 具有抗炎、镇痛、降血糖活性,在脓毒症引起的急性肺损伤中起保护作用。 | |||
T14055 |
5Z-7-Oxozeaenol
FR148083,L783279,LL-Z 1640-2 |
VEGFR; FLT; MEK; MAPK; PDGFR; Antibiotic; Src | Angiogenesis; MAPK; Microbiology/Virology; Tyrosine Kinase/Adaptors |
5Z-7-Oxozeaenol (FR148083) 是一种天然抗原生动物抑制剂,不可逆的选择性抑制 TAK1和 VEGF-R2,IC50值分别为 8 nM 和 52 nM。 | |||
TN5942 |
Dammarenediol II
达玛烯二醇II,Dammar-24-ene-3,20-diol |
||
Dammarenediol II may have the ability to prevent diabetic microvascular complications, including diabetic retinopathy, it can inhibit vascular endothelial growth factor (VEGF)-induced intracellular reactive oxygen species generation and stress fiber forma | |||
TN4356 |
Jolkinolide A
|
Akt; STAT; mTOR | Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem Cells |
Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly inhibited the proliferation and migration of HUVECs. | |||
T75487 | 7-Hydroxyneolamellarin A | ||
7-Hydroxyneolamellarin A,一种从海绵Dendrilla nigra 提取的天然产物,是高效的缺氧诱导因子 1α (HIF-1α) 抑制剂。该化合物能够减弱HIF-1α蛋白的积累,并抑制血管表皮生长因子 (VEGF) 的转录活性,因而在癌症研究中有应用价值。 | |||
T36749 |
Herboxidiene
|
||
Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.3 Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.[4] Herbo... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00865 |
VEGF121 Protein, Human, Recombinant (His)
VEGFA,VEGF-A,Vascular permeability factor,... |
Human | Human Cells |
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel... | |||
TMPK-00823 |
VEGF165 Protein, Human, Recombinant (His & Avi)
血管内皮生长因子,RP1-261G23.1,MVCD1,MGC70609,VEGFA,VEGF... |
Human | HEK293 |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. | |||
TMPY-03698 |
VEGF121b Protein, Human, Recombinant
MVCD1,VEGF,VPF,vascular endothelial growth factor A |
Human | HEK293 |
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular per... | |||
TMPY-01717 |
VEGF164 Protein, Mouse, Recombinant
vascular endothelial growth factor A,Vpf,Vegf,血管内皮生... |
Mouse | Baculovirus-Insect Cells |
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular per... | |||
TMPJ-00864 |
VEGF165 Protein, Human, Recombinant
Vascular Endothelial Growth Factor Isoform 165,血管内皮生长因子,... |
Human | Human Cells |
Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimul... | |||
TMPY-01008 |
VEGFD Protein, Human, Recombinant (His)
VEGFD,c-fos induced growth factor (vascular endothe... |
Human | HEK293 |
Vascular endothelial growth factor D (VEGF-D), also known as C-fos induced growth factor (FIGF), belongs to the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. FIGF protein is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. FIGF protein is secreted as a non-covelent homodimer in an antiparallel fashion. Human FIGF protein is expressed in adult lung, heart, muscle, and small intestine, and is most abundantly expressed in fetal lungs an... | |||
TMPY-01007 |
VEGFC Protein, Human, Recombinant (His)
血管内皮生长因子,LMPH1D,VEGF-C,Flt4-L,vascular endothelial ... |
Human | HEK293 |
Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGF... | |||
TMPY-00949 |
VEGFR3/FLT4 Protein, Human, Recombinant (His)
VEGFR-3,PCL,FLT41,VEGF Receptor 3,VEGF... |
Human | HEK293 |
VEGFR3/FLT4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86 kDa and the accession number is P35916-1. | |||
TMPK-00822 |
VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled
RP1-261G23.1,VEGFA,MGC70609,VEGF,VEGF<... |
Human | HEK293 |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4. | |||
TMPY-01656 |
VEGF183 Protein, Human, Recombinant
血管内皮生长因子,VEGF165,VPF,VEGF,vascular endothe... |
Human | Baculovirus-Insect Cells |
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular per... | |||
TMPY-05798 |
VEGF145 Protein, Human, Recombinant
血管内皮生长因子,vascular endothelial growth factor A,VPF,MVCD1,... |
Human | HEK293 |
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular per... | |||
TMPK-00825 |
VEGF121 Protein, Human, Recombinant (His & Avi)
VPF,VEGF,VEGFA,VEGFMGC70609,血管内皮生... |
Human | HEK293 |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. | |||
TMPK-00826 |
VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated
VAS,VEGFMGC70609,RP1-261G23.1,血管内皮生长因子,VEGF |
Human | HEK293 |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. | |||
TMPK-00972 |
PK-1/PROK1 Protein, Mouse, Recombinant (hFc)
PROK1,Mambakine,Prokineticin-1,EG-VEGF |
Mouse | HEK293 |
PK-1 (Ac10) is a baculovirus-encoded serine/threonine kinase,a pk-1 knockout AcMNPV failed to produce infectious progeny, while the pk-1 repair virus could rescue this defect.the kinase activity of PK-1 is essential in regulating viral propagation. Electron microscopy revealed that pk-1 deletion affected the formation of normal nucleocapsids.PK-1 appears to phosphorylate some viral or cellular proteins that are essential for DNA packaging to regulate nucleocapsid assembly. | |||
TMPK-00450 |
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
FLT1,FRT,FLT,Flt-1,VEGF R1,VEGFR1 |
Human | HEK293 |
VEGFR1 (vascular endothelial growth factor receptor 1), also called Flt-1 (Fms-like tyrosine kinase), is a 180 kDa type I transmembrane glycoprotein in the class III subfamily of receptor tyrosine kinases (RTKs).yrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May pla... | |||
TMPK-00451 |
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated
FLT,Flt-1,FRT,VEGFR1,VEGF R1,FLT1 |
Human | HEK293 |
VEGFR1 (vascular endothelial growth factor receptor 1), also called Flt-1 (Fms-like tyrosine kinase), is a 180 kDa type I transmembrane glycoprotein in the class III subfamily of receptor tyrosine kinases (RTKs).yrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May pla... | |||
TMPY-02432 |
VEGF164 Protein, Rat, Recombinant
血管内皮生长因子,vascular endothelial growth factor A |
Rat | Baculovirus-Insect Cells |
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular per... | |||
TMPK-01044 |
VEGFC Protein, Human, Recombinant (His & Avi), Biotinylated
血管内皮生长因子,Flt4-L,VRP,VEGF-C,VEGFC |
Human | HEK293 |
the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Genetic studies reveal that platelet enhancement of lymphatic growth after wounding is dependent on the release of VEGFC, but not VEGFD, a finding consistent with high expression of VEGFC in both platelets and avian thrombocytes. | |||
TMPK-01043 |
VEGFC Protein, Human, Recombinant (His & Avi)
Flt4-L,血管内皮生长因子,VEGFC,VRP,VEGF-C |
Human | HEK293 |
the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Genetic studies reveal that platelet enhancement of lymphatic growth after wounding is dependent on the release of VEGFC, but not VEGFD, a finding consistent with high expression of VEGFC in both platelets and avian thrombocytes. | |||
TMPY-02945 |
Prokineticin 1/EG-VEGF Protein, Human, Recombinant (His)
PK1,EGVEGF,PRK1,prokineticin 1 |
Human | Baculovirus-Insect Cells |
EG-VEGF, also known as prokineticin-1, is a member of the AVIT (prokineticin) family. Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. EG-VEGF can be detected in the steroidogenic glands, ovary, testis, adrenal and placenta. EG-VEGF has little or no effect on a variety of other endothelial and non-endothelial cell types. It induces proliferation, migration and fenestration (the formation of membrane discontinuities) i... | |||
TMPY-02589 |
VEGFD Protein, Mouse, Recombinant (hFc)
c-fos induced growth factor (vascular endothelial growth fac... |
Mouse | HEK293 |
Vascular endothelial growth factor D (VEGF-D), also known as C-fos induced growth factor (FIGF), belongs to the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. FIGF protein is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. FIGF protein is secreted as a non-covelent homodimer in an antiparallel fashion. Human FIGF protein is expressed in adult lung, heart, muscle, and small intestine, and is most abundantly expressed in fetal lungs an... | |||
TMPY-03150 |
VEGFD Protein, Mouse, Recombinant (His)
VEGF-D,Vegfd,AI325264,c-fos induced growth... |
Mouse | HEK293 |
Vascular endothelial growth factor D (VEGF-D), also known as C-fos induced growth factor (FIGF), belongs to the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. FIGF protein is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. FIGF protein is secreted as a non-covelent homodimer in an antiparallel fashion. Human FIGF protein is expressed in adult lung, heart, muscle, and small intestine, and is most abundantly expressed in fetal lungs an... | |||
TMPY-04911 |
VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated
vascular endothelial growth factor A,血管内皮生长因子 |
Human,Cynomolgus | HEK293 |
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular per... | |||
TMPY-06620 |
VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi), Biotinylated
PCL,VEGFR-3,LMPH1A,fms related tyrosine kinase 4,FL... |
Human | HEK293 |
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR... | |||
TMPY-01069 |
VEGFR3/FLT4 Protein, Human, Recombinant (hFc)
FLT41,fms related tyrosine kinase 4,VEGF Receptor 3... |
Human | HEK293 |
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR... | |||
TMPY-03705 |
VEGF164 Protein, Canine, Recombinant
血管内皮生长因子,vascular endothelial growth factor A |
Canine | HEK293 |
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular per... | |||
TMPY-03080 |
VEGF165 Protein, Danio rerio (zebrafish), Recombinant
血管内皮生长因子,vascular endothelial growth factor A |
Danio rerio (zebrafish) | Baculovirus-Insect Cells |
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular per... | |||
TMPY-03156 |
VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, His)
vascular endothelial growth factor C |
Mouse,Rat | HEK293 |
Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGF... | |||
TMPY-01936 |
VEGFR3/FLT4 Protein, Mouse, Recombinant (His)
Flt-4,VEGFR-3,Chy,fms related tyrosine kinase 4, |
Mouse | HEK293 |
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR... | |||
TMPY-02361 |
VEGFR2/KDR Protein, Human, Recombinant (His)
VEGFR2,kinase insert domain receptor,VEGFR... |
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ... | |||
TMPJ-00412 |
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
Vascular endothelial growth factor receptor 1,Vascular perme... |
Human | Human Cells |
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas... | |||
TMPY-03155 |
VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, hFc)
vascular endothelial growth factor C |
Mouse,Rat | HEK293 |
Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGF... | |||
TMPJ-00593 |
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His)
KDR,Fetal liver kinase 1,VEGFR-2,Kinase insert doma... |
Human | Human Cells |
Human Vascular endothelial growth factor receptor 2(KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in a number of fundamental biological processes such as the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. It also plays an essential role in promoting proliferation, survival, migration and differentiation of endothelial cells, reorganization of the actin cytoskeleton. VEGFR2 is identi... | |||
TMPK-00445 |
VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi)
PCL,PCLFLT41,VEGFR3,FLT-4,LMPH1A,FLT-41,VEGF |
Human | HEK293 |
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosis in several solid tumors.VEGF-R1, -R2 and -R3 were highly expressed in CRC cells and stromal vessels. VEGF-R1 strong positive staining correlated with shorter survival after CRC surgery. | |||
TMPK-00446 |
VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated
PCL,FLT-41,LMPH1A,FLT-4,VEGFR3,PCLFLT41,VEGF |
Human | HEK293 |
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosis in several solid tumors.VEGF-R1, -R2 and -R3 were highly expressed in CRC cells and stromal vessels. VEGF-R1 strong positive staining correlated with shorter survival after CRC surgery. | |||
TMPJ-00414 |
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated
Protein-tyrosine kinase receptor flk-1,KDR,Kinase insert dom... |
Human | Human Cells |
Human Vascular endothelial growth factor receptor 2(KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in a number of fundamental biological processes such as the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. It also plays an essential role in promoting proliferation, survival, migration and differentiation of endothelial cells, reorganization of the actin cytoskeleton. VEGFR2 is identi... | |||
TMPY-03200 |
VEGFD Protein, Rat, Recombinant (hFc)
c-fos induced growth factor (vascular endothelial growth fac... |
Rat | HEK293 |
Vascular endothelial growth factor D (VEGF-D), also known as C-fos induced growth factor (FIGF), belongs to the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. FIGF protein is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. FIGF protein is secreted as a non-covelent homodimer in an antiparallel fashion. Human FIGF protein is expressed in adult lung, heart, muscle, and small intestine, and is most abundantly expressed in fetal lungs an... | |||
TMPY-01937 |
VEGFR3/FLT4 Protein, Mouse, Recombinant (hFc)
VEGFR-3,fms related tyrosine kinase 4,VEGF... |
Mouse | HEK293 |
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR... | |||
TMPY-04327 |
VEGFB Protein, Human, Recombinant (hFc)
VRF,血管内皮生长因子,vascular endothelial growth factor B,VEGF |
Human | HEK293 |
Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. In detail, VEGFB can positively prevent the Ang II-induced rising in the size of cardiomyocyte as well as reduce Ang II-induced mRNA and protein levels of β-MHC (β-myosin heavy chain), BNP (brain natriuretic peptide), and ANP (atrial natriuretic peptide). Moreover, VEGFB can regulate the decline of the Ang I... | |||
TMPY-04924 |
VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated
VEGFR-2,6130401C07,Ly73,Krd-1,kinase insert domain ... |
Mouse | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ... | |||
TMPY-04795 |
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His)
kinase insert domain receptor,VEGFR2,FLK1,Flk-1,CD3... |
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ... | |||
TMPY-04794 |
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)
VEGFR,kinase insert domain receptor,Flk-1,VEGF<... |
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ... | |||
TMPY-04796 |
VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, His)
FLK1,kinase insert domain receptor,CD309,VEGFR2,Flk... |
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ... | |||
TMPY-04530 |
VEGFR2/KDR Protein, Human, Recombinant (His & GST)
Flk-1,VEGFR2,kinase insert domain receptor,FLK1,CD3... |
Human | Baculovirus-Insect Cells |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ... | |||
TMPY-02858 |
VEGFR2/KDR Protein, Mouse, Recombinant (hFc)
VEGFR2,6130401C07,Krd-1,kinase insert domain recept... |
Mouse | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ... | |||
TMPY-02736 |
VEGFR2/KDR Protein, Mouse, Recombinant (His)
sVEGFR-2,6130401C07,kinase insert domain receptor,<... |
Mouse | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ... | |||
TMPY-05657 |
VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated
VEGFR2,Flk-1,kinase insert domain receptor,VEGF... |
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ... | |||
TMPY-04802 |
VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc)
kinase insert domain receptor,CD309,VEGFR2,FLK1,Flk... |
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ... | |||
TMPY-05610 |
VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated
Flk-1,VEGFR,kinase insert domain receptor,VEGF<... |
Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ... | |||
TMPY-02678 |
VEGFR2/KDR Protein, Rat, Recombinant (His)
kinase insert domain receptor |
Rat | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ... | |||
------------------------ 更多 ------------------------ |