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56

抑制剂 & 化合物

39

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Cat. No.	Product Name	Target	Signaling Pathways
T13224	Tubulin inhibitor 6 iHAP1	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 6 (iHAP1) 是一种微管蛋白抑制剂，抑制微管蛋白聚合，IC50为 0.87 μM。它抑制多种癌细胞系，抑制 K562 细胞生长，IC50为 840 nM。
T6641	Rilmenidine Phosphate	Apoptosis; Adrenergic Receptor; Autophagy; Imidazoline Receptor	Apoptosis; Autophagy; GPCR/G Protein; Neuroscience
	Rilmenidine phosphate 是一种新型的抗高血压药物和口服活性选择性 I1 咪唑啉受体激动剂。它可调节白血病细胞增殖，刺激促凋亡蛋白 Bax，从而诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。它可通过减少交感神经过度活跃而发挥中枢作用，并通过抑制 Na+/H+反向转运而在肾脏中发挥作用。
T1448	Dasatinib BMS-354825,达沙替尼	Apoptosis; Bcr-Abl; Src; c-Kit; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Dasatinib (BMS-354825) 是一种酪氨酸激酶抑制剂，抑制 Src 和 Bcr-Abl (Ki=16/30 pM)，具有口服活性和 ATP 竞争性。Dasatinib 具有抗肿瘤活性，用于治疗白血病和淋巴瘤等。
T1448L	Dasatinib monohydrate 达沙替尼,BMS-354825 Monohydrate	Apoptosis; Bcr-Abl; Src; c-Kit; Ephrin Receptor; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Dasatinib monohydrate (BMS-354825 Monohydrate) 是一种具有口服活性的，ATP 竞争性的双重Src/Bcr-Abl 抑制剂，有抗肿瘤活性，还诱导凋亡和自噬。它抑制Src 和Bcr-Abl 的IC50分别为 0.5 nM 和 <1.0 nM，Ki 值分别为 16 pM 和 30 pM。
T16545	Pivanex Pivalyloxymethyl butyrate,AN-9	Apoptosis; HDAC; Bcr-Abl	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors
	Pivanex (Pivalyloxymethyl butyrate) 是丁酸的一种衍生物，是具有口服活性的 HDAC 抑制剂。Pivanex 通过下调 bcr-abl 蛋白增强凋亡。Pivanex 显示出抗转移和抗血管生成的活性。
T5858	Sertindole Lu 23-174,舍吲哚	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Sertindole (Lu 23-174) 是一种非典型抗精神病药，可与多巴胺 D2 受体和血清素受体亚型 5-HT1D、5-HT2A 和 5-HT2C 结合，Kd 值分别为 2.7、20、0.14 和 6 nM。
T2394	Pixantrone dimaleate 匹克生琼来酸盐,BBR-2778,Pixantrone Maleate,BBR 2778 dimaleate,马来酸匹衫琼	Topoisomerase	DNA Damage/DNA Repair
	Pixantrone dimaleate (Pixantrone Maleate) 是一种拓扑异构酶 II 的抑制剂和 DNA 嵌入剂，是一种实验性抗肿瘤药物。
T24838	Stafib-1 Stafib 1,Stafib1	STAT	JAK/STAT signaling; Stem Cells
	Stafib-1 是一种特异性的 STAT5β 抑制剂，靶向 SH2 结构域，IC50 为 154 nM，Ki 为 44 nM。
T6018	Zosuquidar trihydrochloride 唑喹达三盐酸盐,Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride	P-gp	Membrane transporter/Ion channel; Neuroscience
	Zosuquidar trihydrochloride (LY-335979 trihydrochloride) 是一种P-糖蛋白抑制剂，Ki 值为 59 nM。
T13226	Tubulin inhibitor 8	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 8是管蛋白和多种癌症细胞系的抑制剂，对管蛋白聚合和K562细胞生长具有抑制作用，IC50分别为0.73μM 和14nM。
T2539	Fingolimod hydrochloride Fingolimod (FTY720) HCl,FTY720,盐酸芬戈莫德	TRP/TRPV Channel; S1P Receptor; PAK; LPL Receptor	Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel
	Fingolimod hydrochloride (FTY720) 是一种新型免疫调节剂，是一种 1-磷酸鞘氨醇(S1P) 拮抗剂，作用于 K562 和 NK 细胞，IC50为 0.033 nM。它诱导 S1P1 的内化，从而抑制 S1P 活性。它被鞘氨醇激酶磷酸化，尤其是被 SK2 磷酸化，从而可与 S1PR1、3、4 和 5 结合
T12341	P-gp inhibitor 1	Others; P-gp	Membrane transporter/Ion channel; Neuroscience; Others
	P-gp inhibitor 1 抑制逆转 P-糖蛋白介导的多药耐药性，EC50 为 57.9 nM（K562/A02 细胞）。
T16940	STAT5-IN-2	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	STAT5-IN-2 是一种具有抗白血病作用的 STAT5 抑制剂（EC50：在 K562 和 KU812 细胞中分别为 9 μM 和 5 μM）。
T1937	Spautin-1 Spautin 1	Apoptosis; DUB; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	Spautin-1是一种特异性自噬抑制剂，可抑制泛素特异性肽酶 USP10和 USP13，IC50s 约为0.6到0.7 μM。
T4595	YHO-13177 YHO 13177,YHO13177	BCRP	Membrane transporter/Ion channel
	YHO-13177 是高活性乳腺癌耐药蛋白多药转运通道（BCRP）抑制剂，可增强SN-38活性。
T74186	PROTAC-O4I2	Apoptosis; PROTACs	Apoptosis; PROTAC
	PROTAC-O4I2 是一种靶向剪接因子 3B1 (SF3B1) 的 PROTAC连接体，在 K562 细胞中促使 FLAG-SF3B1 降解，IC50 值为 0.244 μM。PROTAC-O4I2 促使 K562 WT 细胞凋亡 (apoptosis)。
T12926	SJB3-019A	Others; DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others; Ubiquitination
	SJB3-019A 是一种有效的、有效的和新型的泛素特异性蛋白酶1（USP1）抑制剂，在 K562细胞中促进 ID1降解和细胞毒性的作用是 SJB2-043的5倍，IC50为0.0781 μM。SJB3-019A 抑制细胞增殖，使细胞凋亡。
T28475	Pyrazoloacridine PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	Pyrazoloacridine (PD 115934) 是一种核酸结合剂，在 K562 细胞中抑制 topo I 和 II 的活性，IC50 为 1.25 μM。 Pyrazoloacridine 具有抗癌活性。
T21911	Rilmenidine hemifumarate Rilmenidine (hemifumarate),S-3341 hemifumarate	Apoptosis; Imidazoline Receptor	Apoptosis; Neuroscience
	Rilmenidine hemifumarate (S-3341 hemifumarate) 是一种新型且具有口服活性和选择性的 I1咪唑啉受体 (I1 imidazoline receptor) 和α2肾上腺素受体激动剂，可诱导自噬，调节白血病细胞增殖，刺激促凋亡蛋白 Bax，诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。
T62745	AMPK-IN-3	VEGFR; AMPK	Angiogenesis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	AMPK-IN-3 是一种新型且选择性和强效性的 AMPK 抑制剂，其对AMPK (α2)、AMPK (α1) 和 KDR 具有抑制作用， IC50 值分别为 60.7、107 和 3820 nM。AMPK-IN-3 在 K562 细胞中显示出抗癌活性。
T77728	Tubulin polymerization-IN-55	Microtubule Associated	Cytoskeletal Signaling
	Tubulin polymerization-IN-55 是一种高效的 Tubulin Polymerization 抑制剂，具有潜在的抗血管生成和抗肿瘤活性，对 A549、K562、HepG2、MDA-MB-231 和 HFL-1 显示出抗增殖作用。
T6691	TAI-1	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	TAI1 是一种具有口服活性的特异性 Hec1 抑制剂，有抗肿瘤活性，在 K562 细胞中的 GI50值为 13.48 nM。
T24912	Tyrphostin AG 568 Tyrphostin AG-568,Tyrphostin AG568
	Tyrphostin AG 568 promotes Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity. It also induces K562 to differentiate.
T24911	Tyrphostin AG 1112 Tyrphostin AG-1112,Tyrphostin AG1112
	Tyrphostin AG 1112 is a Bcr-Abl kinase blocker. It can activate the terminal differentiation of K562 cells and the purging of Ph+ cells.
T77974	PROTAC BCR-ABL Degrader-1	PROTACs	PROTAC
	PROTACBCR-ABLDegrader-1（化合物PROTAC1）是一种含有2-oxoethyl linker的PROTAC。该化合物能通过泛素蛋白酶体（ubiquitinproteasom）系统诱导Bcr-Abl的降解，并对K562细胞表现出抗增殖效果，显示出其在癌症研究中的应用潜力。
T63932	BCR-ABL-IN-4
	BCR-ABL-IN-4 是 BCR-ABLL 抑制剂，表现出抗癌活性。BCR-ABL-IN-4 对癌细胞生长具有抑制作用，能够作用于 K562 细胞 (IC50: 0.67 nM) 和 BCR-ABL T315I 转染的 Ba/F3 细胞 (IC50: 16 nM)。
T23617	Aclacinomycin Aclacinomycins,Siwenmycin
	Aclacinomycin A is an anthracycline drug. It sensitizes K562 chronic myeloid leukemia cells to imatinib through p38MAPK-mediated erythroid differentiation. It is used in the treatment of cancer.
T78815	MOZ-IN-3	Histone Acetyltransferase	Chromatin/Epigenetic
	MOZ-IN-3 (Compound 6j) 是KAT6A (MOZ) 乙酰转移酶的抑制剂，IC50值为30 nM。该化合物在四种髓系白血病细胞系（HL-60、U937、SKNO-1、K562）上展现了抗肿瘤活性，并且显示出良好的代谢稳定性及药代动力学特性。
T82715	Cisplatin-resistant cells-IN-1
	Cisplatin-resistant cells-IN-1（化合物8）对顽固的铂类药物抗性细胞具有较高的细胞毒性。在低纳摩尔浓度范围内（IC50：0.14–1.79 μM in A549/A549-R, K562/K562-R, and MCF-7/MCF-7TamR cells），该化合物能有效降低代谢活性。
T37804	8MDP
	Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor (IC50 = 0.43 nM). Inhibits hENT1 and hENT2 uptake of [H3]uridine in K562 cells and K15NTD cells respectively. Lin et al (2011) Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrativ Bioconjug.Chem. 22 1221 PMID:21539390 \|Lin et al (2007) Synthesis, flow cytometric evaluat...
T82774	Caspase-3 activator 3	Caspase	Apoptosis; Proteases/Proteasome
	Caspase-3 activator 3 (compound 2h) 通过激活caspase 3诱导HL-60和K562细胞apoptosis，表现出抗白血病活性。其对HL-60细胞的IC50值为42.89 μM，对K562细胞的IC50值为33.61 μM。
T63159	Anticancer agent 28
	Anticancer agent 28 在体内 H22 同种异体移植小鼠中具有良好的抗肿瘤作用。Anticancer agent 28 对 K562 细胞的作用是 Oridonin 的50倍，其 IC50 值为 0.09 μM。
T62217	Tubulin polymerization-IN-9
	Tubulin polymerization-IN-9 是一种微管蛋白 (tubulin) 的有效抑制剂 (IC50: 1.82 μM)。Tubulin polymerization-IN-9 能够将 K562 细胞的细胞周期停滞在 G2/M 期，并诱导其凋亡 (apoptosis) 及线粒体去极化。Tubulin polymerization-IN-9 表现出强大的抗血管和抗肿瘤作用。
T63665	EIF2α activator 1
	EIF2α activator 1（Compound 40）为真核生物起始因子2α（eIF2α）磷酸化的激活剂，能够提高EIF2α下游蛋白ATF和CHOP的表达水平。该化合物对K562细胞和PBMC细胞展现出抗增殖活性，其IC50值分别为4.00 μM和19.3 μM。
T37544	Anhydroophiobolin A
	Anhydroophiobolin A is an ophiobolin fungal metabolite that has been found in C. heterostrophus fermentation broths. It is cytotoxic to HepG2 and K562 cancer cells (IC50s = 55.7 and 39.5 μM, respectively).
T13225	Tubulin inhibitor 7	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines (tubulin polymerization (IC50: 0.52 μM), K562 cell growth (IC50: 11 nM)).
T73451	BAY-364 BAY-299N
	BAY-364 (BAY-299N) 为TAF1第二溴结构域抑制剂。对于Kasumi-1细胞、CD34+细胞及K562细胞中的TAF1显示出抑制作用，其IC50值分别为1.0 µM、10.4 µM与10.0 µM。
T28092	MPT0B206
	MPT0B206 is a novel tubulin polymerization inhibitor. MPT0B206 induced G2/M cell cycle arrest and the appearance of the mitotic marker MPM-2 in K562 and K562R cells, which is associated with the upregulation of cyclin B1 and the dephosphorylation of Cdc2.
T38044	Reveromycin B
	Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50 = 6 μg/ml) and exhibits pH-dependent antifungal activity against C. albicans (MICs = 15.6 and >500 μg/ml at pH 3.0 and 7.4, respectively). Unlike reveromycin A and reveromycin C , reveromycin B does not inhibit proliferation of KB and K562 cells.
T62637	EIF2α activator 2
	EIF2α activator 2（Compound 1）是一种真核生物起始因子2α（eIF2α）磷酸化的激活剂。EIF2α 激活剂 2 在 SRB 细胞增殖试验中表现出高效力 (IC50: 0.46 μM)。EIF2α activator 2 对 K562 (IC50: 4.79 μM)和 PBMC (IC50: 10.52 μM) 细胞表现出抗增殖活性。
T82775	Caspase-3 activator 2	Caspase	Apoptosis; Proteases/Proteasome
	Caspase-3 activator 2 (Compound 2f) 是诱导细胞凋亡的caspase 3激活剂，适用于癌症研究。该化合物对 HL-60 细胞和 K562 细胞展示出细胞毒性，IC50 值分别为 33.52 μM 和 76.90 μM。
T33510	MS-073 CP162398,CP-162398,CP 162398,MS 073
	MS-073 (CP-162398) is a P-glycoprotein inhibitor (P-gp). The in vitro resistance to vincristine (VCR) was almost completely reversed in VCR-resistant P388 cells, and the resistance of VCR, adriamycin (ADM), etoposide, and actinomycin D in ADM-resistant hu
T1817	GNF-2 GNF2	SARS-CoV; Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	GNF-2 是一种高选择性的非 ATP 竞争性 Bcr-Abl 抑制剂。它抑制 Ba/F3.p210 增殖，IC50为 138 nM。
T78843	MET/PDGFRA-IN-1	c-Met/HGFR	Tyrosine Kinase/Adaptors
	MET/PDGFRA-IN-1 (compound 8c) 作为MET和PDGFRA蛋白的抑制剂，以36 μM对MET的IC50值显示活性。该化合物能够抑制MET磷酸化并触发细胞凋亡(apoptosis)。此外，MET/PDGFRA-IN-1有效抑止了多种MET阳性细胞系的增殖，包括AsPc-1、EBC-1、MKN-45、Mia-Paca-2、HT-29和K562，其IC50s分别为15.3、19.0、22.0、25.6、21.0、31.5 μM。
T79683	HDAC/CD13-IN-1	Others	Others
	HDAC/CD13-IN-1 (Compound 12) 作为HDAC/CD13抑制剂, 对hCD13的IC50为0.34 μM, 猪CD13为0.53 μM, 对HDAC1/2/3的IC50分别为0.03、0.06、0.02 μM。此化合物有效抑制MV4-11、K562、Jeko-1 和 HL60细胞增殖, IC50范围为0.25-2.04 μM，并诱导癌细胞凋亡。同时表现出抗转移和抗侵袭的特性。
T37423	Reveromycin D
	Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs = 2 and >500 μg/ml at pH 3 and 7.4, respectively). Reveromycin D also inhibits proliferation of KB and K562 cells (IC50s = 1.6 and 1.3 μg/ml, respectively).
T79322	Antiproliferative agent-30
	Antiproliferative agent-30 (Compound 8g) 抑制微管蛋白组装且可抑制FLT3及Abl1。该化合物展现出对血管的破坏活性，并对多种癌细胞系表现出强效的抗增殖能力，包括HCT-116、K562及MV-4-11细胞（IC50值分别为0.054 nM、0.008 nM、0.144 nM）。此外，Antiproliferative agent-30 亦对携带FLT3-ITD-TKD突变的AML显示出抗癌效果。
T79754	JNK-IN-14	JNK	MAPK
	JNK-IN-14是一种激酶（JNK1/2/3）抑制剂，IC50值为1.81、12.7和10.5 nM。它能诱导早期apoptosis，并在G2/M阶段引起细胞周期阻滞。与SP600125相比，在K562白血病细胞中，JNK-IN-14更强有效地抑制了Beclin-1的表达。
T78844	MET/PDGFRA-IN-2	c-Met/HGFR	Tyrosine Kinase/Adaptors
	MET/PDGFRA-IN-2（化合物8h）是一种针对MET和PDGFRA蛋白的抑制剂，具有诱导细胞凋亡（apoptosis）的功能。该化合物能有效抑制多种MET表达细胞系的增殖，包括AsPc-1、EBC-1、MKN-45、Mia-Paca-2、HT-29和K562细胞，其IC50分别为9.7、6.1、12.0、11.5、8.6和34.4μM。
T78608	Anticancer agent 164	Apoptosis	Apoptosis
	CML-IN-1（compound 7）是一种高效抗癌药物，针对人类慢性粒细胞白血病（CML）细胞系K562，能有效诱导凋亡（apoptosis）。该化合物主要通过显著抑制PI3K/Akt信号通路的蛋白磷酸化来发挥作用，同时CML-IN-1（compound 4）也能通过抑制结直肠癌的MEK/ERK信号通路来阻止细胞增殖。

化合物

Tubulin inhibitor 6

Cat.No: T13224

Synonym: iHAP1

Target: Microtubule Associated

Rilmenidine Phosphate

Cat.No: T6641

Target: Apoptosis, Adrenergic Receptor, Autophagy, Imidazoline Receptor

Cat.No: T1448

Synonym: BMS-354825,达沙替尼

Target: Apoptosis, Bcr-Abl, Src, c-Kit, Autophagy

Dasatinib monohydrate

Cat.No: T1448L

Synonym: 达沙替尼,BMS-354825 Monohydrate

Target: Apoptosis, Bcr-Abl, Src, c-Kit, Ephrin Receptor, Autophagy

Cat.No: T16545

Synonym: Pivalyloxymethyl butyrate,AN-9

Target: Apoptosis, HDAC, Bcr-Abl

Cat.No: T5858

Synonym: Lu 23-174,舍吲哚

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Autophagy

Pixantrone dimaleate

Cat.No: T2394

Synonym: 匹克生琼来酸盐,BBR-2778,Pixantrone Maleate,BBR 2778 dimaleate,马来酸匹衫琼

Target: Topoisomerase

Cat.No: T24838

Synonym: Stafib 1,Stafib1

Target: STAT

Zosuquidar trihydrochloride

Cat.No: T6018

Synonym: 唑喹达三盐酸盐,Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride

Target: P-gp

Tubulin inhibitor 8

Cat.No: T13226

Target: Microtubule Associated

Fingolimod hydrochloride

Cat.No: T2539

Synonym: Fingolimod (FTY720) HCl,FTY720,盐酸芬戈莫德

Target: TRP/TRPV Channel, S1P Receptor, PAK, LPL Receptor

P-gp inhibitor 1

Cat.No: T12341

Target: Others, P-gp

Cat.No: T16940

Target: Apoptosis, STAT

Cat.No: T1937

Synonym: Spautin 1

Target: Apoptosis, DUB, Autophagy

Cat.No: T4595

Synonym: YHO 13177,YHO13177

Target: BCRP

Cat.No: T74186

Target: Apoptosis, PROTACs

Cat.No: T12926

Target: Others, DUB

Pyrazoloacridine

Cat.No: T28475

Synonym: PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934

Target: Apoptosis, Topoisomerase

Rilmenidine hemifumarate

Cat.No: T21911

Synonym: Rilmenidine (hemifumarate),S-3341 hemifumarate

Target: Apoptosis, Imidazoline Receptor

Cat.No: T62745

Target: VEGFR, AMPK

Tubulin polymerization-IN-55

Cat.No: T77728

Target: Microtubule Associated

Cat.No: T6691

Target: Apoptosis, Microtubule Associated

Tyrphostin AG 568

Cat.No: T24912

Synonym: Tyrphostin AG-568,Tyrphostin AG568

Tyrphostin AG 1112

Cat.No: T24911

Synonym: Tyrphostin AG-1112,Tyrphostin AG1112

PROTAC BCR-ABL Degrader-1

Cat.No: T77974

Target: PROTACs

Cat.No: T63932

Cat.No: T23617

Synonym: Aclacinomycins,Siwenmycin

Cat.No: T78815

Target: Histone Acetyltransferase

Cisplatin-resistant cells-IN-1

Cat.No: T82715

Cat.No: T37804

Caspase-3 activator 3

Cat.No: T82774

Target: Caspase

Anticancer agent 28

Cat.No: T63159

Tubulin polymerization-IN-9

Cat.No: T62217

EIF2α activator 1

Cat.No: T63665

Anhydroophiobolin A

Cat.No: T37544

Tubulin inhibitor 7

Cat.No: T13225

Target: Microtubule Associated

Cat.No: T73451

Synonym: BAY-299N

Cat.No: T28092

Cat.No: T38044

EIF2α activator 2

Cat.No: T62637

Caspase-3 activator 2

Cat.No: T82775

Target: Caspase

Cat.No: T33510

Synonym: CP162398,CP-162398,CP 162398,MS 073

Cat.No: T1817

Synonym: GNF2

Target: SARS-CoV, Bcr-Abl

MET/PDGFRA-IN-1

Cat.No: T78843

Target: c-Met/HGFR

Cat.No: T79683

Target: Others

Cat.No: T37423

Antiproliferative agent-30

Cat.No: T79322

Cat.No: T79754

Target: JNK

MET/PDGFRA-IN-2

Cat.No: T78844

Target: c-Met/HGFR

Anticancer agent 164

Cat.No: T78608

Target: Apoptosis

Cat. No.	Product Name	Target	Signaling Pathways
T0974	Novobiocin Sodium Albamycinsodium,新生霉素钠,Cathomycin,Albamycin	Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy	Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology
	Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。
T3138	Astaxanthin β-Carotene-4,4'-dione,Ovoester,AstaXin,AstaREAL,trans-Astaxanthin,虾青素	Reactive Oxygen Species; PPAR	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB
	Astaxanthin (trans-Astaxanthin) 是可从雨生红球藻等多种海洋生物中提取得到的红色类胡萝卜素，是过氧化物酶体增殖物活化受体γ 的调节剂，具有抗增殖、神经保护作用和抗炎活性。它是一种抗氧化剂，有用于癌症和心血管疾病的研究潜力，作为颜色添加剂用于动物食品中。
T1511	Daunorubicin hydrochloride Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin	Apoptosis; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Daunorubicin hydrochloride (Rubidomycin hydrochloride) 是一种蒽环类氨基糖苷类抗肿瘤药物，可抑制 DNA 复制和修复以及 RNA 和蛋白质合成。
T7939	Fingolimod 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇,FTY-720A,FTY-720,芬戈莫德	S1P Receptor; PAK; LPL Receptor	Cytoskeletal Signaling; GPCR/G Protein
	Fingolimod (FTY-720A) 是一种 1-磷酸鞘氨醇 (S1P) 拮抗剂，作用于 K562 和 NK 细胞，IC50为 0.033 nM。它还是pak1激活剂和免疫抑制剂。
T6S1843	Tenacissoside I 通关藤苷I,Tenacissimoside B	Others	Others
	Tenacissoside I (Tenacissimoside B) 是一种 C21 甾体，来自于Marsdenia tenacissima 中，在M. tenacissima 含量较高。
TN2755	2-Desoxy-4-epi-pulchellin	Anti-infection	Microbiology/Virology
	2-Desoxy-4-epi-pulchellin 是分离自 Polygonum hydropiper 的二氯甲烷可溶部分的一种化合物。
T4S1943	Kirenol 奇壬醇,奇任醇,Kirel	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的，具有抗氧化、抗炎、抗过敏、抗关节炎活性，可用于缓解疼痛的研究。
TN2211	Silybin B Silibinin B	Apoptosis; Beta Amyloid; Bcr-Abl	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Neuroscience; Tyrosine Kinase/Adaptors
	Silybin B (Silibinin B) 是雷洛昔芬4′-和6-葡萄糖醛酸化的有效抑制剂，是水飞蓟素有效的抗纤维原性和抗低聚物成分，具有清除1,1-二苯基-2-吡啶酰肼(DPPH)自由基的活性，可通过减轻 DNA 损伤和细胞凋亡对顺铂诱导的神经毒性具有保护作用。Silybin B 对人慢性髓系白血病 K562细胞的生长抑制和诱导凋亡有较强的作用。
T4085	Paris saponin VII 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis; BCL; Others; PARP; p38 MAPK; Akt; Caspase; P-gp; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Membrane transporter/Ion channel; Neuroscience; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Paris saponin VII (Dioscini) 是从延龄草的根和根茎中分离的一种甾体皂苷。它减弱线粒体膜电位，增加凋亡相关蛋白的表达，并降低Bcl-2、caspase-9、caspase-3、PARP-1和p-Akt 的蛋白表达水平。它在 K562/ADR 细胞中诱导强烈的自噬，可研究白血病。
T3398	Icaritin Anhydroicaritin,去水淫羊藿黄素,Cycloicaritin	Apoptosis; JAK; STAT; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Icaritin (Anhydroicaritin) 是Epimedium Genusis 的异戊二烯类黄酮衍生物，有效抑制 K562 细胞和原代 CML 细胞的增殖。它可以调节MAPK/ERK/JNK 和JAK2/STAT3/AKT 信号传导，并具有增强成骨的作用。
T6S1315	Oroxylin A 千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether	Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy	Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮，具有较强的抗癌作用。
T2S2215	Crebanine	Apoptosis; Others; Akt	Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
	Crebanine 是来自于韦诺萨千金藤的一种生物碱，通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性，还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。
TN4284	Isodonal	Others	Others
	Isodonal shows abilities to inhibit K562 cells camparable to that of cisplatin.
TN6054	Norglaucine hydrochloride
	(+)-Norglaucine shows cytotoxic activity toward the tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia) and HL-60 (human promyelocytic leukemia) and non-tumor peripheral blood mononuc
T80995	Theasaponin E2
	Theasaponin E2, 一种从茶树分离得到的化合物，对K562和HL60细胞表现出显著的细胞毒性，其半抑制浓度(IC50)为14.7 μg/mL。
TN5358	Eupahualin C
	Eupahualin C shows significant activities against cell lines of human chronic myelogenous leukemia (K562) and human bone cancer (U2OS).
T81318	R-30-Hydroxygambogic acid
	R-30-Hydroxygambogic acid是从藤黄提取的一种聚戊烯酰黄酮外聚体，对K562/R和K562/S两种人白血病细胞系的IC50分别为2.89 μM和1.27 μM。该化合物适用于癌症研究领域。
TN4011	Erythrodiol 3-palmitate	Others	Others
	Erythrodiol 3-palmitate has antitumor activity, it inhibited the proliferation of K562 cells with the inhibition rate of 47% at 100 ug/mL.
TN3528	Bonducellpin D	Antifection	Microbiology/Virology
	Bonducellpin D may show inhibitory activities on the Para3 virus. It also exhibits moderate activity against four tested human cancer cell lines, HepG-2, K562, HeLa, and Du145.
T81232	S-30-Hydroxygambogic acid
	S-30-Hydroxygambogic acid，一聚戊烯酰黄酮外聚体，源自藤黄。针对人白血病细胞系K562/R及K562/S，其IC50值别为4.49 μM与3.61 μM。S-30-Hydroxygambogic acid主用于癌症研究领域。
TN5274	Yunnancoronarin A	Others	Others
	Yunnancoronarin A shows cytotoxicity against the lung adenocarcinoma cells A549 and leukemia cells K562, with the IC(50) value of 2.20 microM.
T37543	Anhydroepiophiobolin A
	Anhydroepiophiobolin A is a sesterterpenoid fungal metabolite that has been found in B. oryzae. It is cytotoxic to HepG2 and K562 cells (IC50s = 47.1 and 35.6 μM, respectively) as well as A549, SKOV3, SK-MEL-2, XF498, and HCT15 cells (IC50s = 1.6-1.9 μg/ml). Anhydroepiophiobolin A is phytotoxic to S. viridis and D. erucoides in a leaf puncture assay.
T80996	Theasaponin E1
	Theasaponin E1，一种可从茶籽分离的茶皂苷，对人肿瘤细胞系K562和HL60展示了抗肿瘤潜能。此外，Theasaponin E1具备醌还原酶(QR)诱导活性，有助于作为抗癌预防药物的研究。
TN5934	2-Hydroxydiplopterol 2,22-Hopanediol
	2-Hydroxydiplopterol exhibits cytotoxicity against K562 cells with an IC50 value of 22 microM.
TN2128	Quercetin 3-O-robinobioside	Others	Others
	Quercetin-3-O-robinobioside is a quercetin-derived flavonol, exhibits antioxidant activities. It exhibits in-vitro inhibitory activities against leukemia K562 cells.
TN4215	Hispidanin B	Others	Others
	Hispidanin B shows significant cytotoxicities against tumor cell lines SGC7901, SMMC7721, and K562, with IC50 values of 10.7, 9.8, and 13.7 uM, respectively.
TN3760	Danshenol A	Reductase	Endocrinology/Hormones; Metabolism
	Danshenol A has strong aldose reductase (AR) inhibitory activity, has IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. Danshenol A also has antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines, shows inhibited growth of K562 (IC50 = 0.53 μg/mL), T-24 (IC50 = 7.94 μg/mL), QGY (IC50 = 4.65 μg/mL) and Me180 (IC50 = 6.89 μg/mL) cell lines.
TN4976	Scutebata E	Others	Others
	Scutebata E shows weak cytotoxicity with IC50 values ranging from 35.11 to 42.73 μM against K562 cell lines.
TN2192	Scutebarbatine B	Others	Others
	Scutebarbatine B shows weak cytotoxicity with IC50 values ranging from 35.11 to 42.73 μM against K562 cell lines and HL60 cell lines.
T75677	Protoneogracillin
	Protoneogracillin 是一种呋甾醇糖苷，具有抑制植物病原真菌 P.oryzae 的活性 (MMDC=94.0 μM)，对 K562 癌细胞的细胞毒活性 (IC50=6.6 μM)。
TN3417	Angophorol	Apoptosis	Apoptosis
	Angophorol 是一种来自蹄盖蕨科植物禾秆蹄盖蕨的黄酮化合物。Angophorol 通过 K562 细胞的生长抑制和凋亡 (apoptosis) 发挥潜在的抗癌活性。
TN1144	Enmein	Antifection; Immunology/Inflammation related	Immunology/Inflammation; Microbiology/Virology
	Enmein 是分离自 I. serra 中，拥有免疫抑制活性。
TN4404	Ladanein	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Ladanein is a phytochemicals inhibitor that is known to disrupt the interactions of core and other hepatitis C virus (HCV) proteins.Ladanein possesses free radicals DPPH and ABTS +.scavenging activity, it also displays moderate (20-40 microM) activities against K562, K562R (imatinib-resistant), and 697 human leukemia cell lines.
T0194	Chloroquine phosphate Chloroquine diphosphate,Aralen phosphate,磷酸氯喹,Chingamin phosphate	SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Chloroquine phosphate (Aralen phosphate) 是广泛用于疟疾和类风湿性关节炎的抗疟疾和抗炎剂。它是autophagy 和toll-like receptors 抑制剂，有效抑制SARS-CoV-2(COVID-19) 感染 (EC50=1.13 μM)。
T37451	Stachybotrysin B
	Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).2 \|1. Zhao, J., Feng, J., Tan, Z., et al. Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. J. Nat. Prod. 80(6), 1819-1826 (2017).\|2. Ma, X.-h., Zhen...
T38243	Hygrolidin
	Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovan...
T37008	Reveromycin A
	Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 μg/ml), displays antiproliferative activity against human KB and K562 tumor cell lines (IC50s = 1.9 and 1.6 μg/ml, respectively), and demonstrates antifungal activity against C. albicans (MIC = 2 μg/ml at pH 3). Reveromycin A also has been shown to inhibit bone resorption by inducing apoptosis in oste...
T1507	Streptozocin STZ,Streptozotocin,链脲佐菌素,NSC-85998,链脲菌素,U 9889	DNA Alkylator/Crosslinker; DNA Alkylation; DNA/RNA Synthesis; Antibacterial; Antibiotic; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Streptozocin (NSC-85998) 是一种抗生素，可诱导 DNA 甲基化。Streptozocin 对产生胰岛素的胰岛 B 细胞具有毒性，常用于构建 1 型糖尿病的动物模型。该产品在溶液中不稳定，建议现配现用。
TN2646	16-Hydroxycleroda-3,13-dien-15,16-olide	Autophagy	Autophagy
	16-Hydroxycleroda-3,13-dien-15,16-olide, and prodigiosin are presented as candidates for autophagy inducers that can trigger cell death in a supplement or alternative medicine for cancer therapy. 16-Hydroxycleroda-3,13-dien-15,16-olide regulates the expre

天然产物

Novobiocin Sodium

Cat.No: T0974

Synonym: Albamycinsodium,新生霉素钠,Cathomycin,Albamycin

Target: Potassium Channel, DNA gyrase, Topoisomerase, Antibacterial, Antibiotic, ABC, Autophagy

Cat.No: T3138

Synonym: β-Carotene-4,4'-dione,Ovoester,AstaXin,AstaREAL,trans-Astaxanthin,虾青素

Target: Reactive Oxygen Species, PPAR

Daunorubicin hydrochloride

Cat.No: T1511

Synonym: Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic, Autophagy

Cat.No: T7939

Synonym: 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇,FTY-720A,FTY-720,芬戈莫德

Target: S1P Receptor, PAK, LPL Receptor

Tenacissoside I

Cat.No: T6S1843

Synonym: 通关藤苷I,Tenacissimoside B

Target: Others

2-Desoxy-4-epi-pulchellin

Cat.No: TN2755

Target: Anti-infection

Cat.No: T4S1943

Synonym: 奇壬醇,奇任醇,Kirel

Target: Wnt/beta-catenin

Cat.No: TN2211

Synonym: Silibinin B

Target: Apoptosis, Beta Amyloid, Bcr-Abl

Paris saponin VII

Cat.No: T4085

Synonym: 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

Cat.No: T3398

Synonym: Anhydroicaritin,去水淫羊藿黄素,Cycloicaritin

Target: Apoptosis, JAK, STAT, Autophagy

Cat.No: T6S1315

Synonym: 千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether

Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy

Cat.No: T2S2215

Target: Apoptosis, Others, Akt

Cat.No: TN4284

Target: Others

Norglaucine hydrochloride

Cat.No: TN6054

Cat.No: T80995

Cat.No: TN5358

R-30-Hydroxygambogic acid

Cat.No: T81318

Erythrodiol 3-palmitate

Cat.No: TN4011

Target: Others

Cat.No: TN3528

Target: Antifection

S-30-Hydroxygambogic acid

Cat.No: T81232

Yunnancoronarin A

Cat.No: TN5274

Target: Others

Anhydroepiophiobolin A

Cat.No: T37543

Cat.No: T80996

2-Hydroxydiplopterol

Cat.No: TN5934

Synonym: 2,22-Hopanediol

Quercetin 3-O-robinobioside

Cat.No: TN2128

Target: Others

Cat.No: TN4215

Target: Others

Cat.No: TN3760

Target: Reductase

Cat.No: TN4976

Target: Others

Scutebarbatine B

Cat.No: TN2192

Target: Others

Protoneogracillin

Cat.No: T75677

Cat.No: TN3417

Target: Apoptosis

Cat.No: TN1144

Target: Antifection, Immunology/Inflammation related

Cat.No: TN4404

Target: HCV Protease

Chloroquine phosphate

Cat.No: T0194

Synonym: Chloroquine diphosphate,Aralen phosphate,磷酸氯喹,Chingamin phosphate

Target: SARS-CoV, TLR, HIV Protease, Antibiotic, Parasite, Autophagy

Stachybotrysin B

Cat.No: T37451

Cat.No: T38243

Cat.No: T37008

Cat.No: T1507

Synonym: STZ,Streptozotocin,链脲佐菌素,NSC-85998,链脲菌素,U 9889

Target: DNA Alkylator/Crosslinker, DNA Alkylation, DNA/RNA Synthesis, Antibacterial, Antibiotic, Autophagy

16-Hydroxycleroda-3,13-dien-15,16-olide

Cat.No: TN2646

Target: Autophagy

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