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Search Results for " antiplatelet "

48

抑制剂 & 化合物

36

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12316	Oral antiplatelet agent 1	Others	Others
	Oral antiplatelet agent 1 is a potent antiplatelet agent with an IC50 of 2.94 μM in vitro.
T63334	Antiplatelet agent 1
	Antiplatelet agent 1 是一种替卡格雷 (Ticagrelor) 类似物，表现出抗血小板作用，能够用于血小板凝集的研究。
T63335	Antiplatelet agent 2
	Antiplatelet agent 2 是一种替卡格雷 (Ticagrelor) 类似物，表现出抗血小板作用，能够用于血小板凝集的研究。
T9153	Picotamide	Others	Others
	Picotamide 具有抗凝和纤维蛋白溶解特性。
T3536	AZD1283	P2Y Receptor	GPCR/G Protein; Neuroscience
	AZD1283是P2Y12受体拮抗剂，EC50为3.0 ug/kg/min，结合的IC50为11 nM。它剂量依赖性地诱导血流量增加和抑制 ADP 诱导的血小板聚集，抗血栓形成的 ED50 值分别为 3.0 和 10 μg/kg/min。
T5036	cangrelor tetrasodium	GPR; P2Y Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Cangrelor tetrasodium 是三磷酸腺苷类似物，是可逆的选择性血小板P2Y12拮抗剂，也是非特异性的GPR17拮抗剂。它直接阻断腺苷二磷酸诱导的血小板活化和聚集，具有迅速有效的抗血小板作用。
T11339	Furegrelate sodium U-63557A	PPAR	DNA Damage/DNA Repair; Metabolism
	Furegrelate sodium (U-63557A) 是口服有效的、血栓素合酶选择性抑制剂，抑制人血小板微粒体血栓素 A2 (TxA2) 合酶的 IC50为 15 nM。它正在开发作为抗血小板药物。
T21712	BAY 41-8543	Others; Guanylate cyclase	GPCR/G Protein; Others
	BAY 41-8543 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶 (sGC) 刺激剂，具有抗血小板作用。它在大鼠的肺和全身血管床中具有血管舒张活性，有用于心血管疾病的研究潜力。
T6236	Ozagrel 奥扎格雷,OKY-046,Domenan	Thrombin; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Ozagrel (Domenan) 是血栓烷 A2(TXA2) 合酶抑制剂，可抑制哮喘。它也是一种抗血小板剂，可选择性抑制人血小板聚集，IC50为 53.12 μM。
T1618	Dipyridamole Persantin,Dypyridamole,Dipyridamol,双嘧达莫,NSC-515776,Dipyudamine	PDE	Metabolism
	Dipyridamole (Persantin) 是一种磷酸二酯酶抑制剂，能阻断红细胞和血管内皮细胞对腺苷的吸收和代谢。
T6625	Ozagrel hydrochloride Ozagrel HCl,盐酸奥扎格雷,OKY-046 HCl	Thrombin; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Ozagrel hydrochloride (OKY-046 HCl) 是一种选择性血栓素 A(2) 合成酶抑制剂，用于改善术后脑血管收缩和伴随的脑缺血。它是一种抗血小板剂，可选择性抑制人血小板聚集，IC50为 53.12 μM。
T0230	Prasugrel LY640315,CS-747,普拉格雷,PCR 4099	P2Y Receptor	GPCR/G Protein; Neuroscience
	Prasugrel (CS-747) 是一种噻吩吡啶和前药，是一种可口服的 P2Y12受体拮抗剂，抑制 ADP 诱导的血小板聚集，用于预防急性冠状动脉综合征患者的血栓形成、不稳定型心绞痛和心肌梗塞，以及接受经皮冠状动脉介入治疗的患者。
T9138	Indirubin-3′-oxime Indirubin-3'-monoxime	GSK-3; CDK; JNK	Cell Cycle/Checkpoint; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	Indirubin-3′-oxime 是一种有效的细胞周期蛋白依赖性蛋白激酶抑制剂，是 indirubin 的合成衍生物。它可通过激活软骨细胞中的 Wnt/β-catenin 信号来促进身高增长，可能在阿尔茨海默病的神经元凋亡中发挥作用。
T6814	Cyproheptadine hydrochloride Periactin hydrochloride,Anarexol,盐酸赛庚啶,Cyproheptadine HCl,Nuran	5-HT Receptor	GPCR/G Protein; Neuroscience
	Cyproheptadine hydrochloride (Periactin hydrochloride) 是一种 5-HT2A 受体拮抗剂，具有抗抑郁和抗血清素作用。它具有抗血小板活性，可用于血栓栓塞性疾病的研究。
T0182L	Clopidogrel hydrogen sulfate 硫酸氢氯吡格雷,(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel,硫酸氯吡格雷	P450; P2Y Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) 是一种抗血小板药物，可防止血栓形成。它抑制 CYP2B6和 CYP2C19，IC50分别为 18.2 和 524 nM。它是一种选择性的高亲和力 P2Y12 受体拮抗剂，可抑制纤维蛋白原与血小板的结合以及血小板的粘附和聚集。
T6952	Prasugrel Hydrochloride LY 640315,PCR 4099 (hydrochloride),盐酸普拉格雷,Effient Hydrochloride,LY 640315 Hydrochloride,Prasugrel HCl	P2Y Receptor	GPCR/G Protein; Neuroscience
	Prasugrel Hydrochloride (LY 640315 Hydrochloride) 是一种噻吩吡啶和前药，是一种可口服的P2Y12受体拮抗剂，抑制 ADP 诱导的血小板聚集，用于预防急性冠状动脉综合征患者的血栓形成、不稳定型心绞痛和心肌梗塞，以及接受经皮冠状动脉介入治疗的患者。
T11177	Elinogrel PRT060128	P2Y Receptor	GPCR/G Protein; Neuroscience
	Elinogrel (PRT060128) 是一种竞争性和可逆的血小板 P2Y12 拮抗剂，IC50 为 20 nM，并表现出有效的抗血小板作用。
T4190	Ticlopidine PCR 5332,Ticlid,噻氯匹定	ATPase; Adiponectin receptor	GPCR/G Protein; Membrane transporter/Ion channel
	Ticlopidine (PCR 5332) 是抗血栓前药。它是CYP2C19人肝细胞色素的抑制剂，抑制 CYP2C9 及 CYP3A4。他是变构CD39的非竞争性抑制剂，能够阻断 NTPDase 同工酶，对NTPDase2和NTPDase3的IC50分别为 170 µM 和 149 µM。
T24733	Roxifiban acetate MK 0853,DMP754,DMP 755,DMP 754 acetate,DMP 754,DMP-754 acetate,DMP754 acetate,DMP-754	Integrin	Cytoskeletal Signaling
	Roxifiban acetate（DMP 754 acetate）是一种有效的GP IIb / IIIa拮抗剂，通过免疫介导展现出抗血小板聚集活性，可用于研究人类血小板减少症。
T11825	LCB-2853	PPAR	DNA Damage/DNA Repair; Metabolism
	LCB-2853 是一种有效的血栓素 A2/前列腺素 H2 （TXA2/PGH2）受体拮抗剂，具有抗血小板聚集、抗血管痉挛和抗血栓作用。
T12596	(4E)-SUN9221	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	(4E)-SUN9221 是一种有效的 α1-adrenergic 受体和 5-HT2 受体双重拮抗剂，在高血压大鼠中显示出抗高血压和抗血小板聚集活性。
T27335	Floctafenine RU 15750,R-4318,R 4318,RU-15750,R4318	COX	Immunology/Inflammation; Neuroscience
	Floctafenine (R-4318) 是一种可口服的非甾体抗炎化合物，是 COX-I 和 COX-2 抑制剂，可干扰阿司匹林的抗血小板作用。Floctafenine 具有镇痛活性，可用于研究疼痛。
T17039	Terbogrel BIBV 308SE	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Terbogrel 是一种可口服的、具有选择性 thromboxane A2 受体拮抗剂（IC50 约为 10 nM），是一种 thromboxane A2 synthase 抑制剂（IC50 约为 10 nM）。Terbogrel 是一种抗血小板化合物，可抑制血小板聚集，是预防血栓的潜在化合物。
T1066	Ketanserin R41468,凯他色林,Ketanserin tartrate,酮色林,Ketanserinum	Potassium Channel; 5-HT Receptor; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Ketanserin (Ketanserinum) 是一种喹唑啉衍生物和 5-羟色胺受体亚型 2 拮抗剂，具有潜在的抗高血压和抗血小板活性。它也浓度依赖性抑制 hERG 电流，IC50为 0.11 μM。
T5146	Eptifibatide acetate (148031-34-9 free base) Eptifibatide acetate,依菲巴特醋酸盐	Others	Others
	Eptifibatide acetate (148031-34-9 free base) (Eptifibatide acetate) 是一种糖蛋白 IIb/IIIa 抑制剂类的抗血小板药物，是一种由 6 个氨基酸和一个巯基丙酰基残基构成的环状七肽。
T0182L2	(±) Clopidogrel hydrogen sulfate 硫酸氢氯吡格雷,Plavix,Clopidogrel hydrogen sulfate,Iscover	P2Y Receptor	GPCR/G Protein; Neuroscience
	(±) Clopidogrel hydrogen sulfate (Iscover) 是一种在药理学和结构上类似于ticlopidine 的抗血小板药物，用于抑制脑血管疾病、外周血管疾病和冠状动脉疾病等各种疾病中的血栓。
T16328	Nitroaspirin 2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016	Apoptosis; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	Nitroaspirin (NCX 4016) 是一氧化氮供体和阿司匹林的硝基衍生物，与 Aspirin 结合可抑制环氧合酶=，可作为 COX-1 的直接和不可逆抑制剂。它通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白，显着诱导顺铂耐药人卵巢癌细胞的细胞周期停滞和凋亡，具有抗血栓和抗血小板特性。
T28427	Plafibride
	Plafibride is an antiplatelet and antilipidemic agent.
T26052	RE 1492 RE1492,RE-1492
	RE 1492 is an oligoamine that gives it an antiplatelet effect when combined with antithrombic drugs.
T10083	Desethyl KBT-3022	Others	Others
	Desethyl KBT-3022 is an active metabolite of the antiplatelet compound KBT-3022.
T24760	Satigrel E 5510,E5510
	Satigrel is a new antiplatelet agent. It also inhibits platelet accumulation in prosthetic arterial grafts.
T7380	Protease-Activated Receptor-4 蛋白酶活化的受体-4	Protease-activated Receptor	GPCR/G Protein
	Protease-Activated Receptor-4 是蛋白酶激活受体 4 激动剂，具有抗血小板治疗。
T26071	Rhamnetin tetraacetate
	Rhamnetin tetraacetate 是一种强效抗血小板化合物，可以强烈抑制花生四烯酸、胶原蛋白和 PAF 诱导的血小板聚集。
T36759	SAR 216471 hydrochloride
	Potent P2Y12 antagonist (IC50 = 17 nM). Displays antiplatelet and antithrombotic activity in vivo. Orally available. Boldron et al (2014) N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist. J.Med.Chem. 57 7293 PMID:25075638
T17200	UDM-001651	Others	Others
	UDM-001651 is an effective and orally bioavailable protease-activated receptor 4 antagonists (IC50=4 nM; Kd=1.4 nM). UDM-001651 displays antiplatelet potency (IC50=25 nM) in a γ-thrombin-induced platelet-rich plasma aggregation assay.
T28044	MIPS-9922
	MIPS-9922 is a potent and selective PI3Kβ inhibitor with antiplatelet activity. MIPS-9922 inhibited integrin αIIbβ3 activation and αIIbβ3 dependent platelet adhesion to immobilized vWF under high shear. MIPS-9922 also potently inhibited ADP-induced washe
T61811	GPVI antagonist 3
	GPVI antagonist 3 (Compound 2) is a potential antagonist that shows promising antiplatelet activity by selectively inhibiting the interaction between the Glycoprotein VI (GPVI) receptor and its ligands. It demonstrates potent inhibitory effects, with IC50 values of 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin, and 51.74 μM for thrombin. GPVI is a major collagen receptor on platelets, making it an ideal target for safe and effective antithrombotic treatment. Therefore, GPVI antago...
T14684	BMS-986120	Others	Others
	BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 (PAR4) antagonist. With IC50s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects[1][2].
T24732	roxifiban DMP-754,DMP754,DMP 754
	Roxifiban 是XV459的前药，是一种抗血小板剂，对血小板糖蛋白IIb/IIIa 复合物(GPIIb/IIIa)受体具有高亲和力和特异性。
T36726	6-keto Prostaglandin E1 6-keto Prostaglandin E1
	6-keto Prostaglandin E1 是 PGE1 的生物活性衍生物，在抗血小板聚集和解聚作用方面发挥作用。
T76979	Tadocizumab
	Tadocizumab（C4G1; YM-337）是针对整合素αIIbβ3的人源化单克隆抗体。它展现出抗血小板与抗血栓功能，适用于心血管疾病的研究。
T82898	Bentracimab PB 2452,MEDI 2452
	Bentracimab (PB 2452) 是高度亲和性的中和单克隆抗体，专门结合于Ticagrelor及其主要活性代谢产物。该抗体能迅速逆转Ticagrelor的抗血小板功能。
T5501	Clopidogrel thiolactone 2-oxoclopidogrel	P2Y Receptor	GPCR/G Protein; Neuroscience
	Clopidogrel thiolactone (2-oxoclopidogrel) 是一种有效的 P2Y12 受体抑制剂, 是一种有效的抗血小板聚集化合物。Clopidogrel thiolactone是Clopidogrel第一次氧化活化产生的活性代谢中间体。
T5020	Eptifibatide Eptifibatide Acetate,Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2,依替巴肽	Others	Others
	Eptifibatide (Eptifibatide Acetate) 是一种糖蛋白 IIb/IIIa 抑制剂类的抗血小板药物，是一种由 6 个氨基酸和一个巯基丙酰基残基构成的环状七肽。
T60576	Cyproheptadine
	Cyproheptadine 是一种有效的口服活性5-HT2A 受体拮抗剂。Cyproheptadine 具有抗抑郁和抗血清素作用。Cyproheptadine 还具有抗血小板和血栓保护活性，可用于研究血栓栓塞性疾病。
T70335	Cangrelor free acid
	Cangrelor is a P2Y12 inhibitor, and was approved in June 2015 as an antiplatelet drug for intravenous application. Cangrelor is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggregate. It is a modified ATP derivative stable to enzymatic degradation. It does not require metabolic conversion to an active metabolite. This allows cangrelor’s immediate effect after infusion, and the therapeutic effects can be maintained with...
T17231	Vicagrel	Others	Others
	Vicagrel 是一种有效的、具有口服活性抗血小板化合物，通过不可逆地抑制 P2Y12 受体，降低代谢失活，增强了阿司匹林对啮齿类动物血小板聚集和血栓形成起抑制作用。Viagrel 可用于治疗冠状动脉疾病、外周血管疾病和脑血管疾病中血栓。
T37176	Edoxaban impurity 6
	Edoxaban impurity 6 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention[1][2]. [1]. Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6(9):1542-9.[2]. Mendell J, Lee F, Chen S, The Effe...

化合物

Oral antiplatelet agent 1

Cat.No: T12316

Target: Others

Antiplatelet agent 1

Cat.No: T63334

Antiplatelet agent 2

Cat.No: T63335

Cat.No: T9153

Target: Others

Cat.No: T3536

Target: P2Y Receptor

cangrelor tetrasodium

Cat.No: T5036

Target: GPR, P2Y Receptor

Furegrelate sodium

Cat.No: T11339

Synonym: U-63557A

Target: PPAR

Cat.No: T21712

Target: Others, Guanylate cyclase

Cat.No: T6236

Synonym: 奥扎格雷,OKY-046,Domenan

Target: Thrombin, Prostaglandin Receptor

Cat.No: T1618

Synonym: Persantin,Dypyridamole,Dipyridamol,双嘧达莫,NSC-515776,Dipyudamine

Target: PDE

Ozagrel hydrochloride

Cat.No: T6625

Synonym: Ozagrel HCl,盐酸奥扎格雷,OKY-046 HCl

Target: Thrombin, Prostaglandin Receptor

Cat.No: T0230

Synonym: LY640315,CS-747,普拉格雷,PCR 4099

Target: P2Y Receptor

Indirubin-3′-oxime

Cat.No: T9138

Synonym: Indirubin-3'-monoxime

Target: GSK-3, CDK, JNK

Cyproheptadine hydrochloride

Cat.No: T6814

Synonym: Periactin hydrochloride,Anarexol,盐酸赛庚啶,Cyproheptadine HCl,Nuran

Target: 5-HT Receptor

Clopidogrel hydrogen sulfate

Cat.No: T0182L

Synonym: 硫酸氢氯吡格雷,(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel,硫酸氯吡格雷

Target: P450, P2Y Receptor

Prasugrel Hydrochloride

Cat.No: T6952

Synonym: LY 640315,PCR 4099 (hydrochloride),盐酸普拉格雷,Effient Hydrochloride,LY 640315 Hydrochloride,Prasugrel HCl

Target: P2Y Receptor

Cat.No: T11177

Synonym: PRT060128

Target: P2Y Receptor

Cat.No: T4190

Synonym: PCR 5332,Ticlid,噻氯匹定

Target: ATPase, Adiponectin receptor

Roxifiban acetate

Cat.No: T24733

Synonym: MK 0853,DMP754,DMP 755,DMP 754 acetate,DMP 754,DMP-754 acetate,DMP754 acetate,DMP-754

Target: Integrin

Cat.No: T11825

Target: PPAR

Cat.No: T12596

Target: 5-HT Receptor, Adrenergic Receptor

Cat.No: T27335

Synonym: RU 15750,R-4318,R 4318,RU-15750,R4318

Target: COX

Cat.No: T17039

Synonym: BIBV 308SE

Target: Prostaglandin Receptor

Cat.No: T1066

Synonym: R41468,凯他色林,Ketanserin tartrate,酮色林,Ketanserinum

Target: Potassium Channel, 5-HT Receptor, Autophagy

Eptifibatide acetate (148031-34-9 free base)

Cat.No: T5146

Synonym: Eptifibatide acetate,依菲巴特醋酸盐

Target: Others

(±) Clopidogrel hydrogen sulfate

Cat.No: T0182L2

Synonym: 硫酸氢氯吡格雷,Plavix,Clopidogrel hydrogen sulfate,Iscover

Target: P2Y Receptor

Cat.No: T16328

Synonym: 2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016

Target: Apoptosis, COX

Cat.No: T28427

Cat.No: T26052

Synonym: RE1492,RE-1492

Desethyl KBT-3022

Cat.No: T10083

Target: Others

Cat.No: T24760

Synonym: E 5510,E5510

Protease-Activated Receptor-4

Cat.No: T7380

Synonym: 蛋白酶活化的受体-4

Target: Protease-activated Receptor

Rhamnetin tetraacetate

Cat.No: T26071

SAR 216471 hydrochloride

Cat.No: T36759

Cat.No: T17200

Target: Others

Cat.No: T28044

GPVI antagonist 3

Cat.No: T61811

Cat.No: T14684

Target: Others

Cat.No: T24732

Synonym: DMP-754,DMP754,DMP 754

6-keto Prostaglandin E1

Cat.No: T36726

Synonym: 6-keto Prostaglandin E1

Cat.No: T76979

Cat.No: T82898

Synonym: PB 2452,MEDI 2452

Clopidogrel thiolactone

Cat.No: T5501

Synonym: 2-oxoclopidogrel

Target: P2Y Receptor

Cat.No: T5020

Synonym: Eptifibatide Acetate,Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2,依替巴肽

Target: Others

Cat.No: T60576

Cangrelor free acid

Cat.No: T70335

Cat.No: T17231

Target: Others

Edoxaban impurity 6

Cat.No: T37176

Cat. No.	Product Name	Target	Signaling Pathways
T5814	Aurantiamide TMC-58B,橙黄胡椒酰胺	p38 MAPK; NF-κB	MAPK; NF-κB
	Aurantiamide 是马齿苋的活性成分，具有多种生物活性（如抗氧化、抗血小板、抗炎、抗肿瘤活性等），具有口服活性。
T2S2109	Skimmianine beta-Fagarine,Skimmianin,茵芋碱,Chloroxylonine,Skimmiamine	Others	Others
	Skimmianine (Chloroxylonine) 是一种呋喹啉类生物碱，主要存在于芸香科，具有抗炎、抗痉挛和抗血小板聚集活性。它对多种癌细胞系具有细胞毒性和基因毒性。
T2230	Paeoniflorin 芍药苷,Peoniflorin	HSP; COX	Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience
	Paeoniflorin (Peoniflorin) 是从芍药根中提取的一种蒎烷单萜糖苷，具有抗癌作用、抗氧化应激、抗血小板聚集、血管扩张、降低血液粘度和抗炎活性等多种生物活性。它是一种热休克蛋白诱导剂，通过自噬途径保护 PC12 细胞免受 MPP+和酸性损伤。
T8121	Octacosanoic acid	Anti-infection	Microbiology/Virology
	Octacosanoic acid 具有抗血小板和抗血栓作用。
T2953	Ligustrazine hydrochloride Tetramethylpyrazine hydrochloride,Tetramethylpyrazine HCl,Chuanxiongzine hydrochloride,Tetrapyrazine HCl,盐酸川芎嗪	Others	Others
	Ligustrazine hydrochloride (Chuanxiongzine hydrochloride) 是一种天然产物。
TN1626	Eugenin	Others	Others
	Eugenin 是一种色酮，分离自滨海前胡，能够抗血小板聚集。
TN2086	Piperlotine A	Antibacterial	Microbiology/Virology
	Piperlotine A 是一种可从罗洛胡椒中提取得到的生物碱，具有抗血小板聚集活性。Piperlotine A 在体外试验中显示出对结核分枝杆菌的抑制作用，MIC 值为 50 ug/mL。
TN2027	Oxysanguinarine 8-Oxosanguinarine,氧化血根碱,Hydroxysanguinarine	Parasite	Microbiology/Virology
	Oxysanguinarine (Hydroxysanguinarine) 是一种来自Meconopsis simplicifolia 的小檗生物碱，具有抗疟和抗血小板聚集活性，对登革热病毒具有潜在的抑制作用。
T3915	Ginsenoside Ro 人参皂苷Ro,Chikusetsusaponin 5,Polysciasaponin P3,人参皂苷 Ro,Chikusetsusaponin V	Calcium Channel; Reductase; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Ginsenoside Ro (Chikusetsusaponin V) 能降低 TXA2产量，较弱降低 COX-1 和 TXAS 活性，具有 Ca2+拮抗剂的抗血小板作用，IC50为 155 μM。
TN3831	(-)-Denudatin B Denudatin B	ATPase; Potassium Channel; Calcium Channel; PAFR	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	(-)-Denudatin B (Denudatin B) 源自 Magnolia fargesii。 (-)-Denudatin B 通过抑制胶原蛋白和凝血酶诱导的磷酸肌醇分解，在高浓度下具有非特异性抗血小板作用。
T2722	Ligustrazine 川芎嗪,四甲基吡嗪,Tetramethylpyrazine	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	Ligustrazine (Tetramethylpyrazine) 是从Ligusticum wallichii 中提取的一种烷基吡嗪，常在薯条、面包、茶、乳制品、豆制品等食物中作为香精。它对大鼠具有潜在的抗神经和抗炎活性。
T5725	Salvianolic acid B 丹酚酸B,lithospermic acid B,Dan Shen Suan B	Sirtuin; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Salvianolic acid B (Dan Shen Suan B) 是一种来自丹参提取物的水溶性抗氧化剂，具有抗血小板聚集、抗凝和抗血栓作用。它常用来研究微循环疾病。
T2727	Salvianolic acid B	Others	Others
	Salvianolic acid B (Dan Shen Suan B) 是一种来自丹参提取物的水溶性抗氧化剂，具有抗血小板聚集、抗凝和抗血栓作用。它常用来研究微循环疾病。
T8061	Citronellal (±)-Citronellal,香茅醛	Others	Others
	Citronellal ((±)-Citronellal) 是多种芳香植物精油的单萜烯，具有促进睡眠、安定和抗伤害的作用。它可以降低机械伤害感受，且部分通过 NO-cGMP-ATP 敏感型 K⁺渠道通道介导的。
T77563	4-Ethylcatechol	DNA	DNA Damage/DNA Repair
	4-Ethylcatechol 存在于红葡萄酒中，可从Glechoma longituba（NaKai）Kupr 中提取。4-Ethylcatechol 在Cu（II）存在下会引起DNA 损伤。4-Ethylcatechol 是一种高效的抗血小板化合物。
T3S0195	Nootkatone 诺卡酮,努特卡酮,诺卡酮	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Nootkatone 是一种神经保护剂，来自于Alpiniae OxyphyllaeFructus ，具有抗氧化和抗炎活性。它能够改善脂多糖诱导的阿尔茨海默氏病小鼠模型的认知障碍。
TN1254	3'-Methoxydaidzein 3'-甲氧基大豆苷元	Sodium Channel	Membrane transporter/Ion channel
	3'-Methoxydaidzein 是一种异黄酮和 Sodium Channel 双重抑制剂。3'-Methoxydaidzein 对NaV1.7、NaV1.8 和 NaV1.3有抑制作用，IC50 分别为 181 nM、397 nM 和 505 nM。 3'-Methoxydaidzein 对胶原诱导的血小板聚集具有特异性，IC50值分别为12.3和61.5µM。。3'-Methoxydaidzein 通过抑制电压门控钠通道发挥镇痛作用。 3'-Methoxydaidzein 具有抗氧化活性和抗血小板聚集活性。
T6S1784	Brazilin Natural Red 24,巴西苏木素;苏枋精,Braziletto,Brasilin,Superbresiline,巴西苏木素	Apoptosis; Others; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	Brazilin (Braziletto) 是来自几种热带硬木的心材的一种红色染料前体，有软骨保护和抗炎活性。它抑制细胞增殖，促进细胞凋亡并通过 AMPK/mTOR 途径诱导自噬。
T5S2358	Dehydrocorydaline Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine	BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome
	Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax，Bcl-2蛋白表达，激活caspase-7，caspase-8，并使PARP 失活。它能增强p38 MAPK 活化，具有抗炎、抗癌等功效。它具有强大的抗疟疾作用，并具低细胞毒性。
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。
TN2087	Piperlotine C	PAFR	GPCR/G Protein
	Piperlotine C shows potent antiplatelet aggregation activity.
T40595	Rubiayannone A
	Rubiayannone A is an anthraquinone glycoside with an antiplatelet aggregation activity.
TN4796	Piperlotine D	PAFR	GPCR/G Protein
	Piperlotine D shows potent antiplatelet aggregation activity.
T10637	Butin	Others	Others
	Butin, a major biologically active flavonoid isolated from the Dalbergia odorifera, has strong antioxidant, anti-inflammatory and antiplatelet activities.
TN1954	Moscatin	Others	Others
	Moscatin exhibits antiplatelet aggregation activity.
TN4373	Kaempferol tetraacetate	Antifection	Microbiology/Virology
	Kaempferol tetraacetate is a potent antiplatelet agent. It exhibits significant cytotoxicity in vitro against three human cell lines HL-60, U937 and SK-MEL-1.
TN4922	Rubiarbonol B	Others	Others
	Rubiarbonol B may have antiplatelet aggregation activities.
TN1044	Quercetin 3-O-neohesperidoside	Others	Others
	Quercetin 3-O-neohesperidoside shows anti-atherosclerosis, and antiplatelet aggregation activities.
TMA0593	Broussoflavonol F	Tyrosinase	Proteases/Proteasome
	Broussoflavonol F has antiplatelet effect, is partially due to an inhibitory effect on cyclooxygenase, can inhibit arachidonic acid (AA)-induced platelet aggregation. Broussoflavonol F shows inhibitory activities on mushroom tyrosinase. Broussoflavonol F
TN2040	Panaxynol	BCL; Caspase; HIF	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Proteases/Proteasome
	Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
TMA1944	Protopine hydrochloride	EGFR; cAMP	Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.Protopine seems to inhibit the heterotypic cell adhesion between MD
TN1953	Morusinol 桑根皮醇,桑树醇	ERK; MEK; Autophagy; Ras	Autophagy; GPCR/G Protein; MAPK
	Morusinol 是从桑树根皮中提取出的类黄酮。 Morusinol 具有抗血小板和抗癌活性，在体内抑制动脉血栓形成，通过诱导自噬、G2/M 细胞周期阻滞、抑制细胞侵袭和迁移以及靶向 Ras/MEK/ERK 通路发挥抗肿瘤活性。
T79948	Kadsurenin B
	Kadsurenin B为PAF（platelet-activating factor）拮抗剂，展现出神经保护作用。该化合物在药理学领域显示出广泛的研究潜力，包括抗菌、抗炎、神经保护、抗氧化、抗血小板聚集、细胞毒性和抗寄生虫等效能。
TN6097	Girinimbine Girinimbin	Apoptosis; Antioxidant; Antibacterial	Apoptosis; Microbiology/Virology; oxidation-reduction
	Girinimbine (Girinimbin) 是一种来自植物九里香、 M. koenigii和Murraya koenigii中分离出的咔唑类生物碱。Girinimbine 具有多种生物学作用，可诱导细胞凋亡 (apoptosis)，具有抗锥虫、抗血小板活性、抗菌活性、抗炎、抗氧化和抗肿瘤活性。
TN5901	Cudratricusxanthone A
	Cudratricusxanthone A has potent anti-proliferative, antioxidative, and monoamine oxidase inhibitory effects, it also possesses anti-cancer activities and provide a basis for developing effective therapeutic agents to inhibit growth and metastasis of brea
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Cat.No: T5814

Synonym: TMC-58B,橙黄胡椒酰胺

Target: p38 MAPK, NF-κB

Cat.No: T2S2109

Synonym: beta-Fagarine,Skimmianin,茵芋碱,Chloroxylonine,Skimmiamine

Target: Others

Cat.No: T2230

Synonym: 芍药苷,Peoniflorin

Target: HSP, COX

Octacosanoic acid

Cat.No: T8121

Target: Anti-infection

Ligustrazine hydrochloride

Cat.No: T2953

Synonym: Tetramethylpyrazine hydrochloride,Tetramethylpyrazine HCl,Chuanxiongzine hydrochloride,Tetrapyrazine HCl,盐酸川芎嗪

Target: Others

Cat.No: TN1626

Target: Others

Cat.No: TN2086

Target: Antibacterial

Oxysanguinarine

Cat.No: TN2027

Synonym: 8-Oxosanguinarine,氧化血根碱,Hydroxysanguinarine

Target: Parasite

Cat.No: T3915

Synonym: 人参皂苷Ro,Chikusetsusaponin 5,Polysciasaponin P3,人参皂苷 Ro,Chikusetsusaponin V

Target: Calcium Channel, Reductase, Prostaglandin Receptor

(-)-Denudatin B

Cat.No: TN3831

Synonym: Denudatin B

Target: ATPase, Potassium Channel, Calcium Channel, PAFR

Cat.No: T2722

Synonym: 川芎嗪,四甲基吡嗪,Tetramethylpyrazine

Target: Apoptosis, Antioxidant

Salvianolic acid B

Cat.No: T5725

Synonym: 丹酚酸B,lithospermic acid B,Dan Shen Suan B

Target: Sirtuin, Autophagy

Salvianolic acid B

Cat.No: T2727

Target: Others

Cat.No: T8061

Synonym: (±)-Citronellal,香茅醛

Target: Others

4-Ethylcatechol

Cat.No: T77563

Target: DNA

Cat.No: T3S0195

Synonym: 诺卡酮,努特卡酮,诺卡酮

Target: AMPK

3'-Methoxydaidzein

Cat.No: TN1254

Synonym: 3'-甲氧基大豆苷元

Target: Sodium Channel

Cat.No: T6S1784

Synonym: Natural Red 24,巴西苏木素;苏枋精,Braziletto,Brasilin,Superbresiline,巴西苏木素

Target: Apoptosis, Others, AMPK, Autophagy

Dehydrocorydaline

Cat.No: T5S2358

Synonym: Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Cat.No: TN2087

Target: PAFR

Cat.No: T40595

Cat.No: TN4796

Target: PAFR

Cat.No: T10637

Target: Others

Cat.No: TN1954

Target: Others

Kaempferol tetraacetate

Cat.No: TN4373

Target: Antifection

Cat.No: TN4922

Target: Others

Quercetin 3-O-neohesperidoside

Cat.No: TN1044

Target: Others

Broussoflavonol F

Cat.No: TMA0593

Target: Tyrosinase

Cat.No: TN2040

Target: BCL, Caspase, HIF

Protopine hydrochloride

Cat.No: TMA1944

Target: EGFR, cAMP

Cat.No: TN1953

Synonym: 桑根皮醇,桑树醇

Target: ERK, MEK, Autophagy, Ras

Cat.No: T79948

Cat.No: TN6097

Synonym: Girinimbin

Target: Apoptosis, Antioxidant, Antibacterial

Cudratricusxanthone A

Cat.No: TN5901

Cat.No: T35624

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