100
33
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T60024 |
CFT7455
Cemsidomide |
Ligand for E3 Ligase | PROTAC |
CFT7455 (Cemsidomide) 是一种抗癌剂,对 cereblon E3 连接酶具有高亲和力,Kd 为 0.9 nM。 CFT7455 是锌指转录因子 Ikaros (IKZF1) 和 Aiolos (IKZF3) 的口服活性降解剂。 | |||
T0459 |
Sulindac
Arthrocine,MK-231,舒林酸,Clinoril,Sulindac sulfoxide |
COX; Autophagy | Autophagy; Immunology/Inflammation; Neuroscience |
Sulindac (Sulindac sulfoxide) 是一种非甾体类抗炎剂,可抑制COX-2的活性,也可抑制 COX-2 的过表达。它是一种亚磺酰基茚衍生物前药,具有潜在的抗肿瘤活性。 | |||
T10342 |
Antitumor agent-2
|
Others | Others |
Antitumor agent-2 具有抗炎和抗肿瘤活性,可用于研究癌症。 | |||
T60852 |
Anticancer agent 46
|
||
Anticancer agent 46是一种有效的抗癌剂, 在细胞实验中显示出抗增殖活性,对 MGC803细胞的 IC50为0.986μM。 | |||
T5538 |
DC661
|
Apoptosis; Autophagy | Apoptosis; Autophagy |
DC661 是一种棕榈酰蛋白硫酯酶 1 抑制剂,抑制自噬,可作为抗溶酶体剂,具有抗肿瘤活性。 | |||
T9104 |
TJ191
|
Apoptosis | Apoptosis |
TJ191 是一种选择性抗癌试剂,靶向低 TβRIII 表达的恶性T 细胞白血病/淋巴瘤细胞,可研究癌症。 | |||
T28475 |
Pyrazoloacridine
PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934 |
Apoptosis; Topoisomerase | Apoptosis; DNA Damage/DNA Repair |
Pyrazoloacridine (PD 115934) 是一种核酸结合剂,在 K562 细胞中抑制 topo I 和 II 的活性,IC50 为 1.25 μM。 Pyrazoloacridine 具有抗癌活性。 | |||
T5822 |
BTR-1
5-Benzylidene-3-ethyl rhodanine |
Apoptosis | Apoptosis |
BTR-1 (5-Benzylidene-3-ethyl rhodanine) 是一种活性抗癌剂, 可激活细胞凋亡并诱导细胞死亡。它能够诱导细胞周期 S 期停滞,影响 DNA 复制。 | |||
T16961 |
Supinoxin
RX-5902 |
Apoptosis; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Supinoxin (RX-5902) 是磷酸化 p68 RNA 解旋酶的强效口服活性抑制剂,是一种抗肿瘤试剂。它与 Y593 磷酸化的 p68 相互作用并减弱 β-catenin 的核穿梭性。它诱导细胞凋亡并抑制 TNBC 癌细胞系的生长,IC50的范围为 10 nM 至 20 nM。 | |||
T39595 |
Disitamab vedotin
RC 48,RC-48,RC48 |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Disitamab vedotin (RC-48) 是一种抗体-活性分子偶联物 (ADC),包含抗人表皮生长因子受体2 (HER2) 的单克隆抗体,该单克隆抗体通过可降解连接子结合到细胞毒性剂 MMAE。Disitamab vedotin 在不同HER-2表达水平胃癌细胞中显示出抗肿瘤和抗增殖活性且抑制胃癌细胞中HER-2蛋白的表达。 | |||
T72048 |
CDK8-IN-12
|
GSK-3; CDK | Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells |
CDK8-IN-12 是一种具有选择性、有效性和口服活性的 CDK8 抑制剂(Ki : 14 nM),是一种抗癌剂。CDK8-IN-12 对 GSK-3α、GSK-3β、PCK-θ 具有抑制作用,Ki 分别为 13 nM、4 nM、109 nM。CDK8-IN-12对 MV4-11 细胞显示出抗增殖活性。 | |||
T0860L |
Mefloquine
Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998 |
Others | Others |
Mefloquine (Ro 215998) 是一种喹啉抗疟药,是一种抗 SARS-CoV-2 进入抑制剂。 Mefloquine 也是一种 K+ 通道 (KvQT1/minK) 拮抗剂,IC50 为 ~1 μM。它可用于疟疾、系统性红斑狼疮和癌症研究。 | |||
T16750 |
Rigosertib
ON-01910,瑞格色替 |
Apoptosis; FLT; PLK; PI3K; Bcr-Abl; CDK; PDGFR; Src | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Rigosertib (ON-01910) 是一种多激酶抑制剂和选择性抗癌剂,通过抑制 PI3K/Akt 途径诱导细胞凋亡,促进组蛋白 H2AX 的磷酸化并诱导细胞周期中的 G2/M 期停滞。它是一种选择性的非 ATP 竞争性PLK1抑制剂,IC50值为 9 nM。 | |||
T4570 |
Pipobroman
Vercyte,A-8103,Amedel,哌泊溴烷 |
Others; DNA Alkylator/Crosslinker | DNA Damage/DNA Repair; Others |
Pipobroman (Vercyte) 是一种烷基化剂,是哌嗪的溴化衍生物。它通过抑制 DNA 和 RNA 聚合酶或减少嘧啶核苷酸掺入 DNA 发挥其作用。它在真性红细胞增多症和原发性血小板增多症中具有良好的临床活性,可用于癌症研究。 | |||
T10331 | Anticancer agent 3 | Others | Others |
Anticancer agent 3 (Compound 4) is a anti-cancer agent. | |||
T38564 | Taccalonolide C | ||
Taccalonolides C is an anti-cancer agent. | |||
T11051 |
DIQ3
|
Others | Others |
DIQ3 is non-toxic to normal human cell lines and is an effective anti-cancer agent. | |||
T25761 |
Lubeluzole
R 87926,R87926,R-87926,Prosynap |
||
Lubeluzole, a well-known neuroprotective agent, is recently proved useful to potentiate the activity of anti-cancer drugs. | |||
T39501 | Anticancer agent 7 | ||
Anticancer agent 7 (Example 5) is an anti-cancer agent that exhibits potent anticancer activity against H1650 lung cancer cells, with an IC50 value of 5 μM. | |||
T70176 | P7170 | ||
P7170 is an anti-cancer agent active as an mTORC1/C2 and activin receptor-like kinase 1 (ALK1) inhibitor. | |||
T72441 |
Anticancer agent 100
|
||
Anticancer agent 100 是一种丁卡因衍生物,具有抗癌活性,可用于癌症研究。 | |||
T74767 | Anticancer agent 102 | ||
Anticancer agent 102 是丁卡因的衍生物。Anticancer agent 102 具有抗癌活性. Anticancer agent 102 诱导细胞凋亡。 | |||
T27982 |
MBRI-001
MBRI 001,MBRI001. BPI-2358-d,plinabulin-d,NPI-2358-d |
||
MBRI-001 is a deuterium-substituted plinabulin derivative and a potent anti-cancer agent with better pharmacokinetic characteristics tand lower toxicity. | |||
T83030 | Antioxidant agent-11 | ||
Antioxidant agent-11 (compound 3d) 是具备抗氧化以及轻度抗癌活性的化学化合物。 | |||
T10015 |
1-Deazaadenosine
|
Others | Others |
1-Deazaadenosine is a potent Adenosine deaminase inhibitor (Ki: 0.66 μM). It exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders. | |||
T64209 | Anticancer agent 55 | ||
Anticancer Agent 是一种有效的抗癌剂。Anticancer Agent 能够以剂量依赖性方式抑制细胞活力和细胞迁移,诱导细胞凋亡 (apoptosis),表现出抗癌效果。Anticancer Agent 具有潜力进行前列腺癌和乳腺癌的研究。 | |||
T27998 |
MDK-4204
Anticancer AgentI,MDK 4204,Anticancer Agent I,MDK4204,Anticancer Agent-I |
||
MDK-4204, an anticancer agent, shows significant anti-cancer activity with IC50 values of 8.8 µM and 9.5 µM in PC-3 and DU-145 cells, respectively. | |||
T28609 |
Rohitukine
NSC623611,NSC-623611,NSC 623611 |
||
Rohitukine is an anti-cancer agent. It modulates apoptosis pathways through gastrin antagonism and H(+) K (+)-ATPase inhibition. Rohitukine ia an antiadipogenic, antidyslipidemic, gastroprotective, antifertility, and antileishmanial compound. | |||
T61973 | Anticancer agent 79 | ||
Anticancer agent 79 (compound 3d) 是一种抗癌化合物,具有良好的抗乳腺癌 (anti-breast cancer) 活性。Anticancer agent 79 对 T47-D 细胞表现出良好的细胞毒性活性(IC50= 13.64±0.26 μM)。 | |||
T35271 |
Yoshi-864
Yoshi864,Improsulfan HCl,NSC102627,Improsulfan hydrochloride |
||
Yoshi-864 alkylates and cross-links DNA, thereby inhibiting DNA replication. It is an alkyl sulfonate DNA cross-linking agent with potential anti-cancer activity. | |||
T61806 |
Antitumor agent-44
|
||
Antitumor agent-44 (Compound 5n) elicits potent antitumor effects by inducing disruption of mitochondrial homeostasis, cell cycle arrest, and apoptosis in human adenocarcinoma cells. Moreover, Antitumor agent-44 demonstrates significant anti-tumor activity in a lung cancer cell xenograft mice model [1]. | |||
T62012 | Antiproliferative agent-8 | ||
Antiproliferative agent-8 (Compound 5a) 是一种抗癌化合物,显示抗增殖活性。Antiproliferative against-8 可以显著增加 P53 水平 | |||
T83095 | Anticancer agent 101 | ||
Anticanceragent 101,一种丁卡因衍生物,展现出抗癌活性。 | |||
T39815 | anti-TNBC agent-1 | ||
anti-TNBC agent-1 is a highly effective compound specifically designed to target and combat triple-negative breast cancer (TNBC). It demonstrates remarkable potency against various breast cancer cell types, with IC50 values spanning from 0.20 μM to 0.27 μM. The mechanism of action of anti-TNBC agent-1 involves inducing apoptosis in SUM-159 cells through the mitochondria pathway, as well as causing G1 phase arrest in these cells. | |||
T79410 | anti-TNBC agent-3 | ||
Anti-TNBC agent-3 (compound 3g) 作为凋亡诱导剂,展现了抗增殖活性针对癌细胞。在三阴性乳腺癌(TNBC)异种移植模型上,该化合物有效地抑制了肿瘤生长及其转移。 | |||
T72479 | Anticancer agent 66 | ||
Anticancer agent 66 是一种抗癌剂。Anticancer agent 66 在 MCF-7 细胞中诱导细胞凋亡 (apoptosis) 并增加亚 G1 细胞群。Anticancer agent 66 是一种环丙沙星类似物。 | |||
T64212 |
Antiproliferative agent-5
|
||
Antiproliferative agent-5 (compound 4o) 能够不可逆的、显著的抑制胃癌细胞增殖。Antiproliferative agent-5 能够将细胞周期阻滞在 G2/M 期,诱导 ROS 积累,激活细胞自噬 (autophagy)。Antiproliferative agent-5 能够用于进行抗癌的研究。 | |||
T62833 |
Myoferlin inhibitor 1
|
||
Myoferlin inhibitor 1 是一种新型抗胰腺癌转移药物,能够肌球蛋白发挥作用。 | |||
T38519 |
YB-0158
Wnt pathway inhibitor 2,YB-0158 |
||
YB-0158 (Wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. This compound acts as a reverse-turn agent, inducing apoptosis in CRC cells and displaying strong anti-cancer activities. | |||
T39523 |
Antitumor agent-28
|
||
Antitumor agent-28 is a compound that specifically targets and inhibits the activity of the ataxia telangiectasia mutated (ATM) kinase. By doing so, it effectively impedes the progression of ATM-mediated diseases and demonstrates significant anti-cancer activity. | |||
T39792 | AMPC | ||
AMPC, a powerful and efficient inhibitor of TFF3, demonstrates inhibitory effects on cell proliferation, survival, oncogenicity, and CSC-like behavior in TFF3-positive CMS4 CRC cells. It acts as a promising standalone anti-cancer agent and also enhances the effects of 5-FU when used in combination, making it a valuable tool for cancer research. | |||
T72205 |
Antiproliferative agent-19
|
||
Antiproliferative agent-19 (化合物 4a) 作为一种抗癌剂,通过诱导细胞凋亡和细胞周期在G2/M期的停滞来对肺癌细胞展现抗增殖活性。 | |||
T61919 | Anticancer agent 78 | ||
Anticancer agent 78 具有抗芳香酶活性(IC50= 0.9 μM)。Anticancer agent 78 是一种有效的抗癌剂,显示细胞毒性。Anticancer agent 78 在乳腺癌中有研究潜力。 | |||
T16354 |
NSC745885
|
Others | Others |
NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 offers possibilities | |||
T74921 | Antiproliferative agent-12 | ||
Antiproliferative agent-10 (compound 1) 是一种钌(II)-三吡唑基甲烷抗肿瘤复合物,能够通过阻断线粒体钙吸收来抑制癌细胞增殖。 | |||
T71150 |
Incadronic acid
|
||
Incadronate, also known as Cimadronate and YM-175, is a bone resorption inhibitor. Incadronate disodium inhibits macrophage migration to site of inflammation in vivo and proliferation and causes apoptosis in cancer cells in vitro. Incadronate disodium is a bone density conservation, antitumor and anti-inflammatory agent. | |||
T63830 | Anticancer agent 76 | ||
Anticancer agent 76 (Compound CT2-3) 是一种能够明显抑制人 NSCLC 细胞增殖、诱导细胞周期阻滞、ROS 生成和细胞凋亡(apoptosis)的抗癌剂。 | |||
T68952 |
NU1064
|
||
NU1064 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which can potentiate the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells. NU1064 potentiated a sublethal concentration of a DNA methylating agent in a concentration-dependent manner. | |||
T40581 |
TIE-2/VEGFR-2 kinase-IN-2
|
||
TIE-2/VEGFR-2 kinase-IN-2 is a powerful inhibitor of both VEGFR2 and Tie-2 kinases, displaying noteworthy pIC 50 values of 8.61 and 8.56, respectively. This compound acts as an anti-angiogenic agent, making it highly relevant for cancer research. | |||
T63787 |
Anticancer agent 62
|
||
Anticancer agent 62 是有效的抗癌剂。Anticancer agent 62 对 HepG2、Bel-7402 和 MCF-7 癌细胞表现出抗增殖作用,其 IC50值分别为 0.019、0.060 和 0.016 μM。Anticancer agent 62 能够抑制肿瘤生长。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6S1255 |
Ophiopogonin-D
麦冬皂苷D |
ROS | Immunology/Inflammation |
Ophiopogonin-D 通过 RIPK1 显着抑制前列腺细胞的体外和体内生长,OPD 可能被开发为潜在的抗前列腺癌药物。 | |||
T6S1027 |
Tussilagone
|
Others | Others |
Tussilagone 是Tussilago farfara 的主要活性成分,具有抗炎作用。它抑制盲肠结扎和穿刺导致脓毒症的小鼠的炎症反应,提高其生存率。它改善葡聚糖硫酸钠诱导的小鼠结肠炎的炎症反应。 | |||
T3870 |
Cyasterone
杯苋甾酮,Cyasteron |
Apoptosis; EGFR | Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Cyasterone (Cyasteron) 是主要分离自金疮小草的一种天然 EGFR 抑制剂。它通过诱导细胞凋亡和细胞周期阻滞表现出抗增殖作用,可用于抗人类肿瘤的相关研究。 | |||
T9715 |
Aplidine
|
SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Aplidine 是有效的eEF1A2(KD=80 nM) 靶向的抗癌药物。Aplidine 具有抗病毒活性,抑制SARS-CoV-2的 IC90为 0.88 nM。Aplidine 在多发性骨髓瘤,晚期癌症及 COVID-19 领域有研究的价值。 | |||
TN1727 |
Helichrysetin
4,2',4'-三羟基-6'-甲氧基查耳酮,蜡菊亭 |
Apoptosis; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Helichrysetin 是从豆蔻果实中分离出的一种天然产物,是一种 DNA 结合抑制剂,可抑制原位导管癌DCIS 的形成。它抑制细胞生长,可诱导 A549 细胞凋亡。 | |||
T2787 |
Picroside I
6'-Cinnamoylcatalpol,胡黄连苦苷I |
MMP; STAT | JAK/STAT signaling; Proteases/Proteasome; Stem Cells |
Picroside I (6'-Cinnamoylcatalpol) 是胡黄连的一种天然产物,是有肝脏保护作用的代谢成分,可用于哮喘研究,有减轻炎症作用,还下调 pSTAT6 和 GATA3 表达。 | |||
T4S1637 |
gamma-Mangostin
Normangostin,γ-倒捻子素 |
Others; 5-HT Receptor | GPCR/G Protein; Neuroscience; Others |
gamma-Mangostin (Normangostin) 是从药用植物山竹的果壳中提纯的一种天然产物,是一种竞争性5-HT2A 受体拮抗剂。它是运甲状腺素蛋白原纤维化抑制剂,与甲状腺素结合位点结合并稳定了 TTR 四聚体,具有抗高血压、预防结肠癌等作用。 | |||
T3867 |
Alpinetin
山姜素,(-)-alpinetin |
BCL; PPAR | Apoptosis; DNA Damage/DNA Repair; Metabolism |
Alpinetin ((-)-alpinetin) 是从草豆蔻中分离得到的一种黄酮类天然产物,能够活化PPAR-γ,具有抗炎、抗菌活性。它通过抑制增殖、调节 Bcl-2 家族和 XIAP 表达、释放细胞色素 c 和激活 caspase 具有很强的抗肝癌和胰腺癌细胞作用。 | |||
T7028 |
Licochalcone C
LICOCHALCONEC,甘草查尔酮C |
Phosphatase; Antioxidant; Glucosidase | Metabolism; oxidation-reduction |
Licochalcone C (LICOCHALCONEC) 能够抑制 α-葡萄糖苷酶,其对 α-葡萄糖苷酶的 IC50 <100 nM,对蛋白酪氨酸磷酸酶 1B 的 IC50=92.43 μM 。 | |||
T5S2059 |
Glaucine
|
Calcium Channel; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; PDE | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Glaucine 是从海罂粟中分离的一种生物碱,具有镇咳、抗炎和支气管扩张作用。它是具有口服活性的磷酸二酯酶 4 选择性抑制剂。它还是非选择性的 α-肾上腺素受体拮抗剂,具有抗氧化和抗病毒活性。 | |||
T5S0754 |
Isoquercetin
3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷 |
NF-κB; Wnt/beta-catenin; NO Synthase | Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; Stem Cells |
Isoquercetin (3-Glucosylquercetin) 是天然存在的多酚,具有抗氧化,抗增殖和抗炎特性。它通过调节核因子-κB 转录调节系统调节一氧化氮合酶 2 的表达。它通过 Nrf2/ARE 抗氧化剂信号传导途径减轻乙醇诱导的肝毒性,氧化应激和炎症反应。它具有高生物利用度和低毒性,是预防糖尿病妊娠出生缺陷的有希望的候选药物。 | |||
T4S2126 |
Ginkgetin
银杏双黄酮,银杏素 |
Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells |
Ginkgetin 是从银杏叶中分离得到的一种双黄酮,具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂,IC50值为 5.92 μM。 | |||
T4S0797 |
Berberine
小檗碱,Berberin,Umbellatine,黄连素 |
Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy | Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶,具有抗肿瘤特性。 | |||
TL0008 |
Gigantol
|
Wnt/beta-catenin; Glucosidase | Cytoskeletal Signaling; Metabolism; Stem Cells |
Gigantol 是一种联苄基化合物,从几种药用兰花中获得,是一种Wnt/β-catenin 通路抑制剂,具有抗肿瘤活性。 | |||
T3S0209 |
Vincristine
|
ERK; p38 MAPK; NF-κB; Akt; JNK; mTOR | Cytoskeletal Signaling; MAPK; NF-κB; PI3K/Akt/mTOR signaling |
Vincristine 与微管蛋白结合并抑制微管的形成,从而抑制癌细胞的有丝分裂。 Vincristine 可用作微管去稳定剂,用于研究治疗血液系统癌症,如白血病和淋巴瘤以及儿童肉瘤的相关研究。 | |||
T4S0969 |
Obtusifolin
决明蒽醌,决明蒽醌;美决明子素 |
Antioxidant; NF-κB | NF-κB; oxidation-reduction |
Obtusifolin 是分离自决明子的种子中,能够抑制NF-kB 通路,调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。 | |||
T6677 |
Sophocarpine
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ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT | Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors |
Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长,具有抗肿瘤活性。 | |||
T13472 | α-Carotene | Others | Others |
α-Carotene is isolated from yellow-orange and dark-green vegetables. α-Carotene is used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs. | |||
T27532 | Helenalin Acetate | ||
Helenalin Acetate is an anti-inflammatory and anti-cancer agent, disrupting the cooperation of CCAAT-box/enhancer-binding protein beta (C/EBPß) and co-activator p300. | |||
TN6651 | Picrasidine Q | ||
Picrasidine Q has the capacity of anti-cell transformation and anti-cancer, it might be a chemopreventive and chemotherapeutic agent by direct targeting FGFR2 and inhibiting cell proliferation of ESCC cells. | |||
T2S2104 |
Sinigrin hydrate
黑芥子苷,Sinigrin monohydrate,芥子甙单水合物,Allylglucosinolate monohydrate |
Antibacterial | Microbiology/Virology |
Sinigrin hydrate (Allylglucosinolate monohydrate) 是一种天然脂肪族芥子油苷,存在于十字花科植物中。它具有消炎、抗癌、抗真菌、抗菌、抗氧化作用。 | |||
TN3737 |
Cycloartane-3,24,25-triol
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ATPase | Membrane transporter/Ion channel |
Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively. | |||
TN1867 | Licoricidin | MMP; VEGFR; ROS | Angiogenesis; Immunology/Inflammation; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells. | |||
T40578 | β-Bisabolene | ||
β-Bisabolene is a sesquiterpene isolated from opoponax ( Commiphora guidotti ). β-Bisabolene, an anti-cancer agent , can be used for the study of breast cancer. | |||
TN1302 |
6,8-Diprenylorobol
6,8-二异戊烯基香豌豆苷元 |
Others; HIV Protease; Antifection | Microbiology/Virology; Others; Proteases/Proteasome |
6,8-Diprenylorobol possesses weaker anti-H. pylori activity, it may be a useful chemopreventive agent for peptic ulcer or gastric cancer in H. pylori-infected individuals. | |||
TN5288 |
Ergosterol peroxide glucoside
过氧化麦角甾醇葡萄糖苷,Ergosterol peroxide 3-O-β-D-glucopyranoside |
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Ergosterol peroxide exhibits anti-cancer, amoebicidal, anticomplementary, antibacterial, antiviral, anti-oxdiant, and anti-melanogenic activities. Ergosterol peroxide could as an anti-atherosclerosis agent, it exhibits hACAT-1 and Lp-PLA2 inhibitory effec | |||
T72964 |
Dictyostatin
Dictyostatin 1,(-)-Dictyostatin ; Dictyostatin 1,(-)-Dictyostatin |
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Dictyostatin ((-)-Dictyostatin ; Dictyostatin 1) 是一种有效的微管稳定剂。 Dictyostatin 也是一种抗癌剂。 Dictyostatin 具有抗增殖活性。Dictyostatin 具有研究 tauopathies 的潜力。 | |||
T72236 |
erythro-Austrobailignan-6
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erythro-Austrobailignan-6 是一种口服活性的抗癌化合物,能够抑制 DNA 拓扑异构酶 I 及 II 的活性,同时诱导细胞凋亡并增加 p38 和 JNK 的磷酸化。 | |||
TN3070 |
4beta-Hydroxywithanolide E
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PARP; HSP; NF-κB; COX | Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB |
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it affects alternative splicing by mo | |||
TN4046 | Excisanin A | MMP; FAK; PARP; GSK-3; NF-κB; Wnt/beta-catenin; Akt; Caspase; PI3K; Prostaglandin Receptor; JNK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors |
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the ... | |||
TN3655 |
Cimiside E
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ERK; TNF; ROS; Akt; PI3K; PKC; PPAR | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling |
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.Cimiside E may be an effective chemopreventive agen | |||
TN3152 |
6-Acetonyldihydrochelerythrine
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ERK; BCL; Akt; HIV Protease; PPAR; p53 | Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively. 6-Acetonyldihydrochelerythrine is | |||
T83117 |
Angeloylbinankadsurin A
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Angeloylbinankadsurin A(化合物7)是一种从黑虎胡的EtOAc和CH2Cl2提取物中分离出的抗RA试剂,它在RA-FLS细胞上显示出显著的抑制活性(IC50=11.70 μM),同时对人类癌细胞系(Hela和BGC-823)表现出较低的毒性(IC50分别为19.9 μM和21.93 μM)。 |