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Search Results for " nf-kb "

Targets Recommended: NF-κB

35

抑制剂 & 化合物

25

天然产物

3

化合物库

11

重组蛋白

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Cat. No.	Product Name
L3800	NF-κB 通路分子库		729 compounds
	729 个 NF-κB 信号通路相关的小分子化合物的特有集合，用于高通量、高内涵筛选；
L3600	细胞因子抑制剂库		604 compounds
	604 个与细胞因子紧密相关的化合物集合，是高通量、高内涵筛选的良好载体；
L4700	免疫/炎症分子化合物库		4720 compounds
	4720 种具有抗炎症活性的化合物的特有集合，可用于高通量筛选和高内涵筛选；

化合物库

NF-κB 通路分子库

Cat.No: L3800

Compounds: 729

细胞因子抑制剂库

Cat.No: L3600

Compounds: 604

免疫/炎症分子化合物库

Cat.No: L4700

Compounds: 4720

Cat. No.	Product Name	Target	Signaling Pathways
T39965	NF-κΒ activator 1	NF-κB	NF-κB
	NF-κΒ activator 1 可激活NF-κΒ基因，EC50 为 0.9 μM。NF-κB 作为一种调控细胞增殖和细胞存活的基因被真核细胞广泛应用。NF-κΒ activator 1 可诱导超氧化物歧化酶 (SOD)2 mRNA 表达。
T39924	NF-κΒ activator 2	NF-κB	NF-κB
	NF-κΒ activator 2 是口服有效的 NF-ҡB 激活剂，EC50为 1.58 μM。它通过增加 NF-κB 的表达和激活来诱导 SOD2。它具有用于研究肌萎缩性侧索硬化症的价值。
T9656	AP-1/NF-κB activation inhibitor 1	NF-κB; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; NF-κB
	AP-1/NF-κB activation inhibitor 1 是一种有效的 AP-1和 NF-κB 介导的转录激活抑制剂(IC50=1 μM)，不阻断 β-actin 启动子驱动的基础转录。AP-1/NF-κB activation inhibitor 1 对受刺激细胞中 IL-2和 IL-8的产生水平有相似的抑制作用。
T9105	NF-κB-IN-1 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-	IκB/IKK; NF-κB	NF-κB
	NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-)是一种 4-亚芳基姜黄素类似物，是抑制有效的NF-κB 信号通路抑制剂。它可有效抑制肺癌细胞的活力并减弱 A549 细胞的克隆活性。它可直接抑制IKK 来阻断 NF-κB 的激活。
T27620	IP7e IP 7e,IP-7e,isoxazolo-pyridinone 7e	Others	Others
	IP7e (isoxazolo-pyridinone 7e) 是一种 Nurr1 激活剂，EC50 值为 3.9 nM。
T37559	NF-κB Control
	NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α. NF-κB control is a peptide that is identical in sequence to NF-κB inhibitor, except two essential, basic residues of the p105 NLS are substituted with non-basic amino acids...
T38153	NF-κB Inhibitor (trifluoroacetate salt)
	NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.1In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.2,3This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.4,5
T60357	NF-κB-IN-2 JEUD-38
	NF-κB-IN-2 抑制 PC-3细胞中 TNF-α诱导的的经典 NF-κB 信号传导。
T20168	Aurothiomalate sodium 金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Aurothiomalate sodium (Miochrysin) 是一种选择性的致癌 PKCι信号传导抑制剂，可抑制肿瘤细胞增殖。它是一种硫氧还蛋白还原酶 (TrxR) 抑制剂，也是一种抗风湿剂。
T4543	Telithromycin HMR3647,泰利霉素,Ketek,RU66647	Antibacterial; Antibiotic	Microbiology/Virology
	Telithromycin (HMR3647) 是一种社区获得性肺炎抗生素。
T21480	Diethylmaleate Maleic acid, diethyl ester,DIETHYL MALEATE,马来酸二乙酯	NF-κB	NF-κB
	Diethylmaleate (Maleic acid, diethyl ester) 是马来酸二乙酯和一种抑制 NF-kB 的谷胱甘肽消耗化合物。
T4361	CBL0137 hydrochloride CBL0137,CBLC137,Curaxin 137,CBL-C137 hydrochloride,Curaxin-137 hydrochloride	Others; NF-κB; p53	Apoptosis; NF-κB; Others
	CBL0137 hydrochloride (Curaxin-137 hydrochloride) 是一种组蛋白分子伴侣FACT 的抑制剂，也可激活p53并抑制NF-κB，对于它们的EC50值分别为 0.37 和 0.47 μM。
T8951	JTP 0819958 - HOIPIN-1	IκB/IKK	NF-κB
	JTP 0819958 - HOIPIN-1 是一种选择性线性泛素链组装复合物 (LUBAC) 抑制剂，IC50 为 2.8 μM。 JTP-0819958 在体外抑制 LUBAC 介导的 NF-kB 活化[2]。
T78557	HOIPIN-1 JTP0819958	NF-κB	NF-κB
	HOIPIN-1 (JTP0819958) 是一种具有选择性和有效性的线性泛素链组装复合物 (LUBAC) 抑制剂（IC50 >2.8 μM）。HOIPIN-1 对LUBAC 介导的 NF-kB 激活有抑制作用。
T8981	WAY-169916 WAY 169916,WAY169916	NF-κB	NF-κB
	WAY-169916 是雌激素受体 (ER) 的通路选择性抑制剂。它通过抑制 NF-kB 转录活性而发挥作用，但没有常规的雌激素活性。
TP1615L	IKKγ NBD Inhibitory Peptide acetate IKKγ NBD Inhibitory Peptide acetate(372146-18-4 free base)	NF-κB	NF-κB
	IKKγ NBD Inhibitory Peptide acetate 是一种 NEMO 结合结构域肽（NBD 肽）乙酸盐，对应于 NEMO 氨基末端 α-螺旋区域。它显示可阻断 TNF-α 诱导的 NF-kB 活化。
T22115	SM-7368	NF-κB	NF-κB
	NF-κB Activation Inhibitor III 是一种NF-kB 抑制剂，抑制 TNF-α 诱导的MMP-9上调，靶向抑制下游的MAPK p38，可用于靶向 TNF-α 介导的肿瘤侵袭和转移的化疗研究。
T0005	Aspirin 阿司匹林,Acetylsalicylate,Acetylsalicylic Acid,邻乙酰水杨酸,ASA	Mitophagy; Virus Protease; COX; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Aspirin (Acetylsalicylic Acid) 是一种选择性 COX 抑制剂，具有多种药理活性。它是组蛋白去乙酰化酶抑制剂，可上调细胞周期阻滞蛋白 p21，抑制携带 COX-1 的卵巢 Y 细胞。它还抑制 HUVEC 和新生大鼠心室心肌细胞中 COX-2 的表达，分别减少 PG 的产生和 ERK 和 NF-KB 的下调。
T0947	Dexamethasone acetate Dexamethasone 21-acetate,醋酸地塞米松,Dexamethason acetate,NSC 39471	Glucocorticoid Receptor; Mitophagy; IL Receptor; Annexin A; NOS; Antibacterial; Autophagy	Autophagy; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology
	Dexamethasone acetate (NSC 39471) 是一种糖皮质素类甾体，有抗炎和免疫抑制活性。它可研究眼部感染。
T11886	LTβR-IN-1	Others; NF-κB; LTR	Immunology/Inflammation; NF-κB; Others
	LTβR-IN-1是一种有作用的、具有选择性的淋巴素β受体(LTβR)抑制剂。LTβR-IN-1 对TNF12A 的的 p52 的核易位抑制作用具有选择性，对 TNF-α 受体介导的 p65 的核易位无明显作用，却抑制受 TWEAK 或 Anti-LTβR 刺激的 p52 核易位，IC50为10 μM。LTβR-IN-1通过配体非依赖性方式实现对 NF-kB 信号通路的调节作用。
T11096	DRI-C21045	NF-κB	NF-κB
	DRI-C21045 是一种有效的 CD40-CD40L 协同刺激蛋白-蛋白质相互作用的选择性抑制剂，IC50 为 0.17 μM。它显示对 CD40L 诱导的 NF-κB 活化和 B 细胞增殖的浓度依赖性抑制，IC50分别为 17.1 μM 和 4.5 μM。
T5209	INH14	IκB/IKK	NF-κB
	INH14 是 IKKα (IC50:8.97 μM) / IKKβ (IC50:3.59 μM) 的抑制剂。它能够抑制 IKKα/β 依赖性 TLR 炎症反应，抑制 TAK1/TAB1 的下游和 NF-kB 信号通路。它具有抗炎和抗癌作用。
T6964	Resiquimod R848,雷西莫特,S28463	HCV Protease; TLR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Resiquimod (R848) 是一种 Toll 样受体7/8的激动剂，可诱导细胞因子上调。
T28065	ML263 ML-263,ML 263
	ML263 inhibits NF-kB activation induced by B-cell specific antigen receptor.
T68729	Coumaperine
	Coumaperine is an NF-kB inhibitor.
T29013	HE 3286 Triolex,HE-3286,HE3286
	Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis.
TP1615	IKKγ NBD Inhibitory Peptide
	A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is vital for t
T63107	Anti-inflammatory agent 6
	Anti-inflammatory agent 6 能够阻断作为炎症关键控制器的 Iκb 激酶 α/β（IKKα/β）、IκBα 和核因子 kB p65（NF-κb p65）的磷酸化，表现出抗炎潜力。
T62359	TLR4/NF-κB/MAPK-IN-1
	TLR4/NF-κB/MAPK-IN-1通过抑制 TLR4/NF-kB/MAPK 途径，是一种新型抗神经炎症剂。
T76024	IKKγ NBD Inhibitory Peptide TFA
	IKKγ NBD 抑制肽 TFA 是一种高度特异性的NF-κB 抑制剂。IKKγ NBD 抑制肽 TFA 通过阻断 IKKγ/NEMO 结合域 (NBD) 与 IKKα 和 IKKβ 之间的相互作用，而阻断 TNF-α 诱导的NF-κB 激活。IKKγ NBD 抑制肽 TFA 可显著降低炎症、改善脑缺血所致的神经功能缺损。
T71827	AG-205
	(rac)-AG-205 是一种对孕激素受体膜组分1 (Pgrmc1) 的有效抑制剂，并能诱导参与甾醇合成的基因表达，这些基因涉及 INSIG1 蛋白与 PGRMC1 形成复合物的过程。(rac)-AG-205 能够抑制 NF-kB 信号及 BDNF/PI3K/AKT 通路的活化，从而防止神经元对缺氧缺血状况的抵抗。
T11240	Ethacrynic acid D5	Others	Others
	Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by...
T71285	Metaxalone-d6
	Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM. Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2 in RAW 264.7 cells. Formulations containing metaxalone ...
T74895	Anti-inflammatory agent 31
	Anti-inflammatory agent 31 是一种穿心莲内酯衍生物，是一种抗炎剂 (anti-inflammatoryagent)。Anti-inflammatory agent 31 通过上游阻断PI3K/Akt 和ERK1/2 MAPK 激活来抑制NF-kB 激活。Anti-inflammatory agent 31 能够恢复细胞内 GSH 水平并对肝脏具有保护作用。
T37449	SR 12460
	SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1It inhibits TNF-α-induced NF-κB activation in a reporter assay when used at concentrations ranging from 25 to 150 μM. It reduces LPS-induced production of IL-6 in RAW 264.7 cells. SR 12460 (30 mg/kg) improves grip strength in themdxmouse model of Duchenne muscular dystrophy. 1.Zhao, J., Zhang...

化合物

NF-κΒ activator 1

Cat.No: T39965

Target: NF-κB

NF-κΒ activator 2

Cat.No: T39924

Target: NF-κB

AP-1/NF-κB activation inhibitor 1

Cat.No: T9656

Target: NF-κB, DNA/RNA Synthesis

Cat.No: T9105

Synonym: 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-

Target: IκB/IKK, NF-κB

Cat.No: T27620

Synonym: IP 7e,IP-7e,isoxazolo-pyridinone 7e

Target: Others

Cat.No: T37559

NF-κB Inhibitor (trifluoroacetate salt)

Cat.No: T38153

Cat.No: T60357

Synonym: JEUD-38

Aurothiomalate sodium

Cat.No: T20168

Synonym: 金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate

Target: Others, PKC

Cat.No: T4543

Synonym: HMR3647,泰利霉素,Ketek,RU66647

Target: Antibacterial, Antibiotic

Cat.No: T21480

Synonym: Maleic acid, diethyl ester,DIETHYL MALEATE,马来酸二乙酯

Target: NF-κB

CBL0137 hydrochloride

Cat.No: T4361

Synonym: CBL0137,CBLC137,Curaxin 137,CBL-C137 hydrochloride,Curaxin-137 hydrochloride

Target: Others, NF-κB, p53

JTP 0819958 - HOIPIN-1

Cat.No: T8951

Target: IκB/IKK

Cat.No: T78557

Synonym: JTP0819958

Target: NF-κB

Cat.No: T8981

Synonym: WAY 169916,WAY169916

Target: NF-κB

IKKγ NBD Inhibitory Peptide acetate

Cat.No: TP1615L

Synonym: IKKγ NBD Inhibitory Peptide acetate(372146-18-4 free base)

Target: NF-κB

Cat.No: T22115

Target: NF-κB

Cat.No: T0005

Synonym: 阿司匹林,Acetylsalicylate,Acetylsalicylic Acid,邻乙酰水杨酸,ASA

Target: Mitophagy, Virus Protease, COX, Autophagy

Dexamethasone acetate

Cat.No: T0947

Synonym: Dexamethasone 21-acetate,醋酸地塞米松,Dexamethason acetate,NSC 39471

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, Annexin A, NOS, Antibacterial, Autophagy

Cat.No: T11886

Target: Others, NF-κB, LTR

Cat.No: T11096

Target: NF-κB

Cat.No: T5209

Target: IκB/IKK

Cat.No: T6964

Synonym: R848,雷西莫特,S28463

Target: HCV Protease, TLR

Cat.No: T28065

Synonym: ML-263,ML 263

Cat.No: T68729

Cat.No: T29013

Synonym: Triolex,HE-3286,HE3286

IKKγ NBD Inhibitory Peptide

Cat.No: TP1615

Anti-inflammatory agent 6

Cat.No: T63107

TLR4/NF-κB/MAPK-IN-1

Cat.No: T62359

IKKγ NBD Inhibitory Peptide TFA

Cat.No: T76024

Cat.No: T71827

Ethacrynic acid D5

Cat.No: T11240

Target: Others

Cat.No: T71285

Anti-inflammatory agent 31

Cat.No: T74895

Cat.No: T37449

Cat. No.	Product Name	Target	Signaling Pathways
T2745	18α-Glycyrrhetinic acid 18-α-甘草次酸,甘草次酸,Enoxolone,Glycyrrhetinic acid	Apoptosis; NF-κB; Proteasome	Apoptosis; NF-κB; Proteases/Proteasome; Ubiquitination
	18α-Glycyrrhetinic acid (Enoxolone) 是 NF-kB 的抑制剂和蛋白酶体的激活剂，在多细胞生物中起到促进长寿和抗聚集因子的作用。它诱导细胞凋亡。
T0335	Sodium salicylate 水杨酸钠,Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt	Apoptosis; NF-κB; COX; S6 Kinase; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; MAPK; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling
	Sodium salicylate (2-Hydroxybenzoic acid sodium salt) 是一种S6K 的抑制剂，可抑制COX-2活性。它还是一种NF-κB 抑制剂，可降低炎症基因的表达，促进老化肌肉的修复。
T5727	CAFESTOL 咖啡醇,咖啡油醇	ERK; NF-κB; COX; PGE Synthase	Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Cafestol 是咖啡特有的一种二萜，可靶向 AP-1 抑制ERK，有化学预防、抗肿瘤、保肝、抗氧化和抗炎作用。它通过抑制NF-kB 活化途径强烈的抑制 PGE2的产生，还抑制 LGE 激活的 RAW264.7 细胞中的PGE2产生和环氧合酶(COX-2)的 mRNA 表达。
T3S1692	Octahydrocurcumin	Anti-infection; NF-κB; Reactive Oxygen Species; ROS	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Octahydrocurcumin 是一种姜黄素的氢化衍生物，是姜黄素的代谢物。
T5754	Kavain	NF-κB; GABA Receptor	Membrane transporter/Ion channel; Neuroscience; NF-κB
	Kavain 是从卡瓦胡椒中分离出来的卡瓦酸内酯，可以正向调控GABAA 受体，具有抗焦虑作用。
T3000	Magnolol NSC 293099,厚朴酚,5,5'-Diallyl-2,2'-biphenyldiol	NF-κB; Retinoid Receptor; Antibacterial; PPAR; p53; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB
	Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) 是RXRα和PPARγ的激动剂，EC50值分别为 10.4 µM 和 17.7 µM。他是从厚朴的树皮中分离得到的一种木脂素。
T5660	Menthone	IL Receptor; TNF; NF-κB; Parasite	Apoptosis; Immunology/Inflammation; Microbiology/Virology; NF-κB
	Menthone 是一种从植物和薄荷油中提取的单萜，是精油的主要挥发性成分，具有抗炎和抗氧化特性。
TN6730	Epoxyazadiradione	NF-κB	NF-κB
	Epoxyazadiradione 是从印楝果实中得到的柠檬苦素。它能够可逆的、非竞争性的抑制人类、约氏疟原虫、疟原虫的互变异构酶活性。它具有抗疟原虫和人类 MIF 诱导的促炎反应的潜力。
T3913	Saikosaponin D	Estrogen Receptor/ERR; NF-κB; Antibacterial; STAT	Endocrinology/Hormones; JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells
	Saikosaponin D 是一种从柴胡中分离到的三萜皂苷类天然产物，具有抗炎，抗菌，抗肿瘤，抗过敏作用。它抑制 selectin，STAT3和 NF-kB 的活性，活化estrogen receptor-β。
T4S1540	Myrislignan	Apoptosis; NF-κB	Apoptosis; NF-κB
	Myrislignan 是一种木酚素，从Myristica fragransHoutt 分离得到，具有抗炎作用。它通过抑制NF-kB 信号通路的激活，减轻LPS 诱导的小鼠巨噬细胞炎症反应。
T3826	Polygalasaponin F 异牡荆苷,瓜子金皂苷己	NF-κB; TLR; Akt; PI3K	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。
T7979	2-Hydroxychalcone 2-(2-Hydroxybenzal)Acetophenone,2-羟基查酮	Apoptosis; BCL; Others; NF-κB	Apoptosis; NF-κB; Others
	2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) 是一种天然黄酮，可通过下调 Bcl-2 诱导凋亡，也可抑制NF-kB 的激活。它是抗氧化剂，抑制脂质过氧化，还可抑制三阴性乳腺癌细胞的侵袭。
T7190	Actein	Apoptosis; Akt; JNK; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Actein 是从升麻的根茎中分离的一种三萜糖苷，通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖，诱导自噬和凋亡。
T5687	WITHAFERIN A 醉茄素 A,醉茄素A	Ferroptosis; NF-κB	Apoptosis; NF-κB
	Withaferin A 是从南非醉茄中分离到的一种甾体内酯，是内皮蛋白 C 受体脱落抑制剂，可以抑制NF-kB 的活性，具有抗炎，抗肿瘤等作用。它是一种新型 NFkappaB 抑制剂，有望成为治疗各种炎症性疾病和癌症的新型抗炎药。
T5S0761	Nitidine chloride	Apoptosis; ERK; FAK; p38 MAPK; NF-κB; Topoisomerase; STAT; Parasite	Angiogenesis; Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的，具有抗疟疾活性。它通过多个靶点通路，起抗癌作用，抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。
T4S0969	Obtusifolin 决明蒽醌,决明蒽醌；美决明子素	Antioxidant; NF-κB	NF-κB; oxidation-reduction
	Obtusifolin 是分离自决明子的种子中，能够抑制NF-kB 通路，调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。
T83358	3-Ethylthio withaferin A
	3-Ethylthio withaferin A为Withaferin A的衍生物，具有抑制NF-kB的活性。
TN3709	Coronarin D ethyl ether	NF-κB	NF-κB
	Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis.It shows promising antifungal activity against C. albicans in vitro.
T39077	Aeruginosin 865
	Aeruginosin 865, isolated from terrestrial cyanobacterium Nostoc sp . Luke ová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation of NF-kB to the nucleus. Aeruginosin 865 has anti-inflammatory effect
TN1874	Liriodendrin 鹅掌楸苦素	ATPase; Potassium Channel; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel
	Liriodendrin 调节肺部炎症、NF-kB (p65) 的磷酸化和血管内皮生长因子 (VEGF) 的表达。Liriodendrin 具有抗炎、镇痛、降血糖活性，在脓毒症引起的急性肺损伤中起保护作用。
TN3219	7,8-Didehydrocimigenol	ERK; IκB/IKK; TNF; NF-κB; Akt; PPAR	Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of VCAM-1 expression.
T75491	3-(2-Hydroxyethyl) thio withaferin A
	3-(2-Hydroxyethyl) thio withaferin A 为Withaferin A衍生物，后者为甾体内酯，能够抑制NF-kB活性并靶向波形蛋白(vimentin)，展现出抗炎及抗肿瘤效果。此外，Withaferin A亦为内皮蛋白C受体(EPCR)脱落的抑制剂。
TN1104	Cyanidin 3-sambubioside chloride 矢车菊素-3-桑布双糖苷,Cyanidin-3-O-sambubioside chloride	NF-κB; ROS	Immunology/Inflammation; NF-κB
	Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NF-kB activity. It inhibits the enzyme activity by competing with the substrate for the active site. Cyanidin-3-O-sambubioside chloride has antioxidant activity and free-radical-scavenging p
TN4194	Heliangin	IL Receptor; TNF; NF-κB; MAPK; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB
	Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-ÎºB pathway on LPS-induced RAW 264.7 cells. Heliangin has anti-cancer activity, it exhibits cytotoxicity against human oral epidermoid (
TN5153	Torilin	MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome
	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症，它可以减轻关节炎的严重程度，改变 dLN 或关节中的白细胞活化，并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成，IC（50）值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性，它可能通过抑制肿瘤侵袭来抑制肿瘤发生，逆转癌细胞的多药耐药性，它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。

天然产物

18α-Glycyrrhetinic acid

Cat.No: T2745

Synonym: 18-α-甘草次酸,甘草次酸,Enoxolone,Glycyrrhetinic acid

Target: Apoptosis, NF-κB, Proteasome

Sodium salicylate

Cat.No: T0335

Synonym: 水杨酸钠,Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt

Target: Apoptosis, NF-κB, COX, S6 Kinase, Autophagy

Cat.No: T5727

Synonym: 咖啡醇,咖啡油醇

Target: ERK, NF-κB, COX, PGE Synthase

Octahydrocurcumin

Cat.No: T3S1692

Target: Anti-infection, NF-κB, Reactive Oxygen Species, ROS

Cat.No: T5754

Target: NF-κB, GABA Receptor

Cat.No: T3000

Synonym: NSC 293099,厚朴酚,5,5'-Diallyl-2,2'-biphenyldiol

Target: NF-κB, Retinoid Receptor, Antibacterial, PPAR, p53, Autophagy

Cat.No: T5660

Target: IL Receptor, TNF, NF-κB, Parasite

Epoxyazadiradione

Cat.No: TN6730

Target: NF-κB

Cat.No: T3913

Target: Estrogen Receptor/ERR, NF-κB, Antibacterial, STAT

Cat.No: T4S1540

Target: Apoptosis, NF-κB

Polygalasaponin F

Cat.No: T3826

Synonym: 异牡荆苷,瓜子金皂苷己

Target: NF-κB, TLR, Akt, PI3K

2-Hydroxychalcone

Cat.No: T7979

Synonym: 2-(2-Hydroxybenzal)Acetophenone,2-羟基查酮

Target: Apoptosis, BCL, Others, NF-κB

Cat.No: T7190

Target: Apoptosis, Akt, JNK, Autophagy

Cat.No: T5687

Synonym: 醉茄素 A,醉茄素A

Target: Ferroptosis, NF-κB

Nitidine chloride

Cat.No: T5S0761

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

Cat.No: T4S0969

Synonym: 决明蒽醌,决明蒽醌；美决明子素

Target: Antioxidant, NF-κB

3-Ethylthio withaferin A

Cat.No: T83358

Coronarin D ethyl ether

Cat.No: TN3709

Target: NF-κB

Aeruginosin 865

Cat.No: T39077

Cat.No: TN1874

Synonym: 鹅掌楸苦素

Target: ATPase, Potassium Channel, Prostaglandin Receptor

7,8-Didehydrocimigenol

Cat.No: TN3219

Target: ERK, IκB/IKK, TNF, NF-κB, Akt, PPAR

3-(2-Hydroxyethyl) thio withaferin A

Cat.No: T75491

Cyanidin 3-sambubioside chloride

Cat.No: TN1104

Synonym: 矢车菊素-3-桑布双糖苷,Cyanidin-3-O-sambubioside chloride

Target: NF-κB, ROS

Cat.No: TN4194

Target: IL Receptor, TNF, NF-κB, MAPK, Prostaglandin Receptor

Cat.No: TN5153

Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00351	RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc) NF-KB,ODFR,PDB2,Rank,OSTS,NFK...	Human	HEK293 Cells
	TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas. RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.85 kDa ...
TMPK-00723	RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc) CD265,Rank,FEO,ODFR,NF-KB,OSTS,TNF	Mouse	HEK293 Cells
	TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas. RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 47.0 kDa and the acce...
TMPJ-00674	RANK/TNFRSF11A Protein, Mouse, Recombinant (His) Receptor activator of NF-KB,TNFRS...	Mouse	HEK293 Cells
	Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, br...
TMPY-02387	NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST) NFKB3,p65,v-rel avian reticuloendotheliosi...	Human	E. coli
	RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-?B complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an eff...
TMPJ-00349	RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His) CD265 antigen,FEO,TRANCER,ODFR,ODFROSTS,TRANCE R,TNF	Human	HEK293 Cells
	Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutive...
TMPY-01710	IkB alpha/NFKBIA Protein, Human, Recombinant (His) IkB α,IKBA,nuclear factor of kappa light p...	Human	E. coli
	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. Also, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper function...
TMPJ-00464	APE Protein, Human, Recombinant APEX,Apurinic-Apyrimidinic Endonuclease 1,APEN,DNA-(Apurinic...	Human	E. coli
	Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down...
TMPY-01176	cIAP1 Protein, Human, Recombinant (Avi) Hiap-2,API1,HIAP2,RNF48,baculoviral IAP repeat cont...	Human	E. coli
	The cellular inhibitor of apoptosis protein-1 (cIAP1) is a member of the Inhibitor of Apoptosis family proteins are (IAP) whose members are characterized by a novel domain of about 70 amino acids termed baculoviral IAP repeats (BIRs). The BIR domains of cIAP1 and cIAP2 bind to caspases, the key effector proteases of apoptosis. The IAP protein family which can enhance cell survival are crucial regulators of programmed cell death. Both cIAP1 and cIAP2 are the E3 ubiquitin protein isopeptide ligase...
TMPH-02173	TRBC2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracell...
TMPH-02168	TRAC Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Constant region of T cell receptor (TR) alpha chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracel...
TMPH-02169	TRBC1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracell...

重组蛋白

RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc)

Cat.No: TMPK-00351

Species: Human

Expression System: HEK293 Cells

RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00723

Species: Mouse

Expression System: HEK293 Cells

RANK/TNFRSF11A Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00674

Species: Mouse

Expression System: HEK293 Cells

NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST)

Cat.No: TMPY-02387

Species: Human

Expression System: E. coli

RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)

Cat.No: TMPJ-00349

Species: Human

Expression System: HEK293 Cells

IkB alpha/NFKBIA Protein, Human, Recombinant (His)

Cat.No: TMPY-01710

Species: Human

Expression System: E. coli

APE Protein, Human, Recombinant

Cat.No: TMPJ-00464

Species: Human

Expression System: E. coli

cIAP1 Protein, Human, Recombinant (Avi)

Cat.No: TMPY-01176

Species: Human

Expression System: E. coli

TRBC2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02173

Species: Human

Expression System: E. coli

TRAC Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-02168

Species: Human

Expression System: E. coli

TRBC1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02169

Species: Human

Expression System: P. pastoris (Yeast)

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