首页工具

登录

搜索结果

Search Results for " interleukin "

199

抑制剂 & 化合物

43

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
TP1422	Interleukin (IL)-6 Receptor	Others	Others
	Interleukin (IL)-6 Receptor 是一种肽，来源于白细胞介素6受体。
T21608L	β-Interleukin I (163-171), human Acetate β-Interleukin I (163-171), human Acetate(106021-96-9 Free base)	Others	Others
	β-Interleukin I (163-171), human Acetate 是一种参与调节免疫反应、炎症反应和造血的肽。
T21048	Interleukin 1beta
	Interleukin 1beta is a bioactive chemical.
TP2261	Interleukin II (60-70)	Others	Others
	Interleukin II (60-70) is a peptide with the sequence NH2- LEU-THR-PHE-LYS-PHE-TYR-MET-PRO-LYS-LYS-ALA-COOH, MW= 1373.7. Interleukin 2 (IL-2) is a type of cytokine signaling molecule in the immune system, and it regulates the activities of the white blood
TP2178	β-Interleukin II (44-56)	Others	Others
	β-Interleukin II is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH.
T21048L	Interleukin 1beta acetate(117027-34-6 Free base)

T82060	Interleukin-6 fragment (human)
	Interleukin-6 fragment (human) 是一种多效性细胞因子，由淋巴细胞及非淋巴细胞产生。该分子的编码基因位于人类第7号染色体，长度大约为5 kb。Interleukin-6 fragment (human) 在免疫响应、急性相应、炎症过程、癌症治疗及血液造血方面均有重要的潜在应用。
T83712	Interleukin-8 (54-72) (human) TFA IL-8 (54-72),C-X-C Motif Chemokine Ligand (54-72),CXCL8 (54-72)
	Interleukin-8 (IL-8) (54-72) 对应于成熟人类IL-8序列的第54至72个氨基酸以及预处理序列的第81至99个氨基酸的肽。它抑制了初级人类中性粒细胞基于流动的黏附至人类脐静脉内皮细胞(HUVECs)。
T9913	Ustekinumab	Interleukin	Immunology/Inflammation
	Ustekinumab 是一种人源化靶向抗IL-12/IL-23的单克隆 IgG1κ 抗体。
T14367	AZ1495	IRAK; CDK; Haspin Kinase	Cell Cycle/Checkpoint; Immunology/Inflammation; NF-κB
	AZ1495 是一种口服有活性的白介素-1受体相关激酶 4(IRAK4)抑制剂，能够作用于 IRAK4 (IC50:5 nM)和 IRAK1 (IC50:23 nM)。可用于研究突变型 MYD88L265P 弥漫性 B 细胞淋巴瘤 (DLBCL) 。
T11634	IL-15-IN-1	IL Receptor; Interleukin	Immunology/Inflammation
	IL-15-IN-1是一种 IL-15依赖性细胞的选择性抑制剂(IC50:0.8 μM)。
T5641	RP-54745	Interleukin	Immunology/Inflammation
	RP-54745 是一种能抑制噬细胞刺激和的白介素-1 的产生的化合物，对风湿病的治疗具有潜在的研究价值。
T5359	RCGD423	Interleukin	Immunology/Inflammation
	RCGD423 是一种gp130调节剂，能阻断关节软骨的退化，并诱导其修复。
T4450	GIBH-130	IL Receptor; TNF; Interleukin	Apoptosis; Immunology/Inflammation
	GIBH130 是一种有效的神经炎症抑制剂，可作用于活化的小胶质细胞，明显抑制IL-1β的分泌(IC50:3.4 nM)。
T2061	APY0201	PI3K; Interleukin	Immunology/Inflammation; PI3K/Akt/mTOR signaling
	APY0201 是PIKfyve 抑制剂，能够抑制 PtdIns3P 转化为PtdIns(3,5)P2 (IC50:5.2 nM)，还能够抑制IL-12/IL-23产生。
T9962	Mepolizumab 美泊利单抗,SB 240563	IL Receptor	Immunology/Inflammation
	Mepolizumab (SB 240563) 是一种中和 IL-5 的人源化单克隆抗体。美泊利单抗可用于严重嗜酸性哮喘和嗜酸性肉芽肿伴多血管炎的研究。
T9631	IRAK-4 protein kinase inhibitor 2	IRAK	Immunology/Inflammation; NF-κB
	IRAK-4 protein kinase inhibitor 2 是有效的白介素 1 受体相关激酶 4 抑制剂，IC50为 4 μM。它在与炎症和免疫相关的疾病领域有研究价值。
T60012	HS-243	IRAK; MAPK; CDK	Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; NF-κB
	HS-243 是 IRAK-4 和 IRAK-1 的抑制剂，IC50 分别为 20 和 24 nM。 HS-243 显示出抗炎和抗癌活性。
T13375	YQ128	IL Receptor; NOD-like Receptor (NLR); NOD; Interleukin	Immunology/Inflammation; NF-κB
	YQ128 是选择性 NLRP3 炎性体抑制剂(IC50:0.30 µM)。它能显著的、选择性抑制 IL-1β的产生，但不影响 TNF-α 的产生。它能够透过血脑屏障到达中枢神经系统。它具有抗炎作用。
T3571	SU5201 NSC 247030	Others; Interleukin	Immunology/Inflammation; Others
	SU5201 (NSC 247030) 对白细胞介素 2 (IL-2) 的产生具有抑制作用。
T9448	IL-17A inhibitor 1	IL Receptor	Immunology/Inflammation
	IL-17A inhibitor 1 是 IL-17A 的抑制剂，在alphalisa assay 中的IC50为 <9.45 nM。IL-17A inhibitor 1抑制HT-29 细胞的 IC50 值为 9.3 nM。
T5110	IRAK inhibitor 6	IRAK	Immunology/Inflammation; NF-κB
	IRAK inhibitor 6 是白细胞介素-1受体相关激酶-4的抑制剂(IC50:160 nM)。
T4140	IRAK4-IN-1	IRAK	Immunology/Inflammation; NF-κB
	IRAK4-IN-1 是白细胞介素-1 受体相关激酶 4 抑制剂(IC50:7 nM)。
T5094	IRAK inhibitor 1	IRAK; JNK	Immunology/Inflammation; MAPK; NF-κB
	IRAK inhibitor 1 是IRAK-4抑制剂(IC50:216 nM)，微弱抑制 JNK-1 (IC50:3.801 μM)和 JNK-2(IC50>10 μM)。
T9911	Tocilizumab	Interleukin	Immunology/Inflammation
	Tocilizumab 是抗人白细胞介素-6 受体 (IL-6R) 的中和抗体，能够阻碍 IL-6 与 IL-6R 的结合，进而抑制经典和反式信号。它可用于研究类风湿性关节炎，对重症 COVID-19 冠状病毒病方面的研究具有显著效果。
T3133	YM-90709 YM90709,YM 90709	IL Receptor; Interleukin	Immunology/Inflammation
	YM-90709是新型的能够抑制IL-5与IL-5受体结合的拮抗剂, 。
T14778	BRD6989	IL Receptor; CDK; Interleukin	Cell Cycle/Checkpoint; Immunology/Inflammation
	BRD6989 是天然产物皮质抑素 A 的类似物，可抑制CDK8并上调IL-10，抑制重组 CDK8 或 CDK19 复合物的激酶活性。它选择性结合 CDK8 复合物，IC50约为 200 nM。
T1846	Y-320 Y320	IL Receptor; Lipase; Interleukin	Immunology/Inflammation; Metabolism
	Y-320 是一种免疫调节剂，能阻碍IL-15刺激CD4 T 细胞后的IL-17的产生，IC50=20~60 nM。
TQ0167	Zimlovisertib PF-06650833,PF06650833	IRAK	Immunology/Inflammation; NF-κB
	Zimlovisertib (PF-06650833) 是口服有活性的、可生物利用的白介素-1 受体相关激酶 4 (IRAK4) 选择性抑制剂，其IC50=0.2 nM，在 PBMC 分析中，IC50=2.4 nM。它具有研究类淋巴瘤、风湿性关节炎、狼疮等疾病的潜力。
T11673	IRAK4-IN-4	IRAK; cGAS	Immunology/Inflammation; NF-κB
	IRAK4-IN-4 （化合物 15）是白介素-1 受体相关激酶抑制剂，IC50为 2.8 nM。它还抑制环 GMP-AM 合酶，IC50为 2.1 nM。
T6207	SC144	Apoptosis; Interleukin	Apoptosis; Immunology/Inflammation
	SC144 是一种口服活性 gp130 抑制剂。它结合 gp130，诱导 gp130 磷酸化(S782) 和去糖基化，消除 Stat3 磷酸化和核易位，进一步抑制下游靶基因的表达。它对 gp130 配体触发的信号转导有明显的抑制作用，可诱导人卵巢癌细胞凋亡。
T4299	AS-2444697	IRAK	Immunology/Inflammation; NF-κB
	AS2444697 是一种口服有效的IRAK-4抑制剂，IC50为 21 nM。它对人和大鼠 IRAK-4 活性具有抑制作用。它通过抗炎作用表现出肾脏保护作用。
T9203	JH-X-119-01	IRAK	Immunology/Inflammation; NF-κB
	JH-X-119-01 是白介素 1 受体相关激酶 1 的选择性抑制剂。它能够改善 LPS 诱导的小鼠败血症。它可以抑制 IRAK1(IC50:9 nM)，在浓度达到 10 μM 时，也不会对 IRAK4 产生抑制作用。
T2018	Apilimod 阿匹莫德,阿吡莫德,STA 5326	IL Receptor; PI3K; Interleukin	Immunology/Inflammation; PI3K/Akt/mTOR signaling
	Apilimod (STA 5326) 是一种有效的、高度选择性的PIKfyve 抑制剂，是一种 IL-12/IL-23 的有效抑制剂，抑制人和猴的 PBMC 细胞中的 IL-12，IC50值为 1 nM 和 2 nM。
T0117	Suplatast (Tosilate) IPD 1151T,甲磺司特,Suplatast tosilate,Suplatast Tosylate	IL Receptor; Interleukin	Immunology/Inflammation
	Suplatast Tosilate (IPD 1151T) 是一种口服有活性的 Th2 细胞因子抑制剂，能够阻碍 Th2 细胞产生 IL-4 和 IL-5 ，并对 IgE 的合成具有抑制作用。它是一种抗过敏剂，它具有抗纤维化、抗哮喘及抗炎特性。
T14687	Deucravacitinib BMS-986165	Tyrosine Kinases; JAK; IFNAR; Interleukin	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Deucravacitinib (BMS-986165) 是一种高选择性、口服生物可利用的变构 TYK2 抑制剂，用于治疗自身免疫性疾病。它通过稳定调节 JH2 结构域来阻断受体介导的 Tyk2 激活，可抑制IL-12/23和 I 型IFN 途径。它选择性结合 TYK2 假激酶 (JH2) 结构域，IC50为1.0 nM。
T11179	Elubrixin SB-656933	IL Receptor; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Elubrixin (SB-656933) 是一种有效和特异性的 CXCR2 和 IL-8 受体拮抗剂。 Elubrixin 可用于炎症性疾病的研究，例如炎症性肠病和气道炎症。
T6761	Ossirene AS101	IL Receptor; Caspase; Interleukin	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Ossirene (AS101) 是一种免疫调节抑制剂，是一种新型 IL-1beta 转化酶抑制剂，可用于自身免疫性疾病和某些恶性肿瘤。它通过抑制IL-10消除 STAT3 的磷酸化，有效抑制Caspase-1。
T0054	Disulfiram 双硫伦,Tetraethylthiuram disulfide,双硫仑,NSC 190940,TETD	Dehydrogenase; Interleukin; Pyroptosis	Apoptosis; Immunology/Inflammation; Metabolism
	Disulfiram (TETD) 是一种乙醛脱氢酶 ALDH 的抑制剂，抑制 hALDH1 和 hALDH2 (IC50=0.15/1.45 μM)，具有特异性。Disulfiram 对酒精产生急性敏感性，还可以抑制 GSDMD 孔形成。
T3533	Apilimod mesylate 阿吡莫德甲磺酸盐,STA 5326 mesylate	IL Receptor; PI3K; Interleukin	Immunology/Inflammation; PI3K/Akt/mTOR signaling
	Apilimod mesylate (STA 5326 mesylate) 是一种 IL-12/IL-23 的有效抑制剂，抑制人和猴的 PBMC 细胞中的 IL-12的IC50值为 1 nM 和 2 nM。Apilimod 是高效的、选择性的PIKfyve 抑制剂。
T1813	VGX-1027 VGX1027,VGX 1027,GIT 27	IL Receptor; TNF; Interleukin	Apoptosis; Immunology/Inflammation
	VGX-1027 (GIT 27) 是一种口服有效的异恶唑化合物，靶向巨噬细胞，减少促炎性介质 TNF-α、IL-1β和 IL-10 的产生，具有免疫调节特性。它通过限制细胞因子介导的免疫炎症而具有抗糖尿病作用。
T5354	IRAK4-IN-7 CA-4948	IRAK	Immunology/Inflammation; NF-κB
	IRAK4-IN-7 (CA-4948) 是白介素 1 受体相关激酶 4 (IRAK4) 的选择性抑制剂，口服有活性。它可用于研究癌症以及炎症疾病。
T4403	AX-024 hydrochloride AX-024 HCl	IL Receptor; TNF; COX; IFNAR; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience
	AX-024 hydrochloride (AX-024 HCl) 是一种细胞因子释放抑制剂，可强烈抑制 IL-6、TNFα、IFN-γ、IL-10 和 IL-17A 的产生。它是口服可利用的 TCR-Nck 相互作用抑制剂，可选择性地抑制 TCR 触发的 T 细胞活化。它通过靶向 SH3结构域调节细胞信号传导，具有低毒、高效和高选择性的特点。
T7649	Tyrphostin A1 AG9,(4-甲氧基苄烯)丙二腈,Tyrphostin 1	EGFR; Interleukin	Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin A1 (Tyrphostin 1) 对巨噬细胞培养中CD40L 刺激的IL-12产生和抗原诱导的Th1细胞生成具有抑制作用。
T9027	CA-4948 Emavusertib	IRAK; FLT	Angiogenesis; Immunology/Inflammation; NF-κB; Tyrosine Kinase/Adaptors
	CA-4948 (Emavusertib) 是一种IRAK4抑制剂，也是一种FLT3抑制剂，具有抗肿瘤作用。
T21389	Enprofylline Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum,恩丙茶碱	Others	Others
	Enprofylline (Enprofilina) 是具有选择性的 A2B 受体竞争性拮抗剂 (Ki:7 μM) ，也是磷酸二酯酶抑制剂。它可用于研究哮喘、慢性阻塞性肺疾病。
T4615	Balsalazide sodium hydrate 巴柳氮钠水合物,Balsalazide disodium dihydrate,巴柳氮钠,Balsalazide disodium salt dihydrate,Balsalazide disodium	STAT; Interleukin	Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Balsalazide sodium hydrate (Balsalazide disodium) 可通过调节IL-6/STAT3通路起抑癌作用，可用于治疗炎症性肠病。
T2601	Vidofludimus SC12267,4sc-101	Dehydrogenase; DNA/RNA Synthesis; Interleukin	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism
	Vidofludimus (SC12267) 是一种新型的二氢乳清酸脱氢酶 (DHODH) 小分子抑制剂，可在不影响淋巴细胞增殖的条件下抑制IL-17的分泌。
T8867	RO2959 Hydrochloride RO2959 HCl	IL Receptor; Calcium Channel; Interleukin	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	RO2959 Hydrochloride (RO2959 HCl) 是选择性CRAC 通道抑制剂，IC50为 402 nM。它是人IL-2产生的有效抑制剂，有效阻断 T 细胞受体触发的基因表达和 T 细胞功能途径。它是由Orai1/Stim1通道介导的钙存储进入的有效阻滞剂，IC50为 25 nM。
T9157	GP130 receptor agonist-1 N-(4-Fluorophenyl)-4-phenyl-2-thiazolami	Interleukin	Immunology/Inflammation
	GP130 receptor agonist-1 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami) 是一种有效的、口服有活性的、可透过血脑屏障的 GP130受体激动剂。它对 NMDA 诱导的神经毒性具有神经保护作用。

化合物

Interleukin (IL)-6 Receptor

Cat.No: TP1422

Target: Others

β-Interleukin I (163-171), human Acetate

Cat.No: T21608L

Synonym: β-Interleukin I (163-171), human Acetate(106021-96-9 Free base)

Target: Others

Interleukin 1beta

Cat.No: T21048

Interleukin II (60-70)

Cat.No: TP2261

Target: Others

β-Interleukin II (44-56)

Cat.No: TP2178

Target: Others

Interleukin 1beta acetate(117027-34-6 Free base)

Cat.No: T21048L

Interleukin-6 fragment (human)

Cat.No: T82060

Interleukin-8 (54-72) (human) TFA

Cat.No: T83712

Synonym: IL-8 (54-72),C-X-C Motif Chemokine Ligand (54-72),CXCL8 (54-72)

Cat.No: T9913

Target: Interleukin

Cat.No: T14367

Target: IRAK, CDK, Haspin Kinase

Cat.No: T11634

Target: IL Receptor, Interleukin

Cat.No: T5641

Target: Interleukin

Cat.No: T5359

Target: Interleukin

Cat.No: T4450

Target: IL Receptor, TNF, Interleukin

Cat.No: T2061

Target: PI3K, Interleukin

Cat.No: T9962

Synonym: 美泊利单抗,SB 240563

Target: IL Receptor

IRAK-4 protein kinase inhibitor 2

Cat.No: T9631

Target: IRAK

Cat.No: T60012

Target: IRAK, MAPK, CDK

Cat.No: T13375

Target: IL Receptor, NOD-like Receptor (NLR), NOD, Interleukin

Cat.No: T3571

Synonym: NSC 247030

Target: Others, Interleukin

IL-17A inhibitor 1

Cat.No: T9448

Target: IL Receptor

IRAK inhibitor 6

Cat.No: T5110

Target: IRAK

Cat.No: T4140

Target: IRAK

IRAK inhibitor 1

Cat.No: T5094

Target: IRAK, JNK

Cat.No: T9911

Target: Interleukin

Cat.No: T3133

Synonym: YM90709,YM 90709

Target: IL Receptor, Interleukin

Cat.No: T14778

Target: IL Receptor, CDK, Interleukin

Cat.No: T1846

Synonym: Y320

Target: IL Receptor, Lipase, Interleukin

Cat.No: TQ0167

Synonym: PF-06650833,PF06650833

Target: IRAK

Cat.No: T11673

Target: IRAK, cGAS

Cat.No: T6207

Target: Apoptosis, Interleukin

Cat.No: T4299

Target: IRAK

Cat.No: T9203

Target: IRAK

Cat.No: T2018

Synonym: 阿匹莫德,阿吡莫德,STA 5326

Target: IL Receptor, PI3K, Interleukin

Suplatast (Tosilate)

Cat.No: T0117

Synonym: IPD 1151T,甲磺司特,Suplatast tosilate,Suplatast Tosylate

Target: IL Receptor, Interleukin

Deucravacitinib

Cat.No: T14687

Synonym: BMS-986165

Target: Tyrosine Kinases, JAK, IFNAR, Interleukin

Cat.No: T11179

Synonym: SB-656933

Target: IL Receptor, CXCR

Cat.No: T6761

Synonym: AS101

Target: IL Receptor, Caspase, Interleukin

Cat.No: T0054

Synonym: 双硫伦,Tetraethylthiuram disulfide,双硫仑,NSC 190940,TETD

Target: Dehydrogenase, Interleukin, Pyroptosis

Apilimod mesylate

Cat.No: T3533

Synonym: 阿吡莫德甲磺酸盐,STA 5326 mesylate

Target: IL Receptor, PI3K, Interleukin

Cat.No: T1813

Synonym: VGX1027,VGX 1027,GIT 27

Target: IL Receptor, TNF, Interleukin

Cat.No: T5354

Synonym: CA-4948

Target: IRAK

AX-024 hydrochloride

Cat.No: T4403

Synonym: AX-024 HCl

Target: IL Receptor, TNF, COX, IFNAR, Interleukin

Cat.No: T7649

Synonym: AG9,(4-甲氧基苄烯)丙二腈,Tyrphostin 1

Target: EGFR, Interleukin

Cat.No: T9027

Synonym: Emavusertib

Target: IRAK, FLT

Cat.No: T21389

Synonym: Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum,恩丙茶碱

Target: Others

Balsalazide sodium hydrate

Cat.No: T4615

Synonym: 巴柳氮钠水合物,Balsalazide disodium dihydrate,巴柳氮钠,Balsalazide disodium salt dihydrate,Balsalazide disodium

Target: STAT, Interleukin

Cat.No: T2601

Synonym: SC12267,4sc-101

Target: Dehydrogenase, DNA/RNA Synthesis, Interleukin

RO2959 Hydrochloride

Cat.No: T8867

Synonym: RO2959 HCl

Target: IL Receptor, Calcium Channel, Interleukin

GP130 receptor agonist-1

Cat.No: T9157

Synonym: N-(4-Fluorophenyl)-4-phenyl-2-thiazolami

Target: Interleukin

Cat. No.	Product Name	Target	Signaling Pathways
TN4379	Kansuinine A	IL Receptor; STAT; Interleukin	Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Kansuinine A 对IL-6 诱导的 Stat3激活有作用。Kansuinine A 显示出抗病毒和抗肿瘤活性。
T2S0342	Armillarisin A	Others; Interleukin	Immunology/Inflammation; Others
	Armillarisin A 具有上调 IL-4和下调 IL-1β 的效果，对溃疡性结肠炎具有潜在的研究价值。
T40660	Kansuinine B	IL Receptor; SARS-CoV	Immunology/Inflammation; Microbiology/Virology
	Kansuinine B 抑制由 IL-6 诱导的 Stat3 活化。 Kansuinine B 具有抗病毒活性，可用于 COVID-19 研究。
T8033	Sodium Thiocyanate	Others; Reactive Oxygen Species; Interleukin	Immunology/Inflammation; Metabolism; NF-κB; Others
	Sodium thiocyanate 能够减少促炎细胞因子 IL-6水平，并增强抗炎细胞因子 IL-10水平，并显著减少 ROS 形成。
T1273	Diacerein 双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein	IL Receptor; Interleukin	Immunology/Inflammation
	Diacerein (Fisiodar) 是一种慢效具有白介素-1β 抑制效果的蒽醌类化合物。
T6S1597	Mulberroside A 桑皮苷 A,桑皮苷A	TNF; Tyrosinase; Interleukin	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Mulberroside A 是桑中的一种主要活性成分，可降低TNF-α、IL-1β和IL-6的表达，抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化。它抑制蘑菇酪氨酸酶，具有抗炎和抗细胞凋亡作用。
T2791	Pectolinarin 柳穿鱼叶苷,大蓟苷	Apoptosis; Others; NO Synthase; Prostaglandin Receptor; Interleukin	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Others
	Pectolinarin 抑制 IL-6和 IL-8分泌以及 PGE2和 NO 产生，可通过抑制 PI3K/Akt 途径来抑制细胞增殖和炎症反应并诱导凋亡，具有抗炎活性。
TQ0218	Deoxyandrographolide 去氧穿心莲内酯,14-deoxyandrographolide	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Deoxyandrographolide (14-deoxyandrographolide) 抑制 LPS 诱导的 iNOS mRNA 水平升高以及促炎症介质 TNF-α 和 IL-6 的产生。它增强 NGF 诱导的神经突起生长。
TN1189	13-Methylberberine chloride 13-甲基小檗碱,13-Methylberberine	Others	Others
	13-Methylberberine chloride 是一种黄连素类似物，可增加 IL-12 的产生，并在 LPS 激活的巨噬细胞转录后抑制 iNOS 的表达，具有抗脂肪和抗肿瘤作用。
T3829	Ginsenoside F3 人参皂苷F3	Others; IFNAR; Interleukin	Immunology/Inflammation; Others
	Ginsenoside F3 是一种皂苷，提取自Panax ginseng 叶片。它能够调节1 型 (IL-2, IFN-γ) 及 2 型细胞因子(IL-4 and IL-10) 的产生和表达，有免疫增强的作用。
T4S1521	1,4-Dicaffeoylquinic acid 1,4-二咖啡酰奎宁酸,洋蓟素	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	1,4-Dicaffeoylquinic acid 是一种苯丙素类物质，从苍耳子中获得，可以减少 LPS 诱导的 TNF-α 的生成，具有抗炎活性。
T8280	Deacetylasperulosidic Acid 去乙酰基车叶草苷酸,去乙酰车叶草苷酸,Desacetyl asperulosidic acid	IL Receptor; Interleukin	Immunology/Inflammation
	Deacetylasperulosidic Acid 是海巴戟果实的主要植物化学成分。它能够防止体外 4-硝基喹啉1-氧化物诱导的 DNA 损伤，抑制 IL-2的产生以及自然杀伤细胞的活化。它具有抗原活性，抑制仓鼠卵巢细胞和小鼠中染色体畸变的诱导。它可增加超氧化物歧化酶活性，从而具有抗氧化活性。
T6S2140	β-Anhydroicaritin Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素	MMP; Others; TNF; Interleukin	Apoptosis; Immunology/Inflammation; Others; Proteases/Proteasome
	β-Anhydroicaritin 是从乳香提取的一种天然产物，具有重要的生物学和药理学作用，如抗骨质疏松症，雌激素调节和抗肿瘤特性。它改善牙周组织的降解，抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。它抑制细胞内 Ca2+的升高，并显著降低 iNOS 蛋白的表达。
T2720	Ginsenoside Rc Panaxoside Rc,人参皂苷Rc,人参皂苷 Rc	Others; TNF; GABA Receptor; Interleukin	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Others
	Ginsenoside Rc (Panaxoside Rc) 是人参中的一种人参皂苷，可抑制 TNF-α 和 IL-1β 的表达。它增强 GABA 受体 A 介导的离子通道电流。
T7786	Tryptanthrin	DNA gyrase	DNA Damage/DNA Repair
	Tryptanthrin 是一种口服具有活性的细胞内Leukotriene (LT) biosynthesis 抑制剂。它能够降低大鼠胸膜炎模型中的 LTB4 水平，并抑制人全血中Leukotriene 的形成 (IC50= 10 µM)。
T2S0843	Negletein 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor; TNF; NOS; Interleukin	Apoptosis; Immunology/Inflammation
	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
TN6796	2'-FUCOSYLLACTOSE 2'-Fucosyl-D-lactose,2'-岩藻糖基乳糖	Others	Others
	2'-FUCOSYLLACTOSE (2'-Fucosyl-D-lactose) 是一种含岩藻糖的寡糖。
T2893	Muscone 3-Methylcyclopentadecanone,Methylexaltone,麝香酮	MMP; TNF; NF-κB; NOD-like Receptor (NLR); P-gp; Interleukin	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; NF-κB; Proteases/Proteasome
	Muscone (3-Methylcyclopentadecanone) 是中药麝香的一种主要活性单体。它抑制NF-κB 和NLRP3炎性小体的活化，显著降低炎性细胞因子水平，并最终改善心脏功能和存活率。
T2758	Madecassic acid 6-Deoxy-L-Galactose,羟基积雪草酸,L-Fucose,Brahmic acid,L-fucopyranose	Others; TNF; COX; NO Synthase; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience; Others
	Madecassic acid (L-fucopyranose) 是分离自积雪草的一种天然产物，抑制iNOS、COX-2、TNF-α、IL-1beta 和IL-6，可通过在 RAW 264.7 巨噬细胞中下调NF-κB 激活而具有抗炎作用。
T6S1538	Neochlorogenic acid 新绿原酸,trans-5-O-Caffeoylquinic acid,Neochlorogenate,金银花,5-O-Caffeoylquinic acid	TNF; NF-κB; COX; Antibacterial; Interleukin	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB
	Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) 是在干果和其他植物中发现的一种多酚类天然产物，可抑制iNOS 和COX-2蛋白表达，抑制TNF-α和IL-1β产生，还抑制磷酸化的NF-κB p65和p38 MAPK 活化。
TN1291	7,3',4'-Tri-O-methylluteolin 5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚	TNF; COX; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience
	7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) 是来自草药马鞭草科的一种类黄酮，具有抗炎，解热，镇咳，抗糖尿病、抗癌和抗黑素生成特性。它以浓度依赖方式明显抑制促炎细胞因子，可显著降低在转录水平的诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。
T2822	Ginsenoside Rb1 Gypenoside Ⅲ,人参皂苷Rb1,人参皂苷 Rb1,Gypenoside III	ATPase; Mitophagy; IRAK; NF-κB; Autophagy; HSV	Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; NF-κB
	Ginsenoside Rb1 (Gypenoside Ⅲ) 是中药人参的成分，可能具有抑制或阻止肿瘤生长的特性。
T2932	Ginsenoside Rh1 Sanchinoside B2,人参皂苷 Rh1,人参皂苷Rh1,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1	IL Receptor; TNF; Endogenous Metabolite; PPAR; Interleukin	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism
	Ginsenoside Rh1 (Sanchinoside B2) 是人参的一种主要成分，具有抗炎作用，抑制PPAR-γ，TNF-α，IL-6和IL-1β的表达。
TN1818	Kaempferol 3-O-β-D-glucuronide Kaempferol-3-O-glucuronide,Kaempferol-3-beta-O-glucuronide,山奈酚葡萄糖醛酸苷,Kaempferol-3-glucuronide	IL Receptor	Immunology/Inflammation
	Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-beta-O-glucuronide) 具有抗氧化活性。类黄酮葡糖苷酸可以被来自各种人体细胞的微粒体 α2-葡糖苷酸酶解偶联。
T7210	Guanosine 5'-diphosphate GDP,鸟苷-5ˊ-二磷酸	Endogenous Metabolite	Metabolism
	Guanosine 5'-diphosphate (GDP) 是核苷二磷酸，是潜在的铁动员剂，能够阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6 (IL-6)/stat-3 途径。
T5660	Menthone	IL Receptor; TNF; NF-κB; Parasite	Apoptosis; Immunology/Inflammation; Microbiology/Virology; NF-κB
	Menthone 是一种从植物和薄荷油中提取的单萜，是精油的主要挥发性成分，具有抗炎和抗氧化特性。
T1168	Desonide Tridesilon,地索奈德,Locapred,Prednacinolone	Glucocorticoid Receptor	Endocrinology/Hormones
	Desonide (Prednacinolone) 是一种非氟化皮质类固醇抗炎剂，能够作用于糖皮质激素受体。
T5680	Aloin(mixture of A&B) 芦荟素,葡糖基蒽酮,芦荟大黄素甙,芦荟苷	MMP; IL Receptor; Antibacterial; Antifungal	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Aloin (mixture of A&B) 是一种从芦荟中分离出来的蒽醌衍生物。它是刺激性粒细胞基质金属蛋白酶的有效抑制剂。它具有多种生物活性，如抗炎、抗菌、抗真菌、抗氧化、抗肿瘤、抗糖尿病和免疫活性。
TN1416	Ayanin	IL Receptor; P450; PARP; PDE	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism
	Ayanin 是从Croton schiedeanus Schlecht 中分离得到的黄酮类物质。它是非选择性的磷酸二酯酶抑制剂，在呼吸道疾病中有研究的价值，如过敏性哮喘等。
T1257	Bestatin Ubenimex,乌苯美司	Others; Aminopeptidase; Antibacterial; Antibiotic; LTR	Immunology/Inflammation; Metabolism; Microbiology/Virology; Others
	Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，可用于癌症研究。
T3S0364	L-Arginine L-精氨酸,L-Arg,(S)-(+)-Arginine	IL Receptor; Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism
	L-Arginine (L-Arg) 是内皮型一氧化氮合酶(eNOS) 的底物。L-Arginine 通过阳离子氨基酸转运体家族转运到血管平滑肌细胞，并被代谢成一氧化氮、多胺或 L-脯氨酸。
T6S1579	Monotropein 水晶兰苷,Monotropeine	Others	Others
	Monotropein (Monotropeine) 是从Morinda officinalis 中获得，能够抑制硫酸葡聚糖硫酸钠诱导的结肠炎小鼠模型中炎性因子的表达。
T3926	Echinatin 刺甘草查尔酮,Retrochalcone	Free radical scavengers	oxidation-reduction
	Echinatin (Retrochalcone) 是分离自中草药甘草中，具有保肝和抗炎活性。在大鼠中，它可以被快速吸收和消除，并广泛分布，绝对生物利用度约为 6.81％。
T0798	Triamcinolone Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone	Glucocorticoid Receptor; COX	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
	Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂，也是一种合成的长效糖皮质激素，具有抗炎活性。
T2S2264	Linalool Linalol,(±)-Linalool,Phantol,沉香醇	Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物，是竞争性NMDA 受体拮抗剂，具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤，具有镇痛、抗菌和抗炎的特性。
TN5187	Triptoquinone B	IL Receptor	Immunology/Inflammation
	Triptoquinone B is a novel interleukin-1 inhibitor, shows extremely potent inhibitory activities against interleukin-lα and β releases for human peripheral mononticlear cells, it shows the significant immunosuppressive activity.
TMA2576	Episappanol	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α).
TN3603	Carpinontriol B	IL Receptor; Antifection	Immunology/Inflammation; Microbiology/Virology
	Carpinontriol B has antimicrobial activity, it at 40 ug/disk caused the formation of zones of inhibition. It also has anti-inflammatory activity, it shows considerable inhibition on the production of nitric oxide and reduces the production of interleukin-6 in dose-dependent manner in RAW 264.7 cells.
TN5186	Triptoquinone A	IL Receptor; NOS	Immunology/Inflammation
	Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammatory activity, it prevents ndotoxin-or interleukin-1 beta-promoted induction of nitric oxide synth
TN4190	Hedycoronen A	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC(50) ranging from 4.1±0.2 to 9.1±0.3 uM, they also show moderate inhibitory activity on
TN5474	Bonducellin
	Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bonducellin shows weak antimalarial ac
TN4490	Manassantin B	ERK; BCL; p38 MAPK; TNF; NF-κB; JNK; STAT; Antifection	Apoptosis; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells
	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in pa...
TN4592	Murrangatin	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line,

天然产物

Cat.No: TN4379

Target: IL Receptor, STAT, Interleukin

Cat.No: T2S0342

Target: Others, Interleukin

Cat.No: T40660

Target: IL Receptor, SARS-CoV

Sodium Thiocyanate

Cat.No: T8033

Target: Others, Reactive Oxygen Species, Interleukin

Cat.No: T1273

Synonym: 双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein

Target: IL Receptor, Interleukin

Cat.No: T6S1597

Synonym: 桑皮苷 A,桑皮苷A

Target: TNF, Tyrosinase, Interleukin

Cat.No: T2791

Synonym: 柳穿鱼叶苷,大蓟苷

Target: Apoptosis, Others, NO Synthase, Prostaglandin Receptor, Interleukin

Deoxyandrographolide

Cat.No: TQ0218

Synonym: 去氧穿心莲内酯,14-deoxyandrographolide

Target: IL Receptor, TNF

13-Methylberberine chloride

Cat.No: TN1189

Synonym: 13-甲基小檗碱,13-Methylberberine

Target: Others

Cat.No: T3829

Synonym: 人参皂苷F3

Target: Others, IFNAR, Interleukin

1,4-Dicaffeoylquinic acid

Cat.No: T4S1521

Synonym: 1,4-二咖啡酰奎宁酸,洋蓟素

Target: HIV Protease

Deacetylasperulosidic Acid

Cat.No: T8280

Synonym: 去乙酰基车叶草苷酸,去乙酰车叶草苷酸,Desacetyl asperulosidic acid

Target: IL Receptor, Interleukin

β-Anhydroicaritin

Cat.No: T6S2140

Synonym: Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素

Target: MMP, Others, TNF, Interleukin

Cat.No: T2720

Synonym: Panaxoside Rc,人参皂苷Rc,人参皂苷 Rc

Target: Others, TNF, GABA Receptor, Interleukin

Cat.No: T7786

Target: DNA gyrase

Cat.No: T2S0843

Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

2'-FUCOSYLLACTOSE

Cat.No: TN6796

Synonym: 2'-Fucosyl-D-lactose,2'-岩藻糖基乳糖

Target: Others

Cat.No: T2893

Synonym: 3-Methylcyclopentadecanone,Methylexaltone,麝香酮

Target: MMP, TNF, NF-κB, NOD-like Receptor (NLR), P-gp, Interleukin

Madecassic acid

Cat.No: T2758

Synonym: 6-Deoxy-L-Galactose,羟基积雪草酸,L-Fucose,Brahmic acid,L-fucopyranose

Target: Others, TNF, COX, NO Synthase, Interleukin

Neochlorogenic acid

Cat.No: T6S1538

Synonym: 新绿原酸,trans-5-O-Caffeoylquinic acid,Neochlorogenate,金银花,5-O-Caffeoylquinic acid

Target: TNF, NF-κB, COX, Antibacterial, Interleukin

7,3',4'-Tri-O-methylluteolin

Cat.No: TN1291

Synonym: 5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚

Target: TNF, COX, Interleukin

Ginsenoside Rb1

Cat.No: T2822

Synonym: Gypenoside Ⅲ,人参皂苷Rb1,人参皂苷 Rb1,Gypenoside III

Target: ATPase, Mitophagy, IRAK, NF-κB, Autophagy, HSV

Ginsenoside Rh1

Cat.No: T2932

Synonym: Sanchinoside B2,人参皂苷 Rh1,人参皂苷Rh1,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1

Target: IL Receptor, TNF, Endogenous Metabolite, PPAR, Interleukin

Kaempferol 3-O-β-D-glucuronide

Cat.No: TN1818

Synonym: Kaempferol-3-O-glucuronide,Kaempferol-3-beta-O-glucuronide,山奈酚葡萄糖醛酸苷,Kaempferol-3-glucuronide

Target: IL Receptor

Guanosine 5'-diphosphate

Cat.No: T7210

Synonym: GDP,鸟苷-5ˊ-二磷酸

Target: Endogenous Metabolite

Cat.No: T5660

Target: IL Receptor, TNF, NF-κB, Parasite

Cat.No: T1168

Synonym: Tridesilon,地索奈德,Locapred,Prednacinolone

Target: Glucocorticoid Receptor

Aloin(mixture of A&B)

Cat.No: T5680

Synonym: 芦荟素,葡糖基蒽酮,芦荟大黄素甙,芦荟苷

Target: MMP, IL Receptor, Antibacterial, Antifungal

Cat.No: TN1416

Target: IL Receptor, P450, PARP, PDE

Cat.No: T1257

Synonym: Ubenimex,乌苯美司

Target: Others, Aminopeptidase, Antibacterial, Antibiotic, LTR

Cat.No: T3S0364

Synonym: L-精氨酸,L-Arg,(S)-(+)-Arginine

Target: IL Receptor, Endogenous Metabolite, NO Synthase

Cat.No: T6S1579

Synonym: 水晶兰苷,Monotropeine

Target: Others

Cat.No: T3926

Synonym: 刺甘草查尔酮,Retrochalcone

Target: Free radical scavengers

Cat.No: T0798

Synonym: Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone

Target: Glucocorticoid Receptor, COX

Cat.No: T2S2264

Synonym: Linalol,(±)-Linalool,Phantol,沉香醇

Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR

Triptoquinone B

Cat.No: TN5187

Target: IL Receptor

Cat.No: TMA2576

Target: IL Receptor, TNF

Carpinontriol B

Cat.No: TN3603

Target: IL Receptor, Antifection

Triptoquinone A

Cat.No: TN5186

Target: IL Receptor, NOS

Cat.No: TN4190

Target: IL Receptor, TNF

Cat.No: TN5474

Cat.No: TN4490

Target: ERK, BCL, p38 MAPK, TNF, NF-κB, JNK, STAT, Antifection

Cat.No: TN4592

Target: IL Receptor, TNF, COX, Prostaglandin Receptor

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼