Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GP130 receptor agonist-1 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami) 是一种有效的、口服有活性的、可透过血脑屏障的 GP130受体激动剂。它对 NMDA 诱导的神经毒性具有神经保护作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 266 | 现货 | ||
2 mg | ¥ 392 | 现货 | ||
5 mg | ¥ 690 | 现货 | ||
10 mg | ¥ 1,120 | 现货 | ||
25 mg | ¥ 2,180 | 现货 | ||
50 mg | ¥ 3,960 | 现货 | ||
100 mg | ¥ 5,650 | 现货 | ||
200 mg | ¥ 7,690 | 现货 | ||
500 mg | ¥ 11,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 796 | 现货 |
产品描述 | GP130 receptor agonist-1 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami) is a potent, brain-penetrant and orally active GP130 receptor agonist. |
体外活性 | Compound 2 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami) treatment showed a 2-fold increase in phosphorylation of STAT3 within 10 min at its regulatory Tyr705 site in SH-SY5Y cells.. Compound 2 treatment increases phosphorylation of AKT at its regulatory Thr308 site and phosphorylation of ERK1/2 at its regulatory Thr202/Tyr204 site in the serum free media condition in SH-SY5Y cells, and in primary cortical neurons. |
体内活性 | For Compound 2 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami), mice are dosed orally at 10 or 30 mg/kg, or injected subcutaneously (SQ) at 10 mg/kg, and euthanized after 1, 2, 4, 6, and 8 h post dose. At 2 h after SQ delivery at 10 mg/kg the brain Cmax is 161 ng/g while dosing at 30 mg/kg orally, results in the brain Cmax of 156 ng/g (0.57 μM). The brain to plasma ratio for 2 is ~4:1 for oral 30 mg/kg and ~7.5:1 for 10 mg/kg SQ injection. |
别名 | N-(4-Fluorophenyl)-4-phenyl-2-thiazolami |
分子量 | 270.32 |
分子式 | C15H11FN2S |
CAS No. | 339303-87-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (203.46 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.6993 mL | 18.4966 mL | 36.9932 mL | 92.483 mL |
5 mM | 0.7399 mL | 3.6993 mL | 7.3986 mL | 18.4966 mL | |
10 mM | 0.3699 mL | 1.8497 mL | 3.6993 mL | 9.2483 mL | |
20 mM | 0.185 mL | 0.9248 mL | 1.8497 mL | 4.6241 mL | |
50 mM | 0.074 mL | 0.3699 mL | 0.7399 mL | 1.8497 mL | |
100 mM | 0.037 mL | 0.185 mL | 0.3699 mL | 0.9248 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
GP130 receptor agonist-1 339303-87-6 Immunology/Inflammation Interleukin neuroprotective Inhibitor penetrant NMDA inhibit GP-130 receptor agonist-1 brain Interleukin Related N-(4-Fluorophenyl)-4-phenyl-2-thiazolami GP130 receptor agonist1 GP130 GP130 receptor agonist 1 inhibitor