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Search Results for " type 1 diabetes "

112

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21729	(±)-Lisofylline	Others	Others
	(±)-Lisofylline 是一种对映异构体特异性、烷基取代的甲基黄嘌呤，在下调白细胞活化方面具有特异性和有效的活性。它是一种抗炎剂。
T0740	Metformin hydrochloride Metformin HCl,盐酸二甲双胍,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride	Mitophagy; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) 是一种抗糖尿病药物，抑制结肠、前列腺等多种 Y 细胞的增殖，具有作为抗 Y 药物的潜在功能。它可以透过血脑屏障，诱导自噬。
T22276	Bis(maltolato)oxovanadium(IV) 双(麦芽醇)氧钒(IV),BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)	Phosphatase; Others	Metabolism; Others
	Bis(maltolato)oxovanadium(IV) (BMOV) 是一种有效的胰岛素增敏剂，也是一种有效的、竞争性的、可逆的、口服具有活性的光谱蛋白酪氨酸磷酸酶 (PTP) 抑制剂。它抑制HCPTPA，PTP1B，HPTPβ和SHP2的IC50分别为 126 nM，109 nM，26 nM 和 201 nM。
T71394	BMS-823778
	BMS-823778 is an orally available potent and selective inhibitor of 11-β-hydroxysteroid-dehydrogenase 1 (11βHSD-1). BMS-823778 is a potential therapeutic agent for type 2 diabetes mellitus (T2DM).
T19850L	Semaglutide Acetate 索玛鲁肽醋酸盐,Semaglutide Acetate(910463-68-2 Free base)	Glucagon Receptor	GPCR/G Protein
	Semaglutide Acetate 是胰高血糖素样肽 1 (GLP-1) 受体的激动剂，可用于治疗 2 型糖尿病的研究。
T11408	Orforglipron LY3502970,GLP-1 receptor agonist 1	Glucagon Receptor	GPCR/G Protein
	Orforglipron (LY3502970; GLP-1 receptor agonist 1) 是一种可口服的胰高血糖素样肽 (GLP-1) 受体激动剂，可用于研究成人肥胖和1型糖尿病。
T40187	GNF2133	DYRK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	GNF2133 是一种有效的特异性 DYRK1A 抑制剂，IC50 为 6.2 nM。 GNF2133 可用于关于 1 型糖尿病的研究。
TP1469	Lixisenatide acetate (320367-13-3 free base) Lixisenatide acetate	Glucagon Receptor	GPCR/G Protein
	Lixisenatide acetate 是一种胰高血糖素样肽 1 受体的激动剂，可用于研究 2 型糖尿病。
T8511	TM38837	Cannabinoid Receptor	GPCR/G Protein
	TM38837 是外周选择性大麻素受体1型受体拮抗剂。它减少精神病副作用的倾向。它对大脑的渗透率有限，以降低或防止 CNS 不良反应，并保留潜在的抗肥胖作用。
T4654	(±)-Ibipinabant (±)-BMS6462,SLV319,(±)-SLV319	Cannabinoid Receptor	GPCR/G Protein
	(±)-Ibipinabant ((±)-SLV319) 是一种有效选择性的大麻素-1 (CB-1) 受体拮抗剂，IC50=22 nM。(±)-SLV319 是 SLV319的消旋体。
TP1796	Albiglutide TFA (782500-75-8 free base) Albiglutide TFA	Glucagon Receptor	GPCR/G Protein
	Albiglutide TFA (782500-75-8 free base) (Albiglutide TFA) 是一种长效 GLP-1 受体激动剂，用于治疗 2 型糖尿病 (T2DM)。
T62512	IHMT-MST1-58	Hippo pathway	Stem Cells
	IHMT-MST1-58 是一种 STE20-like protein 1 kinase (MST1) 抑制剂（IC50 ：23 nM），具有高效性、选择性和口服活性。IHMT-MST1-58 可用于研究 1 型或 2 型糖尿病。
T27439	GS-9667 CVT-3619,CVT 3619	Adenosine Receptor	GPCR/G Protein; Neuroscience
	GS-9667是一种A（1）腺苷受体（AR）的选择性部分激动剂，通过降低游离脂肪酸（FFA）可有效治疗2型糖尿病（T2DM）和血脂异常。
T76763	Teplizumab PRV-031,MGA-031	Others	Others
	Teplizumab (MGA-031) 是一种针对 CD3 的人源化单克隆抗体，可减缓 β 细胞的功能丧失。Teplizumab 可用于治疗 1 型糖尿病。
T24905	TT01001 TT-01001,TT 01001,Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate	Mitochondrial Metabolism	Metabolism
	TT01001 (Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate) 是 mitoNEET 的选择性激动剂，通过改善线粒体功能障碍来减少氧化应激损伤和神经元凋亡。 TT01001可用于治疗 II 型糖尿病的研究。
T21694	(R)-Lisofylline (R)-Lisophylline	STAT	JAK/STAT signaling; Stem Cells
	(R)-Lisofylline ((R)-Lisophylline) 是溶血磷脂酸酰基转移酶的抑制剂 (IC50 = 0.6 µM)。 (R)-Lisofylline 可中断 IL-12 信号介导的 STAT4 激活，可用于治疗 1 型糖尿病和自身免疫性疾病的研究。
T14283	amyloid P-IN-1	Beta Amyloid	Neuroscience
	amyloid P-IN-1 可用于研究血清淀粉样蛋白 P 成分耗尽的疾病，例如阿尔茨海默病、淀粉样变性、骨关节炎和 2 型糖尿病。
T61483	GLP-1R modulator C5	Glucagon Receptor	GPCR/G Protein
	GLP-1R modulator C5 是一种小分子 GLP-1R 正变构调节剂，通过跨膜位点增强GLP-1与GLP-1R的结合，可用于研究 II 型糖尿病。。
T63569	HSD-016
	HSD-016 是选择性的、有效的、口服具有活力的 1 型 11β-羟类固醇脱氢酶（11β-HSD1）抑制剂，能够作用于人 11β-HSD1 (IC50: 11 nM)、小鼠 11β-HSD1 (IC50: 1 nM)、大鼠 11β-HSD1 (IC50: 8 nM)。HSD-016 能够用于研究 2 型糖尿病。
T11016	DGAT-1 inhibitor 2	Transferase	Metabolism
	DGAT-1 inhibitor 2是有效的DGAT-1抑制剂，具有减肥功效。
T77513	2-Chlorophenylboronic acid	FAAH	Metabolism; Neuroscience
	2-Chlorophenylboronic acid 是一种单卤代苯硼酸，是一种重要的医药中间体，在新药合成中应用广泛。2-Chlorophenylboronic acid 对脂肪酸酰胺酶有抑制作用，Ki 值为0.01-1 µM，可用于研究抑郁症、青光眼、神经性疼痛、焦虑、偏头痛、I 型糖尿病和胃炎等疾病。
T78169	Enpp-1-IN-16	PDE	Metabolism
	Enpp-1-IN-16 是一种靶向 ENPP1 的抑制剂，具有潜在的抗癌症活性。Enpp-1-IN-16 可用于研究胰岛素抵抗与II型糖尿病和软骨钙化病和骨关节炎类由 ENPP1介导的各类疾病。
T1766	Empagliflozin BI 10773,恩格列净	SGLT	GPCR/G Protein
	Empagliflozin (BI 10773) 是一种 SGLT-2 抑制剂 (IC50=3.1 nM)，具有有效的和选择性，对 SGLT-1/4/5/6 的选择性高 300 倍以上。Empagliflozin 可用于治疗二型糖尿病。
T9089	FTO-IN-1 UUN44923	Others	Others
	UUN44923 是脂肪及肥胖相关酶(FTO) 抑制剂(IC50<1 μM)。其中FTO-IN-1 (UUN44923) 可用于研究癌症。
T76279L1	Retatrutide sodium salt Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt	Glucagon Receptor	GPCR/G Protein
	Retatrutide sodium salt 是一种有效的胰高血糖素受体 (GCGR)、葡萄糖依赖性促胰岛素多肽受体 (GIPR) 和胰高血糖素样肽-1 受体 (GLP-1R) 的三重激动剂肽。Retatrutide sodium salt 可用于研究2型糖尿病和肥胖症。
T60184	TUG-499	GPR; PPAR	DNA Damage/DNA Repair; Endocrinology/Hormones; GPCR/G Protein; Metabolism
	TUG-499 是一种选择性游离脂肪酸受体 1 (FFAR1 或 GPR40)激动剂（EC50 ： 7.39）。TUG-499对 FFAR1 或 GPR40的亲和力超过相关受体 FFA2、FFA3 和核受体 PPARγ，以及其他不同的受体、离子通道和转运蛋白。TUG-499 可用于研究 2 型糖尿病。
T21623	AS1269574 AS 1269574	GPR; TRP/TRPV Channel	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel
	AS1269574 是口服有效的GPR119激动剂，在表达人 GPR119 的 HEK293 细胞中EC50为 2.5 μM。它激活 TRPA1 阳离子通道，刺激胰高血糖素样肽-1分泌。它仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。它在 2 型糖尿病的研究中具有价值。
T21979	P32/98 (hemifumarate)
	P32/98 hemifumarate 为二肽基肽酶 IV (DPP4) 抑制剂，可在Zucker糖尿病大鼠模型中改善葡萄糖耐量、提高胰岛素敏感性及增强β细胞反应性，具有预防2型糖尿病的潜力。
T50018	1-(3-chloropyridin-2-yl)piperazine dihydrochloride	Others	Others
	1-(3-chloropyridin-2-yl)piperazine dihydrochloride 是一种哌嗪类化合物，常被用作有机合成中的试剂，配位化学中的配体，以及制药中的药物。它是DPP4的抑制剂，DPP4的抑制已被证明在治疗某些疾病（如2型糖尿病和肥胖症）方面具有有益效果。
T0242	Sitagliptin 西他列汀,MK0431,西格列汀	Proteasome; DPP-4; Autophagy	Autophagy; Proteases/Proteasome; Ubiquitination
	Sitagliptin (MK0431) 是一种有效的 DPP4抑制剂，在 Caco-2 细胞中，IC50值为 19 nM。它是一种新型口服降糖药，可单独使用或与二甲双胍或噻唑烷二酮联合用于治疗 2 型糖尿病。
T15810	LY2922470	GPR	Endocrinology/Hormones; GPCR/G Protein
	LY2922470 是选择性口服有效的GPR40激动剂，作用于人 GPR40、小鼠 GPR40、大鼠 GPR40 的EC50值分别为 7 nM、1 nM、3 nM。它可降低血糖水平，同时显著增加胰岛素和 GLP-1，有潜力用于 2 型糖尿病的研究。
T11456	GPR40 Activator 1	Others	Others
	GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes.
T11210	EP1013 F1013	Caspase	Apoptosis; Proteases/Proteasome
	EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.
T1984L	Cinaciguat hydrochloride BAY582667,BAY58-2667,BAY 582667,BAY-582667,BAY 58-2667,BAY-58-2667,Cinaciguat HCl
	Cinaciguat( BAY582667, BAY58-2667) is a soluble guanosine cyclase activator that can prevent cardiac dysfunction in rat models of type 1 diabetes.
T33423	MK-0916 MK 0916
	MK-0916 is a 11β-hydroxysteroid dehydrogenase type 1 inhibitor indicated for the treatment of type 2 diabetes and metabolic syndrome as well as obesity-related diseases.
T13091	Taspoglutide R1583,BIM51077,ITM077	Others	Others
	Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist(EC50 value of 0.06 nM),and for treatment of type 2 diabetes
T12878	Semaglutide TFA (910463-68-2 free base) Semaglutide TFA	Glucagon Receptor	GPCR/G Protein
	Semaglutide TFA is a agonist of glucagon-like peptide-1 (GLP-1) receptor,with a potential for type 2 diabetes treatment.
T40374	Pal-Glu(OSu)-OH
	Pal-Glu(OSu)-OH is a side chain specific to Liraglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist employed in type 2 diabetes mellitus research.
T61124	α-Glucosidase-IN-9
	α-Glucosidase-IN-9 (compound 7) is a highly potent α-glucosidase inhibitor with an IC50 of 55.6 μM, making it suitable for type II diabetes research [1].
T68236	TP0438836
	TP0438836 is a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor for the treatment of type 2 diabetes. TP0438836 showed IC50 values 28nM and 7 nM for hSGLT1 and hSGLT2 resepctively.
TP1340	Lixisenatide
	Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used in the treatment of type 2 diabetes mellitus (T2DM).It is an injectable diabetes medicine that helps control blood sugar levels.
T12892	SGL5213	SGLT	GPCR/G Protein
	SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM , respectively),and has potential to treat type 2 diabetes.
T75718	Dulaglutide
	Dulaglutide (LY2189265)，一种GLP-1受体激动剂，用于2型糖尿病的研究。
T74754	FXR antagonist 2
	Compound A-26, also known as FXR antagonist 2, is a diarylamide derivative that functions as a moderate FXR antagonist. It is utilized in researching hyperlipidemia and type 2 diabetes [1].
T82271	Golocdacimab MEDI6570
	Golocdacimab (MEDI6570) 是一种针对LOX-1的全人源单克隆抗体，潜在可用于研究2型糖尿病。
T76754	Otelixizumab
	Otelixizumab (ChAglyCD3) 是一种抗人 CD3单克隆抗体，可用于 1 型糖尿病的研究。
T81527	Pegloxenatide PEX 168
	Pegloxenatide，一种胰高血糖素样肽-1受体(GLP-1 RA)激动剂，主要用于2型糖尿病的研究。
T30169	ASP-8497 UNII-GC7THT248G,ASP8497,ASP 8497
	ASP8497 is a potent, long-acting DPP-IV inhibitor that improves glucose tolerance by elevating GLP-1 levels in a glucose-dependent insulin-stimulating manner. The compound is used as a therapeutic agent for impaired glucose tolerance and type 2 diabetes.
T76272	Pegapamodutide
	Pegapamodutide (LY-2944876) 是一种glucagon-GLP-1 receptor 激动剂，可用于 2 型糖尿病和肥胖症的研究。
T76876	Volagidemab
	Volagidemab，一种针对胰高血糖素受体(GCGR)的拮抗性单克隆抗体(mAb)，主要应用于1型糖尿病(T1D)的研究。

化合物

(±)-Lisofylline

Cat.No: T21729

Target: Others

Metformin hydrochloride

Cat.No: T0740

Synonym: Metformin HCl,盐酸二甲双胍,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride

Target: Mitophagy, AMPK, Autophagy

Bis(maltolato)oxovanadium(IV)

Cat.No: T22276

Synonym: 双(麦芽醇)氧钒(IV),BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)

Target: Phosphatase, Others

Cat.No: T71394

Semaglutide Acetate

Cat.No: T19850L

Synonym: 索玛鲁肽醋酸盐,Semaglutide Acetate(910463-68-2 Free base)

Target: Glucagon Receptor

Cat.No: T11408

Synonym: LY3502970,GLP-1 receptor agonist 1

Target: Glucagon Receptor

Cat.No: T40187

Target: DYRK

Lixisenatide acetate (320367-13-3 free base)

Cat.No: TP1469

Synonym: Lixisenatide acetate

Target: Glucagon Receptor

Cat.No: T8511

Target: Cannabinoid Receptor

(±)-Ibipinabant

Cat.No: T4654

Synonym: (±)-BMS6462,SLV319,(±)-SLV319

Target: Cannabinoid Receptor

Albiglutide TFA (782500-75-8 free base)

Cat.No: TP1796

Synonym: Albiglutide TFA

Target: Glucagon Receptor

Cat.No: T62512

Target: Hippo pathway

Cat.No: T27439

Synonym: CVT-3619,CVT 3619

Target: Adenosine Receptor

Cat.No: T76763

Synonym: PRV-031,MGA-031

Target: Others

Cat.No: T24905

Synonym: TT-01001,TT 01001,Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate

Target: Mitochondrial Metabolism

(R)-Lisofylline

Cat.No: T21694

Synonym: (R)-Lisophylline

Target: STAT

Cat.No: T14283

Target: Beta Amyloid

GLP-1R modulator C5

Cat.No: T61483

Target: Glucagon Receptor

Cat.No: T63569

DGAT-1 inhibitor 2

Cat.No: T11016

Target: Transferase

2-Chlorophenylboronic acid

Cat.No: T77513

Target: FAAH

Cat.No: T78169

Target: PDE

Cat.No: T1766

Synonym: BI 10773,恩格列净

Target: SGLT

Cat.No: T9089

Synonym: UUN44923

Target: Others

Retatrutide sodium salt

Cat.No: T76279L1

Synonym: Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt

Target: Glucagon Receptor

Cat.No: T60184

Target: GPR, PPAR

Cat.No: T21623

Synonym: AS 1269574

Target: GPR, TRP/TRPV Channel

P32/98 (hemifumarate)

Cat.No: T21979

1-(3-chloropyridin-2-yl)piperazine dihydrochloride

Cat.No: T50018

Target: Others

Cat.No: T0242

Synonym: 西他列汀,MK0431,西格列汀

Target: Proteasome, DPP-4, Autophagy

Cat.No: T15810

Target: GPR

GPR40 Activator 1

Cat.No: T11456

Target: Others

Cat.No: T11210

Synonym: F1013

Target: Caspase

Cinaciguat hydrochloride

Cat.No: T1984L

Synonym: BAY582667,BAY58-2667,BAY 582667,BAY-582667,BAY 58-2667,BAY-58-2667,Cinaciguat HCl

Cat.No: T33423

Synonym: MK 0916

Cat.No: T13091

Synonym: R1583,BIM51077,ITM077

Target: Others

Semaglutide TFA (910463-68-2 free base)

Cat.No: T12878

Synonym: Semaglutide TFA

Target: Glucagon Receptor

Pal-Glu(OSu)-OH

Cat.No: T40374

α-Glucosidase-IN-9

Cat.No: T61124

Cat.No: T68236

Cat.No: TP1340

Cat.No: T12892

Target: SGLT

Cat.No: T75718

FXR antagonist 2

Cat.No: T74754

Cat.No: T82271

Synonym: MEDI6570

Cat.No: T76754

Cat.No: T81527

Synonym: PEX 168

Cat.No: T30169

Synonym: UNII-GC7THT248G,ASP8497,ASP 8497

Cat.No: T76272

Cat.No: T76876

Cat. No.	Product Name	Target	Signaling Pathways
TN1403	Arjunolic acid	IL Receptor; TNF; Reactive Oxygen Species; JNK; AChE	Apoptosis; Immunology/Inflammation; MAPK; Metabolism; Neuroscience; NF-κB
	Arjunolic acid 是分离自蓝莓的皂苷，具有抗氧化、抗菌和抗炎症等多种生物活性，在保护细胞和组织免受活性氧的有害作用中发挥重要作用。
T1507	Streptozocin STZ,Streptozotocin,链脲佐菌素,NSC-85998,链脲菌素,U 9889	DNA Alkylator/Crosslinker; DNA Alkylation; DNA/RNA Synthesis; Antibacterial; Antibiotic; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Streptozocin (NSC-85998) 是一种抗生素，可诱导 DNA 甲基化。Streptozocin 对产生胰岛素的胰岛 B 细胞具有毒性，常用于构建 1 型糖尿病的动物模型。该产品在溶液中不稳定，建议现配现用。
T5S0384	Rhapontin Ponticin,土大黄苷,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside	Apoptosis; Others	Apoptosis; Others
	Rhapontin (Ponticin) 是药用大黄的一种成分，可减轻KK/Ay 糖尿病小鼠肝脏脂肪变性，改善血糖和血脂，表明其具有显着的降糖作用，有望成为治疗2型糖尿病及其并发症的新药。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
TN4383	Kazinol U	IL Receptor; IκB/IKK; NOS; NF-κB	Immunology/Inflammation; NF-κB
	Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-ÎºB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms.
TL0014	Pinusolide	ERK; p38 MAPK; Calcium Channel; Lipoxygenase; PAFR; Caspase; JNK; AMPK	Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.
T60692	Masoprocol
	Masoprocol (meso-Nordihydroguaiaretic acid) 是口服有效的脂氧合酶 (lipoxygenase) 抑制剂。Masoprocol 具有出抗高血糖活性，可用于 II 型糖尿病的研究。 Masoprocol 可降低体内肝甘油三酯和葡萄糖浓度。
T73074	Phanginin A
	Phanginin A 是有效的口服活性SIK1激活剂，通过抑制糖异生、增加p-SIK1表达及降低p-CREB表达，达到降低血糖水平、改善葡萄糖耐量和血脂异常的效果，显示出其在2型糖尿病研究中的潜力。
TN4670	Norlichexanthone	Antibacterial; Parasite	Microbiology/Virology
	Norlichexanthone 具有治疗和/或预防生活方式相关疾病的潜力，例如 2 型糖尿病、代谢综合征、动脉粥样硬化和心血管疾病。它具有抗菌和抗疟活性，对枯草芽孢杆菌有很强的活性，IC50范围为1-5uM，对耐甲氧西林金黄色葡萄球菌的生长也有很强的抑制作用，IC50为20.95±1.56uM。
T36563	(E)-Guggulsterone
	Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy...

天然产物

Cat.No: TN1403

Target: IL Receptor, TNF, Reactive Oxygen Species, JNK, AChE

Cat.No: T1507

Synonym: STZ,Streptozotocin,链脲佐菌素,NSC-85998,链脲菌素,U 9889

Target: DNA Alkylator/Crosslinker, DNA Alkylation, DNA/RNA Synthesis, Antibacterial, Antibiotic, Autophagy

Cat.No: T5S0384

Synonym: Ponticin,土大黄苷,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside

Target: Apoptosis, Others

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Cat.No: TN4383

Target: IL Receptor, IκB/IKK, NOS, NF-κB

Cat.No: TL0014

Target: ERK, p38 MAPK, Calcium Channel, Lipoxygenase, PAFR, Caspase, JNK, AMPK

Cat.No: T60692

Cat.No: T73074

Norlichexanthone

Cat.No: TN4670

Target: Antibacterial, Parasite

(E)-Guggulsterone

Cat.No: T36563

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