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Search Results for " tau "

152

抑制剂 & 化合物

32

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1453	Tau protein (592-597), Human TFA	Others	Others
	Tau protein (592-597), Human TFA 是人 Tau 蛋白的肽片段。
T39660	Tau tracer 1
	Tau tracer 1 is a radiopharmaceutical agent designed specifically for visualizing Tau protein aggregates, commonly associated with neurodegenerative diseases. Its primary application lies in the diagnosis of these conditions.
T6405	Bepotastine Besilate Talion,TAU 284,苯磺酸贝托司汀,Bepreve,Bepotastine Beslilate	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bepotastine Besilate (TAU 284) 是一种选择性可口服的组胺 H1 受体拮抗剂，可用于过敏性鼻炎、过敏性结膜炎、荨麻疹和瘙痒症的研究。
T37051	Tau tracer 2
	Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates. Its primary application lies in the diagnosis of neurodegenerative diseases [1].
T39781	Aβ/tau aggregation-IN-1
	Aβ/tau aggregation-IN-1 is a potent inhibitor of Aβ 1-42 β-sheet formation and tau aggregation. It exhibits K D values of 160 μM and 337 μM with Aβ 1-42 and tau, respectively. Additionally, Aβ/tau aggregation-IN-1 can penetrate the blood-brain barrier efficiently.
T62899	Tau-aggregation and neuroinflammation-IN-1	Microtubule Associated; NO Synthase	Cytoskeletal Signaling; Immunology/Inflammation
	Tau-aggregation and neuroinflammation-IN-1 是一种有效的 Tau 蛋白聚集体抑制剂，对 AcPHF6 和全长 tau 蛋白聚集体显示出显著的抑制活性。Tau-aggregation and neuroinflammation-IN-1具有抗炎活性且可减少 NO 释放。Tau-aggregation and neuroinflammation-IN-1 对 LSP 刺激的 BV2 细胞具有低细胞毒性。Tau-aggregation and neuroinflammation-IN-1 可逆转冈田酸诱导的大鼠记忆障碍。
T40409	Tau Peptide (275-305) (Repeat 2 domain)
	Tau Peptide (275-305), also known as the R2 domain fragment, represents the second repeat unit of the microtubule-binding domain of the Alzheimer's tau peptide. Tau Peptide (275-305) is considered crucial in determining the biochemical characteristics of the complete tau protein.
TP1420	Microtubule-associated protein tau (26-44)
	Microtubule-associated protein tau (26-44) is a synthetic peptide with an amino group conjugated to glutamine and a carboxyl group conjugated to lysine.
T63481	Tau-aggregation-IN-1
	Tau-aggregation-IN-1 是一种 dopamine D2和 D3受体激动剂，也是 tau441 蛋白聚合抑制剂 (IC50: 21 μM)。
T78173	Aβ/tau aggregation-IN-3
	Aβ/tau aggregation-IN-3为一种高效的抗Aβ聚集剂，经Aβ-硫黄素T (Aβ-ThT) 聚集测定显示，其半抑制浓度(IC50)为0.85 μM，表现出显著的抗淀粉样蛋白活性。
T74811	tau/Aβ40 aggregation-IN-1
	tau/Aβ40 aggregation-IN-1 (Compound 20) 是一种tau 和Aβ40聚集抑制剂，其IC50分别为 1.8 μM 和 1.3 μM 。
T79038	Tau protein aggregation-IN-1
	Tau protein aggregation-IN-1（化合物 0c）是一种针对Tau protein聚集的抑制剂。该化合物主要应用于研究蛋白质折叠障碍类疾病，包括阿尔茨海默病、痴呆、帕金森病、亨廷顿舞蹈病及基于朊病毒引起的海绵状脑病。
T76661	Acetyl-Tau Peptide (273-284) amide
	Acetyl-Tau Peptide (273-284) amide 是一种乙酰化的 Tau 肽片段，作为 Ac-Aβ(25-35)-NH2 聚集的抑制剂，限制其大量聚集，并用于研究 Aβ/Tau 交叉相互作用的实验模型。
T81031	tau protein/α-synuclein-IN-1
	tau protein/α-synuclein-IN-1为tau protein与α-synuclein双重抑制剂，能够抑制M17D神经母细胞瘤细胞中α-syn包涵体的形成，适用于阿尔茨海默病相关研究。
T17011	TCH-165	Proteasome	Proteases/Proteasome; Ubiquitination
	TCH-165 是一种蛋白酶体组装的小分子调节剂，可增加游离 20S 水平，进而增强 IDP 蛋白水解。
T1862	PR-619 PR 619,2,6-Diamino-3,5-dithiocyanopyridine	Apoptosis; DUB; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) 是一种 DUB 抑制剂，可诱导内质网应激和内质网应激相关的凋亡，对 USP4、USP8、USP7、USP2和 USP5的 EC50分别为 3.93、4.9、6.86、7.2 和 8.61 μM。
T7530	PD146176 NSC168807	Ferroptosis; Lipoxygenase; Autophagy	Apoptosis; Autophagy; Metabolism
	PD146176 (NSC-168807) 是一种 15-脂氧合酶(15-LO)抑制剂，抑制兔网织红细胞 15-LO，Ki 为 197 nM，IC50 为 0.54 μM。它通过刺激老年三重转基因小鼠的自噬来逆转认知障碍、脑淀粉样变性和 tau 病理学。
T22012	7BIO	FLT; DYRK; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	7BIO 是靛玉红的衍生物，抑制细胞周期蛋白依赖性激酶5 和糖原合酶激酶-3β。它抑制 Aβ 寡聚体诱导的神经炎症、突触损伤、tau 过度磷酸化、星形胶质细胞和小胶质细胞的活化，并减轻 Aβ 寡聚体诱导的小鼠认知障碍。
T9611	PF-04802367	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	PF-04802367是 GSK-3高选择性抑制剂，对 GSK-3β酶的 IC50为 2.1 nM。它抑制两种 GSK-3 亚型（GSK-3α和GSK-3β）效果差不多，IC50值分别为 10.0 和 9.0 nM。它具有理想的中枢神经系统特性和效力。
T22118	NQTrp	Microtubule Associated	Cytoskeletal Signaling
	NQTrp 是芳香萘醌-色氨酸杂交分子，可以抑制 tau 蛋白的聚集，具有抗淀粉样蛋白活性。NQTrp 对六肽 (41GCWMLY46，γD-crystallin 的 N 端)和全长 γD-crystallin 的体外聚集有抑制作用。
T7003	Leucomethylene blue mesylate N3,N3,N7,N7-四甲基-10H-吩噻嗪-3,7-二胺二甲磺酸盐,TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate	Beta Amyloid; Microtubule Associated	Cytoskeletal Signaling; Neuroscience
	Leucomethylene blue mesylate (TRx0237 mesylate) 是一种 Methylene blue (亚甲基蓝)的还原形式, 亚甲基蓝是一种化学指示剂和生物染色剂。它是一种具有口服活性的二代 tau 蛋白聚集的抑制剂 (Ki=为0.12 μM)，可用于阿尔兹海默症的研究。
T13094	Tauroxicum Taurox SB	Others	Others
	Tauroxicum（Taurox）由 COBAT 制成，可用于减少疲劳和提高生活质量。
T9154	Sodium taurodeoxycholate hydrate 牛磺去氧胆酸钠,Taurodeoxycholic acid sodium salt monohydrate	Others	Others
	Sodium taurodeoxycholate hydrate (Taurodeoxycholic acid sodium salt monohydrate) 已用于一项研究，以评估亚胶束浓度的胆汁盐对脂质双层膜的影响。
T64377	AGI-41998 tautomers	Others	Others
	AGI-41998 tautomers 是pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one 的互变异构体。pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one 是S-adenosylmethionine synthase isoform type-2抑制剂, IC50= 0.022μM。
T3211	Midostaurin 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂，有抗肿瘤活性，对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。
T3689	Ruboxistaurin hydrochloride Ruboxistaurin,LY333531 HCl,LY 333531 hydrochloride,芦布妥林	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Ruboxistaurin hydrochloride (LY 333531 hydrochloride) 是蛋白激酶 C(PKC) 的同工酶选择性抑制剂，竞争性且可逆地抑制 PKCβI 和 PKCβII，IC50 值分别为 4.7 和 5.9 nM。
T11035	diABZI STING agonist-1 (Tautomerism) diABZI STING agonist (Compound 3)	STING	Immunology/Inflammation
	diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂，其在人和小鼠中的 EC50 值分别为 130 nM 和 186 nM。。
T6278	Sotrastaurin 索曲妥林,AEB071	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Sotrastaurin (AEB071) 是一种口服有效的泛 PKC 抑制剂，对 PKCθ、PKCβ、PKCα、PKCη、PKCδ 和 PKCε，Ki 分别为 0.22、0.64、0.95、1.8、2.1 和 3.2 nM。
T7533	Taurolidine	Apoptosis; Others; Antibacterial; Antibiotic	Apoptosis; Microbiology/Virology; Others
	Taurolidine 是一种广谱抗菌剂，用于预防中心静脉导管相关感染。它具有抗真菌和抗肿瘤作用。
T6993	Tauroursodeoxycholate sodium 牛磺熊脱氧胆酸钠,Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,牛磺熊去氧胆酸钠,Sodium Tauroursodeoxycholate (TUDC)	Apoptosis; ERK; Caspase	Apoptosis; MAPK; Proteases/Proteasome
	Tauroursodeoxycholate sodium (TUDC) 是一种内质网应激抑制剂。Tauroursodeoxycholate sodium (TUDC) 抑制ERK，显著降低凋亡分子表达，如caspase-3和caspase-12。
T6280	Enzastaurin LY317615,恩扎妥林	Apoptosis; PKC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling
	Enzastaurin (LY317615) 是一种PKCβ抑制剂，IC50值为 6 nM。它对 PKCβ 选择性是 PKCα，PKCγ 和 PKCε 的 6-20 倍。
T37846	Taurohyocholic Acid (sodium salt)
	Taurohyocholic acid (THCA) is a taurine-conjugated form of the porcine-specific primary bile acid hyocholic acid .1THCA inhibits precipitation of cholesterol crystals by stabilizing cholesterol in the liquid-crystalline phase.2It prevents cholestasis and cellular necrosis induced by taurolithocholic acid in isolated rat livers.3THCA levels are increased in the urine of patients with hepatitis B-induced cirrhosis.4
T37416	Tauro-α-muricholic Acid (sodium salt)
	Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid . TαMCA is common in rodents but has also been found in small amounts in human serum.
T33878	Pantoyltaurine NSC 122022,NSC 3086,NSC3086,NSC-3086
	Pantoyltaurine is a biochemical.
T65644	N-Cyclohexyltaurine
	N-Cyclohexyltaurine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65644，CAS号为 103-47-9。
T24815	Sotrastaurin acetate
	Sotrastaurin acetate is a pan-protein kinase C inhibitor. It also has potential immunosuppressive and antineoplastic activities.
T30270	Azidobenzamidotaurocholate
	Azido Benzamido Taurocholate is a bile acid transporter.
T125588	Centaureidin
	Centaureidin 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125588，CAS号为 17313-52-9。
T30003	Ammonium acryloyldimethyltaurate
	Ammonium acryloyldimethyltaurate is a bioactive chemical.
T25455L	Glutaurine aceate	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	含有谷氨酰胺和牛磺酸残基的 Glutaurine aceate 是甲状旁腺的一种口服活性激素。Glutaurine 作为一种激素，从甲状旁腺嗜氧细胞中分离出来。Glutaurine 可用于抗癫痫和抗遗忘的研究。
T77991	Glutaurine TFA Litoralon TFA
	Glutaurine (Litoralon) TFA，含谷氨酰胺与牛磺酸残基，为甲状旁腺源嗜氧细胞分离的口服活性激素。该化合物在抗癫痫与抗健忘症研究中有应用。
T35423	7-oxo Staurosporine
	7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respectively). 7-oxo Staurosporine induces cell cycle arrest in the G2/M phase in human leukemia K562 cells with a minimal effective dose (MED) of 30 ng/ml. It is cytotoxic to P388 mouse leukemia cells that are resistant and susceptible to doxorubicin . 7-oxo Staurosporine inhibits gr...
T35918	N-Arachidonoyl Taurine
	N-Arachidonoyl taurine is an arachidonoyl amino acid. It is oxygenated by 12(S)- and 15(S)-lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages. N-Arachidonoyl taurine is an activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4 (EC50s = 28 and 21 μM, respectively). It increases calcium flux in HIT-T15 pancreatic β-cells and INS-1 rat islet cells when used at a concentration of 10 μM and increases insulin secretio...
T63013	Ruboxistaurin
	Ruboxistaurin (LY333531) 是一种选择性的、口服具有活力的 PKC beta 抑制剂，其 Ki 值为 2 nM。Ruboxistaurin 以 ATP 依赖性的方式竞争性抑制 PKC beta I (IC50: 4.7 nM)。Ruboxistaurin 能够作用于 PKC beta II (IC50: 5.9 nM)。
T19119	3-Hydroxy Midostaurin-D5 CGP52421-D5	Others	Others
	3-Hydroxy Midostaurin-D5 (CGP52421-D5) is a deuterium-labeled 3-Hydroxy Midostaurin which is a metabolite of PKC412. PKC412 effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation (IC50s: 132 nM and 9.8 μM in culture medium and plasma).
T69354	Enzastaurin 2HCl
	Enzastaurin, also known as DB-102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden.
T63793	Tauro-ω-muricholic acid sodium
	Tauro-ω-muricholic acid sodium (TωMCA sodium) 是一种tauro-α-muricholic acid 的类似物，是来源于肝脏的胆汁酸。Tauro-ω-muricholic acid sodium 能用作早发性新生儿败血症 (EOS) 和胆汁淤积的血清标志物。
T37771	Taurolithocholic Acid 3-sulfate (sodium salt)
	Taurolithocholic acid 3-sulfate (TLCA3S) is a metabolite of the conjugated bile acid taurolithocholic acid . TLCA3S has been used to study bile acid transport in cellular models and to induce pancreatitis in mouse models of bile acid infusion pancreatitis.
T13093	Tauro-β-muricholic acid sodium T-βMCA sodium	FXR	Metabolism
	Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
T16941	Stauprimide	Others	Others
	Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which causes down-regulation of MYC transcription.

化合物

Tau protein (592-597), Human TFA

Cat.No: TP1453

Target: Others

Cat.No: T39660

Bepotastine Besilate

Cat.No: T6405

Synonym: Talion,TAU 284,苯磺酸贝托司汀,Bepreve,Bepotastine Beslilate

Target: Histamine Receptor

Cat.No: T37051

Aβ/tau aggregation-IN-1

Cat.No: T39781

Tau-aggregation and neuroinflammation-IN-1

Cat.No: T62899

Target: Microtubule Associated, NO Synthase

Tau Peptide (275-305) (Repeat 2 domain)

Cat.No: T40409

Microtubule-associated protein tau (26-44)

Cat.No: TP1420

Tau-aggregation-IN-1

Cat.No: T63481

Aβ/tau aggregation-IN-3

Cat.No: T78173

tau/Aβ40 aggregation-IN-1

Cat.No: T74811

Tau protein aggregation-IN-1

Cat.No: T79038

Acetyl-Tau Peptide (273-284) amide

Cat.No: T76661

tau protein/α-synuclein-IN-1

Cat.No: T81031

Cat.No: T17011

Target: Proteasome

Cat.No: T1862

Synonym: PR 619,2,6-Diamino-3,5-dithiocyanopyridine

Target: Apoptosis, DUB, Autophagy

Cat.No: T7530

Synonym: NSC168807

Target: Ferroptosis, Lipoxygenase, Autophagy

Cat.No: T22012

Target: FLT, DYRK, Aurora Kinase

Cat.No: T9611

Target: GSK-3

Cat.No: T22118

Target: Microtubule Associated

Leucomethylene blue mesylate

Cat.No: T7003

Synonym: N3,N3,N7,N7-四甲基-10H-吩噻嗪-3,7-二胺二甲磺酸盐,TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate

Target: Beta Amyloid, Microtubule Associated

Cat.No: T13094

Synonym: Taurox SB

Target: Others

Sodium taurodeoxycholate hydrate

Cat.No: T9154

Synonym: 牛磺去氧胆酸钠,Taurodeoxycholic acid sodium salt monohydrate

Target: Others

AGI-41998 tautomers

Cat.No: T64377

Target: Others

Cat.No: T3211

Synonym: 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱

Target: Others, PKC

Ruboxistaurin hydrochloride

Cat.No: T3689

Synonym: Ruboxistaurin,LY333531 HCl,LY 333531 hydrochloride,芦布妥林

Target: PKC

diABZI STING agonist-1 (Tautomerism)

Cat.No: T11035

Synonym: diABZI STING agonist (Compound 3)

Target: STING

Cat.No: T6278

Synonym: 索曲妥林,AEB071

Target: PKC

Cat.No: T7533

Target: Apoptosis, Others, Antibacterial, Antibiotic

Tauroursodeoxycholate sodium

Cat.No: T6993

Synonym: 牛磺熊脱氧胆酸钠,Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,牛磺熊去氧胆酸钠,Sodium Tauroursodeoxycholate (TUDC)

Target: Apoptosis, ERK, Caspase

Cat.No: T6280

Synonym: LY317615,恩扎妥林

Target: Apoptosis, PKC, Autophagy

Taurohyocholic Acid (sodium salt)

Cat.No: T37846

Tauro-α-muricholic Acid (sodium salt)

Cat.No: T37416

Cat.No: T33878

Synonym: NSC 122022,NSC 3086,NSC3086,NSC-3086

N-Cyclohexyltaurine

Cat.No: T65644

Sotrastaurin acetate

Cat.No: T24815

Azidobenzamidotaurocholate

Cat.No: T30270

Cat.No: T125588

Ammonium acryloyldimethyltaurate

Cat.No: T30003

Glutaurine aceate

Cat.No: T25455L

Target: Thyroid hormone receptor(THR)

Cat.No: T77991

Synonym: Litoralon TFA

7-oxo Staurosporine

Cat.No: T35423

N-Arachidonoyl Taurine

Cat.No: T35918

Cat.No: T63013

3-Hydroxy Midostaurin-D5

Cat.No: T19119

Synonym: CGP52421-D5

Target: Others

Enzastaurin 2HCl

Cat.No: T69354

Tauro-ω-muricholic acid sodium

Cat.No: T63793

Taurolithocholic Acid 3-sulfate (sodium salt)

Cat.No: T37771

Tauro-β-muricholic acid sodium

Cat.No: T13093

Synonym: T-βMCA sodium

Target: FXR

Cat.No: T16941

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T14046	Anandamide 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide	Cannabinoid Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism
	Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide) 是一种免疫调节剂，通过大麻素受体 CB1 和 CB2 起作用，还通过中枢神经系统中的其他靶点起作用，如 GPR18/GPR55。
T2A2481	Taurochenodeoxycholic Acid Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine,牛磺鹅去氧胆酸	Apoptosis; TNF; Caspase; Endogenous Metabolite	Apoptosis; Metabolism; Proteases/Proteasome
	Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) 是动物胆汁酸的主要生物活性物质之一，可诱导细胞凋亡，具有明显的抗炎和免疫调节作用。
TWA2417	Sodium taurocholate 牛黄胆酸钠(牛胆酸钠，牛胆酸钠盐，牛磺膽酸鈉，牛磺胆酸钠，牛磺胆酸钠盐，牛胆酸钠水合物，水合牛磺胆酸钠，牛胆酸钠(混合物)，牛黄胆酸钠(水合)，牛磺胆酸钠(标准品)),Taurocholate Sodium	Others	Others
	Sodium taurocholate (Taurocholate Sodium) hydrate 具有显著的生物学效应，例如通过上调 VEGF-A 的表达抑制肝动脉结扎所致的胆道损伤。对免疫系统具有一定的调节作用。
T4727	Taurolithocholic acid sodium salt 牛磺石胆酸钠,Sodium taurolithocholate	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Taurolithocholic acid sodium salt (Sodium taurolithocholate) 是抑胆剂和 Ca2+激动剂，可抑制放射性配体与毒蕈碱 M1 结合。
T8092	Taurohyodeoxycholic acid sodium salt Sodium taurohyodeoxycholate hydrate	Caspase	Apoptosis; Proteases/Proteasome
	Taurohyodeoxycholic acid sodium salt (Sodium taurohyodeoxycholate hydrate) 通过阻断钙介导的细胞凋亡途径以及 Caspase-12 活化来防止细胞凋亡
T75319	Taurodeoxycholic acid Taurodeoxychloic acid	Apoptosis; Calcium Channel; Caspase	Apoptosis; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome
	Taurodeoxycholic acid (Taurodeoxychloic acid) 是脱氧胆酸的胆汁酸牛磺酸共轭物，是一种人体代谢物，可稳定线粒体膜，减少自由基形成。Taurodeoxycholic acid 通过阻断钙介导的凋亡通路以及 Caspase-12 激活来抑制凋亡 (apoptosis)。Taurodeoxycholic acid具有神经保护活性，可用于研究 3-硝基丙酸诱导或稳定遗传的亨廷顿舞蹈病 (HD) 。
TN2349	Taurodeoxycholate sodium salt Sodium taurodeoxylate,牛磺脱氧胆酸钠	Endogenous Metabolite	Metabolism
	Taurodeoxycholate sodium salt (Sodium taurodeoxylate) 是胆盐相关的阴离子洗涤剂，用于分离膜蛋白，包括线粒体内膜蛋白。它还可以抑制各种炎症反应。
TJA2398	Taurodeoxycholic acid sodium hydrate Sodium taurodeoxycholate monohydrate,Taurodeoxychloic Acid sodium hydrate,Taurohyodeoxycholic acid sodium salt,牛磺猪去氧胆酸	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate) 通过阻断钙介导的凋亡通路和 Caspase-12的活化来阻止细胞凋亡。它可用于原发性胆汁性肝硬化、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤积和肌萎缩侧索硬化症。
TN2215	Taurochenodeoxycholic acid sodium 牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡，具有抗炎和免疫调节作用。
T1138	Taurocholic acid sodium salt hydrate 牛胆酸钠,牛磺胆酸钠水合物,Sodium taurocholate hydrate,Taurocholic Acid sodium hydrate	Others; Potassium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Others
	Taurocholic acid sodium salt hydrate (Sodium taurocholate hydrate) 是一种胆汁酸钠盐水合物，作用是参与脂肪的乳化。
T5225	Hypotaurine 2-Aminoethanesulfinic acid,亚牛磺酸,2-Aminoethylsulfinic acid	Chloride channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	Hypotaurine (2-Aminoethanesulfinic acid) 是星形胶质细胞中半胱氨酸生物合成的牛磺酸中间体，是甘氨酸受体 (glycine receptor) 的内源性抑制性氨基酸。Hypotaurine 也是抗氧化剂。
T0022	Taurine 牛磺酸,2-Aminoethanesulfonic acid	LDL; Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	Taurine (2-Aminoethanesulfonic acid) 是一种含硫氨基酸的有机渗透剂，为胆汁盐的形成提供底物，并在调节细胞内游离钙浓度方面发挥作用，有激活脂肪细胞自噬的能力。
TN2259	Taurocholic acid N-Choloyltaurine	TNF; PI3K	Apoptosis; PI3K/Akt/mTOR signaling
	Taurocholic acid (N-Choloyltaurine) 是一种胆汁酸，参与脂肪的乳化。Taurocholic acid 具有细胞保护作用，可通过 PI3K 介导的途径防止肿瘤坏死因子-α 诱导的胆管细胞损伤。
T13092	Tauro-Obeticholic acid	FXR	Metabolism
	Tauro-Obeticholic acid 是一种牛磺酸的特性代谢物。Obeticholic Acid 是口服具有活性的法尼样 X 受体激动剂。
T2532	Tauroursodeoxycholate Taurolite,牛磺熊去氧胆酸,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA	Apoptosis; ERK; P450; Caspase; Endogenous Metabolite	Apoptosis; MAPK; Metabolism; Proteases/Proteasome
	Tauroursodeoxycholate (UR 906)，又称 ursodoxicoltaurine，是一种高度亲水性的三级胆汁酸，在人体内以低浓度产生。Tauroursodeoxycholate 是 ursodeoxycholic acid 更亲水的形式，而 ursodeoxycholic acid 是人类体内自然产生的更丰富的胆汁酸。Tauroursodeoxycholate 正在研究用于几种疾病，如原发性胆汁性肝硬化(PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症。
T6680	Staurosporine Antibiotic AM-2282,星形孢菌素,AM-2282,CGP 41251,星孢菌素	Apoptosis; PKA; Antibacterial; Antibiotic; Src; PKC; Antifungal	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Staurosporine (AM-2282) 是一种蛋白激酶抑制剂，对 PKC、PKA、c-Fgr、Phosphorylase kinase 和 TAOK2 均有抑制活性 (IC50=6/15/2/3/3000 nM)，具有 ATP 竞争性和非选择性。Staurosporine 也可以诱导凋亡。
TN3837	Desmethoxycentaureidin	Others	Others
	Desmethoxycentaureidin shows high inhibitory activity against HeLa cell growth (GI50 9 microM).
TN4010	Erythrocentaurin	Antifection	Microbiology/Virology
	Erythrocentaurin has antibacterial activity; it also exhibits a concentration-dependent α-amylase inhibition (IC(50) 1.67 ± 0.28 mg/mL).
T81030	Tauro-β-muricholic acid TβMCA	FXR	Metabolism
	Tauro-β-muricholic acid (TβMCA) 为一种具有三羟基结构的胆汁酸，是FXR的竞争性、可逆拮抗剂，IC50值为40 μM。此外，Tauro-β-muricholic acid 能够通过维持线粒体膜电位来阻抑胆汁酸引起的肝细胞凋亡，发挥抗凋亡功能。
T81097	Stauntoside M
	Stauntoside M是一种从Cynanchum stauntonii的根中分离得到的类固醇糖苷。
T23421	Tautomycetin	Others	Others
	protein phosphatase (PP)1 inhibitor
TN1233	Lotaustralin 百脉根苷,(2RS)-Lotaustralin	Others	Others
	(2RS)-Lotaustralin is a natural product from Rhodiola rosea L.
T32887	Lotaustralin
	Lotaustralin is a cyanogenic glycoside.
T37770	Taurohyodeoxycholic acid
	Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid .1THDCA decreases the size and weight of human gallstonesin vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats.2Co-administration of THDCA with taurochenodeoxycholic acid prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats.3THDCA also reduces myeloperoxidase activity, expressi...
TN5276	(Z)-Aldosecologanin (Centauroside) 金银花	Others	Others
	(Z)-Aldosecologanin is a natural product from Lonicera japonica.
TN5060	Stauntosaponin A	ATPase; Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively.
TN4009	Erythrocentauric acid	Others	Others
	Erythrocentauric acid is a natural product from Gentiana macrophylla.
T13916	Taurochenodeoxycholate-3-sulfate	Others	Others
	Taurochenodeoxycholate-3-sulfate is a bile salt found in urine.
T4940	3-Methylhistamine dihydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	3-Methylhistamine dihydrochloride 是一种组胺的降解产物，与免疫反应有关，并在接种过疫苗的小鼠中表现出上调作用。
T3914	Saikosaponin C 柴胡皂苷C,柴胡皂苷 C	Beta Amyloid; Caspase	Apoptosis; Neuroscience; Proteases/Proteasome
	Saikosaponin C 是一种柴胡中的活性成分，能够抑制 Aβ1-40 和 Aβ1-42 的释放，抑制异常 tau 蛋白的磷酸化，但对 BACE1 的活性和表达无作用。它在阿尔滋海默症中主要靶作用于amyloid beta 和tau 蛋白。
T32614	L-Clausenamide (-)-Clausenamide	Microtubule Associated	Cytoskeletal Signaling
	L-Clausenamide 是从黄皮 (Clausena lansium (Lour) skeels) 的树叶中提取出来的生物碱，可用于提高认知功能。L-Clausenamide 对β-淀粉样蛋白 (Aβ) 毒性有抑制作用，通过抑制 tau 蛋白磷酸化阻止神经纤维缠结的形成。L-Clausenamide 具有神经保护活性，可用于调节 Aβ25-35 引发的刺激。L-Clausenamide 可用于研究阿尔兹海默症类的神经系统疾病。
T27977	Manzamine A Keramamine A
	Manzamine A is a GSK-3 inhibitor and vacuolar ATPase uncoupler found in marine sponges. It inhibits autophagy and tumor growth in cancer models, suppresses foam cell formation in macrophages, prevents growth of gram negative and gram positive bacteria, an

天然产物

Cat.No: T14046

Synonym: 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide

Target: Cannabinoid Receptor, Endogenous Metabolite

Taurochenodeoxycholic Acid

Cat.No: T2A2481

Synonym: Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine,牛磺鹅去氧胆酸

Target: Apoptosis, TNF, Caspase, Endogenous Metabolite

Sodium taurocholate

Cat.No: TWA2417

Synonym: 牛黄胆酸钠(牛胆酸钠，牛胆酸钠盐，牛磺膽酸鈉，牛磺胆酸钠，牛磺胆酸钠盐，牛胆酸钠水合物，水合牛磺胆酸钠，牛胆酸钠(混合物)，牛黄胆酸钠(水合)，牛磺胆酸钠(标准品)),Taurocholate Sodium

Target: Others

Taurolithocholic acid sodium salt

Cat.No: T4727

Synonym: 牛磺石胆酸钠,Sodium taurolithocholate

Target: Others, Calcium Channel

Taurohyodeoxycholic acid sodium salt

Cat.No: T8092

Synonym: Sodium taurohyodeoxycholate hydrate

Target: Caspase

Taurodeoxycholic acid

Cat.No: T75319

Synonym: Taurodeoxychloic acid

Target: Apoptosis, Calcium Channel, Caspase

Taurodeoxycholate sodium salt

Cat.No: TN2349

Synonym: Sodium taurodeoxylate,牛磺脱氧胆酸钠

Target: Endogenous Metabolite

Taurodeoxycholic acid sodium hydrate

Cat.No: TJA2398

Synonym: Sodium taurodeoxycholate monohydrate,Taurodeoxychloic Acid sodium hydrate,Taurohyodeoxycholic acid sodium salt,牛磺猪去氧胆酸

Target: Apoptosis, Caspase

Taurochenodeoxycholic acid sodium

Cat.No: TN2215

Synonym: 牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠

Target: Apoptosis, Endogenous Metabolite

Taurocholic acid sodium salt hydrate

Cat.No: T1138

Synonym: 牛胆酸钠,牛磺胆酸钠水合物,Sodium taurocholate hydrate,Taurocholic Acid sodium hydrate

Target: Others, Potassium Channel, Endogenous Metabolite

Cat.No: T5225

Synonym: 2-Aminoethanesulfinic acid,亚牛磺酸,2-Aminoethylsulfinic acid

Target: Chloride channel, Endogenous Metabolite

Cat.No: T0022

Synonym: 牛磺酸,2-Aminoethanesulfonic acid

Target: LDL, Endogenous Metabolite, Autophagy

Taurocholic acid

Cat.No: TN2259

Synonym: N-Choloyltaurine

Target: TNF, PI3K

Tauro-Obeticholic acid

Cat.No: T13092

Target: FXR

Tauroursodeoxycholate

Cat.No: T2532

Synonym: Taurolite,牛磺熊去氧胆酸,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA

Target: Apoptosis, ERK, P450, Caspase, Endogenous Metabolite

Cat.No: T6680

Synonym: Antibiotic AM-2282,星形孢菌素,AM-2282,CGP 41251,星孢菌素

Target: Apoptosis, PKA, Antibacterial, Antibiotic, Src, PKC, Antifungal

Desmethoxycentaureidin

Cat.No: TN3837

Target: Others

Erythrocentaurin

Cat.No: TN4010

Target: Antifection

Tauro-β-muricholic acid

Cat.No: T81030

Synonym: TβMCA

Target: FXR

Cat.No: T81097

Cat.No: T23421

Target: Others

Cat.No: TN1233

Synonym: 百脉根苷,(2RS)-Lotaustralin

Target: Others

Cat.No: T32887

Taurohyodeoxycholic acid

Cat.No: T37770

(Z)-Aldosecologanin (Centauroside)

Cat.No: TN5276

Synonym: 金银花

Target: Others

Stauntosaponin A

Cat.No: TN5060

Target: ATPase, Potassium Channel, Sodium Channel

Erythrocentauric acid

Cat.No: TN4009

Target: Others

Taurochenodeoxycholate-3-sulfate

Cat.No: T13916

Target: Others

3-Methylhistamine dihydrochloride

Cat.No: T4940

Target: Others, Endogenous Metabolite

Cat.No: T3914

Synonym: 柴胡皂苷C,柴胡皂苷 C

Target: Beta Amyloid, Caspase

Cat.No: T32614

Synonym: (-)-Clausenamide

Target: Microtubule Associated

Cat.No: T27977

Synonym: Keramamine A

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