Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which causes down-regulation of MYC transcription.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 μg | ¥ 1,587 | 35日内发货 | ||
1 mg | ¥ 2,245 | 35日内发货 | ||
5 mg | ¥ 5,432 | 35日内发货 |
产品描述 | Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which causes down-regulation of MYC transcription. |
体外活性 | Stauprimide (10 μM; 6 hours) inhibits MYC transcription in the majority of cell lines tested (EC50: range of 30 nM-8 μM). It also decreases MYC levels between 15% to over 90%. Stauprimide (5 μM; 3 hours) suppresses MYC Transcription by decreasing NME2 Nuclear Translocation. Stauprimide (2-8 μM; 24-72 hours) down-regulates MYC leads to the inhibition of cell proliferation in vitro (IC50: 780 nM in RXF 393 cells). Stauprimide (4-10 μM; 6 hours) acts with different EC50s and with different degrees of maximal MYC mRNA down-regulation in different cell lines [1]. |
体内活性 | Stauprimide (p.o.; 50 mg/kg; once daily; 30 days, 55 days) blocks tumor growth, decreases MYC protein levels in xenograft mouse with RXF 393 or CAKI-1 cells. It also inhibits MYC transcription in the RXF 393 tumor [1]. |
分子量 | 584.62 |
分子式 | C35H28N4O5 |
CAS No. | 154589-96-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Stauprimide 154589-96-5 Others Inhibitor inhibitor inhibit