store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TCH-165 是一种蛋白酶体组装的小分子调节剂,可增加游离 20S 水平,进而增强 IDP 蛋白水解。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 963 | 现货 | ||
2 mg | ¥ 1,420 | 现货 | ||
5 mg | ¥ 2,330 | 现货 | ||
10 mg | ¥ 3,760 | 现货 | ||
25 mg | ¥ 5,930 | 现货 | ||
50 mg | ¥ 8,360 | 现货 | ||
100 mg | ¥ 11,200 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,150 | 现货 |
产品描述 | TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs. |
体外活性 | TCH-165, resulting in an increase in 20S levels.?The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs, including α-synuclein, tau, ornithine decarboxylase, and c-Fos, but not structured proteins.?Clearance of ubiquitinated protein was largely maintained by single capped proteasome complexes (19S-20S), but accumulation occurs when all 19S capped proteasome complexes are depleted[1]. |
分子量 | 595.73 |
分子式 | C39H37N3O3 |
CAS No. | 1446350-60-2 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (83.93 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6786 mL | 8.3931 mL | 16.7861 mL | 41.9653 mL |
5 mM | 0.3357 mL | 1.6786 mL | 3.3572 mL | 8.3931 mL | |
10 mM | 0.1679 mL | 0.8393 mL | 1.6786 mL | 4.1965 mL | |
20 mM | 0.0839 mL | 0.4197 mL | 0.8393 mL | 2.0983 mL | |
50 mM | 0.0336 mL | 0.1679 mL | 0.3357 mL | 0.8393 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TCH-165 1446350-60-2 Proteases/Proteasome Ubiquitination Proteasome tau trypsin-like 20S IDPs chymotrypsin-like degradation α-syn inhibit TCH 165 caspase-like TCH165 assembly Inhibitor inhibitor