Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Aβ/tau aggregation-IN-1 is a potent inhibitor of Aβ 1-42 β-sheet formation and tau aggregation. It exhibits K D values of 160 μM and 337 μM with Aβ 1-42 and tau, respectively. Additionally, Aβ/tau aggregation-IN-1 can penetrate the blood-brain barrier efficiently.
产品描述 | Aβ/tau aggregation-IN-1 is a potent inhibitor of Aβ 1-42 β-sheet formation and tau aggregation. It exhibits K D values of 160 μM and 337 μM with Aβ 1-42 and tau, respectively. Additionally, Aβ/tau aggregation-IN-1 can penetrate the blood-brain barrier efficiently. |
靶点活性 | β-Amyloid (1–42):160 μM (Kd), Tau:337 μM (Kd) |
体外活性 | Aβ/tau aggregation-IN-1 (1 μM; 24 hours; HEK-293 T cells) significantly declines the tau aggregation foci[1]. Aβ/tau aggregation-IN-1 with N-methylation of the quinolone ring effectively inhibits Aβ 1-42 aggregation by 84.7%–99.5% and tau aggregation by 71.2%–101.8%. Aβ/tau aggregation-IN-1 inhibits self-induced Aβ 1-42 aggregation by inhibiting the formation of β-sheets. Aβ/tau aggregation-IN-1 shows certain binding abilities with Aβ 1-42 and tau. The K D value of Aβ/tau aggregation-IN-1 with Aβ 1-42 is 160 μM. The K D value of Aβ/tau aggregation-IN-1 with tau is 337 μM. Aβ/tau aggregation-IN-1 interacts with Aβ 1-42 and tau through noncovalent interactions[1]. Immunofluorescence[1]Cell Line: HEK-293 T cells Concentration: 1 μM Incubation Time: 24 hours Result: Significantly declined the tau aggregation foci. |
分子量 | 492.36 |
分子式 | C25H21IN2O |
CAS No. | 2252162-81-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
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体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Aβ/tau aggregation-IN-1 2252162-81-3 Aβ/tau aggregation IN 1 Ab/tau aggregation-IN-1 Abeta/tau aggregation-IN-1 Aβ/tau aggregationIN1 Inhibitor inhibitor inhibit