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Search Results for " neurotoxicity "

50

抑制剂 & 化合物

27

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2550	Tolmetin Tolectin,托麦汀	COX	Immunology/Inflammation; Neuroscience
	Tolmetin (Tolectin) 是非甾体类抗炎药，是可口服的 COX 抑制剂，对人 COX-1 和 COX-2 的 IC50值分别为 0.35 和 0.82 µM。
T36964	BML-259 CAY10554	CDK	Cell Cycle/Checkpoint
	BML-259 是 CDK5 和 CDK2 的抑制剂，IC50 分别为 64 和 98 nM。 BML-259 可用于癌症和神经退行性疾病治疗的研究。
T0412	Idebenone 艾地苯醌,CV-2619	Apoptosis; Antioxidant; Mitochondrial Metabolism	Apoptosis; Metabolism; oxidation-reduction
	Idebenone (CV-2619) 是一种线粒体保护剂，具有神经保护功效，可用于研究阿尔茨海默病、亨廷顿舞蹈病，可透过血脑屏障，诱导细胞凋亡。
T6500	Ferrostatin-1 Ferrostatin 1,Ferrostatin-1 (Fer-1)	Ferroptosis; Antifungal	Apoptosis; Microbiology/Virology
	Ferrostatin-1 (Fer-1) 是一种铁死亡抑制剂，具有强效性和选择性。Ferrostatin-1 有效抑制 Erastin 诱导的 HT-1080 细胞铁死亡 (EC50=60 nM)。Ferrostatin-1 还具抗氧化和抗真菌活性。
T2264	AM281 1-(2,4-二氯苯基)-5-(4-碘苯基)-4-甲基-N-4-吗啉基-1H-吡唑-3-甲酰胺	Cannabinoid Receptor	GPCR/G Protein
	AM281 是选择性CB1受体拮抗剂，IC50=9.91 nM。它抑制 CB2 受体，IC50=13000 nM。
T12352L	Oxidopamine hydrobromide 6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide	Mitophagy; Dopamine Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Oxidopamine hydrobromide (6-OHDA hydrobromide) 是一种神经递质多巴胺拮抗剂，可选择性地破坏多巴胺能神经元，是一种广泛使用的神经毒素。
T12352	Oxidopamine hydrochloride 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐	Mitophagy; Dopamine Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) 是一种神经递质多巴胺拮抗剂，可选择性地破坏多巴胺能神经元，是一种广泛使用的神经毒素。
T25384	Erbulozole R-55104,R55104,R 55104	Microtubule Associated	Cytoskeletal Signaling
	Erbulozole (R 55104) 是一种有效的合成微管抑制剂，具有抗侵袭、抗肿瘤和放射增敏活性，可诱发 Wernicke 脑病样神经毒性。
T15055	DB04760 MMP-13 Inhibitor	MMP	Proteases/Proteasome
	DB04760 是一种高选择性和有效的 MMP-13 非锌螯合抑制剂（IC50：8 nM）。DB04760 能明显降低紫杉醇的神经毒性，并具有抗癌活性。
T21470L	Davunetide acetate Davunetide acetate(211439-12-2 Free base)	Beta Amyloid; Microtubule Associated	Cytoskeletal Signaling; Neuroscience
	Davunetide acetate 源自哺乳动物 CNS 中存在的活性依赖性神经保护蛋白。 Davunetide acetate 是一种微管稳定肽，可抑制 Aβ 聚集和 Aβ 诱导的神经毒性。 Davunetide acetate 具有神经保护、神经营养和认知保护特性。
T72059	S1R agonist 2	Sigma receptor; ROS; NMDAR	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	S1R agonist 2 是一种具有选择性的 S1R 激动剂，对 S2R 和 S1R 的 Ki 分别为88 nM 和 1.1 nM，对 ROS 和 NMDA 诱导的神经毒性具有保护作用。
T67981	Copper histidine
	Copper histidine 抑制了Ctr1介导的奥沙利铂在体外的细胞摄取，而不会改变奥沙利铂在体内DRG 组织中的铂或神经毒性的积累。Copper histidine 通过口服治疗 Menkes 疾病。
T6411	Biapenem CLI 86815,比阿培南,Biapenern,Omegacin,L 627,LJC 10627	Antibacterial; Antibiotic	Microbiology/Virology
	Biapenem (CLI 86815) 是不经肠道的广谱碳青霉烯抗生素。
T3570	SU4312 SU 4312,NSC 86429	VEGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	NSC-86429 是一种 (Z)-SU4312 (SU 4312) 和 (E)-SU4312 的外消旋体。其中(Z)-SU4312 能够抑制 PDGFR 和 FLK-1。(E)-SU4312 能够抑制 PDGFR, FLK-1, EGFR, HER-2, 和 IGF-1R。
T12532	PQM130	Beta Amyloid	Neuroscience
	PQM130是一种魏罗酮-多奈哌齐杂化化合物，能透过大脑。PQM130是多靶点的候选药物，可用于Aβ1-42低聚物引起的神经毒性，还具有抗炎活性。它是具有神经保护作用的、有潜力的抗 AD 药物。
T14138	AG-825 Tyrphostin AG-825	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	AG-825（Tyrphostin C15）是一种具有选择性和竞争性且抑制酪氨酸磷酸化的 ErbB2 抑制剂，其 IC50 值为 0.35 μM。AG-825（Tyrphostin C15）对 HER2 具有抑制作用，在小鼠乳腺癌异种模型中显示出抗癌活性。AG-825（Tyrphostin C15）是一种潜在的克服锰诱导的神经毒性或阿尔茨海默病发展的活性分子，能促进人中性粒细胞的凋亡，可用于研究乳腺癌。
T15576	Indibulin 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺,ZIO 301,D 24851	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Indibulin (D 24851) 是一种口服有效的微管蛋白合成抑制剂，具有抗有丝分裂和抗肿瘤活性，且神经毒性小。它降低了肌间神经张力，产生异常的纺锤体，激活有丝分裂检查点蛋白 Mad2 和 BubR1，并诱导有丝分裂停滞和细胞凋亡。
T68599	Orphenadrine Orphenadrine (free base)	Sodium Channel; NMDAR; AChR	Membrane transporter/Ion channel; Neuroscience
	Orphenadrine 是一种非竞争性的 N-甲基-D-天冬氨酸（NMDA）受体拮抗剂，以浓度依赖性方式抑制克隆的 HERG 通道，在 HEK 细胞中产生0.85μM 的 IC。Orphenadrine 是中枢和外周毒蕈碱受体的拮抗剂，通过孔残基 Y652或 F656突变阻断衰减。 Orphenadrine 具有抗痉挛、镇痛和抗胆碱能活性，对在体外和体内对谷氨酸神经毒性具有保护作用。Orphenadrine 对钠离子通道具有抑制作用，可用来治疗帕金森。
T26947	Caprospinol SP 233,SP233,SP-233
	Caprospinol inhibits β-Amyloid (Aβ) protein neurotoxicity.
T19838	Brilliant Blue R250 Acid Blue 83,Brilliant Blue R,Coomassie Brilliant Blue R250,CBBR,Coomassie Brilliant Blue R
	CBBR is an inhibitor of wild type and mutant alpha-synuclein aggregation. CBBR also a modulator of neurotoxicity.
TP2284	Prion Protein 106-126 (human)	Others	Others
	Prion peptide fragment that exhibits neurotoxicity
T61178	Aβ-IN-5
	Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor that also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Furthermore, Aβ-IN-5 exhibits remarkable neuroprotective effects along with low neurotoxicity [1].
T33858	PACA N-Propargyl Caffeamide
	PACA, (N-propargyl Caffeamide)enhances NGF-induced neurite growth and reduces 6-hydroxydopamine neurotoxicity in neuron cultures. Parkinson's disease (PD) is associated with insufficient production of nerve growth factor (NGF).
TP1225	β-Amyloid (22-35) β-Amyloid 22-35,Amyloid β-Protein (22-35)
	β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells. Beta amyloid (22-35) is a synthetic truncated fragment of beta-amyloid peptide.
T60750	Neuronotoxicity-IN-1
	Neuronotoxicity-IN-1 是一种吡啶并噻嗪衍生物。Neuronotoxicity-IN-1 具有神经保护活性，是红藻氨酸神经毒性的抑制剂。
T71611	αSyn-IN-576755
	αSyn-IN-576755 is a novel inhibitor of αSyn fibrillization, blocking fibril growth and suppressing A53T αSyn neurotoxicity.
T75592	Odonthobuthus Doriae Venom
	Odonthobuthus Doriae Venom，一种从Odonthobuthus Doriae获得的蝎子毒液，通过调节离子通道产生神经毒性。
T72642	Cefepime chloride BMY-28142 chloride
	Cefepime (BMY-28142) chloride为能透过血脑屏障的广谱头孢菌素，对革兰氏阳性及革兰氏阴性需氧菌具有抗菌效果，但可能引起神经毒性。
T41179	CL 82198 hydrochloride
	CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibitsin vitroinvasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish.
T14963	CI-943 (±)-CI-943	Others	Others
	CI-943是一种新型潜在的抗精神病药物，它不与多巴胺（DA）受体结合，有一定的发育性神经毒性。
T36092	Fenobucarb
	Fenobucarb, a widely employed carbamate insecticide, poses potential risks to the cardiovascular and cerebrovascular systems in animals[1][2]. It triggers developmental neurotoxicity in zebrafish by engaging pathways related to inflammation, oxidative stress, degeneration, and apoptosis.
T78086	S1R agonist 1 hydrochloride	Sigma receptor	GPCR/G Protein
	S1R agonist 1 (Compound 6b) hydrochloride，是一种高选择性S1R激动剂，其Ki值针对S1R为0.93 nM而对S2R为92 nM。该化合物能对抗反应性氧种（ROS）和N-甲基-D-天冬氨酸（NMDA）引发的神经毒性，显示出神经保护效果。
T62115	HBV-IN-24
	HBV-IN-24 (compound (2 S, 6S)-1a) 是一种 HBV 的有效抑制剂。HBV-IN-24 能够较强的抑制 HBV DNA (EC50: 0.6 nM)、HBsAg (EC50: 0.6 nM) 和 HBeAg (EC50: 4.6 nM)。HBV-IN-24 表现出良好的抗病毒效果，能够改善神经毒性。
T78087	S1R agonist 2 hydrochloride	Sigma receptor	GPCR/G Protein
	S1R agonist 2 (Compound 8b) hydrochloride，作为一种选择性S1R激动剂，对S1R的Ki值为1.1 nM，而对S2R为88 nM。它能够保护神经系统免受ROS和NMDA诱导的毒性损伤。
T60826	GABAA receptor agent 8
	GABAA receptor agent 8 (compoud 5e) 在癫痫研究方面具有潜力。GABAA receptor agent 8 是GABAA 受体的正向变构调节剂，在体内外均具有抗惊厥活性和低神经毒性。
T71554	ARN 14494
	ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.
T78171	QR-0217
	QR-0217是一种有效的Aβ1-40聚集抑制剂，具有7.5 µM的IC50值，阻断α-突触核蛋白的聚集，并可减轻Aβ神经毒性导致的记忆障碍。
T74822	S1R agonist 1
	S1R agonist 1 (Compound 6b) 是一种选择性 S1R 激动剂，对 S1R 和 S2R 的 Ki 分别为 0.93 nM 和 72 nM。S1R agonist 1 对 ROS 和 NMDA 诱导的神经毒性具有神经保护作用。
T62046	HDAC6-IN-5
	HDAC6-IN-5 (化合物 11b) 是有效的、血脑屏障通透性的 HDAC6抑制剂(IC50= 0.025 μM)。HDAC6-IN-5 抑制 AChE 活性和 Aβ1-42自聚集和，IC50分别为 0.88 和 1.1 μM。HDAC6-IN-5 能够促进神经突起生长，且无明显神经毒性。
T73575	SD-6
	SD-6 是一种具有口服活性的hAChE 和hBChE 抑制剂，IC50值分别为 0.907 µM 和 1.579 µM。SD-6 具有优良的血脑屏障 (BBB) 渗透性且无神经毒性，可用于阿尔茨海默病研究。
T81638	NSC363998 free base
	NSC363998 (free base) 是一种具口服活性的化合物，能够抑制 rCGG90 诱导的神经毒性，并可应用于脆性 X 相关震颤/共济失调综合征 (FXTAS) 等神经退行性疾病的研究。
T61052	GABAA receptor agent 7
	GABAA receptor agent 7 (compoud 5c) 在体内外均具有抗惊厥活性和低神经毒性，可用于癫痫研究。 GABAA receptor agent 7 是GABAA 受体的有效正调节剂。
T60954	HDAC6-IN-6
	HDAC6-IN-6 (化合物 6a) 是 HDAC6的有效抑制剂，可以穿透血脑屏障，IC50值为0.025 μM。HDAC6-IN-6 对 AChE 和 Aβ1-42自聚集具有有效的抑制活性，IC50值分别为 0.72 和 3.0 μM。HDAC6-IN-6 可促进神经突起生长而没有显著的神经毒性。
T79342	BChE-IN-17
	BChE-IN-17（compound 6n）是一种高效的BChE选择性抑制剂，对eqBChE和hBChE的IC50值为10.5 nM和32.5 nM。与AChE相比，其对BChE的选择性提高了1000倍，且表现出较低的神经毒性和中等程度的神经保护效果。
T83509	[Arg6]-β-Amyloid (1-40), england mutation
	[Arg6]-β-Amyloid (1-40), England mutation 是具有生物活性的肽，与多种家族性常染色体显性阿尔茨海默病相关。特别地，这种英国突变，即位于第6位的His被Arg所替换，已报告可提高寡聚体形成动力学，加速初级纤维的种子化过程。此类寡聚体对神经元培养细胞展现出较高毒性。
T78874	GSK-3β inhibitor 15
	GSK-3β inhibitor15（Compound 54）是一种高效GSK-3β抑制剂（IC50: 3.4 nM），能够抑制Aβ1-42诱导的GSK-3β与tau蛋白的磷酸化并阻止LPS诱导的iNOS表达，显示出对Aβ1-42引起的神经毒性的神经保护效应。该化合物在阿尔茨海默病（AD）研究中具有潜在应用价值。
T76033	Humanin
	Humanin 是一种 24 个氨基酸组成的抗凋亡肽，是Bax 抑制剂。Humanin 可以阻止Bax 从细胞质向线粒体的转运，阻断Bax 由活性构象向活性构象的转变。Humanin 是一种线粒体相关肽，具有对抗 AD 相关神经毒性的神经保护作用。Humanin 还可以改善动物的整体胰岛素敏感性。Humanin 与衰老有关。HNG，是 Humanin 的 14号位置的丝氨酸被甘氨酸取代的类似物。
T82243	hAChE-IN-5	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	hAChE-IN-5（化合物49）是一种同时针对hAChE和hBuChE的有效抑制剂，其IC50值均为0.17 μM。此外，hAChE-IN-5对GSK3β同样展现出良好的抑制活性，IC50值为0.21 μM。作为tau蛋白聚集和Aβ1-42自聚集的抑制剂，hAChE-IN-5能够结合PAS，进而阻止Aβ依赖的神经毒性。其能穿透血脑屏障（BBB），显示出成为多靶点抗阿尔茨海默病药物研究的潜力。
T65396	Piperazine 2HCl
	Piperazine (2HCl) is gamma-aminobutyric acid (GABA) agonists and its major effects appear to be on the central nervous system. Piperazine was the anthelmintic with the greatest number of reports of toxicoses and suspected toxicoses in cats. Piperazine neurotoxicity in cats and dogs usually was manifested by muscle tremors, ataxia, and/or behavioral disturbances within 24 hours after estimated daily dose(s) between 20 and 110 mg/kg[1]. For di-substituted derivatives, ciprofloxacin was selected an...
T37605	D-DOPA
	D-DOPA is an enantiomer of the dopamine precursor L-DOPA . It can be converted to L-DOPAviasequential oxidation and transamination, which are mediated by D-amino acid oxidase (DAAO) and DOPA transaminase, respectively, in rat kidney homogenates.1It reduces the number of dopaminergic neurons in primary rat embryonic mesencephalic cultures in a concentration-dependent manner.2Intraventricular administration of D-DOPA (200 μg/animal) increases striatal dopamine levels in rats.3D-DOPA (20 mg/kg, i.p...

化合物

Cat.No: T2550

Synonym: Tolectin,托麦汀

Target: COX

Cat.No: T36964

Synonym: CAY10554

Target: CDK

Cat.No: T0412

Synonym: 艾地苯醌,CV-2619

Target: Apoptosis, Antioxidant, Mitochondrial Metabolism

Cat.No: T6500

Synonym: Ferrostatin 1,Ferrostatin-1 (Fer-1)

Target: Ferroptosis, Antifungal

Cat.No: T2264

Synonym: 1-(2,4-二氯苯基)-5-(4-碘苯基)-4-甲基-N-4-吗啉基-1H-吡唑-3-甲酰胺

Target: Cannabinoid Receptor

Oxidopamine hydrobromide

Cat.No: T12352L

Synonym: 6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide

Target: Mitophagy, Dopamine Receptor, Autophagy

Oxidopamine hydrochloride

Cat.No: T12352

Synonym: 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐

Target: Mitophagy, Dopamine Receptor, Autophagy

Cat.No: T25384

Synonym: R-55104,R55104,R 55104

Target: Microtubule Associated

Cat.No: T15055

Synonym: MMP-13 Inhibitor

Target: MMP

Davunetide acetate

Cat.No: T21470L

Synonym: Davunetide acetate(211439-12-2 Free base)

Target: Beta Amyloid, Microtubule Associated

Cat.No: T72059

Target: Sigma receptor, ROS, NMDAR

Copper histidine

Cat.No: T67981

Cat.No: T6411

Synonym: CLI 86815,比阿培南,Biapenern,Omegacin,L 627,LJC 10627

Target: Antibacterial, Antibiotic

Cat.No: T3570

Synonym: SU 4312,NSC 86429

Target: VEGFR, PDGFR

Cat.No: T12532

Target: Beta Amyloid

Cat.No: T14138

Synonym: Tyrphostin AG-825

Target: Apoptosis, EGFR

Cat.No: T15576

Synonym: 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺,ZIO 301,D 24851

Target: Apoptosis, Microtubule Associated

Cat.No: T68599

Synonym: Orphenadrine (free base)

Target: Sodium Channel, NMDAR, AChR

Cat.No: T26947

Synonym: SP 233,SP233,SP-233

Brilliant Blue R250

Cat.No: T19838

Synonym: Acid Blue 83,Brilliant Blue R,Coomassie Brilliant Blue R250,CBBR,Coomassie Brilliant Blue R

Prion Protein 106-126 (human)

Cat.No: TP2284

Target: Others

Cat.No: T61178

Cat.No: T33858

Synonym: N-Propargyl Caffeamide

β-Amyloid (22-35)

Cat.No: TP1225

Synonym: β-Amyloid 22-35,Amyloid β-Protein (22-35)

Neuronotoxicity-IN-1

Cat.No: T60750

αSyn-IN-576755

Cat.No: T71611

Odonthobuthus Doriae Venom

Cat.No: T75592

Cefepime chloride

Cat.No: T72642

Synonym: BMY-28142 chloride

CL 82198 hydrochloride

Cat.No: T41179

Cat.No: T14963

Synonym: (±)-CI-943

Target: Others

Cat.No: T36092

S1R agonist 1 hydrochloride

Cat.No: T78086

Target: Sigma receptor

Cat.No: T62115

S1R agonist 2 hydrochloride

Cat.No: T78087

Target: Sigma receptor

GABAA receptor agent 8

Cat.No: T60826

Cat.No: T71554

Cat.No: T78171

Cat.No: T74822

Cat.No: T62046

Cat.No: T73575

NSC363998 free base

Cat.No: T81638

GABAA receptor agent 7

Cat.No: T61052

Cat.No: T60954

Cat.No: T79342

[Arg6]-β-Amyloid (1-40), england mutation

Cat.No: T83509

GSK-3β inhibitor 15

Cat.No: T78874

Cat.No: T76033

Cat.No: T82243

Target: GSK-3

Piperazine 2HCl

Cat.No: T65396

Cat.No: T37605

Cat. No.	Product Name	Target	Signaling Pathways
T3S1873	Talatisamine 塔拉乌头胺,塔拉萨敏	Potassium Channel	Membrane transporter/Ion channel
	Talatisamine 是一种乌头生物碱，对K+通道有特异性阻滞作用。它能减弱 beta- 淀粉样低聚物对培养的皮层神经元的毒性。
T6780	Benzamide Amid kyseliny benzoove,苯甲酰胺,Phenylcarboxyamide,Benzoylamide	PARP; Endogenous Metabolite	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Benzamide (Amid kyseliny benzoove) 是聚(ADP-核糖)聚合酶的抑制剂，是苯甲酸的衍生物。
TN1736	Hibifolin 棉皮素-8-O-Β-D-葡萄糖醛酸苷,棉花皮素-8-O-葡萄糖醛酸苷	Adenosine deaminase	Metabolism
	Hibifolin 是一种黄酮醇糖苷，是潜在的腺苷脱氨酶抑制剂。它可以保护神经元免受 beta-淀粉样蛋白诱导的毒性。
T9454	4-Hydroxyestrone	Estrogen Receptor/ERR; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	4-Hydroxyestrone 是一种内源性雌激素代谢物，可强烈保护神经元细胞免受氧化损伤。
T6004	Tetrahydropapaverine hydrochloride Tetrahydropapaverine HCl,Norlaudanosine HCl,Tetrahydroalkali hydrochloride,四氢罂粟碱盐酸盐	Hydroxylase	Metabolism
	Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) 是一种四氢异喹啉类药物。它对多巴胺神经元有神经毒性作用。
T3385	Gypenoside XVII GP-17,Gynosaponin S,七叶胆苷XVII	Estrogen Receptor/ERR; GSK-3; Endogenous Metabolite	Endocrinology/Hormones; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	Gypenoside XVII (Gynosaponin S) 是一种绞股蓝皂甙类的新型植物雌激素，能够激活雌激素受体。
TN1449	Brandioside 2'-O-Acetylpoliumoside,2'-Acetylpoliumoside	Antioxidant	oxidation-reduction
	Brandioside (2'-Acetylpoliumoside) 是可从马鞭草科植物 Callicarpa dichotoma Raeuschel 提取得到的苯丙素类糖苷，具有抗氧化活性，可削弱谷氨酸诱导的神经毒性，可用于研究糖尿病。
T6S1587	Notoginsenoside R2 三七皂苷R2,20(S)-Notoginsenoside R2,Ginsenoside Ng-R2	Others; Nrf2	Immunology/Inflammation; Others
	Notoginsenoside R2 (20(S)-Notoginsenoside R2) 是一种新分离三七皂苷，表现出对6-OHDA 诱导的氧化应激及细胞凋亡的保护作用。
T6102	2'-acetylacteoside	Antioxidant; Reductase	Endocrinology/Hormones; Metabolism; oxidation-reduction
	2'-Acetylacteoside 是一种苯乙醇苷类化合物，分离自来江藤中，可抑制自由基诱导的红细胞溶血，具有清除自由基的作用。
TN2082	Pinostrobin	Beta Amyloid; IL Receptor; Serine/threonin kinase; TNF	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Neuroscience
	Pinostrobin 是一种 PCSK9抑制剂，可抑制 PCSK9 的催化活性。它是能够在多种植物中发现的黄酮类化合物，并具有抗氧化，抗炎，抗癌和神经保护作用。它是有前景的胆固醇调节和脂质管理剂。
T6S0659	Rhynchophylline 钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin	Calcium Channel; NF-κB	Membrane transporter/Ion channel; Metabolism; NF-κB
	Rhynchophylline (Mitrinermine) 是一种生物碱类化合物，从钩藤中分离得到，具有很高的生物活性，被广泛用于抗炎、神经保护等方面的研究。
T6S0653	Linarin Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷	TNF; AChE	Apoptosis; Neuroscience
	Linarin (Acacetin-7-O-rutinoside) 是一种选择性的乙酰胆碱酯酶 (AChE) 抑制剂，从薄荷花提取物中分离得到。
TN2211	Silybin B Silibinin B	Apoptosis; Beta Amyloid; Bcr-Abl	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Neuroscience; Tyrosine Kinase/Adaptors
	Silybin B (Silibinin B) 是雷洛昔芬4′-和6-葡萄糖醛酸化的有效抑制剂，是水飞蓟素有效的抗纤维原性和抗低聚物成分，具有清除1,1-二苯基-2-吡啶酰肼(DPPH)自由基的活性，可通过减轻 DNA 损伤和细胞凋亡对顺铂诱导的神经毒性具有保护作用。Silybin B 对人慢性髓系白血病 K562细胞的生长抑制和诱导凋亡有较强的作用。
TN5171	Tricetin	Apoptosis; Others; Nrf2	Apoptosis; Immunology/Inflammation; Others
	Tricetin 是一种从石榴中分离出的类黄酮。Tricetin 是 Keap1-Nrf2 蛋白相互作用（PPI）的强效竞争性抑制剂，通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡通路，保护帕金森病患免受 6-OHDA 诱导的神经毒性的影响。Tricetin 通过 Akt/GSK-1β途径抑制鼻咽癌的迁移和指示性蛋白酶早老素-1（PS-1）表达。Tricetin 抑制由Egr-1介导的氧化LDL 诱导的内皮炎症，保护大鼠软骨细胞免受IL-1β诱导的炎症和细胞凋亡。
T37957	Setosusin
	Setosusin is a meroterpenoid fungal metabolite originally isolated from C. setosus. It reduces neurotoxicity induced by amyloid-β (Aβ) aggregates in PC12 cells (EC50 = 112.6 μM). In vivo, setosusin (30 mg/kg) induces tremors in mice.
TN3808	Dehydroheliobuphthalmin	Others	Others
	Dehydroheliobuphthalmin has significant neuroprotective activities against glutamate- induced neurotoxicity.
TN2037	Paeonilactone C (3S,3AR,6S,7AR)-3-[(苯甲酰基氧基)甲基]四氢-6-羟基-6-甲基-2,5(3H,4H)-苯并呋喃二酮,芍药内苷 C	Others	Others
	Paeonilactone C significantly protects primary cultures of rat cortical cells against H2O2-induced neurotoxicity.
TN1361	(+)-Afzelechin 阿夫儿茶精,(+)-阿夫儿茶精	Others	Others
	(+)-Afzelechin has a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells, it has ABTS cation radical scavenging effects with IC50 values of 23.7 microM
TN3618	Cedrin	Beta Amyloid; BCL; Caspase	Apoptosis; Neuroscience; Proteases/Proteasome
	Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis.
TN4679	Nudiposide	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Nudiposide has significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells. It also exhibits protective effect against sepsis in a mouse model and can decrease the plasma levels of TNF-α, IL-10 and ALT activity.
TN1726	Heishuixiecaoline A	Others	Others
	Heishuixiecaoline A protects against neurotoxicity in PC12 cells.
T83288	5-Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone
	Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone 是一种神经保护剂，对谷氨酸诱导的大鼠皮质细胞原代培养显示显著的神经保护效果。
TN6515	Selaginellin
	Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression of klotho gene. Selaginellin shows
T81524	Peimisine 3-O-β-D-glucopyranoside
	Peimisine 3-O-β-D-glucopyranoside (compound 1) 是一种从单苞贝母鳞茎中分离得到的甾体生物碱。该化合物对鱼藤酮诱导的PC12细胞系神经毒性展现出中等程度的保护效果。
TN3771	Dasycarpol	Others	Others
	Dasycarpol(9beta-Hydroxyfraxinellone) shows significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at a concentration of 0.1 microM. Dasycarpol also shows moderate inhibitory activity on lung
TN2036	Paeonilactone B (+)-Paeonilactone B	NADPH-oxidase	Immunology/Inflammation
	Paeonilactone B ((+)-Paeonilactone B) 是一种来自白芍的单萜类化合物，具有神经保护活性，抑制氧化应激，在大鼠皮质细胞在抑制 H2O2 诱导的神经毒性。
T4752	1-Aminocyclopropane-1-carboxylic acid 1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC	Endogenous Metabolite; NMDAR	Metabolism; Neuroscience
	1-Aminocyclopropane-1-carboxylic acid (ACC) 是内源性代谢产物的一种。

天然产物

Cat.No: T3S1873

Synonym: 塔拉乌头胺,塔拉萨敏

Target: Potassium Channel

Cat.No: T6780

Synonym: Amid kyseliny benzoove,苯甲酰胺,Phenylcarboxyamide,Benzoylamide

Target: PARP, Endogenous Metabolite

Cat.No: TN1736

Synonym: 棉皮素-8-O-Β-D-葡萄糖醛酸苷,棉花皮素-8-O-葡萄糖醛酸苷

Target: Adenosine deaminase

4-Hydroxyestrone

Cat.No: T9454

Target: Estrogen Receptor/ERR, Endogenous Metabolite

Tetrahydropapaverine hydrochloride

Cat.No: T6004

Synonym: Tetrahydropapaverine HCl,Norlaudanosine HCl,Tetrahydroalkali hydrochloride,四氢罂粟碱盐酸盐

Target: Hydroxylase

Gypenoside XVII

Cat.No: T3385

Synonym: GP-17,Gynosaponin S,七叶胆苷XVII

Target: Estrogen Receptor/ERR, GSK-3, Endogenous Metabolite

Cat.No: TN1449

Synonym: 2'-O-Acetylpoliumoside,2'-Acetylpoliumoside

Target: Antioxidant

Notoginsenoside R2

Cat.No: T6S1587

Synonym: 三七皂苷R2,20(S)-Notoginsenoside R2,Ginsenoside Ng-R2

Target: Others, Nrf2

2'-acetylacteoside

Cat.No: T6102

Target: Antioxidant, Reductase

Cat.No: TN2082

Target: Beta Amyloid, IL Receptor, Serine/threonin kinase, TNF

Rhynchophylline

Cat.No: T6S0659

Synonym: 钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin

Target: Calcium Channel, NF-κB

Cat.No: T6S0653

Synonym: Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷

Target: TNF, AChE

Cat.No: TN2211

Synonym: Silibinin B

Target: Apoptosis, Beta Amyloid, Bcr-Abl

Cat.No: TN5171

Target: Apoptosis, Others, Nrf2

Cat.No: T37957

Dehydroheliobuphthalmin

Cat.No: TN3808

Target: Others

Paeonilactone C

Cat.No: TN2037

Synonym: (3S,3AR,6S,7AR)-3-[(苯甲酰基氧基)甲基]四氢-6-羟基-6-甲基-2,5(3H,4H)-苯并呋喃二酮,芍药内苷 C

Target: Others

Cat.No: TN1361

Synonym: 阿夫儿茶精,(+)-阿夫儿茶精

Target: Others

Cat.No: TN3618

Target: Beta Amyloid, BCL, Caspase

Cat.No: TN4679

Target: IL Receptor, TNF

Heishuixiecaoline A

Cat.No: TN1726

Target: Others

5-Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone

Cat.No: T83288

Cat.No: TN6515

Peimisine 3-O-β-D-glucopyranoside

Cat.No: T81524

Cat.No: TN3771

Target: Others

Paeonilactone B

Cat.No: TN2036

Synonym: (+)-Paeonilactone B

Target: NADPH-oxidase

1-Aminocyclopropane-1-carboxylic acid

Cat.No: T4752

Synonym: 1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC

Target: Endogenous Metabolite, NMDAR

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