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Search Results for " inflammatory responses "

57

抑制剂 & 化合物

31

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7954	YM976	PDE	Metabolism
	YM976 是磷酸二酯酶 4 抑制剂(IC50:2.2 nM)。它能够抑制抗原诱导的气道反应，并有抗炎的作用。
T38361	GSK717	IL Receptor; NOD	Immunology/Inflammation; NF-κB
	GSK717 是 NOD2(核苷酸结合寡聚结构域 2) 的选择性抑制剂。它抑制壁酰二肽 (MDP) 诱导的 NOD2 介导的信号转导，抑制 MDP 刺激的 HEK293/hNOD2 细胞分泌 IL-8 (IC50为 400 nM)。
T7511	Cyclo(his-pro)	NF-κB; Endogenous Metabolite	Metabolism; NF-κB
	Cyclo(his-pro) 是一种口服具有活力的，结构上与促甲状腺激素释放激素相关的环状二肽。它能够抑制NF-κB 核积累，也能够穿越脑血屏障并影响多种炎症和应激反应。
T9079	Apostatin-1 Apt-1	Others	Others
	Apostatin-1 (Apt-1) 是一种新型 TRADD 抑制剂。 Apostatin-1 可以与 TRADD 的 N 末端 TRAF2 结合域上的口袋结合。
T21608L	β-Interleukin I (163-171), human Acetate β-Interleukin I (163-171), human Acetate(106021-96-9 Free base)	Others	Others
	β-Interleukin I (163-171), human Acetate 是一种参与调节免疫反应、炎症反应和造血的肽。
T11877	LR-90	Others	Others
	LR-90, 作为一种高级糖基化终产品(AGE)抑制剂，在糖尿病动物模型研究中被广泛使用。LR-90 有效地抑制了人类单核细胞中的炎症反应。
T36716	RO0270608	Integrin	Cytoskeletal Signaling
	RO0270608，是 R411 的活性代谢物，是一种具有口服活性的双重 α4β1/α4β7 整合素拮抗剂，具有抗炎活性，可调节炎症，可用于研究过敏性炎症反应。
T1076	Dexamethasone MK 125,Prednisolone F,NSC 34521,Hexadecadrol,地塞米松	Glucocorticoid Receptor; Mitophagy; IL Receptor; SARS-CoV; Antibacterial; Antibiotic; Autophagy; Complement System	Autophagy; Endocrinology/Hormones; Immunology/Inflammation; Microbiology/Virology
	Dexamethasone (Hexadecadrol) 是一种糖皮质激素受体激动剂和一种 IL 受体调节剂。Dexamethasone 具有抗炎和免疫抑制活性，可诱导自噬。Dexamethasone 抑制 LPS 诱导的巨噬细胞炎症反应。
T78181	MMP-7-IN-2	MMP; Others	Others; Proteases/Proteasome
	MMP-7-IN-2 可作为一种具有选择性和有效性的 MMP7 抑制剂，可用于研究炎症反应和与血管相关的疾病。
T11492	GSK2983559 free acid	Others; RIP kinase	Apoptosis; NF-κB; Others
	GSK2983559 free acid 是一种有效的特异性受体相互作用蛋白 2 (RIP2) 抑制剂。 GSK2983559 free acid 在阻断人类炎症性肠病外植体样品和体内的许多促炎细胞因子反应方面表现出优异的活性。
T9119	SU0268	Others	Others
	SU0268 是有效的 8-8-氧鸟嘌呤 DNA 糖基化酶1的选择性抑制剂，具有调控铜绿假单胞杆菌感染免疫反应的能力。
T31615	Elsibucol AGI-1096,UNII-O7T92N1Y8T,AGI 1096	Antioxidant	oxidation-reduction
	Elsibucol (AGI 1096) 是一种VCAM1抑制剂，可用于研究器官移植排斥。Elsibucol 是一种代谢稳定的丙醇衍生物，具有抗氧化、抗炎和抗增殖的特性。它能降低血液中的胆固醇水平，减少受伤动脉中的氧化应激和炎症反应，从而抑制动脉粥样硬化，保护动脉损伤后的内皮愈合。
T22414	RBN012759	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	RBN012759 是选择性和具有口服活性的 PARP14抑制剂，IC50值小于3 nM，可降低促肿瘤巨噬细胞功能并在肿瘤外植体中引发炎症反应，比对 monoPARPs 的选择性高 300 倍，比对 polyPARPs 的选择性高 1000 倍。
T16478	PF-04447943 PF 04447943,Edelinontrine,PF04447943	PDE	Metabolism
	PF-04447943 (Edelinontrine) 是一种有效且具有选择性的的磷酸二酯酶 9A 抑制剂，IC50 为 12 nM，比作用于其他PDE家族成员选择性高 78 倍 (IC50>1000 nM)。PF-04447943 具有抗炎活性，通过抑制氧化应激、炎症和调节T细胞极化来减轻炎症反应，且可用于研究镰刀型贫血症。
T24997	ABT-510 acetate ABT 510 acetate	Apoptosis	Apoptosis
	ABT-510 acetate 是一种内源性抗血管生成的 TSP 肽抑制剂，是一种凝血酶原类似物，具有抗炎抗癌和抗血管生成活性，能诱导肿瘤细胞凋亡并抑制上皮性卵巢癌正位、同种异体模型中的卵巢肿瘤生长。ABT-510 acetate 可减少小鼠炎症性肠病模型的血管生成和炎症反应，可用于癌症 (尤其是上皮性卵巢癌) 以及炎症性肠病 (IBD) 的研究。
T2401	Alogliptin Benzoate 苯甲酸阿格列汀,SYR 322,Alogliptin(SYR-322)benzoate	Ferroptosis; Proteasome; DPP-4	Apoptosis; Proteases/Proteasome; Ubiquitination
	Alogliptin Benzoate (SYR 322) 是一种有效且特异性的 DPP-4 抑制剂，IC50值小于 10 nM，其选择性比 DPP-8/9 高 10,000 倍以上，可用于研究 2 型糖尿病。
T10865	Cot inhibitor-1	TNF; MAPK	Apoptosis; MAPK
	Cot inhibitor-1 是一种选择性的 Cot 蛋白激酶(也被称为 Tpl2或 MAP3K8)抑制剂(IC50 为 28 nM)。Cot inhibitor-1 抑制人全血中 TNF-alpha 的产生，其 IC50 为 5.7 nM。Cot 参与多种细胞信号通路，特别是与炎症和免疫反应有关的信号通路。Cot inhibitor-1抑制 Cot 活性，可能对类风湿关节炎、炎症性肠病和某些类型的癌症具有潜在的治疗效果。
T38164	MnTBAP chloride Mn(III)TBAP
	MnTBAP chloride (Mn(III)TBAP) 是一种具有细胞渗透性的超氧化物歧化酶 (SOD) 模拟物和过氧亚硝酸盐清除剂，能使SOD-大肠杆菌的加倍时间减少了2倍。 MnTBAP chloride 通过上调 BMPR-II 和抑制 NFκB 信号传导展现抗炎作用。MnTBAP chloride 是一种锰卟啉配合物，具有抗氧化性能，具有用于研究慢性肾脏疾病 (CKDs) 纤维化反应的潜力。
T60149	11β-HSD1-IN-11	Dehydrogenase	Metabolism
	11β-HSD1-IN-11 是一种有效的、具有竞争性的 11- β-羟基类固醇脱氢酶1 (11β-HSD1)抑制剂，对大鼠和人的 11β-HSD1具有抑制作用，IC50 分别为 0.34 μM 和 0.13 μM。11β-HSD1- in -11是一种作为的化合物。11β-HSD1-IN-11是一种参与调节各种生理过程的激素，例如代谢、炎症和应激反应。11β-HSD1-IN-11是治疗代谢紊乱、肥胖和某些炎症状况的潜在化合物。
T28853	SRTCX1003 SRTCX-1003,SRTCX 1003
	SRTCX1003, a SIRT1 activator, suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.
T26226	SRTCX1002 SRTCX 1002,SRTCX-1002
	SRTCX1002 is a SIRT1 Activator Suppressing Inflammatory Responses through Promotion of p65 Deacetylation and NF-κB Activity inhibitor.
T28171	Nifeviroc TD-0232,TD 0232,尼非韦罗,TD0232
	Nifeviroc, a CCR5 antagonist, is used potentially for treatment of inflammatory responses to HIV type-1 infection.
T69733	LM9
	LM9 is a MyD88 inhibitor which prevents atherosclerosis by regulating inflammatory responses and oxidative stress in macrophages.
T27239	Edaglitazone Edaglitazone sodium,BM-13.1258,RO-2052349-602,依格列宗,R-483,RO-2052349-000
	Edaglitazone is a PPARγ agonist. Edarglitazone restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse.
T63092	Anti-inflammatory agent 12
	Anti-inflammatory agent 12 是一种五环三萜化合物，在 LPS 诱导的炎症反应中表现出显着的偏差 (IC50: 2.22 μM)。Anti-inflammatory agent 12 具有潜力用于炎症性疾病的研究。
T34706	SRI-29132 SRI29132,SRI 29132,TPZ-11,TPZ 11,TPZ11
	SRI-29132 is potent; highly permeant of the blood-brain barrier; and selective for LRRK2 kinase activity, therefore effective in attenuating pro-inflammatory responses in macrophages and in rescuing neurite retraction phenotypes in neurons.
TP1961	PR-39 PR 39 (porcine)
	Antibacterial peptide. Stimulates angiogenesis and inhibits inflammatory responses by selectively blocking proteasome degradation of IκBα.
T63660	Anti-inflammatory agent 19
	Anti-inflammatory agent 19 能够抑制 NO (IC50: 36.00 μM)。Anti-inflammatory agent 19 对 HMGB1 诱导的后期炎症反应表现出抑制作用。Anti-inflammatory agent 19 能够用于研究后期炎症疾病，如冠状病毒病 (COVID-19)、败血症等。
T81267	RIPK3-IN-4	RIP kinase	Apoptosis; NF-κB
	RIPK3-IN-4（Compound 42）是一种抑制RIPK3活性的化合物。它能有效减轻HK-2细胞的损伤和凋亡（necroptosis），同时降低急性肾损伤中（Cisplatin）以及缺血/再灌注（I/R）引起的肾脏损伤、炎症及坏死性凋亡现象。
T33653	Neurokinin A (4-10), nle(10)- 10-Nle-neurokinin A (4-10)
	Neurokinin A (4-10), nle(10)- is a neurologically active peptide translated from the pre-protachykinin gene. Neurokinin A has many excitatory effects on mammalian nervous systems and on the mammalian inflammatory and pain responses.
T39683	Human β-defensin-3 Human β-defensin-3,HβD-3
	Human β-defensin-3 (HβD-3) is an antibiotic antimicrobial peptide synthesized by epithelial cells. It exhibits potent antimicrobial properties and mitigates inflammatory cytokine responses. HβD-3 efficiently targets various microorganisms, displaying IC90 values ranging from 6 to 25 μg/ml.
T74872	ODN 105870
	ODN 105870 是一种 G 修饰的抑制性寡核苷酸 (INH-ODN)，是一种选择性 TLR7抑制剂。ODN 105870 可用于炎症免疫反应研究。
T80131	C5a Anaphylatoxin (human)	Complement System	Immunology/Inflammation
	C5a Anaphylatoxin (human)为促炎多肽及白细胞化学引诱剂，主要应用于炎症与免疫领域研究，例如过敏性哮喘。
T83548	(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate
	'(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P (acetate)' 是一种对 Substance P 及 Bombesin 担任拮抗作用的化合物，能针对眼部三叉神经反向刺激引起的炎症反应产生效果。
T74873	ODN 105871
	ODN 105871，一种G修饰的抑制性寡核苷酸(INH-ODN)，作为选择性TLR7抑制剂，适用于炎症免疫反应的研究。
T37842	ASB 14780
	Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor (IC50 = 20 nM). Selective for cPLA2α over secreted PLA2α (sPLA2α; exhibits no inhibition at 10 μM). Inhibits cPLA2α-dependent inflammatory responses in vitro in guinea pig and human whole-blood assays. Improves diet-induced liver injury and CCl4-induced hepatic fibrosis in vivo. Orally bioavailable.
T73058	Cloxacillin 氯唑西林
	Cloxacillin 是一种口服有效的抗菌剂和β-lactamase 抑制剂，其IC50值为 0.04 µM。Cloxacillin 可通过抑制MAPKs、NF-кB 和NLRP3相关蛋白的激活从而抑制金黄色葡萄球菌所引起的炎症反应。
T11357	Gamma-glutamylcysteine TFA γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)	IL Receptor	Immunology/Inflammation
	Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes. Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx).
T3977L	Lifitegrast sodium SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra
	Lifitegrast sodium (SAR-1118) is an LFA-1 antagonist for the therapy of vascular complications of the eye. It inhibits T cell-mediated inflammation by blocking the binding of two cell surface proteins (lymphocyte function-associated antigen 1 and intercel
T74910	ODN 24888
	ODN 24888 是一种鸟嘌呤修饰的抑制性寡核苷酸 (INH-ODN)，对TLR7/TLR9介导的信号通路表现出强烈的抑制作用。ODN 24888 损害 IFN-α 水平和NF-κB 激活，抑制IL-6的释放。ODN 24888 参与免疫和炎症应答，可作为疫苗佐剂使用。
T80258	WRW4-OH
	WRW4-OH 是一种抑制 WKYMVm（一种 FPRL1 激动剂）与其受体结合的生物活性肽。FPRL1，作为典型的趋化受体，在外周血液和大脑的吞噬细胞中有表达，其激活过程与宿主的防御机制及神经退行性疾病相关炎症反应紧密相连。
T76156	Sphingomyelin phosphodiesterase
	Sphingomyelinphosphodiesterase 是一种水解酶，参与鞘磷脂代谢过程。Sphingomyelinphosphodiesterase 水解鞘磷脂，使其向磷酸胆碱和神经酰胺转化。Sphingomyelinphosphodiesterase 还在细胞分化、各种免疫和炎症反应以及细胞内胆固醇运输和代谢中发挥重要作用。
T70394	Deucravacitinib HCl
	Deucravacitinib HCl is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. MS-986165 potently binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. The compound potently inhibited IL-23-, IL-12-, and Type I interferon-driven cellular signaling and transcriptional resp...
T73665	Bufrolin
	Bufrolin，作为Cromoglycate（组胺释放抑制剂）的类似物，是一种高效的GPR35激动剂，能够促进β-arrestin-2与人GPR35a或大鼠GPR35之间的相互作用。此外，Bufrolin亦可作为抗过敏性肥大细胞稳定剂，有效抑制内化肽诱导的抗炎反应，并且在内化肽连接药剂的药物递送研究中，被作为抗炎剂使用。
T83942	IDR 1002
	IDR 1002是一种先天性防御调节肽。在小鼠的鼻窦炎感染和细菌性急性肺部感染模型中减少细菌负荷和炎症反应。它抑制LPS诱导的NF-κB和COX-2，促进p38、ERK1/2、MSK1和CREB的磷酸化/激活。
T64140	RORγt agonist 2
	RORγt agonist 2 是 RORγt 的有效的激动剂。RORγt agonist 2 能够诱导 Th17 细胞分化，增加促炎细胞因子水平，进而增强淋巴细胞的细胞毒性。RORγt agonist 2 对调节性 T 细胞的产生表现出抑制作用，能够抑制免疫反应。
TMIH-0046	3-Indoleacrylic acid-d4
	3-Indoleacrylic acid-d4 是 3-Indoleacrylic acid 的氘代化合物。3-Indoleacrylic acid 的 CAS 号为 1204-06-4。3-Indoleacrylic acid是由链球菌属产生的色氨酸的代谢产物。3-Indoleacrylic acid对肠上皮屏障功能有有益作用，并减轻免疫细胞的炎症反应。
T78095	Demethyleneberberine chloride	NF-κB	NF-κB
	Demethyleneberberine chloride是一种具有线粒体靶向性的天然抗氧化剂，能通过抑制NF-κB通路及调节Th细胞平衡来缓解小鼠结肠炎并抑制炎症。此外，作为一种AMPK激活剂，该化合物亦用于非酒精性脂肪性肝病（NAFLD）的研究。
T38049	Glycerophospho-N-Palmitoyl Ethanolamine
	N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. For example, arachidonoyl ethanolamide (AEA) is an endogenous neurotransmitter that evokes cellular responses by activating the cannabinoid receptors, central cannabinoid (CB1) and peripheral cannabinoid (CB2). The different types of NAE are derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-palmitoyl ethanolamine (GP-NPEA) is the metabo...
T76022	Chemerin-9 (149-157) (TFA)
	Chemerin-9 (149-157) TFA 作为趋化因子样受体1 (CMKLR1) 的有效激动剂，展现出抗炎活性，并能促进Akt与ERK磷酸化及活性氧生成，进而改善Aβ1-42诱发的记忆障碍。此外，该化合物还参与调节免疫反应、脂肪细胞分化以及糖代谢。

化合物

Cat.No: T7954

Target: PDE

Cat.No: T38361

Target: IL Receptor, NOD

Cat.No: T7511

Target: NF-κB, Endogenous Metabolite

Cat.No: T9079

Synonym: Apt-1

Target: Others

β-Interleukin I (163-171), human Acetate

Cat.No: T21608L

Synonym: β-Interleukin I (163-171), human Acetate(106021-96-9 Free base)

Target: Others

Cat.No: T11877

Target: Others

Cat.No: T36716

Target: Integrin

Cat.No: T1076

Synonym: MK 125,Prednisolone F,NSC 34521,Hexadecadrol,地塞米松

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, SARS-CoV, Antibacterial, Antibiotic, Autophagy, Complement System

Cat.No: T78181

Target: MMP, Others

GSK2983559 free acid

Cat.No: T11492

Target: Others, RIP kinase

Cat.No: T9119

Target: Others

Cat.No: T31615

Synonym: AGI-1096,UNII-O7T92N1Y8T,AGI 1096

Target: Antioxidant

Cat.No: T22414

Target: PARP

Cat.No: T16478

Synonym: PF 04447943,Edelinontrine,PF04447943

Target: PDE

ABT-510 acetate

Cat.No: T24997

Synonym: ABT 510 acetate

Target: Apoptosis

Alogliptin Benzoate

Cat.No: T2401

Synonym: 苯甲酸阿格列汀,SYR 322,Alogliptin(SYR-322)benzoate

Target: Ferroptosis, Proteasome, DPP-4

Cot inhibitor-1

Cat.No: T10865

Target: TNF, MAPK

MnTBAP chloride

Cat.No: T38164

Synonym: Mn(III)TBAP

11β-HSD1-IN-11

Cat.No: T60149

Target: Dehydrogenase

Cat.No: T28853

Synonym: SRTCX-1003,SRTCX 1003

Cat.No: T26226

Synonym: SRTCX 1002,SRTCX-1002

Cat.No: T28171

Synonym: TD-0232,TD 0232,尼非韦罗,TD0232

Cat.No: T69733

Cat.No: T27239

Synonym: Edaglitazone sodium,BM-13.1258,RO-2052349-602,依格列宗,R-483,RO-2052349-000

Anti-inflammatory agent 12

Cat.No: T63092

Cat.No: T34706

Synonym: SRI29132,SRI 29132,TPZ-11,TPZ 11,TPZ11

Cat.No: TP1961

Synonym: PR 39 (porcine)

Anti-inflammatory agent 19

Cat.No: T63660

Cat.No: T81267

Target: RIP kinase

Neurokinin A (4-10), nle(10)-

Cat.No: T33653

Synonym: 10-Nle-neurokinin A (4-10)

Human β-defensin-3

Cat.No: T39683

Synonym: Human β-defensin-3,HβD-3

Cat.No: T74872

C5a Anaphylatoxin (human)

Cat.No: T80131

Target: Complement System

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate

Cat.No: T83548

Cat.No: T74873

Cat.No: T37842

Cat.No: T73058

Synonym: 氯唑西林

Gamma-glutamylcysteine TFA

Cat.No: T11357

Synonym: γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)

Target: IL Receptor

Lifitegrast sodium

Cat.No: T3977L

Synonym: SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra

Cat.No: T74910

Cat.No: T80258

Sphingomyelin phosphodiesterase

Cat.No: T76156

Deucravacitinib HCl

Cat.No: T70394

Cat.No: T73665

Cat.No: T83942

RORγt agonist 2

Cat.No: T64140

3-Indoleacrylic acid-d4

Cat.No: TMIH-0046

Demethyleneberberine chloride

Cat.No: T78095

Target: NF-κB

Glycerophospho-N-Palmitoyl Ethanolamine

Cat.No: T38049

Chemerin-9 (149-157) (TFA)

Cat.No: T76022

Cat. No.	Product Name	Target	Signaling Pathways
T5826	Eupalinolide A	HSP	Cytoskeletal Signaling; Metabolism
	Eupalinolide A 是分离于林泽兰中的一种天然产物，通过抑制 HSF1 与 HSP90 的相互作用，激活 HSF1，诱导 HSP70 的表达。它对 A-549、BGC-823、SMMC-7721 和 HL-60 肿瘤细胞系具有强大的细胞毒性。
T3319	Scutellarein 野黄芩素,4',5,6,7-Tetrahydroxyflavone,6-Hydroxyapigenin	SARS-CoV; Src; Autophagy	Angiogenesis; Autophagy; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Scutellarein (6-Hydroxyapigenin) 是一种天然黄酮，具有抗炎功效。
T5235	5-Methoxy-DL-tryptophan	Others; Endogenous Metabolite	Metabolism; Others
	5-Methoxy-DL-tryptophan 是内源性代谢产物的一种。
TN6457	N-trans-caffeoyltyramine Trans-N-Caffeoyltyramine,N-(E)-Caffeoyl-lambda-tyramine,N-cis-Caffeoyltyramine,Typheramide	Immunology/Inflammation related	Immunology/Inflammation
	N-trans-caffeoyltyramine (Trans-N-Caffeoyltyramine) 是炎症反应的调节剂，可用于慢性炎症性疾病治疗的研究。
TN1594	DL-Syringaresinol (±)-Syringaresinol	Antioxidant; Antifungal	Microbiology/Virology; oxidation-reduction
	DL-Syringaresinol ( (±)-Syringaresinol) 是一种来自与人参浆果的木质素，具有抗炎、抗氧化、镇痛活性和较弱的抗分枝杆菌活性。DL-Syringaresinol 可通过自噬延缓氧化应激诱导的皮肤老化，通过抑制炎症反应来缓解奥沙利铂诱导的神经性疼痛和脓毒症引起的心功能障碍。
TN2349	Taurodeoxycholate sodium salt Sodium taurodeoxylate,牛磺脱氧胆酸钠	Endogenous Metabolite	Metabolism
	Taurodeoxycholate sodium salt (Sodium taurodeoxylate) 是胆盐相关的阴离子洗涤剂，用于分离膜蛋白，包括线粒体内膜蛋白。它还可以抑制各种炎症反应。
TN1134	Euscaphic acid	Apoptosis; LDL; PI3K; DNA/RNA Synthesis; NO Synthase; Prostaglandin Receptor	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; PI3K/Akt/mTOR signaling
	Euscaphic acid 是来源于枣的一种三萜，是DNA 聚合酶抑制剂，可诱导细胞凋亡。它抑制小牛 DNA 聚合酶 α 和大鼠 DNA 聚合酶 β 的IC50值分别为 61 和 108 μM。
T5S0993	Kurarinone 苦参酮,苦参黄素	BCL; Others; IκB/IKK; TNF; NF-κB; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; Others; Stem Cells
	Kurarinone 是从灌木苦参中提取的黄酮类化合物，具有抗肿瘤、雌激素和抗炎活性，对免疫反应也有很强的抑制作用。
T67710	3-Indoleacrylic acid	Endogenous Metabolite	Metabolism
	3-Indoleacrylic acid 是由链球菌属产生的色氨酸的代谢产物。3-Indoleacrylic acid 对肠上皮屏障功能有有益作用，并减轻免疫细胞的炎症反应。
T2842	Tangeretin NSC53909,Tangeritin,NSC618905,桔皮素	Apoptosis; Gamma-secretase	Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells
	Tangeretin (NSC-618905) 是一种来自柑橘类水果果皮的类黄酮，是一种Notch-1抑制剂，具有抗炎，保护神经等作用。
TN6774	Emodin 6-O-β-D-glucoside 大黄素-6-O-β-D-葡萄糖苷,Glucoemodin	Others	Others
	Emodin 6-O-β-D-glucoside (Glucoemodin) 是一种从 Reynoutria japonica 中提取的活性化合物。它具有显著的抗炎和屏障保护活性，可用于研究动脉粥样硬化及糖尿病并发症。
T5S1286	(+)-Columbianetin 二氢山芹醇,(S)-Columbianetin,Columbianetin	Antifungal	Microbiology/Virology
	(+)-Columbianetin ((S)-Columbianetin) 是 Columbianetin 的异构体。其中Columbianetin 是一种植物抗毒素，与芹菜贮藏过程中对病原体的抗性有关，具有良好的抗真菌和抗炎作用。
T5S0089	Kaempferol-3-O-glucorhamnoside Kaempferol 3-glucorhamnoside,百蕊草素I	Antioxidant; p38 MAPK; NF-κB	MAPK; NF-κB; oxidation-reduction
	Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside) 是来源于百蕊草的一种类黄酮，在体内外均能通过 MAPK 和 NF-κB 通路抑制炎症反应。
T1614	Hydrocortisone 氢化可的松,Cortisol	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Hydrocortisone (Cortisol) 是一种糖皮质激素，由肾上腺素皮质分泌。Hydrocortisone 激动糖皮质激素受体，可促进蛋白质分解代谢、糖异生、毛细血管壁稳定性、肾脏钙排泄，并抑制免疫和炎症反应。
T3877	Esculentoside A	NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Esculentoside A 是一种三萜皂苷，从商陆根部分离得到。它在具有抗炎活性，对环氧合酶-2 具有选择性抑制活性。它通过抑制NF-κB 和丝裂原活化蛋白激酶信号通路抑制 LPS 诱导的急性肺损伤中的炎症反应。
T5S1895	Norisoboldine Laurelliptine,去甲异波尔定,(+)-Laurelliptine	MAPK; Adenosine Receptor	GPCR/G Protein; MAPK; Neuroscience
	Norisoboldine ((+)-Laurelliptine) 是一种可口服的芳基烃受体激动剂，是乌药中主要的异喹啉类生物碱，可用于类风湿性关节炎和溃疡性结肠炎的研究。
T4S2126	Ginkgetin 银杏双黄酮,银杏素	Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Ginkgetin 是从银杏叶中分离得到的一种双黄酮，具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂，IC50值为 5.92 μM。
T1611	Isotretinoin 13-cis-Retinoic acid,异维A酸	Retinoid Receptor; Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	Isotretinoin (13-cis-Retinoic acid) 是一种天然存在的维甲酸，具有潜在的抗肿瘤活性。它结合并激活核视黄酸受体 (RAR)，活化的 RARs 作为促进细胞分化和凋亡的转录因子。它是一种类维生素A 和维生素A 衍生物，用于治疗严重的痤疮和某些形式的皮肤、头颈癌。
T5S1177	Aloin B Isobarbaloin,芦荟苷B,芦荟素B	Others	Others
	Aloin B (Isobarbaloin) 是一种芦荟素的异构体。其中芦荟素是芦荟中的具生理活性蒽醌化合物。
T3S0737	Flavokawain A 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A	Apoptosis; p38 MAPK	Apoptosis; MAPK
	Flavokawain A (Flavokavain A) 是 kava 提取物中的查耳酮，是一种抗癌试剂，具有抗肿瘤活性。它通过 Bax 蛋白依赖和线粒体依赖的凋亡途径诱导细胞凋亡，有潜力用于膀胱癌的相关研究。
T4868	gamma-Linolenic acid gamolenic acid,γ-Linolenic acid,γ-亚麻酸	Endogenous Metabolite	Metabolism
	gamma-Linolenic acid (gamolenic acid) 是一种 omega-6 (n-6)，18 碳 (18C-) 多不饱和脂肪酸 (PUFA)，可以从人乳和植物种子油中提取。
T4S2326	Cornuside 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside	ERK; p38 MAPK; NF-κB; JNK	MAPK; NF-κB
	Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷，可用于炎症疾病的研究和促进血液循环。它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应，用于炎性过敏性疾病中的潜能。
T3673	Mollugin 大叶茜草素,Rubimaillin	HER; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。
T35749	Thymohydroquinone Thymoquinol	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Thymohydroquinone (Thymoquinol) 是中药材百里香、牛至和其他唇形科植物中含有的单萜酚类化合物。 Thymohydroquinone 抑制癌细胞生长、减少氧化应激和调节炎症反应，在无细胞实验中清除2,2-二苯基-1-picrylhydrazyl 自由基(IC50 = 2.4 μg/ml)，在浓度为1.6至6.4 μg/ml 的氧自由基吸收能力(ORAC)实验中，它的Trolox 当量值为2.6胸腺对苯二酚对A2780、OVCAR-8和CIS-A2780卵巢癌细胞(IC50分别为3.1、8.9和9.8 μM)和人卵巢永生化上皮细胞(IC50 = 14 μM)的生长有抑制作用，体外对恶性疟原虫也有抑制作用(IC50 = 15.9 μM)。
TN3482	Bakkenolide B	NOS; COX	Immunology/Inflammation; Neuroscience
	Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.
TN3614	Cearoin 檀木	ERK; BCL; PARP; IκB/IKK; TNF; NF-κB; ROS; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; NF-κB; Proteases/Proteasome
	Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFα and CCL2. Cearoin induces aut
TN4420	Latifolin 檀木	IL Receptor; IκB/IKK; TNF; NOS; NF-κB; COX; Nrf2; Prostaglandin Receptor; Antifection; Autophagy	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB
	Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Latifolin displays potent anticarcinogenic phase II marker enzyme, quinone reductase (QR) inducing activity and high chemopreventive indices. Latifolin also shows antifungal activity against white- and brown-rot fungi.
T61171	Cyclo(his-pro) TFA
	Cyclo(his-pro) TFA, an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone, has shown inhibitory effects on NF-κB nuclear accumulation. Additionally, it possesses the ability to cross the blood-brain barrier and impact various inflammatory and stress responses [1, 2].
T4S0083	Protostemonine	Others	Others
	Protostemonine 是一种主要从 Stemona sesslifolia 根中分离得到的生物碱，对哮喘及革兰氏阴性菌所致急性肺损伤有抗炎作用。
TN2775	2-Methoxystypandrone	MMP; BCL; IκB/IKK; GSK-3; TNF; NOS; NF-κB; Wnt/beta-catenin; COX; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant
TN3070	4beta-Hydroxywithanolide E	PARP; HSP; NF-κB; COX	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it affects alternative splicing by mo

天然产物

Cat.No: T5826

Target: HSP

Cat.No: T3319

Synonym: 野黄芩素,4',5,6,7-Tetrahydroxyflavone,6-Hydroxyapigenin

Target: SARS-CoV, Src, Autophagy

5-Methoxy-DL-tryptophan

Cat.No: T5235

Target: Others, Endogenous Metabolite

N-trans-caffeoyltyramine

Cat.No: TN6457

Synonym: Trans-N-Caffeoyltyramine,N-(E)-Caffeoyl-lambda-tyramine,N-cis-Caffeoyltyramine,Typheramide

Target: Immunology/Inflammation related

DL-Syringaresinol

Cat.No: TN1594

Synonym: (±)-Syringaresinol

Target: Antioxidant, Antifungal

Taurodeoxycholate sodium salt

Cat.No: TN2349

Synonym: Sodium taurodeoxylate,牛磺脱氧胆酸钠

Target: Endogenous Metabolite

Cat.No: TN1134

Target: Apoptosis, LDL, PI3K, DNA/RNA Synthesis, NO Synthase, Prostaglandin Receptor

Cat.No: T5S0993

Synonym: 苦参酮,苦参黄素

Target: BCL, Others, IκB/IKK, TNF, NF-κB, JAK, STAT

3-Indoleacrylic acid

Cat.No: T67710

Target: Endogenous Metabolite

Cat.No: T2842

Synonym: NSC53909,Tangeritin,NSC618905,桔皮素

Target: Apoptosis, Gamma-secretase

Emodin 6-O-β-D-glucoside

Cat.No: TN6774

Synonym: 大黄素-6-O-β-D-葡萄糖苷,Glucoemodin

Target: Others

(+)-Columbianetin

Cat.No: T5S1286

Synonym: 二氢山芹醇,(S)-Columbianetin,Columbianetin

Target: Antifungal

Kaempferol-3-O-glucorhamnoside

Cat.No: T5S0089

Synonym: Kaempferol 3-glucorhamnoside,百蕊草素I

Target: Antioxidant, p38 MAPK, NF-κB

Cat.No: T1614

Synonym: 氢化可的松,Cortisol

Target: Glucocorticoid Receptor, Endogenous Metabolite

Esculentoside A

Cat.No: T3877

Target: NF-κB, COX

Cat.No: T5S1895

Synonym: Laurelliptine,去甲异波尔定,(+)-Laurelliptine

Target: MAPK, Adenosine Receptor

Cat.No: T4S2126

Synonym: 银杏双黄酮,银杏素

Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy

Cat.No: T1611

Synonym: 13-cis-Retinoic acid,异维A酸

Target: Retinoid Receptor, Endogenous Metabolite, Autophagy

Cat.No: T5S1177

Synonym: Isobarbaloin,芦荟苷B,芦荟素B

Target: Others

Cat.No: T3S0737

Synonym: 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A

Target: Apoptosis, p38 MAPK

gamma-Linolenic acid

Cat.No: T4868

Synonym: gamolenic acid,γ-Linolenic acid,γ-亚麻酸

Target: Endogenous Metabolite

Cat.No: T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Cat.No: T3673

Synonym: 大叶茜草素,Rubimaillin

Target: HER, JAK

Thymohydroquinone

Cat.No: T35749

Synonym: Thymoquinol

Target: Antioxidant, Reactive Oxygen Species

Cat.No: TN3482

Target: NOS, COX

Cat.No: TN3614

Synonym: 檀木

Target: ERK, BCL, PARP, IκB/IKK, TNF, NF-κB, ROS, Caspase

Cat.No: TN4420

Synonym: 檀木

Target: IL Receptor, IκB/IKK, TNF, NOS, NF-κB, COX, Nrf2, Prostaglandin Receptor, Antifection, Autophagy

Cyclo(his-pro) TFA

Cat.No: T61171

Cat.No: T4S0083

Target: Others

2-Methoxystypandrone

Cat.No: TN2775

Target: MMP, BCL, IκB/IKK, GSK-3, TNF, NOS, NF-κB, Wnt/beta-catenin, COX, JAK, STAT

4beta-Hydroxywithanolide E

Cat.No: TN3070

Target: PARP, HSP, NF-κB, COX

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