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193

抑制剂 & 化合物

28

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TD0098	Direct Red 80 Sirius Red,天狼猩红,Sirius Red F 3BA,C.I. direct red 80	Others	Others
	Direct Red 80 (Sirius Red) 是一种聚偶氮染料，在降解时不会释放联苯胺，比许多传统的直接染料更安全，主要用于胶原蛋白和淀粉样蛋白的染色方法。
T20033	Direct Violet 1 NSC75778,NSC 75778,Airedale Violet ND,NSC-75778,直接青莲N,Direct Violet N,CCRIS 2413	SARS-CoV	Microbiology/Virology
	Direct Violet 1 (CCRIS 2413) 是一种偶氮染料，是纺织品染料，也是 SARS-CoV-2 刺突蛋白和 ACE2 抑制剂之间的蛋白质相互作用，IC50为 1.47-2.63 µM。
T2194	Direct Blue 1 Pontamine sky blue,滂胺天蓝,Chicago Sky Blue 6B	GluR	Neuroscience
	Chicago Sky Blue 6B 是免疫荧光组织化学中背景自体荧光的一种复染料。Direct Blue 1 (Pontamine sky blue) 是第一个能够抑制 Aβ 结合的小分子 PrP 配体，在结构上与谷氨酸盐有关，是一种有效且具有竞争性的 VGLUT 抑制剂，不影响质膜转运体。
T18979	Diphenyl Blue 台盼蓝,Direct Blue 14	Others	Others
	Diphenyl Blue (Direct Blue 14) 是一种可用作偶氮染料组的参考染料。
T78234	Brilliant Yellow Direct Yellow 4	transporter	Metabolism
	Brilliant Yellow (Direct Yellow 4) 是一种具有有效性和选择性的的 VGLUT 抑制剂，是一种染料，可被光降解。
T14996	Congo Red 刚果红,Direct Red 28	Others	Others
	Congo Red (Direct Red 28) 是偶氮染料指示剂，在 pH 3.0的环境下呈紫罗兰色，在 pH5.0的环境下呈红色，常用于组织切片中淀粉样蛋白的测定。
T19066	Thioflavine S 硫磺素,Thioflavin S,Direct Yellow 7	Others	Others
	Thioflavine S (Direct Yellow 7) 是荧光组织化学标记物，可用于老年斑块致密核心的标记。
T0313	Evans blue Direct Blue 53,C.I. 23860,伊文思蓝	GluR	Neuroscience
	Evans blue (C.I. 23860) 是一种突触泡谷氨酸吸收的有效抑制剂，同时也是一种AMPA/kainate 受体拮抗剂。
T20032	CI Direct Brown 2 Airedale Brown MD,Brown M,NSC 74701,Direct Brown 2,NSC-74701,NSC74701
	CI Direct Brown 2 is a direct dye. It is soluble in water and ionizable to form colored anions. It also can directly dye cellulose fibers or protein fibers.
T31526	Direct Green 6
	Direct Green 6 is a green dye.
T20031	C.I. Direct Blue 2 NSC 75779,NSC-75779,Pontamine Diazo Black BHSW,Direct Blue 2,CCRIS 6236,NSC75779
	C.I. Direct Blue 2 is an agent of dye.
T15135	Direct Black 38 C.I. 30235,Chlorazol Black E	Others	Others
	Direct Black 38 is an azo dye.It induces unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats in vivo[1].
T15135L	Direct Black 38 free acid NSC8679,Ferristatin II	Others	Others
	Ferristatin II (Direct Black 38 free acid) is a polysulphonated dye and promotes the degradation of transferrin receptor-1 in vitro and in vivo.
T20037	C.I. Direct Black 17 Azine Fast Black D,CERN prima 17,Telon Fast Black PE,Diazol Black SD
	C.I. Direct Black 17 is a compound of dye.
T30665	C.I. Direct Red 1, disodium salt Japanol Fast Red 1,COLUMBIA FAST RED F,Chrome Fast Red F,Neonyl Red 2B,Enianil Fast Red F
	C.I. Direct Red 1, disodium salt is a dye.
T30652	C.I. 24280 NSC 47753,NSC-47753,Direct Blue 22,Chlorazol Blue RW,NS 47753
	C.I. 24280 is a dye.
T11064	DMT1 blocker 2	Others	Others
	DMT1 blocker 2 是一种二价金属转运蛋白 1 的直接抑制剂(IC50:0.83 μM)。它可以阻断体内肠细胞的铁摄取。
T23820	BRD32048 BRD-32048,BRD 32048	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	BRD32048 可以与与 ETV1直接结合，KD 为 17.1 μM。BRD32048调节 ETV1 介导的转录活性和 ETV1 驱动的癌细胞侵袭。 BRD32048可以抑制 ETV1 乙酰化并促进其降解。
T20034	Solaminrot 4B Direct Red 81,Airedale Red KD,Solar Red B,Pryamoi krasnyi svetoprochnyi 2S,Fastusol Red 4BA-CF,C.I. 28160
	Solaminrot 4B is an agent of dye.
T19862	Voxilaprevir 维昔普维,伏西瑞韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Voxilaprevir 是丙型肝炎病毒非结构蛋白 3/4A 蛋白酶的抑制剂，具有抗病毒活性。它抑制基因型 1b 和 3a 野生型 NS3 蛋白酶的 Ki 值分别为 0.038 nM 和 0.066 nM。
T16156	MT 63-78	Apoptosis; AMPK; mTOR	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	MT 63-78 是一种有效的直接AMPK 激活剂，EC50为 25 μM。它诱导细胞有丝分裂阻滞和细胞凋亡，通过抑制脂肪生成和mTORC1途径来阻止前列腺癌的生长，具有抗肿瘤作用。
T25702	Levovirin ICN 17261,L-Ribavirin,ICN-17261,ICN17261
	Levovirin is a monocyclic L-nucleosides with type 1 cytokine-inducing activity. Levovirin is the L-enantiomer of Ribavirin. Levovirin has similar immunomodulatory activity but does not have direct antiviral activity or hemolytic anemia.
T2453	BAM7	BCL	Apoptosis
	BAM7 是一种促凋亡 Bax 的直接和特异性激活剂，IC50为 3.3 μM。
T6775	BAY 41-2272	Guanylate cyclase	GPCR/G Protein
	BAY 41-2272 是一种直接且不依赖一氧化氮的可溶性鸟苷酸环化酶刺激剂。
T0504	Cyclandelate 安脉生,BS 572,环扁桃酯,3,5,5-Trimethylcyclohexyl mandelate	Acyltransferase	Metabolism
	Cyclandelate (BS 572) 是直接作用的平滑肌松弛剂，用于扩张血管。
T31806	Flovagatran TGN 255	Thrombin	Proteases/Proteasome
	Flovagatran (TGN 255) 是一种具有口服活性和有效性的凝血酶和肠外直接因子 II 抑制剂。Flovagatran 可用于研究静脉血栓栓塞。
T7298	FT011	Others	Others
	FT011 是抗纤维化剂，能够抑制胶原蛋白 I 和 III 的 mRNA 表达，减少胶原蛋白合成。
TD0069	5-ROX, SE 5-羧基-X-罗丹明 SE	Others	Others
	5-ROX, SE ([5-Carboxy-X-rhodamine, succinimidyl ester] Single isomer) 是一种标记试剂，用于制备电荷修饰的染料标记的双脱氧核苷酸三磷酸 (ddNTP) 以“直接加载”DNA 测序。
T0324	Isoxsuprine hydrochloride Duvadilan,Isolait,盐酸异克舒令,盐酸苯氧丙酚胺	Adrenergic Receptor; iGluR	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Isoxsuprine hydrochloride (Isolait) 是 β 肾上腺素受体激动剂和NMDA 受体拮抗剂，对子宫肌层和胎盘的 β 肾上腺素受体的Ki 值分别为 13.65 和 3.48 μM。
T14017	2-NBDG 2-(N-7-硝基-2,1,3-苯并恶二唑-4-氨基)-2-脱氧-D-葡萄糖	Others	Others
	2-NBDG 是一种荧光指示剂 (λex=467 nm，λem=542 nm)，是一种荧光 D-葡萄糖类似物，可用于监测活细胞中的葡萄糖吸收。
T67778	dCeMM1	Molecular Glues	PROTAC
	dCeMM1 是 RBM39 分子胶降解剂，可以降低 WT KBM7 细胞中 RBM39 水平的表达。dCeMM1 活性发挥通过重定向 CRL4DCAF15 连接酶进行。
T41302	Itaconate-alkyne ITalk	Others	Others
	Itaconate-alkyne (ITalk) 是一种生物正交探针，用于对炎症性巨噬细胞中的衣康酸进行定量和位点特异性化学蛋白质组学分析，并能够对其直接靶标进行生化评估和蛋白质组学分析。
T28972	Tiaramide hydrochloride FK-1160,NTA-194,FK 1160,FK1160,tiaramide	Others	Others
	Tiaramide hydrochloride (FK-1160) 是一种抗炎药，可抑制肥大细胞释放的介质的作用，并具有直接的平滑肌松弛特性。
T9208	1,3,6,8-Tetrahydroxynaphthalene T4HN,1,3,6,8-THN,naphthalene-1,3,6,8-tetrol	Others	Others
	1,3,6,8-Tetrahydroxynaphthalene (T4HN) 是一种独特的对称聚酮起源化合物，是 DHN 黑色素不可缺少的前体。
T10174	5-R-Rivaroxaban	Factor Xa	Metabolism
	5-R-Rivaroxaban 是一种 Rivaroxaban 的 R 型对映体。其中 Rivaroxaban 是选择性的Factor Xa(FXa) 抑制剂。
T15639	K-756	PARP; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
	K-756 是一种直接的 tankyrase(TNKS) 选择性抑制剂，对 TNKS1和 TNKS2的 ADP-核糖基化活性有抑制作用，IC50分别为 31 和 36 nM。
T1299	3-Pyridinemethanol 烟醇,Nicotinyl alcohol,Roniacol	Others	Others
	3-Pyridinemethanol (Roniacol) 是一种具有降胆固醇作用的吡啶衍生物。
T14932	Ceruletide Cerulein,Caerulein,雨蛙素,FI-6934	cholecystokinin	GPCR/G Protein
	Ceruletide (Caerulein) 是一种十肽，是一种安全有效的胆囊收缩剂，是一种胆囊收缩素受体激动剂，对胆囊肌肉和胆管有直接的痉挛性作用。
TP1724L	PUMA BH3 acetate PUMA BH3 acetate(PUMA BH3 Free base)	BCL	Apoptosis
	PUMA BH3 acetate (PUMA BH3 Free base) 是一种 p53 凋亡阳性调节因子 (PUMA) BH3 结构域多肽，可作为 Bak 的直接激活剂，Kd 为 26 nM。
T14034	3CAI	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	3CAI 是特异性的AKT1和AKT2抑制剂。
T5133	Dabigatran Etexilate Mesylate 甲磺酸达比加群酯,BIBR 1048MS,Dabigatran etexilate methanesulfonate	Thrombin	Proteases/Proteasome
	Dabigatran Etexilate Mesylate (BIBR 1048MS) 是一种口服具有活性的 Dabigatran 前药，具有抗凝作用，能够预防心房颤动引起的静脉血栓栓塞和中风。
T8404	Kasugamycin hydrochloride hydrate Ksg (hydrochloride hydrate),春雷霉素盐酸盐一水合物	Antibacterial; Antibiotic	Microbiology/Virology
	Kasugamycin hydrochloride hydrate (Ksg (hydrochloride hydrate)) 是一种能结合 30s 和 70s 核糖体，但不能结合 50s 亚基的抗生素。它模拟 mRNA 核苷酸破坏 tRNA 结合并抑制典型翻译起始。
T5383	D3-βArr NCGC00379308	TSH Receptor	GPCR/G Protein
	D3-βArr (NCGC00379308) 是一种促甲状腺激素受体正变构调节剂，通过直接激活促甲状腺激素受体启动 β-Arr 1 的易位，EC50为 11.6 μM。它还可增强促甲状腺激素介导的体外成骨细胞分化。
T8408	GKT136901 AK120765	NADPH-oxidase; NADPH	Immunology/Inflammation; Metabolism
	GKT136901 (AK120765) 是选择性的和具有口服活性的 NADPH 氧化酶 NOX-1/4抑制剂，Ki 分别为 160 和 165 nM。它具有抗炎症活性。它也是一种选择性和直接的过氧亚硝酸清除剂。它可用于糖尿病肾病，中风和神经退行性疾病的研究。
T14577	Biotin-DADOO EZ-Link Amine-PEO2-Biotin,Biotinyl-3,6-dioxaoctanediamine	Others	Others
	Biotin-DADOO (Biotinyl-3,6-dioxaoctanediamine) 是生物素酰化试剂，能够与雌二醇结合，形成生物素-雌二醇共轭化合物，进而利用酶免疫测定法测定血浆雌二醇的浓度。
T3570	SU4312 SU 4312,NSC 86429	VEGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	NSC-86429 是一种 (Z)-SU4312 (SU 4312) 和 (E)-SU4312 的外消旋体。其中(Z)-SU4312 能够抑制 PDGFR 和 FLK-1。(E)-SU4312 能够抑制 PDGFR, FLK-1, EGFR, HER-2, 和 IGF-1R。
T2186	Tris(2,2,2-trifluoroethyl) borate SL 75212,硼酸三酯(2,2,2-三氟乙基)	Others	Others
	Tris(2,2,2-trifluoroethyl) borate (SL 75212) 主要用于缩合反应。它已被证明可以促进羧酸和胺直接形成酰胺，以及胺或酰胺与羰基化合物形成亚胺。
T17265	Ximelagatran EXANTA,H 376-95,H37695,希美加群,H 376/95,H-37695,H 37695	Thrombin	Proteases/Proteasome
	Ximelagatran (H 376-95) 是一种口服活性凝血酶抑制剂，可选择性的、竞争性的抑制游离和凝块结合的凝血酶。它是一种抗凝药物，具有快速起效的抗凝作用，可预测的，剂量依赖性的药代动力学和药效学。
T5122	Alofanib RPT835	Apoptosis; FGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Alofanib (RPT835) 是一种高效和选择性的成纤维细胞生长因子受体2的变构抑制剂，具有抗癌和抗血管生成活性。
T11994	Melagatran	Thrombin	Proteases/Proteasome
	Melagatran 是一种直接作用且可口服的凝血酶抑制剂。Melagatran 专一性抑制凝血酶，但不影响凝血级联中的其他酶或纤溶酶。Melagatran不依赖内源性辅因子发挥其抗凝血酶效果，可缓解内毒素血症的有害影响。因此，Melagatran作为预防动脉闭塞的策略显示出前景。

化合物

Direct Red 80

Cat.No: TD0098

Synonym: Sirius Red,天狼猩红,Sirius Red F 3BA,C.I. direct red 80

Target: Others

Direct Violet 1

Cat.No: T20033

Synonym: NSC75778,NSC 75778,Airedale Violet ND,NSC-75778,直接青莲N,Direct Violet N,CCRIS 2413

Target: SARS-CoV

Direct Blue 1

Cat.No: T2194

Synonym: Pontamine sky blue,滂胺天蓝,Chicago Sky Blue 6B

Target: GluR

Cat.No: T18979

Synonym: 台盼蓝,Direct Blue 14

Target: Others

Brilliant Yellow

Cat.No: T78234

Synonym: Direct Yellow 4

Target: transporter

Cat.No: T14996

Synonym: 刚果红,Direct Red 28

Target: Others

Cat.No: T19066

Synonym: 硫磺素,Thioflavin S,Direct Yellow 7

Target: Others

Cat.No: T0313

Synonym: Direct Blue 53,C.I. 23860,伊文思蓝

Target: GluR

CI Direct Brown 2

Cat.No: T20032

Synonym: Airedale Brown MD,Brown M,NSC 74701,Direct Brown 2,NSC-74701,NSC74701

Direct Green 6

Cat.No: T31526

C.I. Direct Blue 2

Cat.No: T20031

Synonym: NSC 75779,NSC-75779,Pontamine Diazo Black BHSW,Direct Blue 2,CCRIS 6236,NSC75779

Direct Black 38

Cat.No: T15135

Synonym: C.I. 30235,Chlorazol Black E

Target: Others

Direct Black 38 free acid

Cat.No: T15135L

Synonym: NSC8679,Ferristatin II

Target: Others

C.I. Direct Black 17

Cat.No: T20037

Synonym: Azine Fast Black D,CERN prima 17,Telon Fast Black PE,Diazol Black SD

C.I. Direct Red 1, disodium salt

Cat.No: T30665

Synonym: Japanol Fast Red 1,COLUMBIA FAST RED F,Chrome Fast Red F,Neonyl Red 2B,Enianil Fast Red F

Cat.No: T30652

Synonym: NSC 47753,NSC-47753,Direct Blue 22,Chlorazol Blue RW,NS 47753

Cat.No: T11064

Target: Others

Cat.No: T23820

Synonym: BRD-32048,BRD 32048

Target: DNA/RNA Synthesis

Cat.No: T20034

Synonym: Direct Red 81,Airedale Red KD,Solar Red B,Pryamoi krasnyi svetoprochnyi 2S,Fastusol Red 4BA-CF,C.I. 28160

Cat.No: T19862

Synonym: 维昔普维,伏西瑞韦

Target: HCV Protease

Cat.No: T16156

Target: Apoptosis, AMPK, mTOR

Cat.No: T25702

Synonym: ICN 17261,L-Ribavirin,ICN-17261,ICN17261

Cat.No: T2453

Target: BCL

Cat.No: T6775

Target: Guanylate cyclase

Cat.No: T0504

Synonym: 安脉生,BS 572,环扁桃酯,3,5,5-Trimethylcyclohexyl mandelate

Target: Acyltransferase

Cat.No: T31806

Synonym: TGN 255

Target: Thrombin

Cat.No: T7298

Target: Others

Cat.No: TD0069

Synonym: 5-羧基-X-罗丹明 SE

Target: Others

Isoxsuprine hydrochloride

Cat.No: T0324

Synonym: Duvadilan,Isolait,盐酸异克舒令,盐酸苯氧丙酚胺

Target: Adrenergic Receptor, iGluR

Cat.No: T14017

Synonym: 2-(N-7-硝基-2,1,3-苯并恶二唑-4-氨基)-2-脱氧-D-葡萄糖

Target: Others

Cat.No: T67778

Target: Molecular Glues

Itaconate-alkyne

Cat.No: T41302

Synonym: ITalk

Target: Others

Tiaramide hydrochloride

Cat.No: T28972

Synonym: FK-1160,NTA-194,FK 1160,FK1160,tiaramide

Target: Others

1,3,6,8-Tetrahydroxynaphthalene

Cat.No: T9208

Synonym: T4HN,1,3,6,8-THN,naphthalene-1,3,6,8-tetrol

Target: Others

5-R-Rivaroxaban

Cat.No: T10174

Target: Factor Xa

Cat.No: T15639

Target: PARP, Wnt/beta-catenin

3-Pyridinemethanol

Cat.No: T1299

Synonym: 烟醇,Nicotinyl alcohol,Roniacol

Target: Others

Cat.No: T14932

Synonym: Cerulein,Caerulein,雨蛙素,FI-6934

Target: cholecystokinin

PUMA BH3 acetate

Cat.No: TP1724L

Synonym: PUMA BH3 acetate(PUMA BH3 Free base)

Target: BCL

Cat.No: T14034

Target: Akt

Dabigatran Etexilate Mesylate

Cat.No: T5133

Synonym: 甲磺酸达比加群酯,BIBR 1048MS,Dabigatran etexilate methanesulfonate

Target: Thrombin

Kasugamycin hydrochloride hydrate

Cat.No: T8404

Synonym: Ksg (hydrochloride hydrate),春雷霉素盐酸盐一水合物

Target: Antibacterial, Antibiotic

Cat.No: T5383

Synonym: NCGC00379308

Target: TSH Receptor

Cat.No: T8408

Synonym: AK120765

Target: NADPH-oxidase, NADPH

Cat.No: T14577

Synonym: EZ-Link Amine-PEO2-Biotin,Biotinyl-3,6-dioxaoctanediamine

Target: Others

Cat.No: T3570

Synonym: SU 4312,NSC 86429

Target: VEGFR, PDGFR

Tris(2,2,2-trifluoroethyl) borate

Cat.No: T2186

Synonym: SL 75212,硼酸三酯(2,2,2-三氟乙基)

Target: Others

Cat.No: T17265

Synonym: EXANTA,H 376-95,H37695,希美加群,H 376/95,H-37695,H 37695

Target: Thrombin

Cat.No: T5122

Synonym: RPT835

Target: Apoptosis, FGFR

Cat.No: T11994

Target: Thrombin

Cat. No.	Product Name	Target	Signaling Pathways
T1064	Norepinephrine bitartrate monohydrate 酒石酸去甲肾上腺素,Levophed,Noradrenaline bitartrate monohydrate,降肾上腺素	Endogenous Metabolite; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Metabolism; Neuroscience
	Norepinephrine bitartrate monohydrate (Levophed) 是一种β1-选择性的肾上腺素能受体激动剂，EC50为 5.37 μM。
T9155	Fumagillol	Others; Antibacterial	Microbiology/Virology; Others
	Fumagillol 是有效的血管生成抑制剂 TNP-470 和 fumagillin 的直接前体。Fumagillin 作为一种抗菌药物，是选择性有效血管生成抑制剂。
T4S1983	Periplogenin 5-beta-Hydroxydigitoxigenin,Desoxostrophanthidin,杠柳苷元	Others	Others
	Periplogenin (Desoxostrophanthidin) 是一种天然呋喃香豆素，存在于白芷根中，可以诱导脂肪细胞分化，具有高抗银屑病作用。
THS1455	DihydroarteMisinic acid 双氢青蒿酸,Dihydro-Artmisinic Acid,二氢青蒿酸	Ferroptosis; Parasite	Apoptosis; Microbiology/Virology
	DihydroarteMisinic acid (Dihydro-Artmisinic Acid) 是青蒿的天然产物，是青蒿素的主要直接前体，青蒿素是一种广泛用于治疗疟疾的药草。
T2A2497	L-Glutamic acid 谷氨酸,(S)-Glutamic acid,glutamic acid,(+)-L-Glutamic acid,Aciglut,L-谷氨酸,glutacid,Glutaminol	Apoptosis; Ferroptosis; Endogenous Metabolite; iGluR	Apoptosis; Membrane transporter/Ion channel; Metabolism; Neuroscience
	L-Glutamic acid (Glutaminol) 作为一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型的激动剂，对多巴胺从神经末梢释放的过程有激动作用。
T5714	5-O-Demethylnobiletin 5-DEMETHYLNOBILETIN,去甲基川陈皮素	Leukotriene Receptor; Lipoxygenase	GPCR/G Protein; Metabolism
	5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) 是从黄芪中分离出的多甲氧基黄酮，具有抗炎活性，可通过直接抑制 5-LOX 发挥作用，IC50为 0.1 μM。
TN2031	γ-Terpinene Moslene,p-Mentha-1,4-diene,Crithmene	Antioxidant	oxidation-reduction
	γ-Terpinene (p-Mentha-1,4-diene) 是一种单萜化合物，具有高抗氧化属性，适合口服。它展示了直接的自由基清除能力，并且已知是一种有效的抗痛剂。
TN1733	Hesperetin 7-O-glucoside	Anti-infection; Antibacterial; HMG-CoA Reductase	Metabolism; Microbiology/Virology
	Hesperetin 7-O-glucoside 是通过 Hesperidin 的酶促转化产生的一种人 HMG-CoA 还原酶抑制剂，具有降压作用，可抑制幽门螺杆菌的生长。
T4S1616	Sanggenon D 桑根酮D,Sanggenone D	NOS; COX; GABA Receptor	Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflammatory activity, it can inhibit NO production from lipopolysaccharide (LPS)-induced RAW 264.7 ce
TWS1977	Kamebakaurin 尾叶香茶菜丙素,Kamebakaurine	NF-κB	NF-κB
	Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物，是一种NF-κB 的抑制剂，能够抑制 p50 的 DNA 结合活性。
T5074	Cholesteryl palmitate	Others; Endogenous Metabolite	Metabolism; Others
	Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。
T4716	Pyrrole-2-carboxylic acid 吡咯-2-羧酸,2-Pyrrolecarboxylic acid,Minaline	Endogenous Metabolite	Metabolism
	Pyrrole-2-carboxylic acid (Minaline) 是一种天然生物碱类，从海洋细菌Pelomonas puraquaesp. Nov 中分离得到。
T3S0013	Ethyl trans-caffeate 咖啡酸乙酯,Ethyl caffeate,Caffeic Acid Ethyl Ester	Others	Others
	Ethyl trans-caffeate (Caffeic Acid Ethyl Ester) 具有抗炎作用。它是一种有前途的天然化合物，未来在慢性肝病中的应用。它是一种有效的化学预防化合物，可防止因太阳紫外线照射引起的皮肤癌变。它是与人胰腺α-淀粉酶复合的代表性抑制剂的高分辨率结构。它强烈抑制 JB6 Cl41细胞的肿瘤转化，无毒性。 PI3K、ERK1/2 和 p38 激酶活性在体外通过与 HOEC 直接结合而受到抑制。
TN3872	Diosbulbin D 山药	ROS	Immunology/Inflammation
	Diosbulbin D shows direct toxic effect on hepatocytes, the mechanism could be associated with oxidative stress.
TN6651	Picrasidine Q
	Picrasidine Q has the capacity of anti-cell transformation and anti-cancer, it might be a chemopreventive and chemotherapeutic agent by direct targeting FGFR2 and inhibiting cell proliferation of ESCC cells.
TMA0291	Dehydroglyasperin D	GSK-3; p38 MAPK; ROS; Akt; COX; PI3K; DNA/RNA Synthesis; Prostaglandin Receptor; JNK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells
	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with phosphatidylinositol 3-kinase; it also mediates suppression of both COX-2 expression and the MLK3 signalling pathway through direct binding and inhibition of MLK3. Dehydroglyasperin D shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet o...
T15255	Etilevodopa Levodopa ethyl ester,L-DOPA ethyl ester	Others	Others
	Etilevodopa is an ethyl-ester prodrug of Levodopa which is used for the treatment of Parkinson's disease (PD). It is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Levodopa is the direct precursor of dop
TN5235	Vinorine	Others	Others
	Vinorine is a direct biosynthetic precursor along the complex pathway to the monoterpenoid indole alkaloid ajmaline, an antiarrhythmic drug from the Indian medicinal plant Rauvolfia serpentina.
T83426	1-Oxomicrostegiol
	1-Oxomicrostegiol，一种二萜类化合物，源自Salvia viridis L. cvar根部，为viroxocin的直接前体。
T15467	Helenalin	Others	Others
	Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine sulfhydryl groups in the p65 subunit of NF-κB, helenalin effectively inhibits its DNA binding.
TN4654	Niazirin	Others	Others
	The Moringa oleifera extract(including niaziridin and Niazirin) can successfully attenuate the development of pulmonary hypertension via direct vasodilatation and a potential increase in antioxidant activity.
TMA0627	Taxiresinol	TNF	Apoptosis
	Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic cell line, KU812. Taxiresinol can protect the hepatocytes from apoptosis via an inhibition of TNF- alpha production by activated macrophages and a direct inhibition of apoptosis induced by TNF- alpha in D-GalN/LPS-treated mice.
TMA1130	2,4-Dihydroxyphenylacetic acid	Others	Others
	2,4-Dihydroxyphenylacetic acid is a functional moiety in the toxin molecule and the biological action of spider toxin is explained by direct interaction with an Fe-S center which is known to play an important role for the glutamate binding.
TN4308	Isolupalbigenin	Antifection	Microbiology/Virology
	Isolupalbigenin shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM), it also shows in vitro inhibitory activity toward human glyoxalase I. Isolupalbigenin shows two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity, it could lead to the development of compounds for new approaches against MRSA infection.
TN4334	Isotaxiresinol	TNF	Apoptosis
	Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. Isotaxiresinol ma
TN2169	Saikogenin D 柴胡皂甙元 D,皂苷元 D	IL Receptor; Calcium Channel; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is attributed to Ca2+ release from intracellular stores. Saikogenin D has immuno
T73856	Anagyrine hydrochloride
	Anagyrine ((-)-Anagyrine) hydrochloride 是一种存在于Lupinus albus 中的喹啉类生物碱。Anagyrine hydrochloride 可与毒蕈碱和烟碱乙酰胆碱受体 (AChR) 结合，IC50值分别为 132 和 2096 µM。Anagyrine hydrochloride 是一种有效的nAChR 脱敏剂，Anagyrine hydrochloride 可以直接脱敏nAChR，不需要代谢。
T78467	trans-10-Heptadecenoic acid
	trans-10-Heptadecenoic acid 是一种能在特定酶作用下参与生物合成与代谢过程的反式脂肪酸。在 2,4-二烯酰基-CoA 还原酶与 Delta3,Delta2-烯酰基-CoA 异构酶催化下，trans-10-Heptadecenoic acid 可合成聚羟基链烷酸酯。当缺乏 2,4-二烯酰基-CoA 还原酶时，该化合物则经由多功能酶 (MFE) 中的烯酰辅酶 A 水合酶 II 进行降解。此外，trans-10-Heptadecenoic acid 能通过还原酶依赖性与直接 MFE 依赖性途径引起细胞内的碳外流。

天然产物

Norepinephrine bitartrate monohydrate

Cat.No: T1064

Synonym: 酒石酸去甲肾上腺素,Levophed,Noradrenaline bitartrate monohydrate,降肾上腺素

Target: Endogenous Metabolite, Adrenergic Receptor, Autophagy

Cat.No: T9155

Target: Others, Antibacterial

Cat.No: T4S1983

Synonym: 5-beta-Hydroxydigitoxigenin,Desoxostrophanthidin,杠柳苷元

Target: Others

DihydroarteMisinic acid

Cat.No: THS1455

Synonym: 双氢青蒿酸,Dihydro-Artmisinic Acid,二氢青蒿酸

Target: Ferroptosis, Parasite

L-Glutamic acid

Cat.No: T2A2497

Synonym: 谷氨酸,(S)-Glutamic acid,glutamic acid,(+)-L-Glutamic acid,Aciglut,L-谷氨酸,glutacid,Glutaminol

Target: Apoptosis, Ferroptosis, Endogenous Metabolite, iGluR

5-O-Demethylnobiletin

Cat.No: T5714

Synonym: 5-DEMETHYLNOBILETIN,去甲基川陈皮素

Target: Leukotriene Receptor, Lipoxygenase

Cat.No: TN2031

Synonym: Moslene,p-Mentha-1,4-diene,Crithmene

Target: Antioxidant

Hesperetin 7-O-glucoside

Cat.No: TN1733

Target: Anti-infection, Antibacterial, HMG-CoA Reductase

Cat.No: T4S1616

Synonym: 桑根酮D,Sanggenone D

Target: NOS, COX, GABA Receptor

Cat.No: TWS1977

Synonym: 尾叶香茶菜丙素,Kamebakaurine

Target: NF-κB

Cholesteryl palmitate

Cat.No: T5074

Target: Others, Endogenous Metabolite

Pyrrole-2-carboxylic acid

Cat.No: T4716

Synonym: 吡咯-2-羧酸,2-Pyrrolecarboxylic acid,Minaline

Target: Endogenous Metabolite

Ethyl trans-caffeate

Cat.No: T3S0013

Synonym: 咖啡酸乙酯,Ethyl caffeate,Caffeic Acid Ethyl Ester

Target: Others

Cat.No: TN3872

Synonym: 山药

Target: ROS

Cat.No: TN6651

Dehydroglyasperin D

Cat.No: TMA0291

Target: GSK-3, p38 MAPK, ROS, Akt, COX, PI3K, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

Cat.No: T15255

Synonym: Levodopa ethyl ester,L-DOPA ethyl ester

Target: Others

Cat.No: TN5235

Target: Others

1-Oxomicrostegiol

Cat.No: T83426

Cat.No: T15467

Target: Others

Cat.No: TN4654

Target: Others

Cat.No: TMA0627

Target: TNF

2,4-Dihydroxyphenylacetic acid

Cat.No: TMA1130

Target: Others

Isolupalbigenin

Cat.No: TN4308

Target: Antifection

Cat.No: TN4334

Target: TNF

Cat.No: TN2169

Synonym: 柴胡皂甙元 D,皂苷元 D

Target: IL Receptor, Calcium Channel, Prostaglandin Receptor

Anagyrine hydrochloride

Cat.No: T73856

trans-10-Heptadecenoic acid

Cat.No: T78467

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