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Search Results for " tnfα "

Targets Recommended: Others

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抑制剂 & 化合物

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Cat. No.	Product Name
L9810	抗纤维化化合物库		1180 compounds
	1180 种潜在的抗纤维化分子，是研究纤维化的有效工具，可以用于高通量筛选和高内涵筛选；

化合物库

抗纤维化化合物库

Cat.No: L9810

Compounds: 1180

Cat. No.	Product Name	Target	Signaling Pathways
T19584L	TNF-α (31-45), human acetate TNF-α (31-45), human acetate(144796-71-4 free base)	Others	Others
	TNF-α (31-45), human acetate(144796-71-4 free base) 是一种肿瘤坏死因子-α 的肽。
T36127	TNF-α Antagonist
	TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destr...
T83628	TNF/IFNγ-IN-1	Antioxidant; TNF; COX	Apoptosis; Immunology/Inflammation; Neuroscience; oxidation-reduction
	TNF/IFNγ-IN-1(TGA) 是 TNF 和 IFN-γ 的双重抑制剂。TNF/IFNγ-IN-1 具有潜在的抗氧化和抗炎活性，可用于类似阿尔茨海默等的神经退行性疾病。
T77494	TNF-α-IN-9	TNF	Apoptosis
	TNF-α-IN-9 是一种 NDM-1 inhibitor-3类似物，是一种 TNF-α 抑制剂。TNF-α-IN-9 显示低抑制活性。
T9192	BIIB068	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	BIIB068 是可逆的、选择性的、具有口服活性的 BTK 抑制剂 (IC50:1 nM;Kd:0.3 nM)。它对 BTK 的选择性比其他激酶高 400 倍。它可用于自身免疫性疾病的研究。
T8316	1V209 TLR7 agonist T7	TLR	Immunology/Inflammation
	1V209 (TLR7 agonist T7) 是一种 Toll 样受体 7 (TLR7) 激动剂，可与各种多糖缀合，以改善其水溶性，增强功效并保持低毒性，具有抗肿瘤作用。
T6649	(S)-(+)-Rolipram (S)-Rolipram,(+)-Rolipram,盐酸环胞苷,S- (+)-Rolipram	Apoptosis; PDE	Apoptosis; Metabolism
	(S)-(+)-Rolipram ((+)-Rolipram) 是一种 cAMP 依赖性磷酸二酯酶 4 (PDE4) 抑制剂，IC50=1100 nM。它能够抑制人单核细胞产生的肿瘤坏死因子 α (TNFα)。
T0137	Mirtazapine 米氮平,6-Azamianserin,Org3770	Dopamine Receptor; 5-HT Receptor; Opioid Receptor; Adrenergic Receptor; Histamine Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mirtazapine (6-Azamianserin) 是一种有效的具有口服活性的去甲肾上腺素能和特异性血清素能抗抑郁剂 (NaSSA)。它也是一种5-HT2、5-HT3、组胺 H1 受体和 α2-肾上腺素受体拮抗剂，pKi 值分别为 8.05、8.1、9.3 和 6.95。
T40321	TNF-α-IN-6
	TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).
T16501	PF-3644022	p38 MAPK; Serine Protease; MAPK	MAPK; Proteases/Proteasome
	PF-3644022 是可口服的，具有 ATP 竞争性的MAPKAPK2 (MK2)选择性抑制剂，IC50为 5.2 nM，Ki 为 3 nM。它有效抑制 TNFα 的产生并具有抗炎作用，还抑制 MK3 和 p38 调节/激活激酶，IC50分别为 53 和 5.0 nM。
T71726	TNFalpha-IN-S10
	TNFalpha-IN-S10 is an inhibitor of TNF-α.
T9034	MK2-IN-3 MK2 Inhibitor III	MAPK	MAPK
	MK2-IN-3 (MK2 Inhibitor III) 是选择性的 MAPKAP-K2 (MK-2)抑制剂(IC50:8.5 nM)，能够抑制 U937 细胞及体内 TNFα 的生成。
T36097	TNF-α-IN-2
	TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in the TNFα trimer upon binding, resulting in disrupted signaling when the trimer interacts with TNFR1. TNF-α-IN-2 holds promise as a valuable tool for investigating the pathogenesis of rheumatoid arthritis[1].
T79025	TNF-α-IN-10
	TNF-α-IN-10 (compound 8a) 作为IL-6与TNF-α的抑制剂，表现出抗炎活性。
TP1537	TNF-α (10-36), human
	TNF-α (10-36), human is a potent pro-inflammatory cytokine involved in the acute phase stress response.
T19584	TNF-α (31-45), human	Others	Others
	TNF-α (31-45), human is a peptide of tumor necrosis factor-α.
TP1626	TNF-α (46-65), human
	Human TNF alpha (46-65) peptide.
T80973	TNF-α-IN-8
	TNF-α-IN-8 (compound I-42) 作为一种TNF-α抑制剂，属于异吲哚-亚胺类化合物，适用于肿瘤、心脏病、骨质疏松、炎症、过敏及自身免疫性疾病的研究。作为点击化学试剂，其Azide基团能与含Alkyne的分子配对，通过铜催化的叠氮－炔环加成反应(CuAAc)产生反应，也可与含DBCO或BCN基团的分子进行菌株促进的炔－叠氮环加成反应(SPAAC)。
T78730	TNF-α-IN-11
	TNF-α-IN-11 (Compound 10)是一种TNF-α抑制剂, KD值为12.06 μM。该化合物通过结合TNF-α并阻断其诱发的caspase和NF-κB信号通路激活，来实现其抑制作用。其具体机制包括抑制IκBα磷酸化和NF κB p65的核转位，适用于研究TNF-α介导的自身免疫性疾病。
T13175	TNF-α-IN-1	TNF	Apoptosis
	TNF-α-IN-1是 TNF-α 抑制剂。
T20033	Direct Violet 1 NSC75778,NSC 75778,Airedale Violet ND,NSC-75778,直接青莲N,Direct Violet N,CCRIS 2413	SARS-CoV	Microbiology/Virology
	Direct Violet 1 (CCRIS 2413) 是一种偶氮染料，是纺织品染料，也是 SARS-CoV-2 刺突蛋白和 ACE2 抑制剂之间的蛋白质相互作用，IC50为 1.47-2.63 µM。
T76026	TNF-α (31-45), human TFA
	TNF-α (31-45), human TFA 是人肿瘤坏死因子-α 的多肽片段。TNF α 是一种炎性细胞因子，可诱导坏死或凋亡。
T9537	N'-Nitro-D-arginine N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid,N'-硝基-D-精氨酸	Others	Others
	N'-Nitro-D-arginine (N'-Nitro-D-arginine) 是一种砌块。
T7162	R1487 Hydrochloride R1487 (Hydrochloride)	p38 MAPK; Autophagy	Autophagy; MAPK
	R1487 Hydrochloride (R1487(Hydrochloride)) 是一种可口服的高选择性 p38α 抑制剂，对 p38α 和 p38β 的Kd 值分别为 0.2 nM 和 29 nM。
T78272	Anti-Mouse TNF alpha Antibody (TN3-19.12)
	Anti-Mouse TNF alpha Antibody为Rat宿主源的IgG类针对小鼠TNF alpha的抗体抑制剂。
T78434	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA
	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA 为基于荧光共振能量转移的多肽底物，通过裂解引起的荧光强度变化来确定其活性。
TP1669	TNF-α (46-65), human TFA (144796-72-5 free base) TNF-α (46-65), human TFA
	TNF-α (46-65), human (TFA) is a peptide of human TNF-α.
TP1636	TNF-α (31-45), human TFA (144796-71-4 free base) TNF-α (31-45), human TFA
	TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α.
T81838	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)
	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) 为一种基于FRET (荧光共振能量转移) 原理的多肽底物，通过其裂解引起的荧光强度变化来评估其活性。
TP1479	TNF-α (10-36), human (TFA) (144796-70-3 free base) TNF-α (10-36), human (TFA)
	TNF-α (10-36), human (TFA) is a peptide of human TNF-α.
T1934	Bay 11-7085 BAY 11-7083	Apoptosis; IκB/IKK; Ferroptosis; NF-κB	Apoptosis; NF-κB
	Bay 11-7085 抑制NF-κB 激活和IκBα磷酸化，其稳定 IκBα 的IC50值为 10 μM。
T4637	R-7050 TNF-α Antagonist III	TNF	Apoptosis
	R-7050 (TNF-α Antagonist III) 是一种肿瘤坏死因子受体拮抗剂，对 TNFα具有更高选择性。
T29857	Alethine β-Alethine	TNF	Apoptosis
	Alethine (β-Alethine) 是一种小分子化合物，具有抗肿瘤活性，可用于治疗肿瘤和感染。 Alethine 诱导的TNFα上调增加T 细胞的细胞毒性。
T14848	C 87	Others; TNF	Apoptosis; Others
	C 87 是一种小分子 TNF-α 抑制剂。 C 87 直接与 TNFα 结合，有效抑制 TNF-α 诱导的细胞毒性 (IC50 = 8.73 μM)，并有效阻断 TNF-α 触发的信号传导活动。
T4403	AX-024 hydrochloride AX-024 HCl	IL Receptor; TNF; COX; IFNAR; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience
	AX-024 hydrochloride (AX-024 HCl) 是一种细胞因子释放抑制剂，可强烈抑制 IL-6、TNFα、IFN-γ、IL-10 和 IL-17A 的产生。它是口服可利用的 TCR-Nck 相互作用抑制剂，可选择性地抑制 TCR 触发的 T 细胞活化。它通过靶向 SH3结构域调节细胞信号传导，具有低毒、高效和高选择性的特点。
T1902	BAY 11-7082 BAY 11-7821	Apoptosis; Others; IκB/IKK; DUB; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; NF-κB; Others; Ubiquitination
	BAY 11-7082 (BAY 11-7821) 是一种 NF-κB 抑制剂，可抑制 TNFα 诱导的 IκBα 磷酸化 (IC50=10 μM)。BAY 11-7082 也是一种泛素特异性蛋白酶 USP7 和 USP21 的抑制剂 (IC50=0.19/0.96 μM)。
T61111	UCB-5307	TNF	Apoptosis
	UCB-5307 是一种小分子化合物，可在体外抑制 TNFR1 信号转导和下游功能。人 TNFα 的 KD 为 9 nM。 TNF 直接通过缓慢的结合动力学结合，KD = 6 nM。 UCB-5307 可以通过预制的 hTNF/hTNFR1 复合物。
T76711	Golimumab MK-8259,SCH 900259,CNTO-148	TNF	Apoptosis
	Golimumab (CNTO-148) 是一种有效的人源化抗 TNFα IgG1κ单克隆抗体。Golimumab 具有抗炎和抗癌活性，对 IL-6 和 IL-1β 的产生有抑制作用，可诱导细胞凋亡。Golimumab 可用来预防炎症发生和软骨或骨骼的破坏，可用于研究类风湿性关节炎和癌症。
T36524	IKK2-IN-4 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide,IKK2 Inhibitor IV	IκB/IKK; TNF	Apoptosis; NF-κB
	IKK2-IN-4 (IKK2 Inhibitor IV)是一种高效的 IKK-2 抑制剂，IC50 值为 25 nM。IKK2-IN-4 对 LPS 诱导的 PBMC 中 TNFα 的产生有抑制作用。
T68321	AS1940477
	AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent c...
T38361	GSK717	IL Receptor; NOD	Immunology/Inflammation; NF-κB
	GSK717 是 NOD2(核苷酸结合寡聚结构域 2) 的选择性抑制剂。它抑制壁酰二肽 (MDP) 诱导的 NOD2 介导的信号转导，抑制 MDP 刺激的 HEK293/hNOD2 细胞分泌 IL-8 (IC50为 400 nM)。
T24185	IW-927 IW927,IW 927
	IW-927 is a potent and selective TNFα/TNFRc1 interaction antagonist.
T61810	Anti-inflammatory agent 16
	Anti-inflammatory agent 16 (compound 14) is a highly effective peptidomimetic with potent anti-inflammatory properties. It effectively reduces the expression levels of TNFα, NO, CD40, and CD86 [1].
T68266	BMS-751324
	BMS-751324 是一种p38αMAPK 抑制剂。BMS-751324 含有氨基甲酰基亚甲基连接的前体，含有羟基苯基乙酸 (HPA) 衍生的酯和磷酸盐官能团。BMS-751324 在关节炎大鼠模型中有效抑制足部肿胀，并抑制 LPS 诱导的 TNFα 的生成。
T79170	Immuno modulator-1
	Immuno modulator-1 (compound 22) 在hPBMC中抑制TNFα和IL-2的分泌，IC50为4.7 nM和26 nM。同时，该化合物对hERG钾通道具阻断活性，3 μM浓度时抑制率达20%。
T77179	Remtolumab
	Remtolumab (ABT-122) 是一种双变量域免疫球蛋白，可以中和肿瘤坏死因子α (TNFα) 和IL-17A。Remtolumab 显示出对 TNFα 和IL-17A 的双重抑制。Remtolumab 可用于类风湿关节炎 (RA) 研究。
T77126	Ozoralizumab
	Ozoralizumab (ATN-103) 为一种针对TNFα的人源化抗体。该化合物为一种三价人源化纳米抗体，由两个针对人TNFα的纳米抗体和一个针对人血清白蛋白(HSA)的纳米抗体构成，适用于关节炎研究。
T27687	JNJ525 JNJ 525,JNJ-525
	JNJ525 is an inhibitor of TNFα. JNJ525 inhibits protein function via an aggregation-based mechanism. JNJ525 prevents the formation of TNFα complexes with TNFR1 and TNFR2, the apparent IC50 values for the inhibition of complex formation are 1.2 ± 0.2 μM an
T16477	PF-03715455	p38 MAPK	MAPK
	PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respective IC50: 0.88 and 23 nM). PF-0371545
T27615	iNUB
	iNUB is a NEMO-Ub binding inhibitor. iNUB inhibits TNFα induced NF-κB signaling and has selectively toxic to IKK/NF-κB dependent ABC-DLBCL.

化合物

TNF-α (31-45), human acetate

Cat.No: T19584L

Synonym: TNF-α (31-45), human acetate(144796-71-4 free base)

Target: Others

TNF-α Antagonist

Cat.No: T36127

Cat.No: T83628

Target: Antioxidant, TNF, COX

Cat.No: T77494

Target: TNF

Cat.No: T9192

Target: BTK

Cat.No: T8316

Synonym: TLR7 agonist T7

Target: TLR

(S)-(+)-Rolipram

Cat.No: T6649

Synonym: (S)-Rolipram,(+)-Rolipram,盐酸环胞苷,S- (+)-Rolipram

Target: Apoptosis, PDE

Cat.No: T0137

Synonym: 米氮平,6-Azamianserin,Org3770

Target: Dopamine Receptor, 5-HT Receptor, Opioid Receptor, Adrenergic Receptor, Histamine Receptor

Cat.No: T40321

Cat.No: T16501

Target: p38 MAPK, Serine Protease, MAPK

TNFalpha-IN-S10

Cat.No: T71726

Cat.No: T9034

Synonym: MK2 Inhibitor III

Target: MAPK

Cat.No: T36097

Cat.No: T79025

TNF-α (10-36), human

Cat.No: TP1537

TNF-α (31-45), human

Cat.No: T19584

Target: Others

TNF-α (46-65), human

Cat.No: TP1626

Cat.No: T80973

Cat.No: T78730

Cat.No: T13175

Target: TNF

Direct Violet 1

Cat.No: T20033

Synonym: NSC75778,NSC 75778,Airedale Violet ND,NSC-75778,直接青莲N,Direct Violet N,CCRIS 2413

Target: SARS-CoV

TNF-α (31-45), human TFA

Cat.No: T76026

N'-Nitro-D-arginine

Cat.No: T9537

Synonym: N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid,N'-硝基-D-精氨酸

Target: Others

R1487 Hydrochloride

Cat.No: T7162

Synonym: R1487 (Hydrochloride)

Target: p38 MAPK, Autophagy

Anti-Mouse TNF alpha Antibody (TN3-19.12)

Cat.No: T78272

Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA

Cat.No: T78434

TNF-α (46-65), human TFA (144796-72-5 free base)

Cat.No: TP1669

Synonym: TNF-α (46-65), human TFA

TNF-α (31-45), human TFA (144796-71-4 free base)

Cat.No: TP1636

Synonym: TNF-α (31-45), human TFA

Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)

Cat.No: T81838

TNF-α (10-36), human (TFA) (144796-70-3 free base)

Cat.No: TP1479

Synonym: TNF-α (10-36), human (TFA)

Cat.No: T1934

Synonym: BAY 11-7083

Target: Apoptosis, IκB/IKK, Ferroptosis, NF-κB

Cat.No: T4637

Synonym: TNF-α Antagonist III

Target: TNF

Cat.No: T29857

Synonym: β-Alethine

Target: TNF

Cat.No: T14848

Target: Others, TNF

AX-024 hydrochloride

Cat.No: T4403

Synonym: AX-024 HCl

Target: IL Receptor, TNF, COX, IFNAR, Interleukin

Cat.No: T1902

Synonym: BAY 11-7821

Target: Apoptosis, Others, IκB/IKK, DUB, Autophagy

Cat.No: T61111

Target: TNF

Cat.No: T76711

Synonym: MK-8259,SCH 900259,CNTO-148

Target: TNF

Cat.No: T36524

Synonym: 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide,IKK2 Inhibitor IV

Target: IκB/IKK, TNF

Cat.No: T68321

Cat.No: T38361

Target: IL Receptor, NOD

Cat.No: T24185

Synonym: IW927,IW 927

Anti-inflammatory agent 16

Cat.No: T61810

Cat.No: T68266

Immuno modulator-1

Cat.No: T79170

Cat.No: T77179

Cat.No: T77126

Cat.No: T27687

Synonym: JNJ 525,JNJ-525

Cat.No: T16477

Target: p38 MAPK

Cat.No: T27615

Cat. No.	Product Name	Target	Signaling Pathways
T5834	Myrcene	Others	Others
	Myrcene 是具有可挥发性的芳香族化合物，对 TNFα 诱导的 NF-κB 具有抑制作用，且具有抗侵袭的能力。
TN1637	Eurycomalactone	Anti-infection; NF-κB	Microbiology/Virology; NF-κB
	Eurycomalactone 是一种NF-κB 抑制剂，IC50=0.5 μM，是一种天然产物。它可抑制蛋白合成，降低 cyclin D1 蛋白水平，但对 TNFα 诱导的 IκBα 降解或 IKKα/β 和 IκBα 的磷酸化水平没有作用。
T3918	Ginsenoside Rb3 人参皂苷 Rb3,Gypenoside IV,人参皂苷Rb3	NF-κB; COX; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB
	Ginsenoside Rb3 (Gypenoside IV) 是从三七中提取的一种天然产物。它在 293T 细胞系中抑制 TNFα 诱导的NF-κB 转录活性，IC50为 8.2 μM。它还抑制COX-2和iNOSmRNA 的诱导。
T2878	Ginsenoside Rd Panaxoside Rd,Sanchinoside Rd,人参皂苷Rd,人参皂苷 Rd,Gypenoside VIII	P450; Calcium Channel; NF-κB; COX; Endogenous Metabolite	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	Ginsenoside Rd (Gypenoside VIII) 抑制 TNFα 诱导的NF-κB 转录活性，还抑制COX-2和iNOSmRNA 的表达。它抑制CYP2D6、CYP1A2、CYP3A4和CYP2C9，也抑制Ca2+内流，有可能抑制或阻止肿瘤生长。
T7917	4'-Hydroxychalcone 4-羟基查耳酮,4′-羟基查耳酮,2-Benzal-4-Hydroxyacetophenone	Proteasome	Proteases/Proteasome; Ubiquitination
	4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) 是从甘草根中分离的一种查尔酮，具有保护肝脏的作用。它能诱导大鼠离体肝线粒体囊泡快速释放钾，并引起其线粒体呼吸控制和氧化磷酸化衰退。它能通过抑制蛋白酶体 (proteasome)，抑制TNFα 诱导的 NF-κB 活性。
T8852	tubuloside B	Apoptosis; Others	Apoptosis; Others
	Tubuloside B 是可从管花肉苁蓉茎中分离出的一种天然产物，具有抗氧化活性，可抑制TNFα 诱导的细胞凋亡。
T79962	Aloenin aglycone	Others	Others
	Aloenin aglycone (compound 13) 作为一种NF-κB抑制剂，可从芦荟渗出液中提取。它在抑制TNFα引发的NF-κB转录活性方面表现显著（IC50: 18.7 μM）。当HepG2细胞经10 ng/mL TNFα处理时，以10 μM Aloenin aglycone处理能有效下调诱导型一氧化氮合酶（iNOS）及细胞间粘附分子1（ICAM-1）的基因表达。
T79961	Aloeresin G
	Aloeresin G, 分离自Aloe的一种色原酮苷，对TNFα诱导的NF-κB转录活性具有抑制效果，其IC 50为40.02 μM。
TN3614	Cearoin 檀木	ERK; BCL; PARP; IκB/IKK; TNF; NF-κB; ROS; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; NF-κB; Proteases/Proteasome
	Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFα and CCL2. Cearoin induces aut
TN5880	Mesuol
	Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway.

天然产物

Cat.No: T5834

Target: Others

Eurycomalactone

Cat.No: TN1637

Target: Anti-infection, NF-κB

Ginsenoside Rb3

Cat.No: T3918

Synonym: 人参皂苷 Rb3,Gypenoside IV,人参皂苷Rb3

Target: NF-κB, COX, NO Synthase

Cat.No: T2878

Synonym: Panaxoside Rd,Sanchinoside Rd,人参皂苷Rd,人参皂苷 Rd,Gypenoside VIII

Target: P450, Calcium Channel, NF-κB, COX, Endogenous Metabolite

4'-Hydroxychalcone

Cat.No: T7917

Synonym: 4-羟基查耳酮,4′-羟基查耳酮,2-Benzal-4-Hydroxyacetophenone

Target: Proteasome

Cat.No: T8852

Target: Apoptosis, Others

Aloenin aglycone

Cat.No: T79962

Target: Others

Cat.No: T79961

Cat.No: TN3614

Synonym: 檀木

Target: ERK, BCL, PARP, IκB/IKK, TNF, NF-κB, ROS, Caspase

Cat.No: TN5880

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01294	TNF alpha Protein, Mouse, Recombinant TNF-α,Tnfsf1a,TNF-alpha,TNF-a,Tnfa,tumor necrosis factor,TNF...	Mouse	E. coli
	TNF alpha Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.39 kDa and the accession number is P06804.
TMPK-00583	TNF alpha Protein, Ferret, Recombinant (His) TNF-α,DIF,TNFα,TNF-alpha,TNF α,Cachectin,APC1 prote...	Ferret	E. coli
	TNF alpha Protein, Ferret, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.88 kDa and the accession number is A3FBF1.
TMPK-00119	TNF alpha Protein, Cynomolgus, Recombinant (His) TNF α,TNFα,APC1 protein,TNF-alpha,TNFA,TNF-α,TNFATN...	Cynomolgus	HEK293 Cells
	TNF alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 18.35 kDa and the accession number is P79337.
TMPK-00120	TNF alpha Protein, Human, Recombinant (His & Avi) TNFα,APC1 protein,肿瘤坏死因子,TNFSF2,TNF,TNF α,TNF-alpha...	Human	HEK293 Cells
	TNF alpha Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375.
TMPK-00121	TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated TNF,TNF-alpha,TNFATNF,DIF,TNFalpha,TNFα,TNFA,TNF-α,...	Human	HEK293 Cells
	TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375.
TMPY-01697	TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) Tnfr-1,TNFR80,TNF-R-II,TNF-αR2,tumor necrosis factor recepto...	Mouse	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is P25119.
TMPJ-00779	TNF alpha Protein, Rabbit, Recombinant TNF-a,Tumor Necrosis Factor,TNF-α,TNF α,Cachectin,肿瘤坏死因子,Tum...	Rabbit	E. coli
	Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor type 2,p75R). TNFα is a pleiotropic cytokine that is capable to promote inflammation, to induce apoptotic cell death, and to inhibit tumorigenesis and viral replication. TNFα is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other ...
TMPY-05187	TNF alpha Protein, Mouse, Recombinant, Biotinylated Tnfa,TNFSF2,肿瘤坏死因子,Tnfsf1a,TNF-alpha,TNFalpha,DIF,TNFα	Mouse	E. coli
	TNF alpha Protein, Mouse, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P06804.
TMPY-02535	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc) TNFalpha-R1,TNFAR,TNF-R-I,TNF-R,TNFRp55,FPF,TNF-R55,TNFR60,T...	Mouse	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.4 kDa and the accession number is P25118.
TMPY-02202	TNF alpha Protein, Rat, Recombinant tumor necrosis factor,肿瘤坏死因子,TNF-α	Rat	E. coli
	TNF alpha Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P16599.
TMPY-02153	TNF beta Protein, Human, Recombinant LT,TNF β,TNFSF1,肿瘤坏死因子,TNFB,lymphotoxin alpha,lymphotoxin α	Human	E. coli
	Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRS...
TMPY-00936	TNF alpha Protein, Human, Recombinant TNFA,TNFSF2,TNF-alpha,TNF-α,DIF,肿瘤坏死因子,tumor necrosis factor	Human	E. coli
	TNF alpha Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375.
TMPY-04146	TNF alpha Protein, Human, Recombinant (hFc) DIF,TNFA,tumor necrosis factor,TNFSF2,TNF-α,TNF-alpha	Human	HEK293 Cells
	TNF alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.8 kDa and the accession number is P01375.
TMPY-01696	TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc) TNF-αR2,TNF-R-II,Tnfr2,TNFalpha-R2,TNFBR,tumor necrosis fact...	Mouse	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.3 kDa and the accession number is P25119.
TMPY-02069	TNF alpha Protein, Cynomolgus, Rhesus, Recombinant 肿瘤坏死因子,TNF-α,tumor necrosis factor	Cynomolgus,Rhesus	E. coli
	TNF alpha Protein, Cynomolgus, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is NP_001040614.1.
TMPJ-00288	TNF RII Protein, Human, Recombinant (mFc) Tumor necrosis factor receptor 2,TNFRSF1B,p75,TNF-RII,TNF-R2...	Human	HEK293 Cells
	TNF RII Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60 KDa and the accession number is P20333.
TMPH-02770	TNF beta Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. TNF beta Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.8 kDa and the accession number is P09225.
TMPY-05516	TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated 肿瘤坏死因子,tumor necrosis factor,TNF-α	Cynomolgus	E. coli
	TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P79337.
TMPY-01639	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His) TNFalpha-R1,TNFRp55,CD120a,TNF-alphaR1,FPF,p55-R,TNF-R,TNFAR...	Mouse	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.8 kDa and the accession number is P25118.
TMPJ-00280	TNF R1 Protein, Mouse, Recombinant Tnfrsf1a,Tumor necrosis factor receptor superfamily member 1...	Mouse	E. coli
	Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor receptor superfamily. Tnfrsf1a is one of the major receptors for the tumor necrosis factor-alpha. It can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the...
TMPH-03745	TNF-alpha Protein, Zebrafish, Recombinant (His)	Danio rerio (Zebrafish)	E. coli
	TNF-alpha Protein, Zebrafish, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.6 kDa and the accession number is Q08CQ3.
TMPY-01594	TNF alpha Protein, Canine, Recombinant 肿瘤坏死因子,TNF-α,tumor necrosis factor	Canine	E. coli
	TNF alpha Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A9LMQ0.
TMPY-02226	TNF alpha Protein, Ferret, Recombinant tumor necrosis factor,肿瘤坏死因子,TNF-α	Ferret	E. coli
	TNF alpha Protein, Ferret, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A3FBF1.
TMPY-05237	TNF alpha Protein, Human, Recombinant, Biotinylated TNFSF2,DIF,TNF-α,tumor necrosis factor,肿瘤坏死因子,TNF-alpha,TNFA	Human	E. coli
	TNF alpha Protein, Human, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375.
TMPJ-00287	TNF RII Protein, Human, Recombinant (hFc) TNF-R2,Tumor necrosis factor receptor superfamily member 1B,...	Human	HEK293 Cells
	TNF RII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-90 KDa and the accession number is P20333.
TMPJ-00619	TNF RII Protein, Rhesus macaque, Recombinant (His) Tumor necrosis factor receptor superfamily member 1b,Tnfrsf1...	Rhesus	HEK293 Cells
	TNF RII Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-45 KDa and the accession number is F7EAF8.
TMPH-01620	TNF beta Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
TMPJ-00618	TNF RII Protein, Rhesus macaque, Recombinant (hFc) Tnfrsf1b,Tumor necrosis factor receptor superfamily member 1...	Rhesus	HEK293 Cells
	TNF RII Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-80 KDa and the accession number is F7EAF8.
TMPJ-00124	TNF alpha Protein, Human, Recombinant (aa 77-233, His) TNF-a,TNF-α,Tumor Necrosis Factor,TNFA,Tumor Necrosis Factor...	Human	E. coli
	TNF alpha Protein, Human, Recombinant (aa 77-233, His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 16 KDa and the accession number is P01375.
TMPJ-00296	TNF RII Protein, Mouse, Recombinant (His & Avi), Biotinylated Tumor necrosis factor receptor superfamily member 1b,Tnfrsf1...	Mouse	HEK293 Cells
	TNF RII Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 35-50 KDa and the accession number is Q545P4.
TMPJ-00125	TNF alpha Protein, Human, Recombinant (aa 57-233, His) TNFA,TNF-α,Cachectin,肿瘤坏死因子,TNF-Alpha,TNF-a,TNF α,Tumor Necr...	Human	E. coli
	TNF alpha Protein, Human, Recombinant (aa 57-233, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18 KDa and the accession number is P01375.
TMPK-00745	PGLYRP1 Protein, Human, Recombinant (hFc) PGLYRP1,TAG7,PGLYRP,PGRP-SMGC126894,PGRP,Tasg7,TNFSF3L,PGRP-...	Human	HEK293 Cells
	Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway. PGLYRP1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.2 kDa and the accessio...
TMPK-00749	PGLYRP1 Protein, Mouse, Recombinant (hFc) PGRPSMGC126896,TNFSF3L,PGLYRP1,TAG7,PGLYRP,PGRP,PGRP-SMGC126...	Mouse	HEK293 Cells
	Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway. PGLYRP1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 45.7 kDa and the accessio...
TMPY-01176	cIAP1 Protein, Human, Recombinant (Avi) Hiap-2,API1,HIAP2,RNF48,baculoviral IAP repeat containing 2,...	Human	E. coli
	The cellular inhibitor of apoptosis protein-1 (cIAP1) is a member of the Inhibitor of Apoptosis family proteins are (IAP) whose members are characterized by a novel domain of about 70 amino acids termed baculoviral IAP repeats (BIRs). The BIR domains of cIAP1 and cIAP2 bind to caspases, the key effector proteases of apoptosis. The IAP protein family which can enhance cell survival are crucial regulators of programmed cell death. Both cIAP1 and cIAP2 are the E3 ubiquitin protein isopeptide ligase...

重组蛋白

TNF alpha Protein, Mouse, Recombinant

Cat.No: TMPY-01294

Species: Mouse

Expression System: E. coli

TNF alpha Protein, Ferret, Recombinant (His)

Cat.No: TMPK-00583

Species: Ferret

Expression System: E. coli

TNF alpha Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00119

Species: Cynomolgus

Expression System: HEK293 Cells

TNF alpha Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00120

Species: Human

Expression System: HEK293 Cells

TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00121

Species: Human

Expression System: HEK293 Cells

TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01697

Species: Mouse

Expression System: HEK293 Cells

TNF alpha Protein, Rabbit, Recombinant

Cat.No: TMPJ-00779

Species: Rabbit

Expression System: E. coli

TNF alpha Protein, Mouse, Recombinant, Biotinylated

Cat.No: TMPY-05187

Species: Mouse

Expression System: E. coli

TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02535

Species: Mouse

Expression System: HEK293 Cells

TNF alpha Protein, Rat, Recombinant

Cat.No: TMPY-02202

Species: Rat

Expression System: E. coli

TNF beta Protein, Human, Recombinant

Cat.No: TMPY-02153

Species: Human

Expression System: E. coli

TNF alpha Protein, Human, Recombinant

Cat.No: TMPY-00936

Species: Human

Expression System: E. coli

TNF alpha Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04146

Species: Human

Expression System: HEK293 Cells

TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01696

Species: Mouse

Expression System: HEK293 Cells

TNF alpha Protein, Cynomolgus, Rhesus, Recombinant

Cat.No: TMPY-02069

Species: Cynomolgus,Rhesus

Expression System: E. coli

TNF RII Protein, Human, Recombinant (mFc)

Cat.No: TMPJ-00288

Species: Human

Expression System: HEK293 Cells

TNF beta Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02770

Species: Mouse

Expression System: E. coli

TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated

Cat.No: TMPY-05516

Species: Cynomolgus

Expression System: E. coli

TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01639

Species: Mouse

Expression System: HEK293 Cells

TNF R1 Protein, Mouse, Recombinant

Cat.No: TMPJ-00280

Species: Mouse

Expression System: E. coli

TNF-alpha Protein, Zebrafish, Recombinant (His)

Cat.No: TMPH-03745

Species: Danio rerio (Zebrafish)

Expression System: E. coli

TNF alpha Protein, Canine, Recombinant

Cat.No: TMPY-01594

Species: Canine

Expression System: E. coli

TNF alpha Protein, Ferret, Recombinant

Cat.No: TMPY-02226

Species: Ferret

Expression System: E. coli

TNF alpha Protein, Human, Recombinant, Biotinylated

Cat.No: TMPY-05237

Species: Human

Expression System: E. coli

TNF RII Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00287

Species: Human

Expression System: HEK293 Cells

TNF RII Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPJ-00619

Species: Rhesus

Expression System: HEK293 Cells

TNF beta Protein, Human, Recombinant (His)

Cat.No: TMPH-01620

Species: Human

Expression System: HEK293 Cells

TNF RII Protein, Rhesus macaque, Recombinant (hFc)

Cat.No: TMPJ-00618

Species: Rhesus

Expression System: HEK293 Cells

TNF alpha Protein, Human, Recombinant (aa 77-233, His)

Cat.No: TMPJ-00124

Species: Human

Expression System: E. coli

TNF RII Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00296

Species: Mouse

Expression System: HEK293 Cells

TNF alpha Protein, Human, Recombinant (aa 57-233, His)

Cat.No: TMPJ-00125

Species: Human

Expression System: E. coli

PGLYRP1 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00745

Species: Human

Expression System: HEK293 Cells

PGLYRP1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00749

Species: Mouse

Expression System: HEK293 Cells

cIAP1 Protein, Human, Recombinant (Avi)

Cat.No: TMPY-01176

Species: Human

Expression System: E. coli

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