Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BIIB068 是可逆的、选择性的、具有口服活性的 BTK 抑制剂 (IC50:1 nM;Kd:0.3 nM)。它对 BTK 的选择性比其他激酶高 400 倍。它可用于自身免疫性疾病的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 619 | 现货 | ||
2 mg | ¥ 898 | 现货 | ||
5 mg | ¥ 1,490 | 现货 | ||
10 mg | ¥ 2,480 | 现货 | ||
25 mg | ¥ 3,970 | 现货 | ||
50 mg | ¥ 5,830 | 现货 | ||
100 mg | ¥ 7,880 | 现货 | ||
500 mg | ¥ 15,700 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,630 | 现货 |
产品描述 | BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases. |
靶点活性 | BTK:0.3 nM (Kd), BTK:1 nM (IC50) |
体外活性 | BIIB068 inhibits B cell, neutrophil and monocyte activation in vitro, but not T cell responses. |
体内活性 | BIIB068 demonstrated good PK/PD correlation with in vivo EC50 = 0.16 μM based on antibody esponse, similar to in vivo WB pBTK potency in mice. BIIB068 exhibited no adverse effects in the single dose CNS and respiratory studies in rats nor in a single dose cardiovascular study in monkeys. BIIB068 was well tolerated and effective at inhibiting BTK phosphorylation in healthy subjects. |
分子量 | 435.52 |
分子式 | C23H29N7O2 |
CAS No. | 1798787-27-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL(68.88 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2961 mL | 11.4805 mL | 22.9611 mL | 57.4026 mL |
5 mM | 0.4592 mL | 2.2961 mL | 4.5922 mL | 11.4805 mL | |
10 mM | 0.2296 mL | 1.1481 mL | 2.2961 mL | 5.7403 mL | |
20 mM | 0.1148 mL | 0.574 mL | 1.1481 mL | 2.8701 mL | |
50 mM | 0.0459 mL | 0.2296 mL | 0.4592 mL | 1.1481 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
BIIB068 1798787-27-5 Angiogenesis Tyrosine Kinase/Adaptors BTK ADME inhibit FcγR Autoimmune Bruton tyrosine kinase TNFα BIIB 068 BIIB-068 ROS Inhibitor reversible Btk anti-IgD phosphorylation anti-IgM inhibitor