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Search Results for " melanoma cell "

74

抑制剂 & 化合物

20

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21679	4'-bromo-Resveratrol	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	4'-Bromo-resveratrol 是Sirtuin-1和Sirtuin-3的双重抑制剂。它通过线粒体代谢重编程，使黑色素瘤细胞的生长受到抑制。它通过代谢重编程、影响细胞周期以及细胞凋亡的信号传导，使其在黑色素瘤细胞中发挥抗增殖作用。
T1120	Dacarbazine Imidazole Carboxamide,达卡巴嗪,DTIC-Dome	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Dacarbazine (DTIC-Dome) 是一种抗肿瘤剂，对黑色素瘤具有显着的活性。
T11553	Heptamidine dimethanesulfonate SBi4211 dimethanesulfonate	Others	Others
	Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) 是一种与喷他脒有关的、强效的钙结合蛋白 S100B 的抑制剂 (Kd=6.9 μM)，选择性地杀死表达 S100B 的黑素瘤细胞。它是有效的强直性肌营养不良 (DM) 研究工具。
T36573	NHWD-870	Apoptosis; Epigenetic Reader Domain	Apoptosis; Chromatin/Epigenetic
	NHWD-870 是一种有效且特异性的 BET 家族溴结构域抑制剂，仅与 BRD2、BRD3、BRD4 (IC50 = 2.7 nM) 和 BRDT 结合。 NHWD-870 具有强大的抗肿瘤功效，并通过增加肿瘤细胞凋亡和抑制肿瘤增殖来抑制癌细胞-巨噬细胞相互作用。
T10395L	ATM-3507	Others	Others
	ATM-3507 is an inhibitor of tropomyosin. In human melanoma cell lines, the IC50s are from 3.83-6.84 μM.
T10104	3,4-Dihydroxybenzylamine hydrobromide NSC 263475 hydrobromide,3,4-二羟基苄胺·氢溴酸	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) 抑制黑色素瘤细胞中的 DNA 聚合酶活性，并在具有不同程度酪氨酸酶活性的黑色素瘤细胞系中显示出生长抑制活性。
T28206	NSC49652 NSC 49652,NSC-49652	Apoptosis	Apoptosis
	NSC49652 在神经元和黑色素瘤细胞中触发依赖于 p75NTR 和 JNK 活性的凋亡细胞死亡，并抑制黑色素瘤小鼠模型中的肿瘤生长。
T17195	UC-112	Others	Others
	UC-112是凋亡抑制蛋白IAP 新型高效抑制剂，癌细胞IC50值0.7-3.4uM。
T11209	EOAI3402143	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	EOAI3402143 是一种去泛素化酶抑制剂，以剂量依赖性抑制 Usp9x/Usp24和 Usp5，增加肿瘤细胞凋亡。
T77751	Imaprelimab PRX-003	Others	Others
	Imaprelimab (PRX-003) 是一种人源化抗黑素瘤细胞粘附分子 (MCAM) 的 IgG1κ 单克隆抗体。Imaprelimab 具有抗肿瘤活性，可用于研究炎症、肿瘤、银屑病。
T28145	ND-322 HCl ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl	MMP	Proteases/Proteasome
	ND-322 HCl (ND 322 Hydrochloride) 是 MT1-MMP 和 MMP2 的选择性抑制剂，可减少体外黑色素瘤细胞的生长、迁移和侵袭。
T35391	Vibostolimab (anti-TIGIT) Vibostolimab (anti-TIGIT)	Others	Others
	Vibostolimab 是一种抗 T 细胞免疫蛋白和 ITIM 域的单克隆抗体。Vibostolimab 在体外实验中显示出抗肿瘤活性，可用于研究非小细胞肺癌 (NSCLC) 和黑色素瘤。
T4356	POL1-IN-1 Compound 3A	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	POL1-IN-1 (Compound 3A) 是一种RNA 聚合酶 1 POL1抑制剂，IC50值低于 0.5 uM。它能有效抑制A375恶性黑色素瘤细胞系中RNA 聚合酶I 的转录。
T35407	Ζ-Stat	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	ζ-Stat 是非典型的、特异性的PKC-ζ抑制剂，IC50为 5 μM。ζ-Stat 能够减少黑色素瘤细胞系的增殖并诱导细胞凋亡，在体外显示除抗肿瘤活性。
T60197	UNC 1025	Others	Others
	UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK. This compound effectively suppresses MERTK-mediated downstream signaling, induces apoptosis in cell cultures, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. Notably, UNC1062 demonstrates potent inhibition of MERTK kinase activity, with an IC50 of 1.1 nM and a Morrison Ki of 0.33 nM. It also displays specificity within the TAM family, exhibiting IC50 values of 60 nM for TYRO3 ...
T6248	XL888	HSP	Cytoskeletal Signaling; Metabolism
	XL888 是一种 ATP 竞争性的 Hsp90 抑制剂，IC50值为 24 nM。
T60757	SB-216	Microtubule Associated	Cytoskeletal Signaling
	SB-216 可用于研究癌症，是微管蛋白聚合的有效抑制剂。SB-216 在一组人类癌细胞系中表现出强大的抗增殖能力，包括黑色素瘤、乳腺癌和肺癌。
T63228	Simmiparib SMOCL-9112	Apoptosis; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Simmiparib (SMOCL-9112) 是一种新型有效的 PARP1 和 PARP2 抑制剂，是一种Olaparib 衍生物。Simmiparib 在同源重组修复 (HR) 缺陷细胞中诱导 DNA 双链断裂 (DSB) 和细胞周期阻滞，从而促使细胞凋亡 (apoptosis)。Simmiparib 可用于研究帕金森病、阿尔茨海默病、乳腺癌和黑色素瘤。
T17228	Sabizabulin ABI-231,VERU-111	Microtubule Associated	Cytoskeletal Signaling
	Sabizabulin (ABI-231) 是一种有效且具有口服生物利用度的 α 和 β 微管蛋白抑制剂，可对抗黑色素瘤和前列腺癌细胞系。 Sabizabulin 通过靶向 HPV E6 和 E7 抑制宫颈癌细胞的肿瘤生长和转移表型。 Sabizabulin 显示出抗增殖活性，可用于前列腺癌研究。
T14884	CBR-5884	Others; Dehydrogenase	Metabolism; Others
	CBR-5884 是一种磷酸甘油酸脱氢酶抑制剂，IC50为 33 μM。它抑制癌细胞中的丝氨酸合成，选择性地抑制黑素瘤和乳腺癌细胞系的增殖，对具有高丝氨酸生物合成活性的癌细胞系有选择性毒性。
T36674	DMU-212	Apoptosis; ERK	Apoptosis; MAPK
	DMU-212 是具有口服活性的白藜芦醇的甲基化衍生物，表现出抗分裂、抗增殖、抗氧化和促进细胞凋亡的活性。它通过诱导凋亡和激活ERK1/2蛋白阻止有丝分裂。
T10395	ATM-3507 trihydrochloride (1861449-70-8 free base) ATM-3507 trihydrochloride	Others	Others
	ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines).
T24880	THPN
	THPN is a Nur77 agonist. It also induces autophagy in melanoma cell lines.
T27999	MDK-4624 AMPKα1 activator C13,C13, Compound 13
	MDK-4624 is a AMPKα1 activator. MDK-4624 inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. MDK-4624 attenuates dexamethasone-induced osteoblast cell death. MDK-4624 potently inhibits melanoma cell proliferation
T68468	FJ9
	FJ9 is a FZD7 inhibitor which disrupts protein-protein interaction between Frz7 and the PDZ domain of DVL, and induces apoptosis in melanoma cell line and non-small cell lung cancer cell line.
T29973	AMG-628 AMG628,AMG 628,CHEMBL226574,UNII-28J966TN3X
	AMG-628 is an effective and ATP-competitive RAF kinase inhibitor. AMG-628 has been shown to inhibit growth and induce cell cycle arrest and apoptosis in colon and melanoma cell lines with B-RAFV600E mutations.
T40330	Anticancer agent 15
	Anticancer agent 15, an anticancer agent, exerts its efficacy by elevating intracellular levels of reactive oxygen species (ROS) and inducing cell death in melanoma cancer cells through necroptosis.
T69557	ABI-231 HCl
	ABI-231 is a potent, orally bioavailable tubulin inhibitor that interacts with the colchicine binding site and is currently undergoing clinical trials for prostate cancer. ABI-231, has an average IC50 = 5.2 nM against panels of melanoma and prostate cancer cell lines, is orally bioavailable, and strongly suppress melanoma tumors in vivo. ABI-231 holds great promise as a new generation of orally available tubulin inhibitor.
T36460	CAY10736 CAY10736
	CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a ...
T1120L2	Dacarbazine citrate DTIC citrate
	Dacarbazine citrate is an alkylating agent used to treat cancers of the lymphatic system and malignant melanoma (a type of skin cancer) in patients with certain conditions: islet cell carcinoma (part of the pancreas) Soft tissue sarcoma (cancer of muscles
T71736	AMG-628, (R)-
	AMG-628, (R)- is the R isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. AMG-628 has shown to inhibit growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.
T40395	ζ-Stat trisodium NSC37044 trisodium,ζ-Stat trisodium
	ζ-Stat trisodium (NSC37044 trisodium) is a potent and selective inhibitor of protein kinase C-ζ (PKC-ζ), exhibiting an IC50 of 5 μM. It effectively suppresses the proliferation of melanoma cell lines and promotes apoptosis. Moreover, ζ-Stat trisodium demonstrates notable antitumor activity in vitro.
T72218	ATM-3507 trihydrochloride
	ATM-3507 trihydrochloride 是原肌球蛋白 (tropomyosin)的一个有效抑制剂，其在人类黑色素瘤细胞系中的 IC50值约为 3.83-6.84 μM。
T72188	Nicotinamide Hydrochloride Niacinamide Hydrochloride,Nicotinic acid amide Hydrochloride,Niacinamide Hydrochloride ; Nicotinic acid amide Hydrochloride
	Nicotinamide Hydrochloride 是维生素 B3 或烟酸的一种形式，可抑制SIRT2的体外活性，其EC50值为 2 μM。 Nicotinamide Hydrochloride 可抑制 90% 的黑色素瘤细胞数量，并增加细胞内 NAD+、ATP、ROS 水平。Nicotinamide Hydrochloride 抑制黑色素瘤小鼠的肿瘤生长并提高生存率，可用于黑色素瘤等皮肤癌相关的研究。
T12003	Mensacarcin	Others	Others
	Mensacarcin, a highly complex polyketide compound, exhibits multifaceted effects on cellular processes. Specifically, it targets mitochondria, perturbs energy metabolism within these organelles, and activates caspase-dependent apoptotic pathways. Functionally, Mensacarcin can serve as a cytotoxic constituent in antibody-drug conjugates (ADCs). Furthermore, this antibiotic compound displays broad-spectrum inhibition of cell growth across various cancer cell lines and demonstrates potent induction...
T69269	DMGF
	DMGF, also known as 7,7-dimethoxyagastisfavone, is a biflavonoid isolated from Taxus × media cv. Hicksii. DMGF induces apoptotic and autophagic cell death. DMGF could effectively attenuate the motility of B16F10 cells, and the results of real-time PCR revealed that DMGF also suppressed the expressions of matrix metalloproteinase-2 (MMP-2). MGF can inhibit the metastasis of highly invasive melanoma cancer cells through the down-regulation of F-actin polymerization DMGF may be further developed to...
T76843	Tebentafusp
	Tebentafusp (IMCgp100) 是靶向 gp100（一种黑色素瘤相关抗原）的双特异性融合蛋白。该药物通过其 T 细胞受体 (TCR) 高亲和力结合域以及抗 CD3 T 细胞接合域，指引 T 细胞针对表达 gp100 的肿瘤细胞进行杀伤。进一步，Tebentafusp 促进炎症细胞因子和细胞溶解酶的释放，直接导致肿瘤细胞裂解。
T70805	Diethylnorspermine HBr
	Diethylnorspermine, also known as DENSPM, BE-333, DE-333 and N(1),N(11)-Diethylnorspermine, is a highly potent known inducer of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT). A designed polyamines (PAs) analog which induces cell cycle arrest, inhibits proliferation and induces apoptosis in melanoma, breast, prostate, lung and colon cancer cells..
T36497	CAY10735 CAY10735
	CAY10735 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells ...
T78103	Box5 TFA
	Box5 TFA是一种Wnt5a拮抗剂，能有效抑制Wnt5a信号及其介导的Ca2+释放，并可阻碍细胞迁移，显示出在黑色素瘤研究中的应用潜力。
T32162	Ingenol disoxate LEO-43204,LEO43204,LEO 43204
	Ingenol disoxate, also known as LEO43204, is a Novel 4-Isoxazolecarboxylate Ester of Ingenol with Improved Properties for Treatment of Actinic Keratosis and Other Non-Melanoma Skin Cancers. Ingenol is a natural product found in the sap of the plant Euphor
T68523	AMG-628, (S)-
	AMG-628, (S)-, is the S isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. AMG-628 has shown to inhibit growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.
T82403	Fibronectin Type III Connecting Segment Fragment 1-25
	Fibronectin Type III Connecting Segment Fragment 1-25，一种多肽，主要作用于黑色素瘤细胞的粘附，并在鸡的周围神经系统发育中扮演关键角色。
T63210	Everafenib
	Everafenib 是有效的、能够透过血脑屏障的 BRAF 抑制剂，对 MAPK 通路也具有抑制作用。Everafenib 能够抑制一系列 V600EBRAF 黑色素瘤细胞系的活性 (IC50: 2-10 nM)，且效果比Dabrafenib 和Vemurafenib 好。Everafenib 可有效延长颅内转移性黑色素瘤小鼠模型的存活天数。
T36968	ARN-21934	Topoisomerase	DNA Damage/DNA Repair
	ARN-21934 是高选择性的人拓扑异构酶 II α 抑制剂，具有血脑屏障通透性。依托泊苷抑制 DNA 松弛的IC50为120 μM，ARN-21934 抑制 DNA 松弛的IC50为 2 μM。ARN-21934具有良好的体内药代动力学特性。
T73565	Box5
	Box5是一种有效的Wnt5a拮抗剂，能够抑制Wnt5a信号并阻止Wnt5a介导的Ca2+释放，同时也能够抑制细胞迁移。此外，Box5在黑色素瘤的研究中显示出潜在应用价值。
T36138	BMP-22
	BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM). It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngene...
T80744	Zanolimumab Anti-Human CD4 Recombinant Antibody
	Zanolimumab（Anti-HumanCD4Recombinant Antibody）是靶向CD4的人源单克隆抗体，能有效地抑制T细胞受体（TCR）的信号转导。它在类风湿性关节炎、银屑病、黑色素瘤、皮肤及周围T细胞淋巴瘤的研究中有应用。
T60821	ACA-28
	ACA-28 (compound 2a) 是ERK MAPK 信号的有效调节剂，可通过过度激活 ERK 诱导细胞凋亡，从而选择性抑制癌细胞生长。ACA-28 对黑色素瘤细胞 (SK-MEL-28) 和正常黑色素细胞 (NHEM) 细胞生长的IC50值分别为 5.3 和 10.1 μM。
T79451	WES-1	Carbonic Anhydrase	Metabolism
	WES-1（Compound 8g）是一种针对碳酸酐酶IX的抑制剂，其抑制常数（Ki）为55.9 μM。该化合物对包括白血病细胞系（K-562、MOLT-4）、非小细胞肺癌（NCI-H460）、结肠癌（HCT 116、HCT-15）以及黑色素瘤（LOX IMVI）在内的多种癌细胞表现出抗增殖效果。

化合物

4'-bromo-Resveratrol

Cat.No: T21679

Target: Sirtuin

Cat.No: T1120

Synonym: Imidazole Carboxamide,达卡巴嗪,DTIC-Dome

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Heptamidine dimethanesulfonate

Cat.No: T11553

Synonym: SBi4211 dimethanesulfonate

Target: Others

Cat.No: T36573

Target: Apoptosis, Epigenetic Reader Domain

Cat.No: T10395L

Target: Others

3,4-Dihydroxybenzylamine hydrobromide

Cat.No: T10104

Synonym: NSC 263475 hydrobromide,3,4-二羟基苄胺·氢溴酸

Target: Others, DNA/RNA Synthesis

Cat.No: T28206

Synonym: NSC 49652,NSC-49652

Target: Apoptosis

Cat.No: T17195

Target: Others

Cat.No: T11209

Target: DUB

Cat.No: T77751

Synonym: PRX-003

Target: Others

Cat.No: T28145

Synonym: ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl

Target: MMP

Vibostolimab (anti-TIGIT)

Cat.No: T35391

Synonym: Vibostolimab (anti-TIGIT)

Target: Others

Cat.No: T4356

Synonym: Compound 3A

Target: DNA/RNA Synthesis

Cat.No: T35407

Target: PKC

Cat.No: T60197

Target: Others

Cat.No: T6248

Target: HSP

Cat.No: T60757

Target: Microtubule Associated

Cat.No: T63228

Synonym: SMOCL-9112

Target: Apoptosis, PARP

Cat.No: T17228

Synonym: ABI-231,VERU-111

Target: Microtubule Associated

Cat.No: T14884

Target: Others, Dehydrogenase

Cat.No: T36674

Target: Apoptosis, ERK

ATM-3507 trihydrochloride (1861449-70-8 free base)

Cat.No: T10395

Synonym: ATM-3507 trihydrochloride

Target: Others

Cat.No: T24880

Cat.No: T27999

Synonym: AMPKα1 activator C13,C13, Compound 13

Cat.No: T68468

Cat.No: T29973

Synonym: AMG628,AMG 628,CHEMBL226574,UNII-28J966TN3X

Anticancer agent 15

Cat.No: T40330

Cat.No: T69557

Cat.No: T36460

Synonym: CAY10736

Dacarbazine citrate

Cat.No: T1120L2

Synonym: DTIC citrate

Cat.No: T71736

ζ-Stat trisodium

Cat.No: T40395

Synonym: NSC37044 trisodium,ζ-Stat trisodium

ATM-3507 trihydrochloride

Cat.No: T72218

Nicotinamide Hydrochloride

Cat.No: T72188

Synonym: Niacinamide Hydrochloride,Nicotinic acid amide Hydrochloride,Niacinamide Hydrochloride ; Nicotinic acid amide Hydrochloride

Cat.No: T12003

Target: Others

Cat.No: T69269

Cat.No: T76843

Diethylnorspermine HBr

Cat.No: T70805

Cat.No: T36497

Synonym: CAY10735

Cat.No: T78103

Ingenol disoxate

Cat.No: T32162

Synonym: LEO-43204,LEO43204,LEO 43204

Cat.No: T68523

Fibronectin Type III Connecting Segment Fragment 1-25

Cat.No: T82403

Cat.No: T63210

Cat.No: T36968

Target: Topoisomerase

Cat.No: T73565

Cat.No: T36138

Cat.No: T80744

Synonym: Anti-Human CD4 Recombinant Antibody

Cat.No: T60821

Cat.No: T79451

Target: Carbonic Anhydrase

Cat. No.	Product Name	Target	Signaling Pathways
T5S0055	Chelidonine Helidonine,Khelidonin,白屈菜碱,Stylophorin	Apoptosis; Others; Influenza Virus	Apoptosis; Microbiology/Virology; Others
	Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱，有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞，诱导 caspase 依赖和非依赖性的细胞凋亡。
T5646	Cinnamic acid 3-Phenylacrylic acid,β-Phenylacrylic acid,肉桂酸	Endogenous Metabolite	Metabolism
	Cinnamic acid (β-Phenylacrylic acid) 在癌症干预中具有潜在的应用价值，对胶质母细胞瘤，黑色素瘤，前列腺癌，肺癌细胞的IC50=1-4.5 mM。
T3S0153	Xanthatin 苍耳亭,叶黄制菌素	Apoptosis; VEGFR; Lipoxygenase; Wnt/beta-catenin; Antibacterial	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Metabolism; Microbiology/Virology; Stem Cells; Tyrosine Kinase/Adaptors
	Xanthatin 是一种从Xanthium strumarium 叶子中提取的天然产物，可诱导细胞凋亡。它抑制布鲁氏菌的IC50值为 2.63 μg/ mL，对寄生虫特异性锥虫硫磷还原酶具有不可逆的弱抑制作用。它通过抑制PGE2的合成和 5-脂氧合酶的活性而显示出抗炎活性。
T5S0506	Rotundic acid Rutundic acid,铁冬青酸	Apoptosis; Others; p38 MAPK; Akt; mTOR	Apoptosis; Cytoskeletal Signaling; MAPK; Others; PI3K/Akt/mTOR signaling
	Rotundic acid (Rutundic acid) 是一种从圆形肠球菌中获得的三萜类天然产物，具有抗炎和保护心脏的能力。它可通过 AKT/mTOR 和 MAPK 途径在肝细胞癌中诱导 DNA 损伤和细胞凋亡。
T2P2806	Hederacolchiside A1 黑海常春藤苷A1,革叶常春藤皂苷 A1,Raddeanoside R13	Apoptosis; ERK; MEK; Akt; PI3K; Parasite; mTOR	Apoptosis; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Hederacolchiside A1 (Raddeanoside R13) 是从白头翁中分离的一种有抗利什曼原虫和抗肿瘤增殖活性的天然产物。
TN1516	Cnidicin 蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮	NOS; NO Synthase	Immunology/Inflammation
	Cnidicin 是一种香豆素，对肥大细胞脱颗粒及 RAW 264.7 细胞产生一氧化氮具有抑制作用。
T4518	Licochalcone D	ERK; NF-κB	MAPK; NF-κB
	Licochalcone D 是一种 NF-κB p65的有效抑制剂，是一种存在于 Glycyrrhiza inflate 中的黄酮类化合物，具有抗氧化、抗炎、抗癌等作用。
T3229	Cytochalasin D	ATPase; p38 MAPK; Calcium Channel; Akt; PI3K	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit
TN6054	Norglaucine hydrochloride
	(+)-Norglaucine shows cytotoxic activity toward the tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia) and HL-60 (human promyelocytic leukemia) and non-tumor peripheral blood mononuc
TN5212	Uvedalin	Others	Others
	Uvedalin shows cytotoxicity against HeLa, HL-60, and Murine B16-F10 melanoma cell lines.
T28522	Reticulol
	Reticulol is an isocoumarin derivative produced by certain species of Streptomyces. Reticulol inhibits cAMP phosphodiesterase (IC50 = 41 µM). Recticulol (M.W. 222.2) exhibits a potent in vitro cytotoxicity against the human lung tumor cell line A427 and the mouse melanoma cell line B16F10.
TN3726	Cudraflavone B	IκB/IKK; MAO; ROS; Akt; COX; PI3K; Nrf2; Autophagy	Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling
	Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mouse melanoma cells, and hepatoprotective activity. It may be a lead for the development of a potential candidate for human oral squamous cell carcinoma cells.
TN4699	Ohchinin	Others	Others
	Ohchinin exhibits potent inhibitory activities with 26 - 66% reduction of melanin content at 100 μm concentration with almost no or low toxicity to the B16 melanoma cells (70 - 99% cell viability at 100 μm).
T82273	Gochnatiolide A
	Gochnatiolide A是从Ainsliaea henryi中提取的一种二聚倍半萜烯，对肾脏、黑色素瘤、卵巢抵抗和神经胶质瘤细胞系显示出抗增殖活性。
T72965	Inuviscolide
	Inuviscolide，一种诱导细胞凋亡(apoptosis)的化合物，能够引起人黑素瘤细胞系在G2/M期的停滞，并展现出抗肿瘤和抗炎活性。
TN4263	Isoangustone A	MMP; GSK-3; NF-κB; ROS; Akt; PI3K; CDK; JNK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-ÎºB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.
T37055	Cytostatin
	Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.
T81951	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid
	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid，亦称为灵芝酸24，展现了强大的细胞毒性能，能够抑制多种癌细胞株的增殖，包括人肺癌细胞CH27、黑色素瘤细胞M21和口腔癌细胞HSC-3。
T81201	Sartorypyrone B
	Sartorypyrone B为Chevalone C的2β-乙酰氧基衍生物，由海绵源真菌Neosartorya tsunodae(KUFC 9213)的培养物中乙酸乙酯提取得到。该化合物对MCF-7、NCI-H460和A375-C5细胞系展示出较强的生长抑制活性，GI50s值分别为17.8、20.5和25.0 μM，显示其在乳腺癌、非小细胞肺癌和黑色素瘤研究中的应用潜力。
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Cat.No: T5S0055

Synonym: Helidonine,Khelidonin,白屈菜碱,Stylophorin

Target: Apoptosis, Others, Influenza Virus

Cat.No: T5646

Synonym: 3-Phenylacrylic acid,β-Phenylacrylic acid,肉桂酸

Target: Endogenous Metabolite

Cat.No: T3S0153

Synonym: 苍耳亭,叶黄制菌素

Target: Apoptosis, VEGFR, Lipoxygenase, Wnt/beta-catenin, Antibacterial

Cat.No: T5S0506

Synonym: Rutundic acid,铁冬青酸

Target: Apoptosis, Others, p38 MAPK, Akt, mTOR

Hederacolchiside A1

Cat.No: T2P2806

Synonym: 黑海常春藤苷A1,革叶常春藤皂苷 A1,Raddeanoside R13

Target: Apoptosis, ERK, MEK, Akt, PI3K, Parasite, mTOR

Cat.No: TN1516

Synonym: 蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮

Target: NOS, NO Synthase

Cat.No: T4518

Target: ERK, NF-κB

Cat.No: T3229

Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K

Norglaucine hydrochloride

Cat.No: TN6054

Cat.No: TN5212

Target: Others

Cat.No: T28522

Cat.No: TN3726

Target: IκB/IKK, MAO, ROS, Akt, COX, PI3K, Nrf2, Autophagy

Cat.No: TN4699

Target: Others

Gochnatiolide A

Cat.No: T82273

Cat.No: T72965

Cat.No: TN4263

Target: MMP, GSK-3, NF-κB, ROS, Akt, PI3K, CDK, JNK

Cat.No: T37055

Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid

Cat.No: T81951

Sartorypyrone B

Cat.No: T81201

Cat.No: T35624

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