Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 1,185 | 待询 | ||
10 mg | ¥ 1,990 | 待询 | ||
50 mg | ¥ 5,985 | 待询 | ||
100 mg | ¥ 10,235 | 待询 | ||
200 mg | 待询 | 待询 | ||
500 mg | 待询 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,855 | 待询 |
ATM-3507 trihydrochloride (1861449-70-8 free base) 的其他形式现货产品:
产品描述 | ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines). |
靶点活性 | Tropomyosin (human melanoma cell lines):3.83-6.84 μM |
体内活性 | The maximal tolerance dose (MTD) for TR100 and ATM-3507 is 60 and 150 mg/kg, respectively. The median survival of mice increased from 18 days for mice treated with ATM-3507 to more than 49 days for mice treated with the combination. It is also found that twice-weekly intravenous administration of ATM-3507 also shows combination efficacy. The impact of each treatment or the combination of body weight is minimal. Drug levels are measured following the intravenous administration of ATM-3507 at 30 mg/kg in Balb/c mice (n=3 per time point). The mean half-life of ATM-3507 is 5.01 hrs for the terminal elimination phase. The mean AUC0-t in the plasma is 14,548 ng/h/mL. The Cmax of ATM-3507 is 5,758 ng/mL and the t1/2 is 5.01 h. The observed plasma clearance and volume of distribution at steady state of ATM-3507 is 33.8 mL/min/kg and 7.23 L/kg, respectively. |
别名 | ATM-3507 trihydrochloride |
分子量 | 721.17 |
分子式 | C37H49Cl3FN5O2 |
CAS No. | T10395 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (346.66 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.3866 mL | 6.9332 mL | 13.8664 mL | 34.6659 mL |
5 mM | 0.2773 mL | 1.3866 mL | 2.7733 mL | 6.9332 mL | |
10 mM | 0.1387 mL | 0.6933 mL | 1.3866 mL | 3.4666 mL | |
20 mM | 0.0693 mL | 0.3467 mL | 0.6933 mL | 1.7333 mL | |
50 mM | 0.0277 mL | 0.1387 mL | 0.2773 mL | 0.6933 mL | |
100 mM | 0.0139 mL | 0.0693 mL | 0.1387 mL | 0.3467 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ATM-3507 trihydrochloride (1861449-70-8 free base) T10395 Others 1861449-70-8 free base 1861449-70-8 ATM-3507 Trihydrochloride ATM-3507 trihydrochloride ATM3507 ATM-3507 ATM 3507 trihydrochloride (1861449 70 8 free base) ATM 3507 Trihydrochloride ATM3507 Trihydrochloride ATM 3507 ATM3507 trihydrochloride (1861449708 free base) Inhibitor inhibitor inhibit