75
18
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7736 |
2-Chloroadenosine
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
2-Chloroadenosine 是腺苷类似物,可防止大鼠海马缺血细胞长期丢失。它是尿苷内流 (Ki:33 μM) 的竞争性抑制剂,高亲和力与硝基苄基硫肌苷结合 (Ki:0.18 mM)。它是一种人红细胞核苷转运体的转运渗透剂。 | |||
T6777 |
Bay K 8644
(±)-BAY-K-8644,SQ 28,873 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Bay K 8644 (SQ 28,873)是一种二氢吡啶化合物,是一种选择性的 L 型 Ca2+ 通道激活剂,IC50 为 17.3 nM。它通过增加通道的开放时间来增加通过肌膜 Ca2+通道的 Ca2+流入。 | |||
T0370 |
Pheniramine maleate
Daneral,Inhiston,Trimetose,马来酸非尼拉敏 |
5-HT Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Pheniramine maleate (Trimetose) 是一种具有抗组胺和血管扩张特性的烷基胺衍生物,可与组胺 H1 受体结合,从而抑制磷脂酶 A2 和内皮源性松弛因子一氧化氮的产生。 | |||
T40101 |
(±)-1,2-Diolein
1,2-Dioleoyl-rac-glycerol,甘油1,2-二油酸酯 |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) 是一种PKC 激活剂,可以增加肌小管 Ca2+内流。 | |||
T2711 |
Chembridge-5861528
TCS 5861528 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Chembridge-5861528 (TCS 5861528) 是有效的 TRPA1离子通道阻断剂。 | |||
T6530 |
HC-030031
2-(1,3-二甲基-2,6-二氧代-2,3-二氢-1H-嘌呤-7(6H)-基)-N-(4-异丙基苯基)乙酰胺,HC030031,TOSLAB 829227 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
HC-030031 (TOSLAB 829227) 是一种有效的TRPA1选择性抑制剂,拮抗福尔马林和AITC 诱发的钙流入,IC50分别为5.3±0.2和6.2±0.2μM。 | |||
T12234 |
NMDA-IN-1
|
NMDAR | Neuroscience |
NMDA-IN-1是一种 NR2B 选择性 NMDA 拮抗剂,对NMDA 的Ki 值为 0.85 nM,对NR2B Ca2+ influx 的IC50值为 9.7 nM。 | |||
TNU0864 |
HUP30
|
Potassium Channel; Calcium Channel | Membrane transporter/Ion channel; Metabolism |
HUP30是一种强效的血管舒张剂。HUP30可以刺激可溶性鸟苷酸环化酶,激活 K+离子通道,阻断细胞外 Ca2+的内流。 | |||
T16687 |
Pyr3
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
Pyr3 是一种选择性瞬时受体电位经典通道 3 抑制剂。 Pyr3 以剂量依赖性方式抑制 TRPC3 介导的 Ca2+ 内流 (IC50 = 700 nM)。 | |||
T1425 |
Pemirolast potassium
BMY 26517,TWT-8152,吡嘧司特钾 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Pemirolast potassium (TWT-8152) 是 H1组胺受体拮抗剂和肥大细胞稳定剂,是一种具有抗过敏特性的嘧啶酮衍生物。 | |||
T6645 |
Ropivacaine hydrochloride monohydrate
Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,盐酸罗哌卡因,盐酸罗哌卡因一水合物,LEA-103 HCl |
Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Ropivacaine hydrochloride monohydrate (LEA-103 HCl) 是钠通道阻断剂,通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine HCl monohydrate 也是 K2P(双孔钾通道)TREK-1的抑制剂。在动物实验模型中,Ropivacaine HCl monohydrate 可用于神经性疼痛的缓解。 | |||
T1768 |
7ACC2
|
Mitochondrial Metabolism; Monocarboxylate transporter | Membrane transporter/Ion channel; Metabolism |
7ACC2 是单羧酸盐转运蛋白抑制剂,IC50为 11 nM。它还是线粒体丙酮酸转运的有效抑制剂,可抑制乳酸涌入,通过抑制乳酸通量来发挥抗癌作用。 | |||
T5845 |
7ACC1
DEAC,香豆素D1421,Coumarin D 1421,7-(二乙胺基)-2-氧代-2-苯并吡喃-3-羧酸,7-(Diethylamino)coumarin-3-carboxylic acid,D 1421 |
Monocarboxylate transporter | Membrane transporter/Ion channel |
7ACC1 (D 142) 抑制表达MCT1和MCT4肿瘤细胞的乳酸涌入,能选择性干扰肿瘤微环境乳酸通量。 | |||
T16688 |
Pyr6
N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide)是选择性的 TRPC3抑制剂,IC50值为0.49uM。 | |||
T11102 |
DS16570511
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
DS16570511 是一种细胞渗透性的线粒体钙单核转运蛋白(mitochondrial calcium uniporter)小分子抑制剂,阻断了依赖于 MCU 或 MICU1 的 Ca2+流入增加。 | |||
T10782 |
CGP52411
DAPH |
EGFR; Beta Amyloid | Angiogenesis; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors |
CGP52411 是一种具有口服活性的 ATP 竞争性 EGFR 抑制剂(IC50:0.3 μM)。 CGP52411 阻止 Ca2+ 离子有毒流入神经元细胞,并显着抑制和逆转 β-淀粉样蛋白 Aβ42 原纤维聚集体的形成。 CGP52411 可用于阿尔茨海默病的研究。 | |||
T0468 |
Lidocaine
Lignocaine,Alphacaine,Xylocaine,利多卡因 |
Apoptosis; ERK; NF-κB; MEK; Sodium Channel; Histamine Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Neuroscience; NF-κB |
Lidocaine (Alphacaine) 是一种酰胺衍生物,抑制涉及复杂电压和依赖性的钠通道,可用于研究室性心律失常。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长,迁移和侵袭。 | |||
T0018 |
Procainamide hydrochloride
Procapan,Procainamide HCl,Pronestyl,Procanbid,盐酸普鲁卡因胺 |
DNA Methyltransferase; Sodium Channel; AChR; Autophagy | Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; Neuroscience |
Procainamide hydrochloride (Procapan) 是一种用于研究心律失常的抗心律失常制剂。 | |||
TP1910L1 |
CALP1 acetate
CALP1 acetate(145224-99-3 free base) |
CaMK | Neuroscience |
CALP1 acetate 是一种钙调蛋白 (CaM) 激动剂(Kd 为 88 µM),可与 CaM EF-hand/Ca2+ 结合位点结合。 CALP1 通过抑制钙通道的开放来阻断钙流入和细胞凋亡(IC50 为 44.78 µM)。 CALP1 阻断谷氨酸受体通道并阻断储存操作的非选择性阳离子通道。 CALP1 激活依赖于 CaM 的磷酸二酯酶活性。 | |||
T1435 |
Praziquantel
吡喹酮,Pyquiton,Droncit,Biltricide |
Calcium Channel; Antibiotic; Parasite | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Praziquantel (Droncit) 是一种外消旋混合物,由 (R)-Praziquantel 和 (S)-Praziquantel 组成。它可研究血吸虫病。 | |||
T16686 |
Pyr10
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
Pyr10 是吡唑衍生物,是TRPC3通道的选择性抑制剂。Pyr10抑制卡巴可刺激的TRPC3转染的 HEK293 细胞中的 Ca2+流入。它具有区分受体操纵的TRPC3和天然基质相互作用分子 1 (STIM1)/Orai1 通道的能力。 | |||
T15257 |
Etripamil
MSP-2017,(-)-MSP-2017 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Etripamil (MSP-2017) 是一种短效L 型钙通道拮抗剂,可用于治疗阵发性室上性心动过速的研究。它通过抑制房室结细胞中钙慢通道的钙离子流入,显示房室结传导并延长房室结不应期 | |||
T1613 |
Hydralazine hydrochloride
Hydralazine HCl,Apresoline,盐酸肼屈嗪 |
MAO; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Neuroscience |
Hydralazine hydrochloride (Apresoline) 是一种直接作用的血管舒张剂,可抗高血压。 | |||
T1146 |
Nifedipine
BAY-a-1040,Procardia XL,Procardia,硝苯地平,Adalat |
CaMK; Potassium Channel; Calcium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Nifedipine (Procardia) 是一种二氢吡啶类钙通道阻滞剂,可抑制细胞外钙离子跨膜流入心肌和血管平滑肌细胞,导致主要冠状动脉和全身动脉扩张,降低心肌收缩力。它常用于心肌功能不全的相关研究。 | |||
T4996 |
Atosiban
阿托西班,RWJ22164,RW22164 |
Oxytocin Receptor; Vasopressin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Atosiban (RW22164) 是一种脱氨基催产素类似物,是一种九肽,也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂,可用于自发早产的研究。 | |||
T22043 |
BCATc Inhibitor 2
|
Others | Others |
BCATc Inhibitor 2 是选择性分支链氨基转移酶抑制剂,可用于神经退行性疾病的研究。能够抑制 rBCATc (IC50:0.2 μM),hBCATc (IC50:0.8 μM)、 rBCATm (IC50:3.0 μM)。其中BCATc 也称为 BCAT1,存在于细胞质基质中的亚型。 | |||
T3979 |
Emedastine
LY188695,依美斯汀,Emadine |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Emedastine (LY188695) 是一种可口服的,选择性和高亲和力的组胺 H1受体拮抗剂,Ki 值为 1.3 nM。它是苯并咪唑衍生物,可用于过敏性鼻炎、过敏性皮肤疾病和过敏性结膜炎的研究。 | |||
T5148 |
Atosiban acetate
RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164,醋酸阿托西班 |
Oxytocin Receptor; Vasopressin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Atosiban acetate (RW22164) 是一种脱氨基催产素类似物,是一种九肽,也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂,可用于自发早产的研究。 | |||
T4316 |
ML365
|
Potassium Channel | Membrane transporter/Ion channel |
ML365 是有效的,选择性的双孔结构域钾通道TASK1/KCNK3抑制剂,IC50为 4 nM。它可用于检查 TASK1 通道的特定作用。 | |||
T27639 |
ITH-12575
|
||
ITH-12575 is an inhibitor of Mitochondrial Na+/Ca2+ exchange (mNCX). ITH12575 reduces Ca(2+) influx through CALHM1 at low micromolar concentrations. | |||
T26376 |
11-deoxy-PGF2a
11-deoxyPGF2a,11-deoxy PGF2a |
||
11-deoxy-PGF2a, a selective activator of TREK-2 channels, stimulates DRG c-fiber nociceptor K2P currents and limits calcium influx. | |||
T68742 | Inamrinone lactate | ||
Inamrinone lactate is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell. | |||
T11480 | GSK205 | Others | Others |
GSK205 is a selective TRPV4 antagonist (IC50: 4.19 μM) for inhibiting TRPV4-mediated Ca2+ influx. | |||
T37763 |
BTD
|
||
Selective TRPC5 activator (EC50 = 1.4 μM in a calcium influx assay, 1.3 μM in whole cell patch clamp assay). Displays >14.5-fold selectivity for TRPC5 over other TRP channels (EC50 = 20.6 μM for TRPM8). Also activates TRPC1:5 and TRPC4:5 heteromers. Beckmann et al (2017) A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels. Cell Calcium. 66 10 PMID:28807145 | |||
T71735 | AAL1 | ||
AAL1 is an inhibitor of dark-grown Arabidopsis thaliana seedlings, functioning through auxin receptor Transport Inhibitor Response1 (TIR1) and depending on auxin influx and efflux carriers. | |||
T14829 |
Bromoenol lactone
(6E)-Bromoenol lactone |
Phospholipase | Metabolism |
Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx. | |||
T40750 |
12,14-Dichlorodehydroabietic acid
|
||
12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, exhibits potent calcium-activated potassium (BK) channel opening activity. It effectively inhibits GABA-dependent chloride influx in the mammalian brain, functioning as a non-competitive antagonist of GABA A receptors. Moreover, 12,14-Dichlorodehydroabietic acid induces an elevation in cytosolic free calcium levels and promotes the release of neurotransmitters. | |||
T68361 |
Asocainol hydrochloride
|
||
Asocainol hydrochloride ia an antiarrhythmic drug which inhibits slow Ca2+ influx. This is accompanied by alterations in normal Na+-carried action potentials. Therefore, Asocainol not only inhibits Ca2+ inflow but also interferes with the fast inward Na+ current. | |||
T62660 |
MLN3126
|
||
MLN3126 是一种口服具有活力的强效 CCR9 拮抗剂。 MLN3126 抑制 CCL25 诱导的钙动员 (calcium mobilization) 和小鼠初级胸腺细胞趋化 (chemotaxis) (IC50: 6.3 nM)。 | |||
T61438 |
Propiverine
|
||
Propiverine is a potent antimuscarinic agent that effectively inhibits cellular calcium influx, leading to the reduction of muscle spasm. It exhibits neurotropic and musculotropic effects specifically on the smooth muscles of the urinary bladder. Propiverine proves valuable in research concerning overactive bladder (OAB) [1] [2]. | |||
T79618 |
M3/PDE4 modulator-1
|
||
M3/PDE4 modulator-1 (10f) 为多功能化合物,具备M3mAChR拮抗和PDE4抑制作用。于OVA大鼠模型中,M3/PDE4 modulator-1 (10-1000 nM/kg;iv) 能降低半胱氨酸嗜酸性粒细胞内流。 | |||
T80441 |
FS-2
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
FS-2,一种特异性L型CaV通道抑制剂,能够阻断RIN beta 细胞中,高K+或葡萄糖刺激导致的L型Ca2+内流。 | |||
T37759 |
Fura-2 (potassium salt)
|
||
Fura-2 is a ratiometric fluorescent calcium indicator that can be used to detect calcium in cells. [1] It is a pentacarboxylate that displays excitation maxima of 340 and 380 nm at high and low calcium concentrations, respectively, when the emission is fixed at 510 nm, enabling determination of ratiometric measurements of calcium influx in live cells. | |||
T37475 |
Cyclic ADP-Ribose (ammonium salt)
cADP-Ribose,cADPR,Cyclic ADP-Ribose (ammonium salt) |
||
Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8] In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with i... | |||
T26447 |
A 78773
A78773,A-78773 |
||
A 78773 is a potent, selective, direct, and reversible 5-lipoxygenase inhibitor. It has activity in a variety of purified cells and in more complex biological systems such as whole blood, lung fragments, and tracheal tissues. A 78773 acts against inflamma | |||
T37760 |
Fura-2 (sodium salt)
|
||
Fura-2 is a ratiometric fluorescent calcium indicator that can be used to detect calcium in cells. It is a pentacarboxylate that displays excitation maxima of 340 and 380 nm at high and low calcium concentrations, respectively, when the emission is fixed at 510 nm, enabling determination of ratiometric measurements of calcium influx in live cells. | |||
T70224 |
Bupivacaine tartrate
|
||
Bupivacaine is a BK/SK, Kv1, Kv3, TASK-2 K Channel and voltage-gated Na channel blocker used as an anesthetic. It maybe neurotoxic at high does, inducing apoptosis in neuroblastoma cells. It acts by binding to the intracellular portion of voltage-gated sodium channels and blocking sodium influx into nerve cells. | |||
T23102 |
OBAA
|
Others | Others |
OBAA 是一种有效的磷脂酶 A2 (PLA2) 抑制剂(IC50= 70 nM),并且在布氏锥虫中阻断 Melittin 诱导的 Ca2+流入(IC50= 0.4 μM)。 | |||
T37058 |
D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt)
|
||
D-myo-Inositol-1,3,4,5-tetraphosphate (Ins(1,3,4,5)-P4) is formed by the phosphorylation of Ins(1,4,5)P3 by inositol 1,4,5-triphosphate 3-kinase. Ins(1,3,4,5)-P4 increases intracellular calcium levels by two distinct mechanisms: opening calcium channels on both the endoplasmic reticulum to release calcium from internal stores and on the plasma membrane to allow the influx of calcium from outside the cell. | |||
T61475 | Ropivacaine mesylate | ||
Ropivacaine mesylate 是一种高效的钠通道 (sodium channel) 阻断剂,通过可逆性抑制钠离子内流 (sodium ion influx),引致神经纤维脉冲传导阻滞。此外,Ropivacaine 还能抑制 K2P(双孔钾通道)TREK-1,其在 COS-7 细胞膜上的 IC50 值为 402.7 μM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1121 |
Evocarpine
|
Apoptosis; cAMP; Anti-infection; Calcium Channel; Antibacterial | Apoptosis; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Evocarpine 是从 Evodiae fructus 分离得到的一种喹诺酮类生物碱,有抗细菌活性。它可通过电压依赖性钙通道抑制 Ca2+内流。 | |||
T8118 |
Bekanamycin
Kanamycin B,卡那霉素,卡那霉素 B |
Antibacterial; Antibiotic | Microbiology/Virology |
Bekanamycin (Kanamycin B) 是一种提取自 Streptomyces kanamyceticus 的氨基糖苷类抗生素,抑制一系列革兰氏阳性和阴性细菌。 | |||
T23735 |
Jamaicin
An-Co-A4,AnCoA-4,An Co A4,AnCoA4 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Jamaicin (AnCoA4) 是一种从鸡血藤植物中提取的异黄酮,是一种 STIM1-Orai1 通道的抑制剂,可阻断钙离子流入,减少其与 STIM1 的相互作用,抑制 T 细胞的活化。 | |||
TN1154 |
Nepetin
6-Methoxyluteolin,泽兰黄酮,6-甲氧基藤黄菌素 |
Calcium Channel; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Nepetin (6-Methoxyluteolin) 是一种分离自Eupatorium ballotaefoliumHBK 中的天然类黄酮,具有有效的抗炎作用。它在 ARPE-19 细胞中能够抑制IL-6(IC50:4.43 μM) 、IL-8 (IC50:43.42 μM) 、MCP-1 (IC50:4.17 μM) 的分泌。 | |||
TN1136 |
Procyanidin A1
原花青素 A1,Proanthocyanidin A1,原花色素A1 |
LDL; Calcium Channel; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism |
Procyanidin A1 (Proanthocyanidin A1) 是一种原花青素二聚体,具有抗过敏作用,可抑制蛋白激酶 C 激活下游脱粒或 RBL-213 细胞内部储存的 Ca2+流入。 | |||
TN2322 |
Yangambin
|
Calcium Channel; PAFR | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
Yangambin 是从诸如番荔枝科植物中分离出来的呋喃木脂素,是选择性PAF 受体拮抗剂,通过调控Ca2+通道抑制 Ca2+流入,导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少,具有降压作用。 | |||
T5S0890 |
Oleandrin
Neriostene,Folinerin,Foliandrin,欧夹竹桃苷 |
Apoptosis; ATPase; Potassium Channel; Sodium Channel | Apoptosis; Membrane transporter/Ion channel |
Oleandrin (Folinerin) 是夹竹桃属中的一种类固醇,可抑制Na+/K+-ATPase 活性,IC50为 620 nM。 | |||
T5120 |
Rhamnose
6-Deoxyhexopyranose,L-鼠李糖,6-Deoxy-L-mannose,alpha-L-Rhamnose |
Calcium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
alpha-L-Rhamnose (6-Deoxy-L-mannose) 是存在植物和细菌中的一种单糖。Rhamnose- 免疫原连接物能被用于免疫疗法。Rhamnose 能通过胞外途径穿过上皮细胞,能够作为肠吸收的标志。 | |||
TN1065 |
Hirsutine
|
Apoptosis | Apoptosis |
Hirsutine 是一种来自钩藤的吲哚生物碱,可诱导细胞凋亡,是一种登革热病毒抑制剂,且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血管舒张活性。 | |||
T4S1422 |
Praeruptorin E
白花前胡素 E,白花前胡素E |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Praeruptorin E 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.2。 | |||
T6S2140 |
β-Anhydroicaritin
Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素 |
MMP; Others; TNF; Interleukin | Apoptosis; Immunology/Inflammation; Others; Proteases/Proteasome |
β-Anhydroicaritin 是从乳香提取的一种天然产物,具有重要的生物学和药理学作用,如抗骨质疏松症,雌激素调节和抗肿瘤特性。它改善牙周组织的降解,抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。它抑制细胞内 Ca2+的升高,并显著降低 iNOS 蛋白的表达。 | |||
T37687 | Cyclic ADP-ribose ammonium | ||
Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-mediated release from the endoplasmic reticulum, while also facilitating extracellular influx through the opening of TRPM2 channels [1][2][3]. | |||
T19253 |
Cyclic ADP-ribose
cADPR |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-mediated endoplasmic reticulum release | |||
T82753 | Celangulin | ||
Celangulin是一种从Celastrus angulatus中提取的天然杀虫成分,该化合物通过激活细胞质膜上的钙通道来增加细胞内Ca2+浓度,并能激活内质网钙通道。 | |||
TN2511 |
Britannilactone diacetate
1,6-O,O-Diacetylbritannilactone |
IL Receptor; PARP; ROS; MAPK; Caspase; JAK; JNK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; JAK/STAT signaling; MAPK; Proteases/Proteasome; Stem Cells |
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 pro | |||
TN4624 | Nantenine | Others | Others |
Nantenine is an acetylcholinesterase inhibitor, it functions as an effective antagonist against a wide range of MDMA-induced effects in mice. Nantenine has anticonvulsant effect, which seems attributable to its stimulation and the resultant decrease of Ca | |||
TN2534 |
1-Hydroxy-2,3,5-trimethoxyxanthone
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IκB/IKK; Calcium Channel; NOS; 5-HT Receptor; COX | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-c... | |||
T37219 |
N-Palmitoyl Glycine
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The acyl amides are a family of endogenous lipids that act as potent modulators of pain and inflammation. The best characterized members of this family are the arachidonoyl amides, which includes N-arachidonoyl ethanolamide (AEA; anandamide). N-palmitoyl glycine (PalGly) contains an 18-carbon saturated fatty acid that is amide-linked to glycine and is structurally similar to the phospholipid-derived N-acyl ethanolamines. Endogenously produced in rat skin and spinal cord, PalGly is present in 100... |