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207

抑制剂 & 化合物

46

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Cat. No.	Product Name	Target	Signaling Pathways
T7262	Methuosis inducer 1	Others	Others
	Methuosis inducer 1 是methuosis 诱导剂，表现出抗肿瘤特性。
T30480	BiP inducer X BIX	Apoptosis	Apoptosis
	BiP inducer X (BIX) 是免疫球蛋白重链结合蛋白 (BiP)/GRP78 的选择性诱导剂和 ER 伴侣诱导剂。 BiP inducer X 可防止神经元和视网膜细胞系中的细胞死亡。
T13736	Interferon receptor inducer-1	IFNAR	Immunology/Inflammation
	Interferon receptor inducer-1 是一种干扰素(IFN)受体诱导剂，可用于干扰素诱导参与的紊乱性疾病的研究。
T13809	P62-mediated mitophagy inducer PMI	Mitophagy	Autophagy
	P62-mediated mitophagy inducer (PMI) 是一种线粒体自噬调节剂，能激活线粒体自噬，可在缺乏完整功能的 PINK1/Parkin 通路的细胞中保留活性。
T8871	C/EBPα inducer 1 4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-	Others	Others
	C/EBPα inducer 1 (4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-) 是一种C/EBPα和骨髓细胞分化的诱导剂。
T3221	Oct3/4-inducer-1 2-(4-(4-methoxybenzyloxy)phenyl)acetonitrile,2-(4-[(4-甲氧基苄基)氧基]苯基)乙腈	Others; OCT	Membrane transporter/Ion channel; Others
	Oct3/4-inducer-1 (2-(4-(4-methoxybenzyloxy)phenyl)acetonitrile) 是Oct3/4诱导剂，能够促进 Oct3/4 的表达和稳定，提高其在多种人体细胞中的转录活性。
T77753	EBV lytic cycle inducer-1 Dp44mT	Antifection	Microbiology/Virology
	EBV lytic cycle inducer-1 是一种铁螯合类似物，可诱导EBV 裂解循环。
T77574	ROS inducer 1	ROS; Antibiotic	Immunology/Inflammation; Microbiology/Virology
	ROS inducer 1 是一种具有杀菌作用的小分子化合物，对 Xanthomonas axonopodis pv. citri (Xac)、Xanthomonas oryzae pv. oryzae (Xoo)和 Pseudomonas syringae pv. actinidiae (Psa) 具有抑制作用。ROS inducer 1 诱 Xanthomonas 细胞内 ROS 的产生可用于研究农作物细菌感染。
T19246	Codon readthrough inducer 1	Others	Others
	Codon readthrough inducer 1 contains pyrimidine bases and shows good readthrough activity.
T30102	Apoptosis inducer 5d
	Apoptosis inducer 5D is a new type of inducer that induces cell death by activating the apoptosis of cancer cells.
T63232	Apoptosis inducer 6
	Apoptosis inducer 6 是一种抗癌剂，具有广谱抗癌活性，能够诱导细胞凋亡 (apoptosis) 触发细胞死亡。
T79252	Apoptosis inducer 13	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Apoptosisinducer 13（Compound Ru4）能够诱导癌细胞进入凋亡并抑制其迁移与侵袭。该化合物能促进NADH向NAD+的转化，同时提升细胞内ROS的水平。
T79517	ROS inducer 2	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	ROS inducer 2 (Compound I16) 是一种经体外测试显示具有良好活性的活性氧诱导剂，其EC50值为3.43 μg/mL。在体内实验中，该化合物对Xanthomonas axonopodis pv. citri表现出优异的生物活性，可以作为研究难治性植物细菌性疾病的杀菌剂。
T74493	Apoptosis inducer 4
	Apoptosisinducer 4 (Compound 12b) 是一种具有抗癌活性的细胞凋亡 (apoptosis) 诱导剂。
T79208	Oct4 inducer-2
	Oct4 inducer-2, 作为OCT4诱导剂，维持hiPSC形成通过促进内源性OCT4表达，适用于抗衰老研究。
T74490	Apoptosis inducer 3
	Apoptosisinducer 3 (Compound 3) 是一种能够选择性诱导细胞凋亡(apoptosis)及其后期过程的化合物，对癌细胞表现出特有的毒性。
T61580	Autophagy inducer 3
	Autophagy Inducer 3 is a chemical compound that exhibits autophagy-induced activity, specifically inducing robust autophagic cell death in various cancer cells while sparing normal cells. This compound induces lethal autophagy through the formation of distinct autophagic vacuoles, LC3 puncta formation, and upregulation of signature autophagy markers such as Beclin and Atg family proteins [1].
T62399	Apoptosis inducer 10
	Apoptosis inducer 10 是一种有效的细胞凋亡诱导剂，具有抗增殖活性。Apoptosis inducer 10 利用线粒体依赖性内源性途径，诱导 HeLa 癌细胞凋亡 (apoptosis)。
T63485	Apoptosis inducer 8
	Apoptosis inducer 8 是一种galectin-1 (gal-1)介导的凋亡 (apoptosis) 诱导剂，也是一种PET 显像剂，能够明显减少 gal-1 蛋白水平，可用于全球主要的肺癌的研究。
T78686	Apoptosis inducer 11	Apoptosis	Apoptosis
	Apoptosisinducer 11（compound 3u）通过线粒体途径引发细胞凋亡。在非霍奇金淋巴瘤细胞系中，该化合物导致G2/M期停滞和S期显著减少。
T63744	Autophagy inducer 4
	Autophagy inducer 4 是基于 Magnolol 的曼尼希碱衍生物，能够用作抗癌剂。Autophagy inducer 4 能够诱导自噬 (autophagy) 进而抑制癌细胞。Autophagy inducer 4 对 T47D 细胞的毒性是 Magnolol 的 76 倍。Autophagy inducer 4 也能够抑制 T47D 和 Hela 癌细胞的迁移。
T79518	ROS inducer 3	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	ROS inducer 3 (Compound I6) 是活性氧诱导剂，体外活性良好，其 EC50 值为 2.86 μg/mL。该化合物在体内展现对 Pseudomonas syringae pv. actinidiae 的卓越生物活性，因此可作为研究难治性植物细菌性疾病的杀菌剂。
T74787	Apoptosis inducer 12
	Apoptosisinducer 12 (Compound 3z)，一种凋亡诱导剂，通过线粒体途径促进细胞凋亡(apoptosis)，主要应用于癌症研究。
T72403	Ferroptosis inducer-1
	Ferroptosisinducer-1 是一种铁凋亡 (Ferroptosis) 诱导剂，具有抗肿瘤的潜力。
T82952	ATF3 inducer 1
	ATF3 inducer 1, 作为一种高效ATF3诱导剂，能显著提高ATF3蛋白及其mRNA的表达水平，并在小鼠模型中展现出对MetS的抗性活性。
T60898	HbF inducer-1
	HbF inducer-1 是一种胎儿血红蛋白诱导剂，具有口服生物活性。
T74225	ROS-ERS inducer 1
	ROS-ERS inducer 1 是一种基于4,5-二芳基咪唑的Pt(II)-N-杂环卡宾 (Pt(II)-NHC) 复合物，属于 II 型免疫原性细胞死亡(ICD)诱导剂。它能促使内质网应激(ERS)并伴随活性氧(ROS)的生成，进而在HCC细胞中触发损伤相关分子模式(DAMP)的释放。相比Cisplatin，ROS-ERS inducer 1 表现出更高的抗癌效能。
T13554	Arimoclomol maleate BRX-220	HSP	Cytoskeletal Signaling; Metabolism
	Arimoclomol maleate (BRX-220) 是一种热休克蛋白 (HSP) 的共诱导剂。它通过增强 Hsp 表达来保护运动神经元，进而通过蛋白酶体-泛素系统直接影响蛋白质聚集和错误折叠装配体的清除
T13553	Arimoclomol 阿瑞洛莫,BRX-220 free base	HSP	Cytoskeletal Signaling; Metabolism
	Arimoclomol (BRX-220 free base) 是热休克蛋白 (HSP) 的共诱导剂，可用于治疗肌萎缩侧索硬化症的研究。
T60262	Cholera autoinducer 1
	Cholera autoinducer 1 是霍乱弧菌的自诱导剂。Cholera autoinducer 1 影响秀丽隐杆线虫的趋化性。
T33857	PA Autoinducer 3O-C12 autoinducer,PA-Autoinducer
	PA Autoinducer is a Pseudomonas aeruginosa autoinducer.
T19583	TN1	Others	Others
	TN1 是一种有效的胎儿型血红蛋白 (HbF) 诱导剂。
T16901	SMIP004	Apoptosis; Others; E1/E2/E3 Enzyme	Apoptosis; Others; Ubiquitination
	SMIP004 是一种 SKP2 E3 连接酶抑制剂。 SMIP004 是人前列腺癌细胞的癌细胞特异性凋亡诱导剂。
T21082	2,5-Dihydroxybiphenyl TFIIH Modulator 12,2,5-二羟基联苯,TFIIH Modulator12	Others	Others
	2,5-Dihydroxybiphenyl (TFIIH Modulator12) 是一种小分子去稳定诱导剂，可诱导毛发硫营养不良组 A 蛋白的二聚化，从而调节 TFIIH 转录活性。
T1743	Aprepitant MK-869,MK-0869,阿瑞匹坦,L-754030,Aprepitant`	HIV Protease; Antibacterial; Antibiotic; Neurokinin receptor	GPCR/G Protein; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Aprepitant (Aprepitant`) 是选择性和高亲和力的神经激肽1受体拮抗剂，Kd 值为86 pM。
T4066	FIN56	Ferroptosis	Apoptosis
	FIN56 是一种铁死亡特异性诱导剂，能结合并激活角鲨烯合酶，可通过诱导 GPX4 降解来诱导铁死亡。
T8762	SW106065 SW-106065	Apoptosis	Apoptosis
	SW106065 是一种恶性外周神经鞘瘤（MPNST）细胞凋亡诱导剂。它抑制 sMPNST 和其他 MPNST 模型的 ATP 消耗，EC50 为 1 µM。
T10687	Casein Kinase II Inhibitor IV	Casein Kinase	Metabolism; Stem Cells
	Casein Kinase II Inhibitor IV 是一种小分子诱导剂，可诱导表皮角质形成细胞分化。
T15561	Imanixil HOE-402(free base)	Others	Others
	Imanixil is an inducer of the LDL receptor (LDLR) and it is also a potent cholesterol-lowering compound. It also inhibits very low density-lipoprotein (VLDL) production and consequently decreases atherosclerosis development.
T2439	O4I1	OCT	Membrane transporter/Ion channel
	O4I1 是一种Oct3/4诱导剂。
T2055	WS3	EGFR; IκB/IKK	Angiogenesis; JAK/STAT signaling; NF-κB; Tyrosine Kinase/Adaptors
	WS3 是一种可促进鼠和人原代胰岛的胰腺 β 细胞增殖的增殖分子。它可用于研究 I 型糖尿病。
T6149	YH239-EE	Apoptosis; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	YH239-EE 是 YH239 的乙酯，是 p53-MDM2 拮抗剂和凋亡诱导剂。
TP1170L	Flagelin 22 acetate Flagelin 22 acetate(304642-91-9 free base)	Others	Others
	Flagelin 22 acetate 是细菌鞭毛蛋白的一部分，是在植物和藻类中一种有效的诱导剂。
T22661	CHM-1	Apoptosis; Others; Microtubule Associated	Apoptosis; Cytoskeletal Signaling; Others
	CHM-1 是细胞凋亡的诱导剂，通过激活 Cdc2 激酶活性在人肝细胞癌中显示出有效的抗肿瘤能力。 CHM-1 在体外和体内抑制微管蛋白聚合。
T20436	DHQ 2,3-dihydroxy-quinoxalin,2,3-二羟基喹喔啉	ATPase	Membrane transporter/Ion channel
	DHQ (2,3-dihydroxy-quinoxalin) 是单纯疱疹病毒胸苷激酶的 ATPase 活性诱导剂。
T19783	Dehydroabiethylamine NSC-2955,NSC 2955,Dehydroabietylamine,NSC2955,Leelamine free base,Leelamine,脱氢松香胺	P450; PDK	Metabolism; PI3K/Akt/mTOR signaling
	Dehydroabiethylamine (NSC-2955) 是肝脏 CYP2B 活性的诱导剂。 Dehydroabiethylamine 抑制丙酮酸脱氢酶激酶 (PDK) 和细胞内胆固醇转运，具有抗肿瘤活性。
T8468	CIL62	Caspase	Apoptosis; Proteases/Proteasome
	CIL62 是一种不依赖 caspase-3/7 的细胞死亡诱导剂。CIL62的作用机制是 Necrostatin-1 依赖性细胞死亡。
T8331	NUN82647 CU-242	Others	Others
	NUN82647 (CU-242) 是 G2 期细胞周期抑制剂和凋亡诱导剂。
T5008	Teprenone Tetraprenylacetone,Geranylgeranylacetone,替普瑞酮	HSP	Cytoskeletal Signaling; Metabolism
	Teprenone (Geranylgeranylacetone) 是一种热休克蛋白诱导剂，有抗溃疡作用。
T2003	ISX-9 Isoxazole 9,Isoxazole 9 (ISX-9)	Calcium Channel; Wnt/beta-catenin	Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Stem Cells
	ISX-9 (Isoxazole 9) 是一种神经干细胞分化的有效诱导剂，可诱导 Notch 激活的心外膜衍生细胞(NEC) 的心肌分化。它可通过电压门控的 Ca2+通道和 NMDA 受体来激活 Ca2+流入，并增加 NeuroD 表达。

化合物

Methuosis inducer 1

Cat.No: T7262

Target: Others

BiP inducer X

Cat.No: T30480

Synonym: BIX

Target: Apoptosis

Interferon receptor inducer-1

Cat.No: T13736

Target: IFNAR

P62-mediated mitophagy inducer

Cat.No: T13809

Synonym: PMI

Target: Mitophagy

C/EBPα inducer 1

Cat.No: T8871

Synonym: 4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-

Target: Others

Oct3/4-inducer-1

Cat.No: T3221

Synonym: 2-(4-(4-methoxybenzyloxy)phenyl)acetonitrile,2-(4-[(4-甲氧基苄基)氧基]苯基)乙腈

Target: Others, OCT

EBV lytic cycle inducer-1

Cat.No: T77753

Synonym: Dp44mT

Target: Antifection

ROS inducer 1

Cat.No: T77574

Target: ROS, Antibiotic

Codon readthrough inducer 1

Cat.No: T19246

Target: Others

Apoptosis inducer 5d

Cat.No: T30102

Apoptosis inducer 6

Cat.No: T63232

Apoptosis inducer 13

Cat.No: T79252

Target: Reactive Oxygen Species

ROS inducer 2

Cat.No: T79517

Target: Reactive Oxygen Species

Apoptosis inducer 4

Cat.No: T74493

Oct4 inducer-2

Cat.No: T79208

Apoptosis inducer 3

Cat.No: T74490

Autophagy inducer 3

Cat.No: T61580

Apoptosis inducer 10

Cat.No: T62399

Apoptosis inducer 8

Cat.No: T63485

Apoptosis inducer 11

Cat.No: T78686

Target: Apoptosis

Autophagy inducer 4

Cat.No: T63744

ROS inducer 3

Cat.No: T79518

Target: Reactive Oxygen Species

Apoptosis inducer 12

Cat.No: T74787

Ferroptosis inducer-1

Cat.No: T72403

ATF3 inducer 1

Cat.No: T82952

HbF inducer-1

Cat.No: T60898

ROS-ERS inducer 1

Cat.No: T74225

Arimoclomol maleate

Cat.No: T13554

Synonym: BRX-220

Target: HSP

Cat.No: T13553

Synonym: 阿瑞洛莫,BRX-220 free base

Target: HSP

Cholera autoinducer 1

Cat.No: T60262

Cat.No: T33857

Synonym: 3O-C12 autoinducer,PA-Autoinducer

Cat.No: T19583

Target: Others

Cat.No: T16901

Target: Apoptosis, Others, E1/E2/E3 Enzyme

2,5-Dihydroxybiphenyl

Cat.No: T21082

Synonym: TFIIH Modulator 12,2,5-二羟基联苯,TFIIH Modulator12

Target: Others

Cat.No: T1743

Synonym: MK-869,MK-0869,阿瑞匹坦,L-754030,Aprepitant`

Target: HIV Protease, Antibacterial, Antibiotic, Neurokinin receptor

Cat.No: T4066

Target: Ferroptosis

Cat.No: T8762

Synonym: SW-106065

Target: Apoptosis

Casein Kinase II Inhibitor IV

Cat.No: T10687

Target: Casein Kinase

Cat.No: T15561

Synonym: HOE-402(free base)

Target: Others

Cat.No: T2439

Target: OCT

Cat.No: T2055

Target: EGFR, IκB/IKK

Cat.No: T6149

Target: Apoptosis, E1/E2/E3 Enzyme

Flagelin 22 acetate

Cat.No: TP1170L

Synonym: Flagelin 22 acetate(304642-91-9 free base)

Target: Others

Cat.No: T22661

Target: Apoptosis, Others, Microtubule Associated

Cat.No: T20436

Synonym: 2,3-dihydroxy-quinoxalin,2,3-二羟基喹喔啉

Target: ATPase

Dehydroabiethylamine

Cat.No: T19783

Synonym: NSC-2955,NSC 2955,Dehydroabietylamine,NSC2955,Leelamine free base,Leelamine,脱氢松香胺

Target: P450, PDK

Cat.No: T8468

Target: Caspase

Cat.No: T8331

Synonym: CU-242

Target: Others

Cat.No: T5008

Synonym: Tetraprenylacetone,Geranylgeranylacetone,替普瑞酮

Target: HSP

Cat.No: T2003

Synonym: Isoxazole 9,Isoxazole 9 (ISX-9)

Target: Calcium Channel, Wnt/beta-catenin

Cat. No.	Product Name	Target	Signaling Pathways
T72509	Apoptosis inducer 5
	Apoptosisinducer 5 是一种木脂素对映异构体，存在于Crataegus pinnatifida 中。Apoptosisinducer 5 通过 Hep3B 细胞中的凋亡和自噬表现出细胞毒性作用。
T2O2707	D-(+)-Fucose	Others	Others
	D-(+)-Fucose 是一种 l-阿拉伯糖的非代谢类似物，也是 β-甲基半乳糖苷透皮酶诱导剂。它能够抑制 l-阿拉伯糖操纵子的诱导，阻断大肠杆菌 B/r 在矿物盐培养基上加 l-阿拉伯糖的生长。
T8281	(R)-Sulforaphane L-Sulforaphane,(R)-1-异硫氰酰-4-(甲基亚磺酰)丁烷	Nrf2	Immunology/Inflammation
	(R)-Sulforaphane (L-Sulforaphane) 是高效的Keap1/Nrf2/ARE 途径诱导剂。与 S-异构体相比，它对大鼠肝脏和肺部的致癌解毒酶系统的诱导能力更强。
T5132	9-dihydro-13-acetylbaccatin III 13-乙酰基-9-羟基巴卡丁 III,13-Acetyl-9-dihydrobaccatin III,9-DHAB III	Apoptosis	Apoptosis
	9-dihydro-13-acetylbaccatin III (9-DHAB III) 是一种制备紫杉醇类似物的中间体。
T5080	Spermidine trihydrochloride Spermidine hydrochloride,4-Azaoctamethylenediamine trihydrochloride,三盐酸亚精胺,亚精胺盐酸盐	NMDAR; Autophagy	Autophagy; Neuroscience
	Spermidine trihydrochloride (4-Azaoctamethylenediamine trihydrochloride) 能够维持细胞膜稳定性，提高抗氧化酶特性，改善光系统 II (PSII) 以及相关基因表达，也能够显著抑制 H2O2和 O2.-含量。
TN6705	Graveoline 1-甲基-2- [3' ,4' - (亚甲二氧基)苯基] -4-喹诺酮,2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one,Foliosine	Autophagy	Autophagy
	Graveoline (2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one) 是皮肤黑色素瘤癌细胞的凋亡和自噬诱导剂。
T41335	cis-Vaccenic acid cis-11-Octadecenoic acid,Asclepic acid,(Z)-octadec-11-enoic acid	Antiviral	Immunology/Inflammation
	cis-Vaccenic acid (Asclepic acid) 是来自 Rhodopseudomonas capsulate 的抗病毒提取物，是 Rhodopseudomonas capsulate 的主要活性成分，cis-Vaccenic acid 可用作潜在的胎儿血红蛋白诱导剂。
T2799	(20S)-Protopanaxadiol 20-Epiprotopanaxadiol,20(S)-APPD,20 (S)-原人参二醇,原人参二醇	Apoptosis; Reactive Oxygen Species; P-gp	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) 是人参皂甙的代谢产物，是一种凋亡诱导剂，抑制Akt 活性并诱导多种肿瘤细胞凋亡。
T5515	Hemin 氯化血红素,Hemin chloride	Mitophagy; Ferroptosis; Autophagy	Apoptosis; Autophagy
	Hemin (Hemin chloride) 是一种含有氯的含铁卟啉，一种血红素加氧酶 (HO)-1 诱导剂。Hemin 对卟啉病具有治疗活性，可以减少患者的血红素缺乏，从而通过生物化学反馈抑制 δ-氨基乙酰丙酸合成酶的活性。
TN2082	Pinostrobin	Beta Amyloid; IL Receptor; Serine/threonin kinase; TNF	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Neuroscience
	Pinostrobin 是一种 PCSK9抑制剂，可抑制 PCSK9 的催化活性。它是能够在多种植物中发现的黄酮类化合物，并具有抗氧化，抗炎，抗癌和神经保护作用。它是有前景的胆固醇调节和脂质管理剂。
T4519	Alisol A Alisol-A,泽泻醇 A	Autophagy	Autophagy
	Alisol A (Alisol-A) 是泽泻中的一种三萜类天然产物，可能是一种自噬诱导剂，具有抗癌活性。
T5701	OPHIOPOGONIN D 麦冬皂苷 D,麦冬皂苷D	RAAS; Calcium Channel; NF-κB; PPAR	DNA Damage/DNA Repair; Endocrinology/Hormones; Membrane transporter/Ion channel; Metabolism; NF-κB
	Ophiopogonin D 是从麦冬的块茎中分离的一种天然产物，是罕见的天然存在的 C29甾体糖苷。它是一种 CYP2J3 诱导剂，用于炎症和心血管疾病的相关研究。
TN2272	Tigloylgomisin H	Nrf2	Immunology/Inflammation
	Tigloylgomisin H 是分离自S. chinensis 果实中的木酚素。Tigloylgomisin H 能诱导小鼠肝癌细胞 Hepa1c1c7 中醌还原酶活性。Tigloylgomisin H 是单功能诱导剂，通过 Nrf2-ARE 途径特异性上调 II 期解毒酶 NQO1。Tigloylgomisin H 是潜在的肝癌预防剂。
T5429	Theaflavin 3,3'-digallate 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG	Virus Protease; Antioxidant; HIV Protease; HSV	Microbiology/Virology; oxidation-reduction; Proteases/Proteasome
	Theaflavin 3,3'-digallate (8-Gingerol) 是一种寨卡病毒蛋白酶抑制剂，IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制，可抑制 gp41 和 NS2B-3 蛋白酶的活性，并具有抗 HSV 和 HIV-1病毒活性。它是红茶中的主要多酚，有抗肿瘤作用。
TN3609	Catalposide Hydroxybenzoyl catalpol	ERK; IL Receptor; TNF; NOS; NF-κB; NO Synthase; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; NF-κB
	Catalposide 是一种有效的 (HO)-1 诱导剂，从 Catalpa ovate G. Don（紫葳科）中分离出来。 Catalposide 具有抗氧化、抗细胞凋亡、抗微生物、抗肿瘤和抗炎特性。
TQ0302	Thapsigargin 毒胡萝卜素	Apoptosis; SARS-CoV; Calcium Channel	Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Thapsigargin 属于天然产物，是一种肌/内质网 Ca2+ ATP 酶 (SERCA) 的抑制剂，也是一种内质网应激诱导剂。Thapsigargin 通过阻断细胞将钙泵入肌浆和内质网的能力来提高胞浆钙浓度。
T15027	Cyclopiazonic acid 环匹阿尼酸,环二氮酸	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Cyclopiazonic acid 是一种神经毒性次级代谢产物 (SM)，源于A. flavus，是一种纳摩尔内质网钙 ATP 酶抑制剂 (Ca2+ATPase; SERCA)，是植物细胞死亡的有效诱导剂。
TN5888	Toddaculin	Others	Others
	Toddaculin 是一种天然香豆素，抑制过度的破骨细胞活性并增强成骨细胞分化和矿化。它可诱导白血病细胞分化和凋亡，具有抗炎活性。
T6S1027	Tussilagone	Others	Others
	Tussilagone 是Tussilago farfara 的主要活性成分，具有抗炎作用。它抑制盲肠结扎和穿刺导致脓毒症的小鼠的炎症反应，提高其生存率。它改善葡聚糖硫酸钠诱导的小鼠结肠炎的炎症反应。
T4956	Tetrahydroxystilbene-2-O-β-D-glucoside tetrahydroxyl diphenylethylene-2-o-gluco,何首乌苷,EH-201	Others	Others
	Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) 是一种低分子量的促红细胞生成素诱导剂。
TN1245	3-Deoxysappanchalcone	Others; Akt; mTOR	Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
	3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.
T29462	5-OH-HxMF
	5-OH-HxMF is an inducer of neurite growth in PC12 cells through the camp / PKA / CREB pathway.
T21005	Lupulon
	Lupulon has a role as an apoptosis inducer, antimicrobial agent, angiogenesis inhibitor, and antineoplastic agent.
TN4127	Gentiside J	Others	Others
	Gentiside J is a potent inducer of neurite outgrowth on PC12 cells.
T6569L	Mimocine Mimocine
	Mimosine, a plant amino acid, is known to act as a normoxic inducer of hypoxia-inducible factor (HIF).
T13624	Conophylline	Others	Others
	Conophylline is a natural alkaloid extracted from a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells and suppresses HSC and induces apoptosis.
T4954L	Smilagenin PYM50028,Cogane,AI3-44895,PYM 50028
	Smilagenin is an orally active inducer of nonpeptide neurotrophic factor. It also prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons, and by MPTP in a mouse model of Parkinson's disease.
TN6422	Ethyl (E)-ferulate
	Ethyl ferulate could be used for therapeutic purposes as a potent inducer of HO-1 for the protection of brain cells against oxidative and neurodegenerative conditions.
TQ0258	Corynoxine B 柯诺辛碱 B,柯诺辛碱B	Autophagy	Autophagy
	Corynoxine B is a Beclin-1-dependent autophagy inducer. It is an natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese).
TN4126	Gentiside B	Others	Others
	Gentiside B is a potent inducer of neurite outgrowth on PC12 cells, it shows a significant neuritogenic activity at 30 microM against PC12 cells that is comparable to that seen for the best nerve growth factor (NGF) concentration of 40 ng/mL.
T35605	Apoptolidin
	Apoptolidin is an apoptosis inducer originally isolated from Nocardiopsis bacteria. It inhibits the mitochondrial F1FO ATPase (Ki = 4-5 μM). Apoptolidin selectively kills transformed glial cells without significantly affecting untransformed cells. It also has antibiotic and antifungal actions.
T75508	Bleomycin A5
	Bleomycin A5 (Pingyangmycin)，一种具有口服活性的糖肽类抗生素，既是抗肿瘤剂、细胞凋亡诱导剂，又是细菌代谢产物。
TN4651	Neuchromenin	Others	Others
	(-)-Neuchromenin is an inducer of neurite outgrowth of PC12 cells at concentration of 2.5-10 ug/ml.
TN3572	Calyxin H	HSP	Cytoskeletal Signaling; Metabolism
	Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
TQ0112	Tubulysin A TubA	Microtubule Associated	Cytoskeletal Signaling
	Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, and anti-angiogenic.
TN5486	Pinobanksin 3-(2-methyl)butyrate	Apoptosis	Apoptosis
	Pinobanksin 3-(2-methyl)butyrate 是 Pinobanksin 衍生物。pinobanksin 是一种细胞凋亡诱导剂，可诱导 F6细胞凋亡。
TN3838	Desmethylrocaglamide	Others	Others
	Desmethylrocaglamide is a novel inducer of cellular differentiation using HL-60 promyelocytic cells, it may be a drug for the prevention and therapy of cancer. It also has insecticidal activity.
T72965	Inuviscolide
	Inuviscolide，一种诱导细胞凋亡(apoptosis)的化合物，能够引起人黑素瘤细胞系在G2/M期的停滞，并展现出抗肿瘤和抗炎活性。
TN3616	Cedrelone	Apoptosis; MMP; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Cedrelone 是一种柠檬苦素类化合物，是一种吩嗪生物合成样结构域蛋白 (PBLD) 激活剂。Cedrelone 可诱导癌细胞凋亡 (apoptosis)。Cedrelone 是一种非常有效的细胞凋亡诱导剂，它能导致细胞周期停止。Cedrelone 具有杀虫活性，可抑制 P. saucia 的箭毒生长，并可抑制乳草蝽（Oncopeltus fasciatus）的蜕皮。Cedrelone具有抗肿瘤作用，对SMMC-7721、A-549、MCF-7 和 SW480 等癌细胞株具有显著的细胞毒性。
TN3806	Dehydroglyasperin C	ERK; IκB/IKK; p38 MAPK; TNF; NF-κB; Akt; COX; PI3K; NADPH; DNA/RNA Synthesis; Nrf2; JNK; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling
	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases
TN3057	4-O-Methylbutein	Autophagy	Autophagy
	4-O-Methylbutein (2',3,4'-trihydroxy-4-methoxychalcone) may have anti-inflammation activity, it is a potent heme oxygenase-1 (HO-1) inducer, the upregulation of HO-1 has proven to be a useful tool for fighting inflammation.
T14121	Actinonin (-)-Actinonin	Aminopeptidase	Metabolism
	Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].
T11712	Jasplakinolide Jaspamide,NSC-613009	Microtubule Associated; Antifungal	Cytoskeletal Signaling; Microbiology/Virology
	Jasplakinolide(Jaspamide) 是一种来自海洋海绵 (marine sponge) 的天然环状肽，是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂。Jasplakinolide 具有抗真菌和抗肿瘤活性，可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白，对 F-肌动蛋白的 Kd 值为 15 nM。
TN3152	6-Acetonyldihydrochelerythrine	ERK; BCL; Akt; HIV Protease; PPAR; p53	Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively. 6-Acetonyldihydrochelerythrine is
TN6501	Isololiolide
	Isololiolide has phytotoxicity, it inhibited seedling growth of cress and barnyard grass. It also showed in vitro activity against both trypomastigote and intracellular amastigotes of Trypanosoma cruzi, with IC50 values of 32 μM and 40 μM, respectively. I
T79971	Asparanin A	Apoptosis	Apoptosis
	Asparanin A 是一种具有抗癌活性的凋亡 (apoptosis) 诱导剂。它能够通过线粒体和 PI3K/AKT 信号通路使细胞周期在 G0/G1 期停滞，并有效抑制癌细胞生长。此外，Asparanin A 在小鼠Ishikawa子宫内膜癌异种移植模型中显示出显著的体内抑制肿瘤生长效力。

天然产物

Apoptosis inducer 5

Cat.No: T72509

Cat.No: T2O2707

Target: Others

(R)-Sulforaphane

Cat.No: T8281

Synonym: L-Sulforaphane,(R)-1-异硫氰酰-4-(甲基亚磺酰)丁烷

Target: Nrf2

9-dihydro-13-acetylbaccatin III

Cat.No: T5132

Synonym: 13-乙酰基-9-羟基巴卡丁 III,13-Acetyl-9-dihydrobaccatin III,9-DHAB III

Target: Apoptosis

Spermidine trihydrochloride

Cat.No: T5080

Synonym: Spermidine hydrochloride,4-Azaoctamethylenediamine trihydrochloride,三盐酸亚精胺,亚精胺盐酸盐

Target: NMDAR, Autophagy

Cat.No: TN6705

Synonym: 1-甲基-2- [3' ,4' - (亚甲二氧基)苯基] -4-喹诺酮,2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one,Foliosine

Target: Autophagy

cis-Vaccenic acid

Cat.No: T41335

Synonym: cis-11-Octadecenoic acid,Asclepic acid,(Z)-octadec-11-enoic acid

Target: Antiviral

(20S)-Protopanaxadiol

Cat.No: T2799

Synonym: 20-Epiprotopanaxadiol,20(S)-APPD,20 (S)-原人参二醇,原人参二醇

Target: Apoptosis, Reactive Oxygen Species, P-gp

Cat.No: T5515

Synonym: 氯化血红素,Hemin chloride

Target: Mitophagy, Ferroptosis, Autophagy

Cat.No: TN2082

Target: Beta Amyloid, IL Receptor, Serine/threonin kinase, TNF

Cat.No: T4519

Synonym: Alisol-A,泽泻醇 A

Target: Autophagy

Cat.No: T5701

Synonym: 麦冬皂苷 D,麦冬皂苷D

Target: RAAS, Calcium Channel, NF-κB, PPAR

Tigloylgomisin H

Cat.No: TN2272

Target: Nrf2

Theaflavin 3,3'-digallate

Cat.No: T5429

Synonym: 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG

Target: Virus Protease, Antioxidant, HIV Protease, HSV

Cat.No: TN3609

Synonym: Hydroxybenzoyl catalpol

Target: ERK, IL Receptor, TNF, NOS, NF-κB, NO Synthase, PPAR, Autophagy

Cat.No: TQ0302

Synonym: 毒胡萝卜素

Target: Apoptosis, SARS-CoV, Calcium Channel

Cyclopiazonic acid

Cat.No: T15027

Synonym: 环匹阿尼酸,环二氮酸

Target: Calcium Channel

Cat.No: TN5888

Target: Others

Cat.No: T6S1027

Target: Others

Tetrahydroxystilbene-2-O-β-D-glucoside

Cat.No: T4956

Synonym: tetrahydroxyl diphenylethylene-2-o-gluco,何首乌苷,EH-201

Target: Others

3-Deoxysappanchalcone

Cat.No: TN1245

Target: Others, Akt, mTOR

Cat.No: T29462

Cat.No: T21005

Cat.No: TN4127

Target: Others

Cat.No: T6569L

Synonym: Mimocine

Cat.No: T13624

Target: Others

Cat.No: T4954L

Synonym: PYM50028,Cogane,AI3-44895,PYM 50028

Ethyl (E)-ferulate

Cat.No: TN6422

Cat.No: TQ0258

Synonym: 柯诺辛碱 B,柯诺辛碱B

Target: Autophagy

Cat.No: TN4126

Target: Others

Cat.No: T35605

Cat.No: T75508

Cat.No: TN4651

Target: Others

Cat.No: TN3572

Target: HSP

Cat.No: TQ0112

Synonym: TubA

Target: Microtubule Associated

Pinobanksin 3-(2-methyl)butyrate

Cat.No: TN5486

Target: Apoptosis

Desmethylrocaglamide

Cat.No: TN3838

Target: Others

Cat.No: T72965

Cat.No: TN3616

Target: Apoptosis, MMP, Antifection

Dehydroglyasperin C

Cat.No: TN3806

Target: ERK, IκB/IKK, p38 MAPK, TNF, NF-κB, Akt, COX, PI3K, NADPH, DNA/RNA Synthesis, Nrf2, JNK, Autophagy

4-O-Methylbutein

Cat.No: TN3057

Target: Autophagy

Cat.No: T14121

Synonym: (-)-Actinonin

Target: Aminopeptidase

Cat.No: T11712

Synonym: Jaspamide,NSC-613009

Target: Microtubule Associated, Antifungal

6-Acetonyldihydrochelerythrine

Cat.No: TN3152

Target: ERK, BCL, Akt, HIV Protease, PPAR, p53

Cat.No: TN6501

Cat.No: T79971

Target: Apoptosis

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