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Ethyl (E)-ferulate

产品编号 TN6422 CAS 28028-62-8

Ethyl ferulate could be used for therapeutic purposes as a potent inducer of HO-1 for the protection of brain cells against oxidative and neurodegenerative conditions.

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Ethyl (E)-ferulate, CAS 28028-62-8

规格	价格/CNY		货期	数量
20 mg	￥ 1,350		待询

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Ethyl (E)-ferulate 的其他形式现货产品:

Ethyl ferulate

其他形式的 Ethyl (E)-ferulate:

Ethyl ferulate
现货

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天然产物信息

生物活性

化学信息

存储 & 溶解度

参考文献

植物来源	天然产物 > 茄科 > 茄属
结构类型	天然产物 > 其他

产品描述

Ethyl ferulate could be used for therapeutic purposes as a potent inducer of HO-1 for the protection of brain cells against oxidative and neurodegenerative conditions.

体外活性

In the CNS, the heme oxygenase (HO) system has been reported to be active and to operate as a fundamental defensive mechanism for neurons exposed to an oxidant challenge. We have recently shown that both curcumin and caffeic acid phenethyl ester, two phenolic natural compounds, potently induce HO-1 expression and activity in rat astrocytes. We have extended our previous findings examining the effects of two other plant-derived phenolic compounds, with analogous chemical structures, in rat astrocytes and neurons. METHODS AND RESULTS: Ethyl ferulate (Ethyl (E)-ferulate, ethyl 4-hydroxy-3-methoxycinnamate) (EFE), the naturally occurring ester of ferulic acid, was able to induce HO-1 protein expression. Maximal expression of HO-1 mRNA and protein and a significant increase in HO activity were detected after 6 h of incubation with 15 microM EFE in astrocytes and 5 microM EFE in neurons. Higher concentrations of EFE (50 microM) caused a substantial cytotoxic effect with no change in HO-1 protein expression and activity. Exposure of astrocytes to resveratrol, a phytoalexin derived from grapes, resulted in an increase of HO-1 mRNA, but it was not able to induce HO-1 protein expression and activity. Interestingly, preincubation (12 h) of neurons with EFE resulted in an enhanced cellular resistance to glucose oxidase-mediated oxidative damage; this cytoprotective effect was considerably attenuated by zinc protoporphyrin IX, an inhibitor of HO activity. CONCLUSIONS: This study identifies a novel natural compound that could be used for therapeutic purposes as a potent inducer of HO-1 for the protection of brain cells against oxidative and neurodegenerative conditions.

分子量	222.24
分子式	C12H14O4
CAS No.	28028-62-8

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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参考文献

1. Solvent-free enzymatic transesterification of ethyl ferulate and monostearin: Optimized by response surface methodology. Journal of Biotechnology, 2013, 164(2):340-345.

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请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

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