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87

抑制剂 & 化合物

103

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3587	NOD-IN-1 Compound 4	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	NOD-IN-1 (Compound 4) 是核苷酸结合寡聚化结构域样受体 NOD1(IC50:5.74 μM)和 NOD2 (IC50:6.45 μM)的抑制剂。
T4217	INF39	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	INF39 是无细胞毒性的NLRP3不可逆抑制剂。
T4164	CY-09 CY 09	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	CY-09 是NLRP3选择性抑制剂。它能够直接与 NLRP3 NACHT 结构域的 ATP 结合基序结合，对 NLRP3 ATP 酶的活性产生抑制作用，进而抑制 NLRP3 炎症小体的组装和活化。
T15052	Dapansutrile	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	Dapansutrile 是一种口服有活性的 NLRP3 炎性小体选择性抑制剂。它具有抗炎特性，可用于研究缓解疼痛。
T13375	YQ128	IL Receptor; NOD-like Receptor (NLR); NOD; Interleukin	Immunology/Inflammation; NF-κB
	YQ128 是选择性 NLRP3 炎性体抑制剂(IC50:0.30 µM)。它能显著的、选择性抑制 IL-1β的产生，但不影响 TNF-α 的产生。它能够透过血脑屏障到达中枢神经系统。它具有抗炎作用。
T9222	Emlenoflast MCC7840	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	Emlenoflast (MCC7840) 是一种 NLRP3炎症小体 (NLRP3 inflammasome) 的选择性抑制剂(IC50<100 nM)。它可用于研究炎性疾病。
T8828	CP 424174	IL Receptor	Immunology/Inflammation
	CP 424174 是一种具有可逆性的 IL-1β抑制剂(IC50:210 nM)，也能够间接性抑制 NLRP3。
T38361	GSK717	IL Receptor; NOD	Immunology/Inflammation; NF-κB
	GSK717 是 NOD2(核苷酸结合寡聚结构域 2) 的选择性抑制剂。它抑制壁酰二肽 (MDP) 诱导的 NOD2 介导的信号转导，抑制 MDP 刺激的 HEK293/hNOD2 细胞分泌 IL-8 (IC50为 400 nM)。
T16159	Muramyl dipeptide MDP	NOD	Immunology/Inflammation; NF-κB
	Muramyl dipeptide (MDP) 是合成的免疫反应肽，由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。它通过MAPK 途径上调 Runx2 基因表达，直接促进成骨细胞分化，通过降低 RANKL/OPG 比值间接抑制破骨细胞分化。它是通过Runx2诱导骨形成的诱导因子，也是NLRP1激动剂。
T6591	Nodinitib-1 ML130,CID-1088438	TNF; NOD-like Receptor (NLR); NOD	Apoptosis; Immunology/Inflammation; NF-κB
	Nodinitib-1 (CID-1088438) 是 NOD1抑制剂(IC50:0.56 μM)。
T3701	MCC950 CP-456773	NOD	Immunology/Inflammation; NF-κB
	MCC950 (CP-456773) 是NLRP3的选择性抑制剂，能够作用于BMDMs(IC50:7.5 nM) 和 HMDMs(IC50:8.1 nM)。
T6454	CORM-3 CORM3,(OC-6-44)-三羰基氯(甘氨酸基)钌	Others; NF-κB; NOD-like Receptor (NLR)	Immunology/Inflammation; NF-κB; Others
	CORM-3 是一种 CO 释放分子，能够减少 NLRP3炎症小体的激活，可以减弱 NF-κB p65的核异位，减少 ROS 的生成，并提高细胞内谷胱甘肽和超氧化物歧化酶的水平。
T28178	NLRP3-IN-9 INF-4E,INF 4E,INF4E	NOD	Immunology/Inflammation; NF-κB
	NLRP3-IN-9 (INF-4E) 是 NLRP3 ATPase 和 caspase-1 的抑制剂。 NLRP3-IN-9 通过不可逆地捕获硫醇亲核体发挥作用，以时间和浓度依赖性方式防止 ATP 和尼日利亚菌素触发的人 THP-1 细胞焦亡。
T1404	Stavudine d4T,Sanilvudine,BMY-27857,NSC 163661,司他夫定	Apoptosis; Nucleoside Antimetabolite/Analog; HIV Protease; NOD-like Receptor (NLR); Reverse Transcriptase; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Stavudine (BMY-27857) 是一种口服活性核苷逆转录酶抑制剂，还抑制线粒体 DNA 的复制，具有抗HIV-1和HIV-2的活性。它降低 NLRP3 炎症小体激活，调节淀粉样 β 自噬，诱导细胞凋亡。
T63088	NOD2 antagonist 1
	NOD2 antagonist 1 (compound 32) 是一种有效的、选择性的 NOD2 拮抗剂 (IC50: 5.23 μM)。NOD2 antagonist 1 在 THP-1 细胞，对 Muramyl dipeptide (MDP) 诱导的 IL-8 分泌表现出抑制作用。NOD2 antagonist 1 在 PBMCs 细胞，可以抑制 MDP 诱导的 IL-6、IL-10 和 TNF-α 的水平升高。
T6887	MCC950 sodium CRID3 sodium salt,CP-456773,CP-456773 sodium,MCC950	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	MCC950 sodium (CP-456773 sodium) 是一种炎症小体 NLRP3 的抑制剂 (IC50=7.5 nM in BMDMs; IC50=8.1 nM in HMDMs)，具有高效选择性。MCC950 sodium 对其他炎症小体，如 AIM2、 NLRC4 或 NLRP1 没有作用。
T68396	AC1NOD4Q
	AC1NOD4Q is a novel blocker of hox antisense intergenic rna (hotair) by abrogating the scaffold interaction with ezh2
T72473	NOD1/2 antagonist-1
	NOD1/2 antagonist-1 是一种有效的NOD1/2双拮抗剂，其IC50值分别为 1.13 (NOD1) 和 0.77 μM (NOD2)。NOD1/2 antagonist-1 有可接受的 T1/2(67.6 min)。NOD1/2 antagonist-1 可提高紫杉醇 (PTX) 的抗肿瘤作用。
T2131	Articaine hydrochloride Ultracaine,盐酸阿替卡因,阿替卡因,Articaine HCl,Hoe-045	Sodium Channel	Membrane transporter/Ion channel
	Articaine hydrochloride (Hoe-045) 一种牙科局部麻醉剂。
T3230	NLRP3-IN-2 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺,NLRP3 Inflammasome Inhibitor I	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide) 是一种能够合成格列本脲的中间物，对心肌细胞中NLRP3炎症小体的形成具有抑制作用，在小鼠心肌缺血/再灌注后限制梗死面积，且对代谢无影响。
T7417	Avatrombopag YM477,AKR-501,1-[3-氯-5-[[[4-(4-氯-2-噻吩基)-5-(4-环己基-1-哌嗪基)-2-噻唑基]氨基]羰基]-2-吡啶基]-4-哌啶羧酸,E5501	Thrombin; Thrombopoietin Receptor	Immunology/Inflammation; Proteases/Proteasome
	Avatrombopag (YM477) 是一种新型口服血小板生成素 (TPO) 受体激动剂，可激活 TPO 受体并增加巨核细胞增殖/分化和血小板生成。
T8489	Minodronic acid monohydrate	Transferase	Metabolism
	Minodronic acid monohydrate 是一种法尼基二磷酸合成酶抑制剂，可作为骨吸收抑制剂。
T0996	Ethynodiol diacetate Ethynodiol acetate,双醋炔诺醇,8080 CB	Estrogen/progestogen Receptor; Progesterone Receptor	Endocrinology/Hormones; Others
	Ethynodiol diacetate (Ethynodiol acetate) 是一种可用作激素避孕药的甾体孕激素，具有相对较少或没有雄激素效果，而具有显著雌激素作用。
T13507	4,4'-Iminodiphenol 4-(4-羟基苯胺)苯酚,Leucoindophenol	Estrogen/progestogen Receptor	Endocrinology/Hormones
	4,4'-Iminodiphenol (Leucoindophenol) 是基于二苯胺骨架的无活性雌激素受体配体。
T16335	Nonaethylene glycol monododecyl ether Nonaoxyethylene monododecyl ether,Polidocanol,聚醚醇	Others	Others
	Nonaethylene glycol monododecyl ether (Polidocanol) 是一种非离子表面活性剂和聚乙二醇清洁剂，可用于蛋白质分离和纯化，以及用于形成初始聚结的 O/W 乳剂液滴。
T8436	Minodronic acid Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-,ONO-5920,YM-529	Apoptosis; P2X Receptor	Apoptosis; Membrane transporter/Ion channel; Neuroscience
	Minodronic acid(YM-529) 是一种 P2X2/3 受体拮抗剂，具有抗癌活性，可直接或间接的抑制癌细胞增殖，诱导细胞凋亡。Minodronic-acid 对各种类型的癌细胞的转移具有抑制作用。Minodronic-acid 可用于研究骨质疏松。
T3601	Benodanil 麦锈灵,Calirus	Antifungal	Microbiology/Virology
	Benodanil (Calirus) 是一种杀菌剂。
T9516	Binodenoson WRC 0470,MRE-0470,比诺地松,2-(cyclohexylmethylidenehydrazino)adenos	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Binodenoson (WRC 0470) 是一种选择性A2A 腺苷受体激动剂，KD 为270 nM。它是一种短效冠状动脉血管扩张剂，作为放射性示踪剂的辅助剂，用于心肌应激成像。
T1364	7-Aminodeacetoxycephalosporanic acid 7-ADCA,Cephalexin Impurity B,Cefalexine EP IMpurity B,Deacetoxycephalosporanic Acid,头孢氨苄杂质B,7-Aminodesacetoxycephalosporanic acid	Antibiotic	Microbiology/Virology
	7-Aminodeacetoxycephalosporanic acid (Cefalexine EP IMpurity B) 是一种头孢菌素合成中的关键中间体。
T0628	Iminodibenzyl	Others	Others
	Iminodibenzyl 用作抗癫痫药carbamazepine 的中间体。
T15719	Latanoprostene bunod LBN,NCX116	Others	Others
	Latanoprostene bunod (LBN) 是一氧化氮 (NO) 供体前列腺素 F2a 类似物，有用于开角型青光眼或高眼压 (OHT) 患者降低眼压 (IOP) 的局部眼科的研究潜力。
T30465	Bis(2-methylpropyl)phosphinodithioic acid J663.879A,Diisobutyl dithiophosphinate,Diisobutyldithiophosphinic acid
	Bis(2-methylpropyl)phosphinodithioic acid is a bioactive chemical.
T23662	Aganodine Aganodin
	Aganodine is a guanidine that activates presynaptic imidazoline receptors. Aganodine inhibits the presynaptic release of norepinephrine through its agonism at imidazoline receptors.
T72467	5-Iminodaunorubicin 5-亚氨基柔红霉素
	5-Iminodaunorubicin 是一种醌改性蒽环类药物，具有抗肿瘤活性。5-Iminodaunorubicin 在癌细胞中可诱导 DNA 链断裂。
T76216	Lonodelestat TFA
	Lonodelestat TFA (POL6014 TFA) 是一种有效的、口服活性的、选择性的肽类hNE抑制剂，展现了治疗囊性纤维化(CF)的潜力。
T0171	Norethynodrel Lynestrol,异炔诺酮	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Norethynodrel (Lynestrol) 是一种合成的孕激素，其作用和用途类似于孕酮。它已被用于治疗功能性子宫出血和子宫内膜异位症。它作为避孕药，通常与 MESTRANOL 联合使用。
TF0042	Sucrose Monododecanoate
	Sucrose Monododecanoate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0042，CAS号为 25339-99-5。
T33595	Naproxcinod AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582
	Naproxcinod, a nitric oxide-releasing NSAID derivative, significantly improved skeletal muscle strength and fatigue resistance in sedentary and exercise mice, reducing inflammatory infiltration and fibrotic deposition in the myocardium and diaphragm. In a
T126126	Ganoderitriol M
	Ganoderitriol M 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126126，CAS号为 1265906-35-1。
T34269	Razinodil Razinodilum
	Razinodil is a vasodilator.
T126539	Ganoderic acid M
	Ganoderic acid M 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126539。
T36908	Bimatoprost grenod 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α
	Bimatoprost grenod(15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α.1It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2α(0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey mode...
T124467	Vernodalol
	Vernodalol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124467，CAS号为 65388-17-2。
T68327	Dexnafenodone Free Base
	Dexnafenodone Free Base is a potent inhibitor of noradrenaline, and to a lesser degree of serotonin reuptake, induced changes in the pattern of sleep which are comparable to those of non‐sedating tricyclic antidepressants.
T14967	Cimlanod BMS-986231,CXL-1427	Others	Others
	Cimlanod is a second-generation Nitroxyl (HNO) donor for heart failure with positive lusitropic and inotropic as well as vasodilatory effects. Cimlanod delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloo
T34605	Selenodiglutathione Seleno-di-glutathione,Bis(glutathione) selenide
	Selenodiglutathione is a primary Se metabolite conjugated with two glutathione (GSH) moieties.
T18488	NH2-MPAA-NODA	Others	Others
	NH2-MPAA-NODA, a nitroveratryl-based photocleavable linker featuring a NODA motif and a methyl phenyl acetic acid (MPAA) backbone, serves as a radiolabel when labeled with 18F-fluoride.
TF0071	Hexaethylene Glycol Monododecyl Ether (C12E6)
	Hexaethylene Glycol Monododecyl Ether (C12E6) 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0071，CAS号为 3055-96-7。
T71919	Boc-10-Aminodecanoic acid
	Boc-10-Aminodecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-10-Aminodecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
T69147	Cinodine (free base)
	Cinodine (free base) is a glycocinnamoylspermidine antibiotic; gyrase inhibitor found in Nocardia.

化合物

Cat.No: T3587

Synonym: Compound 4

Target: NOD-like Receptor (NLR), NOD

Cat.No: T4217

Target: NOD-like Receptor (NLR), NOD

Cat.No: T4164

Synonym: CY 09

Target: NOD-like Receptor (NLR), NOD

Cat.No: T15052

Target: NOD-like Receptor (NLR), NOD

Cat.No: T13375

Target: IL Receptor, NOD-like Receptor (NLR), NOD, Interleukin

Cat.No: T9222

Synonym: MCC7840

Target: NOD-like Receptor (NLR), NOD

Cat.No: T8828

Target: IL Receptor

Cat.No: T38361

Target: IL Receptor, NOD

Muramyl dipeptide

Cat.No: T16159

Synonym: MDP

Target: NOD

Cat.No: T6591

Synonym: ML130,CID-1088438

Target: TNF, NOD-like Receptor (NLR), NOD

Cat.No: T3701

Synonym: CP-456773

Target: NOD

Cat.No: T6454

Synonym: CORM3,(OC-6-44)-三羰基氯(甘氨酸基)钌

Target: Others, NF-κB, NOD-like Receptor (NLR)

Cat.No: T28178

Synonym: INF-4E,INF 4E,INF4E

Target: NOD

Cat.No: T1404

Synonym: d4T,Sanilvudine,BMY-27857,NSC 163661,司他夫定

Target: Apoptosis, Nucleoside Antimetabolite/Analog, HIV Protease, NOD-like Receptor (NLR), Reverse Transcriptase, Autophagy

NOD2 antagonist 1

Cat.No: T63088

Cat.No: T6887

Synonym: CRID3 sodium salt,CP-456773,CP-456773 sodium,MCC950

Target: NOD-like Receptor (NLR), NOD

Cat.No: T68396

NOD1/2 antagonist-1

Cat.No: T72473

Articaine hydrochloride

Cat.No: T2131

Synonym: Ultracaine,盐酸阿替卡因,阿替卡因,Articaine HCl,Hoe-045

Target: Sodium Channel

Cat.No: T3230

Synonym: 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺,NLRP3 Inflammasome Inhibitor I

Target: NOD-like Receptor (NLR), NOD

Cat.No: T7417

Synonym: YM477,AKR-501,1-[3-氯-5-[[[4-(4-氯-2-噻吩基)-5-(4-环己基-1-哌嗪基)-2-噻唑基]氨基]羰基]-2-吡啶基]-4-哌啶羧酸,E5501

Target: Thrombin, Thrombopoietin Receptor

Minodronic acid monohydrate

Cat.No: T8489

Target: Transferase

Ethynodiol diacetate

Cat.No: T0996

Synonym: Ethynodiol acetate,双醋炔诺醇,8080 CB

Target: Estrogen/progestogen Receptor, Progesterone Receptor

4,4'-Iminodiphenol

Cat.No: T13507

Synonym: 4-(4-羟基苯胺)苯酚,Leucoindophenol

Target: Estrogen/progestogen Receptor

Nonaethylene glycol monododecyl ether

Cat.No: T16335

Synonym: Nonaoxyethylene monododecyl ether,Polidocanol,聚醚醇

Target: Others

Minodronic acid

Cat.No: T8436

Synonym: Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-,ONO-5920,YM-529

Target: Apoptosis, P2X Receptor

Cat.No: T3601

Synonym: 麦锈灵,Calirus

Target: Antifungal

Cat.No: T9516

Synonym: WRC 0470,MRE-0470,比诺地松,2-(cyclohexylmethylidenehydrazino)adenos

Target: Adenosine Receptor

7-Aminodeacetoxycephalosporanic acid

Cat.No: T1364

Synonym: 7-ADCA,Cephalexin Impurity B,Cefalexine EP IMpurity B,Deacetoxycephalosporanic Acid,头孢氨苄杂质B,7-Aminodesacetoxycephalosporanic acid

Target: Antibiotic

Cat.No: T0628

Target: Others

Latanoprostene bunod

Cat.No: T15719

Synonym: LBN,NCX116

Target: Others

Bis(2-methylpropyl)phosphinodithioic acid

Cat.No: T30465

Synonym: J663.879A,Diisobutyl dithiophosphinate,Diisobutyldithiophosphinic acid

Cat.No: T23662

Synonym: Aganodin

5-Iminodaunorubicin

Cat.No: T72467

Synonym: 5-亚氨基柔红霉素

Lonodelestat TFA

Cat.No: T76216

Cat.No: T0171

Synonym: Lynestrol,异炔诺酮

Target: Estrogen/progestogen Receptor

Sucrose Monododecanoate

Cat.No: TF0042

Cat.No: T33595

Synonym: AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582

Ganoderitriol M

Cat.No: T126126

Cat.No: T34269

Synonym: Razinodilum

Ganoderic acid M

Cat.No: T126539

Bimatoprost grenod

Cat.No: T36908

Synonym: 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α

Cat.No: T124467

Dexnafenodone Free Base

Cat.No: T68327

Cat.No: T14967

Synonym: BMS-986231,CXL-1427

Target: Others

Selenodiglutathione

Cat.No: T34605

Synonym: Seleno-di-glutathione,Bis(glutathione) selenide

NH2-MPAA-NODA

Cat.No: T18488

Target: Others

Hexaethylene Glycol Monododecyl Ether (C12E6)

Cat.No: TF0071

Boc-10-Aminodecanoic acid

Cat.No: T71919

Cinodine (free base)

Cat.No: T69147

Cat. No.	Product Name	Target	Signaling Pathways
T6S1256	Ruscogenin	NOS; NF-κB; NOD-like Receptor (NLR)	Immunology/Inflammation; NF-κB
	Ruscogenin 是一种重要甾体皂苷元，提取自麦冬。它能够抑制 TXNIP/NLRP3炎症体激活和 MAPK 途径，改善脑缺血诱导的血脑屏障功能障碍，具有显著抗血栓、抗炎作用。
T0772	Troxerutin 曲克芦丁,Trihydroxyethylrutin,维脑路通	NOD-like Receptor (NLR)	Immunology/Inflammation
	Troxerutin (Trihydroxyethylrutin) 是一种天然生物类黄酮芦丁的三羟乙基化衍生物，也被称为维生素 P4，可抑制活性氧的产生并抑制 ER 应激介导的NOD 活化。
TQ0165	Arglabin 阿格拉宾,(+)-Arglabin	NOD-like Receptor (NLR); Transferase; NOD; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Arglabin ((+)-Arglabin) 是从青蒿中分离出的一种天然产物，是一种 NLRP3 炎性体抑制剂，具有抗动脉粥样硬化和抗癌作用。
T4S0350	Licochalcone B 甘草查尔酮 B,甘草查尔酮B	Beta Amyloid; Others	Neuroscience; Others
	Licochalcone B 是从Glycyrrhiza inflate 根中提取的。它能够抑制淀粉样蛋白 β 自聚集作用 (IC50=2.16 μM) ，分解预先形成的 Aβ42原纤维，并通过螯合金属离子抑制金属诱导的 Aβ42聚集。
T3092	Nigericin sodium salt 尼日利亚菌素,尼日利亚菌素钠盐	Potassium Channel; NOD-like Receptor (NLR); Antibacterial; Antibiotic; NOD	Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; NF-κB
	Nigericin sodium salt 属于抗生素，是一种 NLRP3 激活剂，也是一种阳离子离子载体。Nigericin sodium 可以触发 NALP3 炎性体的激活，可抑制高尔基体功能并抑制革兰氏阳性菌的生长。
T2893	Muscone 3-Methylcyclopentadecanone,Methylexaltone,麝香酮	MMP; TNF; NF-κB; NOD-like Receptor (NLR); P-gp; Interleukin	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; NF-κB; Proteases/Proteasome
	Muscone (3-Methylcyclopentadecanone) 是中药麝香的一种主要活性单体。它抑制NF-κB 和NLRP3炎性小体的活化，显著降低炎性细胞因子水平，并最终改善心脏功能和存活率。
T5247	Trimethylamine N-oxide dihydrate 二水氧化三甲胺,TMANO Dihydrate	Others; Endogenous Metabolite	Metabolism; Others
	Trimethylamine N-oxide dihydrate (TMANO Dihydrate) 是内源性代谢产物的一种。
T5S1131	Ganoderic acid C6 灵芝酸C6	Others	Others
	Ganoderic acid C6 是醛糖还原酶活性的抑制剂。
TN4661	Nodosin	IL Receptor; Autophagy	Autophagy; Immunology/Inflammation
	Nodosin 是一种二萜化合物，从Isodon trichocarpusKudo 和I. JaponicusHARA 中提取得到。
TN2215	Taurochenodeoxycholic acid sodium 牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡，具有抗炎和免疫调节作用。
TN1553	Deacetyl ganoderic acid F	Others	Others
	Deacetyl ganoderic acid F (DeGA F) 是从灵芝 Ganoderma lucidum 中提取的三萜类化合物，在体外和体内对脂多糖（LPS）诱导的炎症有抑制作用。
TN1651	Furanodiene	Apoptosis; PARP; Reactive Oxygen Species; Caspase; CDK; P-gp	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB; Proteases/Proteasome
	Furanodiene 是从姜黄中提取的一种萜类天然产物，可抑制外排转运蛋白Pgp 功能并降低 Pgp 蛋白水平。它通过抗血管生成和诱导ROS 产生，DNA 链断裂和细胞凋亡发挥抗癌作用。
TN1059	Ganoderic acid B	IL Receptor; HIV Protease; JAK; STAT	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells
	Ganoderic acid B 是从灵芝中分离的一种三萜类天然产物。它是端粒酶抑制剂，抑制 Epstein-Barr 病毒抗原的活化。它是 HIV-1 蛋白酶抑制剂。
TN1661	Ganoderic acid C2 灵芝酸 C2	Reductase; Histamine Receptor; Immunology/Inflammation related	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Ganoderic acid C2 是分离自灵芝的一种三萜化合物，具有潜在的抗肿瘤生物活性，以及抗组胺、抗衰老和细胞毒性作用。它对rat lens aldose reductase 具有很高的抑制活性，IC50为 3.8 µM。
TN1658	Ganoderenic acid D	Apoptosis; Others	Apoptosis; Others
	Ganoderenic acid D 是从灵芝提取物 (GLE) 的有效化合物中分离出来的天然产物。 Ganoderenic acid D 诱导细胞周期停滞和细胞凋亡并抑制癌细胞的增殖。
T5259	Glycochenodeoxycholic acid sodium salt GCDCA,甘氨鹅脱氧胆酸钠,Sodium glycochenodeoxycholate	Apoptosis; Others; Endogenous Metabolite	Apoptosis; Metabolism; Others
	Glycochenodeoxycholic acid sodium salt (GCDCA) 是一种从脱氧鹅胆酸和甘氨酸在肝脏中形成的胆汁盐，可诱导肝细胞凋亡。它起到洗涤剂的作用，可溶解脂肪吸收，并本身被吸收。
TN1656	Ganoderenic acid A 灵芝烯酸A,灵芝烯酸 A	Others	Others
	Ganoderenic acid A 是三萜类化合物。它对 CCl4 诱导的肝损伤具有保护作用。它是β-葡萄糖醛酸酶抑制剂。
T3875	CLINODISIDE A	Others	Others
	Clinodiside A 是来自中草药Clinopodium chinensis 中。
T4588	Glycochenodeoxycholic Acid 甘氨鹅脱氧胆酸,Glycine chenodeoxycholate,Chenodeoxycholylglycine,GCDCA,Glycochenodeoxycholate,Lithocholylglycine	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Glycochenodeoxycholic Acid (Lithocholylglycine) 是一种从脱氧鹅胆酸和甘氨酸在肝脏中形成的胆汁盐，可诱导肝细胞凋亡。它有洗涤剂的作用，可溶解脂肪吸收，并本身被吸收。
T2A2481	Taurochenodeoxycholic Acid Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine,牛磺鹅去氧胆酸	Apoptosis; TNF; Caspase; Endogenous Metabolite	Apoptosis; Metabolism; Proteases/Proteasome
	Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) 是动物胆汁酸的主要生物活性物质之一，可诱导细胞凋亡，具有明显的抗炎和免疫调节作用。
T4S0544	Furanodienone 呋喃二烯酮,莪术呋喃二烯酮	Apoptosis; HER	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Furanodienone 是来源于姜黄根茎的一种主要生物活性成分，可诱导细胞凋亡。
T3872	Nodakenin 紫花前胡苷,(+)-Marmesinin	AChE	Neuroscience
	Nodakenin ((+)-Marmesinin) 是一种Peucedanum decursivum Maxim 根中的主要香豆素苷。它能够抑制乙酰胆碱酯酶活性，IC50=84.7 μM。
T11363	Ganoderic acid F	Others	Others
	Ganoderic acid F 是一种灵芝酸。它具有抗肿瘤和抗转移的活性，与抑制血管生成和涉及细胞增殖和细胞死亡，致癌作用，氧化应激，钙信号传导和内质网应激的蛋白质改变等机制相关。
TN1664	Ganoderic acid H	NF-κB; DNA/RNA Synthesis; CDK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; NF-κB
	Ganoderic acid H 是一种羊毛脂烷型三萜，提取自灵芝中。它能够抑制转录因子AP-1 和 NF-kappaB 信号，并抑制乳腺癌细胞细胞的生长和入侵。
T5S1413	Nodakenetin 闹达柯裂亭,Prangeferol,(-)-Prangeferol,Nodakenitin	Others	Others
	Nodakenetin ((-)-Prangeferol) 是分离自Angelica decursiva 中，具有抗氧化、抗炎作用、抗关节炎及神经强化的作用。
T6S1141	Ganoderic acid A 灵芝酸 A,灵芝酸A	Apoptosis; NF-κB; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Metabolism; NF-κB
	Ganoderic acid A 能够抑制 JAK-STAT3信号通路，也能抑制细胞增殖，存活率和 ROS。它对人骨肉瘤 HOS 和MG-63细胞具有增殖抑制、凋亡和侵袭抑制作用。
T3S1149	Ganoderic acid G	Others	Others
	Ganoderic acid G 分离自灵芝菌管层表面。
TN1219	20-Hydroxyganoderic acid G
	20-Hydroxyganoderic acid G 是从灵芝 (Ganoderma curtisii) 子实体乙醇提取物中获得的羊毛甾烷三萜类化合物。20-Hydroxyganoderic Acid G 对由 LPS 激活的 BV-2 小胶质细胞有抑制作用，IC50 值为 21.33 μM。20-Hydroxyganoderic Acid G 用于研究由LPS 激活的小胶质细胞相关的神经炎症疾病。
T2S1120	Ganoderenic acid B	P-gp	Membrane transporter/Ion channel; Neuroscience
	Ganoderenic acid B 是一种从Ganoderma lucidum 中提取的天然产物，可以通过抑制ABCB1的转运功能，增强化疗药物对ABCB1介导的耐多药癌细胞的细胞毒性来发挥作用。
T0847	Chenodeoxycholic acid CDCA,鹅去氧胆酸,Chenodiol	Potassium Channel; FXR; Endogenous Metabolite; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Chenodeoxycholic acid (CDCA) 是一种胆汁酸，通常与甘氨酸或牛磺酸结合。它作为清洁剂溶解脂肪以供肠道吸收，并被小肠重新吸收。它被用作利胆剂、利胆泻药，以及预防或溶解胆结石。
T5S1133	Ganoderic acid D 灵芝酸D,灵芝酸 D	Apoptosis; Sirtuin	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Ganoderic acid D 是高度氧化的四环三萜，是灵芝的主要活性成分，可诱导 HeLa 人宫颈癌细胞凋亡。它上调 SIRT3的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D 。它抑制结肠癌细胞的能量重编程，包括结肠癌细胞中的葡萄糖摄取，乳酸、丙酮酸和乙酰辅酶的产生。
TN1061	Ganoderol B	Androgen Receptor	Endocrinology/Hormones
	Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of andr
T25445	Ganoderiol B
	Ganoderiol B is a moderately active HIV-1 PR inhibitor (IC50: 0.17-0.23 mM).
T75562	Ganoderic acid GS-1
	Ganoderic acid GS-1 是一种高度氧化的羊毛甾烷型三萜类化合物，具有抗 HIV-1蛋白酶活性，IC50为 58 μM。
T75626	Ganoderenic acid K
	Ganoderenic acid K，一种从灵芝子实体分离得到的天然产物，对HMG-CoA还原酶(HMGCR)显示出强抑制作用，IC50值为16.5 μM。
TN6246	Actinodaphnine
	Actinodaphnine 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6246，CAS号为 517-69-1。
TN1655	Ganoderal A	Others	Others
	The oxygenated sterols( 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and ganoderic acid Y) from G. lucidum can inhibit cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol.
TN4107	Ganoderic acid X	ERK; Mdm2; MAPK; Caspase; Topoisomerase; JNK; p53	Apoptosis; DNA Damage/DNA Repair; MAPK; Proteases/Proteasome
	Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
TMA0993	Ganoderic acid E 灵芝酸F,Ganoderic acid F	Antiviral	Immunology/Inflammation
	Ganoderic acid F has anti-hepatitis B, anti-inflammatory, and anti-tumor-promoting activities.
TN3696	Conodurine	AChR	Neuroscience
	Conodurine shows leishmanicidal and antibacterial activities, it shows inhibition activity for acetyl (AChE) and butyrylcholinesterase (BuChE).
T72737	Ganoderic acid R
	Ganoderic acid R为一种高效的抗癌化合物，通过促进肿瘤细胞系的凋亡(apoptosis)机制来抑制其生长。它对多药耐药(MDR)肿瘤细胞系(KB-A-1/Dox)及敏感肿瘤细胞系(KB-A-1)展现出显著的细胞毒性效应。
T75630	Ganoderic acid Mf
	Ganoderic acid Mf为具有抗肿瘤活性的三萜类化合物，能导致细胞周期在G1期停滞，并在正常细胞与癌细胞中显示高度选择性，通过线粒体介导途径促进细胞凋亡(apoptosis)。
TN1663	Ganoderic acid DM 灵芝酸DM,灵芝酸 DM	PARP; Androgen Receptor; CDK	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones
	Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane pr
TMA0986	Ganoderenic acid F	Others	Others
	Ganoderenic acid F 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TMA0986，CAS号为 120462-47-7。
T25788	Melianodiol
	Melianodiol is potential used as a biopesticide against Aedes aegypti.
T69213	Cynodontin
	Cynodontin was tested in vitro for fungitoxicity and was found to be a potent inhibitor of the growth of Sclerotinia minor, Sclerotinia sclerotiorum, and Botrytis cinerea and, to a lesser extent, of Verticillium dahliae.
T72798	Ganodermaones B
	Ganodermaones B 是一种肾纤维化抑制剂，抑制 TGF-β1诱导的 collagen I 和 fibronectin 的表达。
TN3973	Epinodosin	Others	Others
	Epinodosin induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner.Epinodosin has a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in Lactuca sativa L. seedlings.
TN1671	Ganoderone A	Integrase; HSV	Microbiology/Virology
	Ganoderone A exhibits potent inhibitory activity against herpes simplex virus.
T82335	Ganodermacetal
	Ganodermacetal是从G. amboinense中分离的高度氧化羊毛甾烷三萜类化合物，对丰年虾幼虫表现出显著毒性。
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天然产物

Cat.No: T6S1256

Target: NOS, NF-κB, NOD-like Receptor (NLR)

Cat.No: T0772

Synonym: 曲克芦丁,Trihydroxyethylrutin,维脑路通

Target: NOD-like Receptor (NLR)

Cat.No: TQ0165

Synonym: 阿格拉宾,(+)-Arglabin

Target: NOD-like Receptor (NLR), Transferase, NOD, Autophagy

Cat.No: T4S0350

Synonym: 甘草查尔酮 B,甘草查尔酮B

Target: Beta Amyloid, Others

Nigericin sodium salt

Cat.No: T3092

Synonym: 尼日利亚菌素,尼日利亚菌素钠盐

Target: Potassium Channel, NOD-like Receptor (NLR), Antibacterial, Antibiotic, NOD

Cat.No: T2893

Synonym: 3-Methylcyclopentadecanone,Methylexaltone,麝香酮

Target: MMP, TNF, NF-κB, NOD-like Receptor (NLR), P-gp, Interleukin

Trimethylamine N-oxide dihydrate

Cat.No: T5247

Synonym: 二水氧化三甲胺,TMANO Dihydrate

Target: Others, Endogenous Metabolite

Ganoderic acid C6

Cat.No: T5S1131

Synonym: 灵芝酸C6

Target: Others

Cat.No: TN4661

Target: IL Receptor, Autophagy

Taurochenodeoxycholic acid sodium

Cat.No: TN2215

Synonym: 牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠

Target: Apoptosis, Endogenous Metabolite

Deacetyl ganoderic acid F

Cat.No: TN1553

Target: Others

Cat.No: TN1651

Target: Apoptosis, PARP, Reactive Oxygen Species, Caspase, CDK, P-gp

Ganoderic acid B

Cat.No: TN1059

Target: IL Receptor, HIV Protease, JAK, STAT

Ganoderic acid C2

Cat.No: TN1661

Synonym: 灵芝酸 C2

Target: Reductase, Histamine Receptor, Immunology/Inflammation related

Ganoderenic acid D

Cat.No: TN1658

Target: Apoptosis, Others

Glycochenodeoxycholic acid sodium salt

Cat.No: T5259

Synonym: GCDCA,甘氨鹅脱氧胆酸钠,Sodium glycochenodeoxycholate

Target: Apoptosis, Others, Endogenous Metabolite

Ganoderenic acid A

Cat.No: TN1656

Synonym: 灵芝烯酸A,灵芝烯酸 A

Target: Others

Cat.No: T3875

Target: Others

Glycochenodeoxycholic Acid

Cat.No: T4588

Synonym: 甘氨鹅脱氧胆酸,Glycine chenodeoxycholate,Chenodeoxycholylglycine,GCDCA,Glycochenodeoxycholate,Lithocholylglycine

Target: Apoptosis, Endogenous Metabolite

Taurochenodeoxycholic Acid

Cat.No: T2A2481

Synonym: Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine,牛磺鹅去氧胆酸

Target: Apoptosis, TNF, Caspase, Endogenous Metabolite

Cat.No: T4S0544

Synonym: 呋喃二烯酮,莪术呋喃二烯酮

Target: Apoptosis, HER

Cat.No: T3872

Synonym: 紫花前胡苷,(+)-Marmesinin

Target: AChE

Ganoderic acid F

Cat.No: T11363

Target: Others

Ganoderic acid H

Cat.No: TN1664

Target: NF-κB, DNA/RNA Synthesis, CDK

Cat.No: T5S1413

Synonym: 闹达柯裂亭,Prangeferol,(-)-Prangeferol,Nodakenitin

Target: Others

Ganoderic acid A

Cat.No: T6S1141

Synonym: 灵芝酸 A,灵芝酸A

Target: Apoptosis, NF-κB, Endogenous Metabolite, Autophagy

Ganoderic acid G

Cat.No: T3S1149

Target: Others

20-Hydroxyganoderic acid G

Cat.No: TN1219

Ganoderenic acid B

Cat.No: T2S1120

Target: P-gp

Chenodeoxycholic acid

Cat.No: T0847

Synonym: CDCA,鹅去氧胆酸,Chenodiol

Target: Potassium Channel, FXR, Endogenous Metabolite, Autophagy

Ganoderic acid D

Cat.No: T5S1133

Synonym: 灵芝酸D,灵芝酸 D

Target: Apoptosis, Sirtuin

Cat.No: TN1061

Target: Androgen Receptor

Cat.No: T25445

Ganoderic acid GS-1

Cat.No: T75562

Ganoderenic acid K

Cat.No: T75626

Cat.No: TN6246

Cat.No: TN1655

Target: Others

Ganoderic acid X

Cat.No: TN4107

Target: ERK, Mdm2, MAPK, Caspase, Topoisomerase, JNK, p53

Ganoderic acid E

Cat.No: TMA0993

Synonym: 灵芝酸F,Ganoderic acid F

Target: Antiviral

Cat.No: TN3696

Target: AChR

Ganoderic acid R

Cat.No: T72737

Ganoderic acid Mf

Cat.No: T75630

Ganoderic acid DM

Cat.No: TN1663

Synonym: 灵芝酸DM,灵芝酸 DM

Target: PARP, Androgen Receptor, CDK

Ganoderenic acid F

Cat.No: TMA0986

Target: Others

Cat.No: T25788

Cat.No: T69213

Ganodermaones B

Cat.No: T72798

Cat.No: TN3973

Target: Others

Cat.No: TN1671

Target: Integrase, HSV

Cat.No: T82335

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