keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Binodenoson (WRC 0470) 是一种选择性A2A 腺苷受体激动剂,KD 为270 nM。它是一种短效冠状动脉血管扩张剂,作为放射性示踪剂的辅助剂,用于心肌应激成像。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,130 | 现货 | ||
5 mg | ¥ 2,920 | 现货 | ||
10 mg | ¥ 4,320 | 现货 | ||
25 mg | ¥ 6,880 | 现货 | ||
50 mg | ¥ 9,330 | 现货 | ||
100 mg | ¥ 12,500 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,290 | 现货 |
产品描述 | Binodenoson (WRC 0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging[1]. |
靶点活性 | A2A:270 nM(kd) |
体外活性 | 2-(cyclohexylmethylidenehydrazino)adenos (30-300 nM) decreases oxidative activity of tumor necrosis factor-α–primed FMLP-stimulated polymorphonuclear leukocytes in human whole blood and acts synergistically with Rolipram[1]. |
体内活性 | 2-(cyclohexylmethylidenehydrazino)adenos (infused 0-0.9 μg/kg/h; adult Wistar rat; rat bacterial meningitis model), with or without rolipram (0-0.01 μg/kg/h), inhibits pleocytosis and reduces the lipopolysaccharide-induced increase in blood-brain barrier permeability (BBBP), indicative of decreased neutrophil-induced damage[1]. |
别名 | WRC 0470, MRE-0470, 比诺地松, 2-(cyclohexylmethylidenehydrazino)adenos |
分子量 | 391.42 |
分子式 | C17H25N7O4 |
CAS No. | 144348-08-3 |
keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (28.1 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5548 mL | 12.774 mL | 25.548 mL | 63.87 mL |
5 mM | 0.511 mL | 2.5548 mL | 5.1096 mL | 12.774 mL | |
10 mM | 0.2555 mL | 1.2774 mL | 2.5548 mL | 6.387 mL | |
20 mM | 0.1277 mL | 0.6387 mL | 1.2774 mL | 3.1935 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Binodenoson 144348-08-3 GPCR/G Protein Neuroscience Adenosine Receptor imaging P1 receptor WRC-0470 WRC 0470 stress oxidative neutrophil MRE-0470 WRC0470 inhibit 比诺地松 radiotracers Inhibitor 2-(cyclohexylmethylidenehydrazino)adenos MRE0470 myocardial MRE 0470 inhibitor