117
60
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21992 |
Vacuolin-1
|
PI3K; Autophagy | Autophagy; PI3K/Akt/mTOR signaling |
Vacuolin-1 是一种细胞渗透性抑制剂,可抑制 Ca2+ 依赖性溶酶体与细胞膜的融合。它通过抑制溶酶体内容物的释放起作用。它是一种有效的选择性 PIKfyve 抑制剂,通过损害溶酶体成熟来抑制晚期自噬。 | |||
T6421 |
BRD73954
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
BRD73954 是一种有效且特异性的 HDAC 抑制剂,对 HDAC6 和 HDAC8 的 IC50 分别为 36 nM 和 120 nM。 | |||
T12579 |
RAMB4
PTP1B-IN-9 |
Proteasome | Proteases/Proteasome; Ubiquitination |
RAMB4 (PTP1B-IN-9) 是一种泛素-蛋白酶体系统(UPS)应激源,是通过抑制 20S 蛋白酶体催化活性物质上游泛素介导的蛋白质降解而产生。它能够在不影响 20S 蛋白酶体催化活性的情况下触发泛素蛋白酶体系统 (UPS) 应激反应。 | |||
T7020 |
Z-VAD-FMK
Z-VAD(OH)-FMK,Caspase Inhibitor VI,Z-VAD |
Caspase | Apoptosis; Proteases/Proteasome |
Z-VAD-FMK (Caspase Inhibitor VI) 是一种 caspase 的广谱抑制剂,具有不可逆性。Z-VAD-FMK 与活化的 caspase 结合,从而抑制细胞凋亡。 | |||
T9079 |
Apostatin-1
Apt-1 |
Others | Others |
Apostatin-1 (Apt-1) 是一种新型 TRADD 抑制剂。 Apostatin-1 可以与 TRADD 的 N 末端 TRAF2 结合域上的口袋结合。 | |||
T11657 |
INH154
|
Others | Others |
INH154 是一种高效的 Nek2 和 Hec1 结合抑制剂,能够抑制 Hela 细胞(IC50:200 nM)、 MB468 细胞(IC50:120 nM)。 | |||
T25214 |
CCR-11
CCR11,CCR 11 |
Antibiotic | Microbiology/Virology |
CCR-11 是一种具有抗菌活性的绕丹宁衍生物。 CCR-11 可以抑制 B. subtilis细胞和 HeLa 细胞增殖。 CCR-11 通过抑制 FtsZ 的组装和 GTPase 活性来抑制细菌增殖和细菌胞质分裂。 CCR-11 具有潜在的抗肿瘤活性,可用于研究乳腺癌和小儿骨髓增生异常。 | |||
T77771 |
Compound 10w
|
Others | Others |
Compound 10w,一种取代吡唑并[1,5-a]嘧啶酰胺化合物,是一种ZSTK474 类似物,对 HeLa细胞显示出抗癌活性。 | |||
T5342 |
IWP-O1
|
Wnt/beta-catenin; Porcupine | Cytoskeletal Signaling; Stem Cells |
IWP-O1 是 Porcn 抑制剂,在 L-Wnt-STF 细胞中的 EC50值为 80 pM。它能够抑制 Wnt 蛋白分泌,可以抑制 HeLa 细胞中 Dvl2/3 和 LRP6 磷酸化。 | |||
T25969 |
Poloxin-2
Poloxin2,Poloxin 2 |
PLK | Cell Cycle/Checkpoint |
Poloxin-2 是一种具有有效性和选择性的 Plk1 PBD 抑制剂,具有抗肿瘤活性,可降低HeLa细胞中Plk1的蛋白水平。 | |||
T8623 |
TMIFRY8XAG
4,4,-二(4-氟苯)氯丁烷,1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE),4-oxo-1,4-dihydroquinoline-2-carboxylic acid |
Others | Others |
TMIFRY8XAG (4-oxo-1,4-dihydroquinoline-2-carboxylic acid) 是 Zerumbone 的衍生物,对 HeLa 癌细胞具有潜在的抗肿瘤作用。 | |||
T8903 |
Retro-2
Retro 2,2-{[(5-methyl-2-thienyl)methylene]amino} |
Others; Virus Protease; Parasite; Autophagy | Autophagy; Microbiology/Virology; Others |
Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) 是一种植物毒素蓖麻毒素抑制剂,它保护 HeLa 细胞免受蓖麻毒素、Stx1 和 Stx2 的侵害,选择性地阻断早期内体蛋白质-高尔基体界面处的逆行毒素运输。 | |||
T7426 |
ALSTERPAULLONE
|
Apoptosis; GSK-3; CDK | Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells |
Alsterpaullone 是高效的 CDK 抑制剂,是一种 ATP 竞争性的 GSK-3alpha/GSK-3beta 抑制剂,且作用的 IC50值都为 4 nM。它有用于神经退行性和增生性疾病的研究潜力,具有抗肿瘤活性,诱导白血病细胞凋亡。 | |||
T22264 |
AZ9482
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
AZ9482 是一种选择性 PARP1/2/6的三重抑制剂,IC50值分别为 1 、1 和640 nM。 | |||
T60485 |
DIF-3
|
||
DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. This compound exerts a potent antiproliferative effect on the HeLa human cervical cancer cell line by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression [1]. | |||
T37020 |
Endosidin-2
ES2,Endosidin 2 |
||
Endosidin-2是一种囊外囊抑制剂,具有细胞渗透性的亚苄基苯甲酰肼,可与外囊复合体70 kDa(EXO70)亚基的外囊成分结合(Kd = 253 μM,EXO70A1)。Endosidin-2会破坏蛋白质在内质体和质膜之间的转运,从而促进蛋白质转运至液泡降解。它还能抑制 HeLa 细胞中内吞转铁蛋白向质膜的再循环,并能靶向哺乳动物 EXO70的多种异构体,导致外泌失调。Endosidin2 可作为工具分子研究胞吐。 | |||
T13858 |
RA190
|
Proteasome | Proteases/Proteasome; Ubiquitination |
RA190 能够与泛素受体 RPN13 的半胱氨酸 88 共价结合,并抑制蛋白酶体功能。 | |||
T73590 |
8-Phenyl-2,6-dibromo-1,3,5,7-tetramethyl BODIPY
|
||
8-Phenyl-2,6-dibromo-1,3,5,7-tetramethyl BODIPY 可用于光动力疗法。 | |||
T76784 |
Tildrakizumab
MK 3222,SCH 900222 |
IL Receptor | Immunology/Inflammation |
Tildrakizumab (SCH 900222) 是一种有效的人源化抗-IL-23 (p19 亚基) 单克隆抗体。Tildrakizumab 靶向单链 IL-23 ,Kd 值为 136 pM。Tildrakizumab 可用于研究银屑病和牛皮癣。 | |||
T35610 |
2,5-dimethyl Celecoxib
|
Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor | Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells |
2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂,mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。 | |||
T3594 |
ML346
|
HSP | Cytoskeletal Signaling; Metabolism |
ML346是 Hsp70和 HSF-1活性的激活剂,针对 Hsp70 的 EC50为 4.6 μM。它诱导热休克反应 (HSR) 的基因和蛋白质效应子的特异性增加,如 Hsp70、Hsp40 和 Hsp27。 | |||
T19841 |
Tribenoside
Glyvenol,Glyvenal,Ba 2140,BG-356,Glivenol,三苄糖苷,TBGF |
Others | Others |
Tribenoside (BG-356) 是血管保护剂,能够温和的镇痛、抗炎及伤口愈合,可用研究痔疮。 | |||
T18981 |
DMA
|
Others | Others |
DMA 是一种荧光试剂 (λex=340 nm, λem=478 nm)。 | |||
T68147 |
T-900607
|
Microtubule Associated | Cytoskeletal Signaling |
T-900607是一种新型微管蛋白活性剂,通过独特的作用机制破坏微管聚合。t-900607具有心脏毒性。 | |||
T15362 |
FX-11
LDHA Inhibitor FX11 |
Dehydrogenase | Metabolism |
FX-11 (LDHA Inhibitor FX11) 是一种有效的、选择性的和竞争性的乳酸脱氢酶 A (LDHA) 的特异性抑制剂,对LDHA 的Ki 为 8 μM。FX-11 对PKM2 (丙酮酸激酶 M2)具有激活作用。FX-11 可降低 ATP 水平,诱导氧化应激和ROS 生成,可引起细胞死亡。FX-11 在淋巴瘤和胰腺癌异种移植过程中表现出抗肿瘤 活性。 | |||
T7181 |
IDO-IN-1
4-氨基-N-(3-溴-4-氟苯基)-N'-羟基-1,2,5-恶二唑-3-甲脒 |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
IDO-IN-1 是吲哚胺-2,3-双加氧酶抑制剂,IC50=59 nM。 | |||
T16334 |
NMS-P515
|
Others | Others |
NMS-P515 is an effective, orally active, and stereospecific PARP-1 inhibitor (Kd: 16 nM and an IC50: 27 nM (in Hela cells)). It has anti-tumor activity. | |||
T4057 |
Hoechst 33258 trihydrochloride
Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258 |
Parasite | Microbiology/Virology |
Hoechst 33258 trihydrochloride (Bisbenzimide) 是一种能够用于 DNA 染色的荧光染料。 | |||
T36816 |
S-trityl-L-Cysteine
STLC |
Kinesin | Cytoskeletal Signaling |
S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM,抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。 | |||
T24530 |
NHI-2
NHI 2 |
||
NHI-2 is an inhibitor of LDHA that acts by reducing lactate production in HeLa cells. | |||
T63765 | L5-DA | ||
L5-DA 是一种 G-四链体(G4)配体,能够选择性稳定 G4s。L5-DA 对 HeLa 细胞表现出明显的细胞毒性,其 IC50 值为 4.3 μM。L5-DA 能够稳定 HeLa 细胞中的 G4s,并可阻滞细胞周期及诱导细胞凋亡。 | |||
T10464L |
Atuveciclib Racemate
BAY-1143572 Racemate,阿维西利 |
CDK | Cell Cycle/Checkpoint |
Atuveciclib Racemate (BAY-1143572 Racemate) 是 Atuveciclib 的外消旋混合物。 Atuveciclib 是口服有效的 P-TEFb/CDK9高选择性抑制剂,CDK9/CycT1的 IC50为13 nM。 | |||
T29014 | Tripartin | ||
Tripartin specifically inhibits the histone H3 lysine 9 demethylase KDM4 in HeLa cells. | |||
T73111 | IDO1-IN-17 | ||
IDO1-IN-17 (I-4) 是IDO1的抑制剂,其在 hela 细胞中的IC50值为 0.44 μM。 | |||
T36202 |
Citreoindole
|
||
Citreoindole is a diketopiperazine metabolite isolated from a hybrid cell fusion of two strains of P. citreovirde that is cytotoxic in vitro against HeLa cells at 8.4 μM. | |||
T82632 |
Cys-C-cGMP
|
AUTACs | PROTAC |
Cys-C-cGMP 为一种AUTACs自噬标签。它能够促进HeLa细胞线粒体K63链式连接的泛素化增加。 | |||
T36693 |
FD-211
|
||
FD-211 is a δ lactone originally isolated from M. lutea with anticancer activity.1 It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 μg/ml, respectively), as well as adriamycin-resistant HL-60/ADR cells (IC50 = 0.1 μg/ml). FD-211 also inhibits DNA, RNA, and protein synthesis in HeLa cells (IC50 = 1.25 μg/ml for all). |1. Nozawa, O., Okazaki, T., Sakai, N., et al. A novel bioactive δ lactone FD-211. Taxonomy, isolation and char... | |||
T63455 |
PI3K/Akt/mTOR-IN-3
|
||
PI3K/Akt/mTOR-IN-3 是 PI3K/Akt/mTOR 的有效抑制剂。PI3K/Akt/mTOR-IN-3 能够抑制 MCF-7 细胞 (IC50: 0.77 μM)、HeLa 细胞 (IC50: 1.23 μM) 和 HepG2 细胞(IC50: 4.57 μM)。PI3K/Akt/mTOR-IN-3 在 4 μM 浓度下可抑制 MCF-7 和 HeLa 细胞的迁移。PI3K/Akt/mTOR-IN-3 能够将细胞周期阻滞在 S 期,并诱导细胞凋亡 (apoptosis)。 | |||
T63879 | microRNA-21-IN-1 | ||
microRNA-21-IN-1(compound 7A)是一种高效microRNA抑制剂,对Hela和HCT-116细胞显示出抗增殖活性,IC50值分别为5.5 μM和2.8 μM,并能促进Hela细胞凋亡(apoptosis)。该化合物通过上调microRNA-21下游功能靶点(PTEN、EGR1、SLIT2)的表达,有助于抗癌研究。 | |||
T11419 |
O6BTG-octylglucoside
Glucose-conjugated MGMT inhibitor |
Others | Others |
O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)). | |||
T63354 | Anticancer agent 17 | ||
Anticancer agent 17 对 HeLa 细胞 (IC50: 0.19 μM) 和 A2780 细胞 (IC50: 0.09 μM) 具有有效抗癌作用。 | |||
T10200 |
9-Hydroxyellipticine hydrochloride
|
Others | Others |
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. It exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride inihibits Hela S-3 and 293T cells (IC50s: 1.6 μM and 1.2μM). | |||
T81962 | Lactate transportor 1 | Monocarboxylate transporter | Membrane transporter/Ion channel |
Lactate transporter 1 (compound 1) 作为一种活性乳酸运输蛋白,主要在活细胞内发挥作用。在Hela、CAL27、MCF7和MCF10A细胞系中,Lactate transporter 1 均显示出了明显的毒性,其半抑制浓度(IC50)值依次为3.36、3.27、5.58和7.66 μM。此外,在HeLa细胞中,Lactate transporter 1 与Cisplatin表现出了协同抑制的作用。 | |||
T37198 |
Ethyl LipotF
|
||
Selective FTO inhibitor (IC50 = 0.81 μM). Exhibits >30-fold selectivity for FTO over ALKBH2, 3 and 5 and >100-fold selectivity over PHD2 and JMJD2A. Increases levels of modified N6-methyladenosine (m6A) in HeLa cells in a concentration-dependent manner. | |||
T62399 |
Apoptosis inducer 10
|
||
Apoptosis inducer 10 是一种有效的细胞凋亡诱导剂,具有抗增殖活性。Apoptosis inducer 10 利用线粒体依赖性内源性途径,诱导 HeLa 癌细胞凋亡 (apoptosis)。 | |||
T69073 |
COTC
|
||
COTC is a bacterial metabolite that has anticancer activity and inhibits glyoxalase in the presence of glutathione (GSH) and the proliferation of HeLa cells, as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model. | |||
T62966 |
IQTub4P
|
||
IQTub4P 是一种有效的微管 (microtubule) 抑制剂。IQTub4P 在 HeLa 细胞中表现出细胞毒性 (EC50: 170 nM)。IQTub4P 在体内耐受良好,可以抑制微管结构和功能。 | |||
T36969 | ARN24139 | ||
ARN24139 is a topoisomerase II poison (IC50= 7.3 μM in a topoisomerase II decatenation assay).1It inhibits proliferation of DU145, HeLa, and A549 cells (IC50s = 4.7, 3.8, and 3.1 μM, respectively). 1.Arencibia, J.M., Brindani, N., Franco-Ulloa, S., et al.Design, synthesis, dynamic docking, biochemical characterization, and in vivo pharmacokinetics studies of novel topoisomerase II poisons with promising antiproliferative activityJ. Med. Chem.63(7)3508-3521(2020) | |||
T63268 | ERK5-IN-3 | ||
ERK5-IN-3 是选择性的、有效的 ERK5 (细胞外信号相关激酶 5) 抑制剂 (IC50: 6 nM)。ERK5-IN-3 对 Hela 细胞表现出抗增殖作用 (IC50: 31 nM)。 | |||
T62163 |
Hsp90-IN-15
|
||
Hsp90-IN-15 是一种 Hsp90 抑制剂,具有抗癌作用。Hsp90-IN-15 能够将细胞周期阻滞在 S 期,诱导细胞凋亡 (apoptosis),并可以减少 Hela 细胞中 Hsp90 的表达水平。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11363 |
Ganoderic acid F
|
Others | Others |
Ganoderic acid F 是一种灵芝酸。它具有抗肿瘤和抗转移的活性,与抑制血管生成和涉及细胞增殖和细胞死亡,致癌作用,氧化应激,钙信号传导和内质网应激的蛋白质改变等机制相关。 | |||
T3673 |
Mollugin
大叶茜草素,Rubimaillin |
HER; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。 | |||
T13475 |
β-Aminopropionitrile
3-氨基丙腈,3-Aminopropionitrile,BAPN |
Others; Endogenous Metabolite | Metabolism; Others |
β-Aminopropionitrile (3-Aminopropionitrile) 是赖氨酰氧化酶的特异性抑制剂。 | |||
T14046 |
Anandamide
花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide |
Cannabinoid Receptor; Endogenous Metabolite | GPCR/G Protein; Metabolism |
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide) 是一种免疫调节剂,通过大麻素受体 CB1 和 CB2 起作用,还通过中枢神经系统中的其他靶点起作用,如 GPR18/GPR55。 | |||
TN4375 | Kamebanin | Antifection | Microbiology/Virology |
Kamebanin 是一种天然二萜类化合物,具有抗菌活性。它对 HeLa 和 HL-60 细胞显示出有效的细胞毒活性。 | |||
TN7041 |
(-)-Epipodophyllotoxin
|
Apoptosis | Apoptosis |
(-)-Epipodophyllotoxin 是一种从八角莲中分离的癌细胞抗增殖剂,在 HeLa 细胞和 MCF-7 细胞中的GI50值分别为 0.36 和 0.24 μM。它可在体外抑制有丝分裂纺锤体组装。 | |||
TQ0170 |
Desacetylcinobufagin
Deacetylcinobufagin,去乙酰华蟾蜍精 |
Others | Others |
Desacetylcinobufagin (Deacetylcinobufagin) 是一种天然化合物,可用于微生物转化。 | |||
T5738 |
7-Epi 10-desacetyl paclitaxel
10-Deacetyl-7-epipaclitaxel,7-Epi-10-deacetyltaxol,7-表-10-去乙酰基云南紫杉宁A |
Others | Others |
7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) 是紫杉醇衍生物,对 HeLa 细胞具有细胞毒性(IC50:85 μM)。 | |||
TN1916 |
Matairesinol
罗汉松树脂酚 |
ATPase; p38 MAPK; ROS | Immunology/Inflammation; MAPK; Membrane transporter/Ion channel |
Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells. | |||
T5S1133 |
Ganoderic acid D
灵芝酸D,灵芝酸 D |
Apoptosis; Sirtuin | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Ganoderic acid D 是高度氧化的四环三萜,是灵芝的主要活性成分,可诱导 HeLa 人宫颈癌细胞凋亡。它上调 SIRT3的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D 。它抑制结肠癌细胞的能量重编程,包括结肠癌细胞中的葡萄糖摄取,乳酸、丙酮酸和乙酰辅酶的产生。 | |||
T3395 |
Timosaponin AIII
Filiferin B,知母皂苷 A-III,AneMarsaponin A3,Timosaponin A3 |
AChE; mTOR | Neuroscience; PI3K/Akt/mTOR signaling |
Timosaponin AIII (Timosaponin A3) 是一种乙酰胆碱酯酶活性抑制剂,其IC50=35.4 μM。 | |||
TN1393 |
(-)-Anonaine
番荔枝碱 |
Apoptosis; Antioxidant; Parasite; Antifungal | Apoptosis; Microbiology/Virology; oxidation-reduction |
(-)-Anonaine 可从木兰科和安妮科的几个物种中提取出来,具有抗疟、抗菌、抗真菌、抗氧化、抗癌、抗抑郁和血管舒张的活性。(-)-Anonaine 通过 Bax 和 caspase 依赖性途径诱导人类宫颈癌(HeLa)细胞的凋亡,诱导 DNA 损伤并抑制人类肺癌 h1299细胞的生长和迁移。 | |||
T3386 |
Kaempferitrin
Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷 |
cell cycle arrest; Glucokinase; IGF-1R | Cell Cycle/Checkpoint; Metabolism; Tyrosine Kinase/Adaptors |
Kaempferitrin (Lespenephryl) 是天然黄酮苷类化合物,具有缓解疼痛、抗糖尿病、消炎、抗肿瘤和化疗作用,可激活胰岛素信号传导。 | |||
T5S0055 |
Chelidonine
Helidonine,Khelidonin,白屈菜碱,Stylophorin |
Apoptosis; Others; Influenza Virus | Apoptosis; Microbiology/Virology; Others |
Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱,有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞,诱导 caspase 依赖和非依赖性的细胞凋亡。 | |||
T1879 |
3-Methyladenine
3-MA,3-甲基腺嘌呤,NSC 66389 |
Mitophagy; PI3K; Endogenous Metabolite; Autophagy | Autophagy; Metabolism; PI3K/Akt/mTOR signaling |
3-Methyladenine (3-MA) 是一种 PI3K 抑制剂,选择性抑制 IB 类 PI3Kγ (IC50=60 μM) 和 III 类 VPS34 (IC50=25 μM)。3-Methyladenine 具有自噬抑制活性。 | |||
T4036 |
Solasodine
Solancarpidine,Purapuridine,澳洲茄铵,Solasodin |
Apoptosis; Others; E1/E2/E3 Enzyme; Antifungal | Apoptosis; Microbiology/Virology; Others; Ubiquitination |
Solasodine (Purapuridine) 是存在于茄科植物中的一种类固醇生物碱。它具有神经保护、降压、抗真菌、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。 | |||
T0190 |
Vinorelbine
长春瑞宾,KW-2307 base |
Microtubule Associated | Cytoskeletal Signaling |
Vinorelbine (KW-2307 base) 是一种半合成的长春花生物碱。它与微管蛋白结合并阻止有丝分裂纺锤体的形成,导致中期肿瘤细胞生长停滞。 | |||
T0122 |
Bergenin
Cuscutin,Bengenin,岩白菜素 |
Apoptosis; IL Receptor; Virus Protease; TNF; NF-κB; Antibacterial; NOD; Autophagy; Antifungal | Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology; NF-κB |
Bergenin (Bengenin) 是一种在许多药用植物中发现的多酚,有细胞保护和抗氧化作用。它还具有广泛的保肝、抗炎、抗肿瘤、抗病毒、抗真菌以及免疫调节作用。 | |||
TN6569 | cis-Moschamine | ||
cis-Moschamine exerts antitumour effects on HeLa, MCF7 and A431 cells. | |||
TN3619 | Cedrusin | PARP; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome |
Cedrusin shows a cytotoxic effect on A375 and HeLa cells. | |||
T83481 |
1,1′-Disinomenine
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1,1'-Disinomenine,一种从Sinomenium acutum茎部分离得到的生物碱,对A549和Hela细胞表现出较弱的抑制效果。 | |||
TN3605 |
Casegravol
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Others | Others |
Casegravol shows antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells. | |||
T35234 |
Yadanzioside B
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Yadanzioside B 是提取自鸦胆子的苦木素苷类化合物。Yadanzioside B 能够抑制HeLa细胞中的蛋白质合成,但对体外翻译几乎没有影响。 | |||
TN2964 | 3'-Methylflavokawin | Others | Others |
3'-Methylflavokawin shows cytotoxicity against HeLa cells, the IC 50 value comparable to xanthohumol (8.2-19.2 microM). | |||
T13764 |
Lycopodine
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Lipoxygenase; Caspase | Apoptosis; Metabolism; Proteases/Proteasome |
Lycopodine, a bioactive compound derived from Lycopodium clavatum spores, effectively inhibits the proliferation of HeLa cells through the induction of apoptosis. This process is mediated by caspase-3 activation. In refractory prostate cancer cells, Lycopodine triggers apoptosis by modulating 5-lipoxygenase and depolarizing the mitochondrial membrane potential, without altering p53 activity. | |||
T82982 | Aplyronine C | ||
Aplyronine C是一种抗肿瘤活性化合物,对HeLa-S3细胞表现出细胞毒性,其IC50为2.9 nM,适用于癌症研究。 | |||
TN1776 |
Isocucurbitacin B
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Others | Others |
Isocucurbitacin B 对 HeLa 和 HT-29 人类癌细胞具有显着的抑制活性,IC50 值范围为 0.93 至 9.73uM。 | |||
TN5336 |
9-Oxo-10,11-dehydroageraphorone
4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone,泽兰二酮 |
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9-Oxo-10,11-dehydroageraphorone has acaricidal activity. It induces hepatotoxicity and cholestasis in rats. 9-Oxo-10,11-dehydroageraphorone also effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M pha | |||
T40440 |
Isobyakangelicol
Isobyakangelicol,Anhydrobyakangelicin |
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Isobyakangelicol, a coumarin compound present in Angelica dahurica roots, exhibits inhibitory effects on the growth of HeLa and HepG2 cells, with IC50 values of 70.04 μM and 17.97 μM, respectively. | |||
T82983 |
Aplyronine B
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Aplyronine B是一种具有抗肿瘤活性的活性化合物,对HeLa-S3细胞表现出细胞毒性,IC50值为2.9 nM,适用于癌症研究。 | |||
T37444 |
Aranorosin
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Aranorosin is a fungal metabolite originally isolated from P. roseus. It has antimicrobial activity against B. subtilis, A. niger, and C. albicans when used at a concentration of 1 mg/ml. Aranorosin also reduces viability in apoptosis-resistant HeLa/Bcl-2 cells. | |||
T79991 |
Condurango glycoside A
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Condurango glycoside A 作为p53激活剂,能够促进ROS的生成并且上调p53的表达。此外,Condurango glycoside A 还能够诱导HeLa细胞发生与DNA损伤相关的凋亡及过早老化。 | |||
T81818 | Metachromins X | ||
Metachromins X,一倍半萜醌类化合物,能阻碍HeLa/Fucci2细胞在S/G2/M期的细胞周期。 | |||
TN6010 |
Picrasidine S
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Picrasidine S shows the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells, it also shows the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus | |||
TN3049 |
4-Methoxycinnamyl alcohol
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Others | Others |
4-Methoxycinnamyl alcohol 对MCF-7、HeLa 和DU145癌症细胞系显示出毒性,IC50值分别为14.24、7.82和22.10μg/mL。4-methoxycinnamyl alcohol 是从Foeniculum vulgare 中分离出来的。4-Methoxycinnamyl alcohol 没有显示出凋亡作用,却在10μg/mL DNA 碎片研究显示48小时后发生了坏死。 | |||
TN6645 | Lucidumol A | ||
Lucidumol A has relatively good effect against aldose reductase with IC50 of 19.1uM. Lucidumol A has cytotoxic activity, it reduced cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependently with LC50s from 20.87 to 84.36 | |||
TN5093 | Taiwanhomoflavone A | COX | Immunology/Inflammation; Neuroscience |
Taiwanhomoflavone A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, Hepa-3B hepatoma, and Hela cervix tumor cells. | |||
TN4102 | Ganoderic acid AM1 | Others | Others |
Ganoderic acid AM1 treatment for 48 h inhibited the proliferation of HeLa human cervical carcinoma cells with IC(50) values of 19.8+/-0.7 microM. | |||
T75488 | Leptosphaerodione | ||
Leptosphaerodione,可从 Remotididymellasp. 中分离得到,是一种有效的泛素-蛋白酶体系统 (UPS) 抑制剂。Leptosphaerodione 在 HeLa 细胞中具有细胞毒性,IC50为 3.2 μM。抗肿瘤剂。 | |||
T69368 |
GKK1032B
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GKK1032B is a fungal metabolite that has antiproliferative and antibacterial activities. GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells and Vero cells. It also inhibits the growth of B. subtilis and M. tuberculosis. | |||
T75490 | 27-O-(tert-Butyldimethylsilyl)withaferin A | ||
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a) 为一种天然茄内酯类化合物,具备诱导细胞凋亡 (apoptosis) 的能力。该化合物对人类癌细胞系HeLa、A-549、MCF-7以及正常Vero细胞展现出抗增殖活性。 | |||
TN2872 |
3,4-Di-O-caffeoylquinic acid methyl ester
金银花 |
HSV | Microbiology/Virology |
3,4-Di-O-caffeoylquinic acid methyl ester shows high efficiency and low toxicity with antivirus activity against RSV; it exhibits cytotoxicity actions against human cervix carcinoma HeLa cells. | |||
T36797 | 1-Alaninechlamydocin | ||
1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. and an inhibitor of histone deacetylases (HDACs). It reduces total HDAC activity in HeLa cell lysates in a concentration-dependent manner. 1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively). | |||
TN2894 |
3,5-Di-O-caffeoylquinic acid methyl ester
金银花 |
HSV | Microbiology/Virology |
3,5-Di-O-caffeoylquinic acid methyl ester exhibits potent inhibitory activities against the formation of advanced glycation end products (AGEs); it exhibits cytotoxicity actions against human cervix carcinoma HeLa cells. 3,5-Di-O-caffeoylquinic acid methyl ester shows high efficiency and low toxicity with antivirus activity against RSV. | |||
T75629 | Ganoderic acid Mk | ||
Ganoderic acid Mk (GA-Mk)为来源于灵芝菌丝的三萜酸类化合物,能有效抑制细胞增殖,并通过线粒体途径诱导HeLa细胞的细胞凋亡(apoptosis),在宫颈癌研究中具有应用价值。 | |||
TN4194 |
Heliangin
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IL Receptor; TNF; NF-κB; MAPK; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB |
Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells. Heliangin has anti-cancer activity, it exhibits cytotoxicity against human oral epidermoid ( | |||
T37451 |
Stachybotrysin B
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Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).2 |1. Zhao, J., Feng, J., Tan, Z., et al. Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. J. Nat. Prod. 80(6), 1819-1826 (2017).|2. Ma, X.-h., Zhen... | |||
T82859 |
Blepharotriol
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Blepharotriol为Maytenus blepharodes中发现的一种酚类三萜化合物。该化合物具有抗菌特性,对Bacillus subtilis的最小抑菌浓度(MIC)为8-4 µg/ml。此外,Blepharotriol在HeLa、Hep-2、Vero细胞上的半数抑制浓度(IC50)分别为12.2、>20、>20 µM,表明其具有一定的细胞毒性。 | |||
T36749 |
Herboxidiene
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Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.3 Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.[4] Herbo... | |||
TMA1008 |
Ganoderic acid S
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Others | Others |
A novel combination of triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the treatment or prophylaxis of colon ca | |||
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