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78

抑制剂 & 化合物

35

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1534	HSV-gB2 (498-505) HSV-gB2 498-505
	This is the immunodominant epitope gB-8p from herpes simplex virus (HSV) glycoprotein B (gB), amino acids 498 to 505.
T11582	HSV-TK substrate	Others	Others
	HSV-TK substrate is a substrate for HSV-TK with antitumor activity. It induces multi-log cytotoxicity in HSV-TK-expressing and bystander cells.
T61563	HSV-1/HSV-2-IN-2
	HSV-1/HSV-2-IN-2是一种 HSV-1、HSV-2和 VV 抑制剂，EC50值为6.8、8.9和8.9 μM，并显示出抗病毒活性。
T62075	HSV-1/HSV-2-IN-1
	HSV-1/HSV-2-IN-1 是一种 HSV-1 和 HSV-2 抑制剂，能够作用于 HSV-1 (KOS) (EC50: 7.6 μM)，HSV-2 (G) (EC50: 7.6 μM)，HSV-1 TK-KOS ACVr (EC50: 4 μM) 和牛痘病毒 (EC50: 12 μM)。
T3045	Salubrinal	Apoptosis; Phosphatase; PERK; Autophagy; HSV	Apoptosis; Autophagy; Metabolism; Microbiology/Virology
	Salubrinal 是一种磷酸酶抑制剂，对真核翻译起始因子 2 亚基 (eIF2α) 发挥作用。它作为双特异性磷酸酶 2 抑制剂，抑制抗胶原蛋白抗体诱导的关节炎。它具有抗HSV-1病毒的活性，并抑制由HSV-1蛋白 ICP34.5 介导的eIF2α的去磷酸化。
T8972	FIT-039	Others; DNA/RNA Synthesis; CDK; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	FIT-039 是一种选择性和 ATP 竞争性的口服活性 CDK9 抑制剂，对CKD9/cyclin T1的IC50为 5.8 μM。它抑制HSV-1(IC50为 0.69 μM)，HSV-2，人腺病毒和人CMV 的复制。它可抑制耐药性HSV 和其他 DNA 病毒，是有前途的抗病毒药物。
T2504	Pritelivir 普瑞利韦,BAY 57-1293,AIC316	DNA/RNA Synthesis; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Pritelivir (BAY 57-1293) 是一种病毒解旋酶-引物酶复合物抑制剂，有抗病毒活性。它对 HSV-1 和 HSV-2 具有活性，IC50值为 20 nM。
T1848	Dynasore Dynamin Inhibitor I	Dynamin; Virus Protease; Autophagy; HSV	Autophagy; Cytoskeletal Signaling; Microbiology/Virology
	Dynasore (Dynamin Inhibitor I) 是一种可渗透细胞的化学物质，可逆且非竞争性地抑制 dynamin 1/2 的 GTPase 活性。它还抑制线粒体动力蛋白 Drp1，对其他小 GTPase 没有影响。
T4226	Amenamevir ASP2151,阿莫奈韦	DNA/RNA Synthesis; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Amenamevir (ASP2151) 是一种新型解旋酶引发酶抑制剂，对水痘带状疱疹病毒和 1 型和 2 型单纯疱疹病毒具有活性，EC50值为 14 ng/mL。
T12908	SIBA 5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine,5ˊ-异丁硫基-5ˊ-脱氧腺苷	Nucleoside Antimetabolite/Analog; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	SIBA (5'-Deoxy-5'-isobutylthioadenosine) 是 SAH 的合成类似物，可作为 S-腺苷甲硫氨酸介导的甲基转移的抑制剂。它干扰多种酶活性，可逆地阻断单纯疱疹病毒 1 型病毒的繁殖。
T4051	LDC4297 LDC044297	CDK; HSV	Cell Cycle/Checkpoint; Microbiology/Virology
	LDC4297 (LDC044297)是 CDK7的一种高效选择性抑制剂，IC50值为0.13 nM。
T0944	Levamisole hydrochloride (-)-Tetramisole hydrochloride,盐酸左旋咪唑	Phospholipase; AChR; Parasite; HSV	Metabolism; Microbiology/Virology; Neuroscience
	Levamisole hydrochloride ((-)-Tetramisole hydrochloride) 是驱虫剂和免疫调节剂。它对HSV 病毒有明显抗病毒作用。
T0355	Valpromide Depamide,Valpramide,丙戊酰胺,Dipropylacetamide,2-propylpentanamide	Epoxide Hydrolase; HSV	Metabolism; Microbiology/Virology
	Valpromide (Dipropylacetamide) 是丙戊酸的羧酰胺衍生物，用于治疗癫痫和一些情感障碍。
T1087	Valacyclovir hydrochloride Valaciclovir hydrochloride,盐酸伐昔洛韦,盐酸万乃洛韦,Valaciclovir HCl	DNA/RNA Synthesis; Antibiotic; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Valacyclovir hydrochloride (Valaciclovir hydrochloride) 是一种口服有效的抗病毒药物，能抑制疱疹 B，单纯疱疹和带状疱疹。它抑制 HSV-1W，IC50为2.9 μg/ml。它是 Aciclovir 的前药。
T6787	BIO-acetoxime BIA,GSK-3 Inhibitor X	Apoptosis; GSK-3; HSV	Apoptosis; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells
	BIO-acetoxime (GSK-3 Inhibitor X) 是一种 GSK3α/β 抑制剂，IC50值均为 10 nM，具有抗惊厥和抗感染作用。
T15280	Fiacitabine 非西他滨,FOAC,FIAC,NSC 382097	HSV	Microbiology/Virology
	Fiacitabine (NSC-382097) 是单纯疱疹病毒 (HSV) DNA 复制的选择性抑制剂，对 HSV1和 HSV2的 IC50分别为2.5 nM 和12.6 nM。
T15394	Glyceryl monocaprate 2,3-Dihydroxypropyl decanoate,一癸酸甘油酯,DECANOIN,Monocaprin	Antibacterial; HSV	Microbiology/Virology
	Glyceryl monocaprate (2,3-Dihydroxypropyl decanoate) 对单纯疱疹病毒具有抑制作用，有潜力治疗唇疱疹。它是一种癸酸的1-单甘油酯，可抗革兰氏阳性细菌感染。
T1454	Acyclovir Aciclovir,Acycloguanosine,阿昔洛韦	Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic; HSV	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Acyclovir (Aciclovir) 是鸟嘌呤类似物和具有口服活性的抗病毒剂。它对HSV-1(IC50为 0.85 μM)，HSV-2(IC50为 0.86 μM) 和水痘带状疱疹病毒有活性。
T1646	Famciclovir 泛昔洛韦,BRL 42810	DNA/RNA Synthesis; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Famciclovir (BRL 42810) 是一种单纯疱疹病毒核苷类似物 DNA 聚合酶抑制剂。
T6073	OG-L002	Histone Demethylase; Monoamine Oxidase; HSV	Chromatin/Epigenetic; Microbiology/Virology; Neuroscience
	OG-L002 是一种高度选择性的 LSD1有效抑制剂，IC50为 0.02 μM。它抑制HSV IE 基因的表达，还是单胺氧化酶抑制剂，对 MAO-A 和 MAO-B 的IC50分别为 1.38 μM 和 0.72 μM。
T1643	Penciclovir 喷昔洛韦,BRL 39123,VSA 671	HCV Protease; Antifection; HSV	Microbiology/Virology; Proteases/Proteasome
	Penciclovir (BRL 39123) 是一种疱疹病毒核苷类似物 DNA 聚合酶抑制剂。它作用于HSV1 和 2，IC50分别为 0.04-1.8 μg/mL 和 0.06-4.4 μg/mL。
T6593	ML324	Histone Demethylase; Others; HSV	Chromatin/Epigenetic; Microbiology/Virology; Others
	ML324 是 jumonji 组蛋白去甲基化酶的特异性抑制剂，IC50值为920 nM。
TQ0095	Brincidofovir CMX001,HDP-CDV	Others; Antiviral; HSV	Immunology/Inflammation; Microbiology/Virology; Others
	Brincidofovir (HDP-CDV) 是 Cidofovir 的一种具有口服活性的亲脂性形式的前体药物，是一种口服长效的抗病毒药物，有广泛的抗 DNA 病毒活性。
T1109	(Z)-Capsaicin Zucapsaicin,Civamide,cis-Capsaicin,珠卡赛辛,(Z)-辣椒素	TRP/TRPV Channel; HSV	Membrane transporter/Ion channel; Microbiology/Virology
	(Z)-Capsaicin (Zucapsaicin) 是天然辣椒素的合成顺式异构体，用于治疗膝骨关节炎。它是一种可口服的 TRPV1激动剂，可研究神经性疼痛。
T1428	Trifluridine 曲氟尿苷,NSC 529182,Trifluorothymidine,5-Trifluorothymidine,NSC 75520,曲氟胸苷,Viroptic,Trifluridina	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Trifluridine (NSC-75520) 是一种氟化胸苷类似物，具有潜在的抗肿瘤活性，还具有抗病毒活性。它掺入 DNA 并抑制胸苷酸合酶，从而抑制 DNA 合成、抑制蛋白质合成和细胞凋亡。
T0134	Imiquimod 咪喹莫特,R 837,S-26308	SARS-CoV; TLR; Autophagy; HSV	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Imiquimod (R 837) 是一种免疫反应修饰剂，可作为 toll 样受体7 激动剂。它有抗病毒和抗肿瘤作用，可研究外生殖器、肛周疣、癌症和 COVID-19。
T0929	Docusate sodium Aerosol OT,多库脂钠,Dioctyl sulfosuccinate sodium salt,Bis(2-ethylhexyl) sulfosuccinate sodium salt,Constonate	Opioid Receptor; HSV	Endocrinology/Hormones; GPCR/G Protein; Microbiology/Virology; Neuroscience
	Docusate sodium (Aerosol OT) 是一种口服的非处方泻药和大便软化剂，可用于研究便秘。
T0964	Floxuridine 氟尿苷,5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640	Apoptosis; Nucleoside Antimetabolite/Analog; Others; DNA/RNA Synthesis; Antibacterial; HSV	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Floxuridine (FUDR) 是一种嘧啶类似物，也是一种抗肿瘤代谢物。它抑制胸苷酸合成酶，导致 DNA 合成中断和细胞毒性。它是一种可诱导细胞凋亡的金黄色葡萄球菌感染抑制剂，具有抗HSV 和CMV 病毒的作用。
T22419	S-Methylisothiourea sulfate (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐	NOS; NO Synthase; HSV	Immunology/Inflammation; Microbiology/Virology
	S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂，在感染性休克的啮齿动物模型中发挥有益作用。
T0688	Ganciclovir BW 759,更昔洛韦,RS-21592,2'-Nor-2'-deoxyguanosine	Nucleoside Antimetabolite/Analog; Others; Antibiotic; Antifection; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Ganciclovir (2'-Nor-2'-deoxyguanosine) 是核苷类似物和口服抗病毒药物，对CMV 具有抗病毒活性。它用于治疗与艾滋病相关的巨细胞病毒感染的并发症。
T22337	Ganciclovir sodium RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium,更昔洛韦钠	Nucleoside Antimetabolite/Analog; Others; Antifection; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Ganciclovir sodium (Cytovene IV sodium) 是核苷类似物和口服抗病毒药物，具有抗病毒活性，尤其是针对巨细胞病毒和单纯疱疹病毒 1 型。
T10445	B220	HSV	Microbiology/Virology
	B220 是一种能抑制 HSV-1，HSV-2 和人巨细胞病毒 (CMV) 生长的抗病毒剂。
T60272	Isatin-β-thiosemicarbazone IBT	HSV	Microbiology/Virology
	Isatin-β-thiosemicarbazone 是一种有效的单纯疱疹病毒 (HSV) 抑制剂。Isatin-β-thiosemicarbazone 在对 HSV-1 和 HSV-2 都具有抑制作用，表现出抗病毒活性。Isatin-β-thiosemicarbazone 是一种有效的抗痘病毒剂 (anti-poxvirus）可用用于治疗猴痘病毒、正痘病毒和牛痘病毒。
T50026	Aquacycline	HSV	Microbiology/Virology
	Aquacycline 是一种广谱抗生素，通过抑制细菌中的蛋白质合成起作用。它可防止氨酰-tRNA 与复杂的 m-核糖体 RNA 结合。它还具有抗 HSV-1 活性。
T50031	Virstatin	Others	Others
	Virstatin 是一种新型抗病毒药物，是一种有效的病毒复制抑制剂，已被证明对多种病毒有效，包括单纯疱疹病毒（HSV）、人类免疫缺陷病毒（HIV）和流感病毒等。
T74809	STING agonist-30	STING; Antifection	Immunology/Inflammation; Microbiology/Virology
	STING agonist-30 是一种高效的 STING 激动剂，能激发STING依赖的免疫激活。STING agonist-30 对包括HSV（单纯疱疹病毒）、轮状病毒及SARS-CoV-2（严重急性呼吸系统综合症冠状病毒2）在内的多种病毒显示出广谱抑制效果。
T80672	1,4-Dihydroxynaphthalene Naphthalene-1,4-diol	HSV	Microbiology/Virology
	1,4-Dihydroxynaphthalene 一种有效的 HSV-1蛋白酶抑制剂，对HCMV蛋白酶有抑制作用，可用于研究疱疹病毒。
T7055	Bz-RS-ISer(3-Ph)-Ome Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) 是紫杉醇衍生物，在低细胞毒性下抑制 HSV 复制周期，阻断 Vero 细胞的有丝分裂，影响 M-MSV 诱导的肿瘤大小，并通过抑制 PHA 诱导的 T 淋巴细胞增殖而影响免疫应答。
T1272L	Cytarabine hydrochloride Ara-C hydrochloride,Cytosine Arabinoside hydrochloride	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Cytarabine hydrochloride (Ara-C hydrochloride) 是一种核苷类似物，可导致 S 期细胞周期停滞并抑制DNA 聚合酶。Cytarabine 抑制DNA 合成，IC50为 16 nM。Cytarabine hydrochloride 对HSV 具有抗病毒作用。
T67836	AT-533	HSP; HSV	Cytoskeletal Signaling; Metabolism; Microbiology/Virology
	AT-533 是有效的 HSV 和 Hsp90 抑制剂。AT-533 可以阻断 HIF-1α/VEGF/VEGFR-2 信号通路，从而抑制血管生成和肿瘤生长。AT-533 也抑制下游通路的激活，包括 Erk1/2, FAK, Akt/mTOR/p70S6K。AT-533 抑制人脐静脉内皮细胞 (HUVEC) 的细胞迁移、侵袭和管形成。
T13209L	Tromantadine hydrochloride	HSV	Microbiology/Virology
	Tromantadine hydrochloride is an amantadine derivative with antiherpetic activity (inhibits HSV-1 and HSV-2 replication).
T24385	L-Acosamine nucleoside
	L-Acosamine nucleoside has antiviral activity against HIV and HSV-1.
T1454L	Acyclovir sodium Aciclovir sodium
	Acyclovir sodium is an antimetabolite. Acyclovir sodium inhibits HSV-specified DNA polymerases and prevents further viral DNA synthesis.
T80295	GLR-19	HSV	Microbiology/Virology
	GLR-19 为一种具有抗HIV功能的肽类化合物，亦展现出对HSV-2的抗病毒活性。
T80374	HBA(111–142)	HSV	Microbiology/Virology
	HBA(111-142) 是一种源于 α-血红蛋白 C 端的32-聚体抗菌肽片段，对 ESKAPE 病原体展示出了抗菌效果。它能形成淀粉样原纤维结构，并表现出针对多种病毒，包括麻疹病毒和疱疹病毒（HSV-1、HSV-2、HCMV）的抗病毒活性。
T76336	Astodrimer
	Astodrimer (SPL7013 free base) 是一种体积较大（3-4 nm, ~ 16.5 kDa）、带负电荷、高度分支化的树状高分子，有效抑制并杀灭多种病毒，包括 SARS-CoV-2、HIV-1、HSV-1、HSV-2、HPV 等，具有广谱的抗病毒和杀病毒活性，同时展现出抗菌特性。
T73983	Cidofovir diphosphate tri(triethylamine)
	Cidofovir diphosphate tri triethylamine 是西多福韦的细胞内活性代谢物。diphosphate tri triethylamine 是病毒 DNA 聚合酶的选择性抑制剂，对 HCMV，HSV-1和 HSV-2的 Ki 值分别为 6.6，0.86 和 1.4 μM。
T75518	Galactofucan
	Galactofucan (Fucogalactan) 是一种硫酸多糖。Galactofucan 可以从棕色海藻 Saccharina longicruris 中提取，具有抗凝血、抗肿瘤、抗血栓形成、抗炎、抗病毒等特性。Galactofucan 对 HSV-1和 HSV-2具有抗病毒活性，IC50值分别为 0.76 和 1.34 µg/mL 。Galactofucan 可用于癌症和炎症的研究。
TP1536	Histone H4 (2-21)
	Histone H4 (2-21) is a pivotal core histone involved in the process of chromatinization specific to the genomes of herpes simplex virus 1 (HSV-1).
T68619	FR-48217
	FR-48217 is an immunoactive peptide that inhibits multiplication of HSV-1 and HSV-2.

化合物

HSV-gB2 (498-505)

Cat.No: TP1534

Synonym: HSV-gB2 498-505

HSV-TK substrate

Cat.No: T11582

Target: Others

HSV-1/HSV-2-IN-2

Cat.No: T61563

HSV-1/HSV-2-IN-1

Cat.No: T62075

Cat.No: T3045

Target: Apoptosis, Phosphatase, PERK, Autophagy, HSV

Cat.No: T8972

Target: Others, DNA/RNA Synthesis, CDK, HSV

Cat.No: T2504

Synonym: 普瑞利韦,BAY 57-1293,AIC316

Target: DNA/RNA Synthesis, HSV

Cat.No: T1848

Synonym: Dynamin Inhibitor I

Target: Dynamin, Virus Protease, Autophagy, HSV

Cat.No: T4226

Synonym: ASP2151,阿莫奈韦

Target: DNA/RNA Synthesis, HSV

Cat.No: T12908

Synonym: 5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine,5ˊ-异丁硫基-5ˊ-脱氧腺苷

Target: Nucleoside Antimetabolite/Analog, HSV

Cat.No: T4051

Synonym: LDC044297

Target: CDK, HSV

Levamisole hydrochloride

Cat.No: T0944

Synonym: (-)-Tetramisole hydrochloride,盐酸左旋咪唑

Target: Phospholipase, AChR, Parasite, HSV

Cat.No: T0355

Synonym: Depamide,Valpramide,丙戊酰胺,Dipropylacetamide,2-propylpentanamide

Target: Epoxide Hydrolase, HSV

Valacyclovir hydrochloride

Cat.No: T1087

Synonym: Valaciclovir hydrochloride,盐酸伐昔洛韦,盐酸万乃洛韦,Valaciclovir HCl

Target: DNA/RNA Synthesis, Antibiotic, HSV

Cat.No: T6787

Synonym: BIA,GSK-3 Inhibitor X

Target: Apoptosis, GSK-3, HSV

Cat.No: T15280

Synonym: 非西他滨,FOAC,FIAC,NSC 382097

Target: HSV

Glyceryl monocaprate

Cat.No: T15394

Synonym: 2,3-Dihydroxypropyl decanoate,一癸酸甘油酯,DECANOIN,Monocaprin

Target: Antibacterial, HSV

Cat.No: T1454

Synonym: Aciclovir,Acycloguanosine,阿昔洛韦

Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic, HSV

Cat.No: T1646

Synonym: 泛昔洛韦,BRL 42810

Target: DNA/RNA Synthesis, HSV

Cat.No: T6073

Target: Histone Demethylase, Monoamine Oxidase, HSV

Cat.No: T1643

Synonym: 喷昔洛韦,BRL 39123,VSA 671

Target: HCV Protease, Antifection, HSV

Cat.No: T6593

Target: Histone Demethylase, Others, HSV

Cat.No: TQ0095

Synonym: CMX001,HDP-CDV

Target: Others, Antiviral, HSV

Cat.No: T1109

Synonym: Zucapsaicin,Civamide,cis-Capsaicin,珠卡赛辛,(Z)-辣椒素

Target: TRP/TRPV Channel, HSV

Cat.No: T1428

Synonym: 曲氟尿苷,NSC 529182,Trifluorothymidine,5-Trifluorothymidine,NSC 75520,曲氟胸苷,Viroptic,Trifluridina

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, HSV

Cat.No: T0134

Synonym: 咪喹莫特,R 837,S-26308

Target: SARS-CoV, TLR, Autophagy, HSV

Docusate sodium

Cat.No: T0929

Synonym: Aerosol OT,多库脂钠,Dioctyl sulfosuccinate sodium salt,Bis(2-ethylhexyl) sulfosuccinate sodium salt,Constonate

Target: Opioid Receptor, HSV

Cat.No: T0964

Synonym: 氟尿苷,5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Others, DNA/RNA Synthesis, Antibacterial, HSV

S-Methylisothiourea sulfate

Cat.No: T22419

Synonym: (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐

Target: NOS, NO Synthase, HSV

Cat.No: T0688

Synonym: BW 759,更昔洛韦,RS-21592,2'-Nor-2'-deoxyguanosine

Target: Nucleoside Antimetabolite/Analog, Others, Antibiotic, Antifection, HSV

Ganciclovir sodium

Cat.No: T22337

Synonym: RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium,更昔洛韦钠

Target: Nucleoside Antimetabolite/Analog, Others, Antifection, HSV

Cat.No: T10445

Target: HSV

Isatin-β-thiosemicarbazone

Cat.No: T60272

Synonym: IBT

Target: HSV

Cat.No: T50026

Target: HSV

Cat.No: T50031

Target: Others

STING agonist-30

Cat.No: T74809

Target: STING, Antifection

1,4-Dihydroxynaphthalene

Cat.No: T80672

Synonym: Naphthalene-1,4-diol

Target: HSV

Bz-RS-ISer(3-Ph)-Ome

Cat.No: T7055

Synonym: Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate

Target: Others, HIV Protease

Cytarabine hydrochloride

Cat.No: T1272L

Synonym: Ara-C hydrochloride,Cytosine Arabinoside hydrochloride

Target: DNA/RNA Synthesis

Cat.No: T67836

Target: HSP, HSV

Tromantadine hydrochloride

Cat.No: T13209L

Target: HSV

L-Acosamine nucleoside

Cat.No: T24385

Acyclovir sodium

Cat.No: T1454L

Synonym: Aciclovir sodium

Cat.No: T80295

Target: HSV

Cat.No: T80374

Target: HSV

Cat.No: T76336

Cidofovir diphosphate tri(triethylamine)

Cat.No: T73983

Cat.No: T75518

Histone H4 (2-21)

Cat.No: TP1536

Cat.No: T68619

Cat. No.	Product Name	Target	Signaling Pathways
T6624	Oxytetracycline Dihydrate 土霉素二水合物,地霉素,Terramycin Dihydrate	Others; Endogenous Metabolite; Antibacterial; Antibiotic; HSV	Metabolism; Microbiology/Virology; Others
	Oxytetracycline Dihydrate (Terramycin Dihydrate) 是一种四环素类抗生素，可抑制革兰氏阴性和革兰氏阳性细菌。它是一种蛋白质合成抑制剂，可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合，还具有抗 HSV-1的活性。
T3S1068	Oxyresveratrol trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,氧化白藜芦醇,Tetrahydroxystilbene	Tyrosinase; Autophagy; HSV	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Oxyresveratrol (trans-Oxyresveratrol) 是非竞争性酪氨酸酶抑制剂，对蘑菇酪氨酸酶的 IC50值为 1.2 µM。它抑制HSV-1，HSV-2和水痘带状疱疹病毒，具有神经保护作用。它是天然抗氧化剂和自由基清除剂。
T0895	Oxytetracycline 土霉素,Terramycin	ribosome; Endogenous Metabolite; Antibacterial; Antibiotic; HSV	Metabolism; Microbiology/Virology
	Oxytetracycline (Terramycin) 是一种四环素类抗生素。它强力抑制革兰氏阴性和革兰氏阳性细菌。它是一种蛋白质合成抑制剂，可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合，具有抗 HSV-1的活性。
T6523	Guanosine 鸟苷,DL-Guanosine,Vernine,Guanozin	Endogenous Metabolite; HSV	Metabolism; Microbiology/Virology
	Guanosine (DL-Guanosine) 是由鸟嘌呤与核糖环组成的一种核苷，两者之间由 β-N9-配糖键相连，具有抗HSV 的活性。
T5S0018	Betulonic acid 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid	Parasite; HSV	Microbiology/Virology
	Betulonic acid (Liquidambaric acid) 是一种在许多植物中存在的三萜类天然产物，具有抗肿瘤，抗炎，抗寄生虫和抗病毒的活性。
TN1788	Isookanin	Amylase	Metabolism
	Isookanin 在多种疾病领域有研究价值，包括肿瘤，皮疹，蛇和昆虫叮咬，糖尿病，腹泻。它可作为抗病毒剂对抗 HSV 和水痘带状疱疹病毒。它也具有抗氧化特性。
T5712	zerumbone 花薑酮,球姜酮	Antioxidant; HSV	Microbiology/Virology; oxidation-reduction
	Zerumbone 是从Zingiber zerumbetSmith 的根茎中分离的一种单环倍半萜烯，可有效抑制Epstein-Barr 病毒的激活，IC50为 0.14 mM，具有抗癌、抗炎、抗氧化和抗增殖的作用。
T3342	Xanthohumol	Apoptosis; Others; Influenza Virus; COX; Acyltransferase; HSV	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; Others
	Xanthohumol 是从啤酒花中分离到的黄酮类化合物，可抑制 COX-1 和 COX-2 活性，具有抗肿瘤，抗血管生成的作用，还具有抗多种病毒的活性。
T21430	Oxytetracycline Hydrochloride Biosolvomycin,盐酸土霉素,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin	Antiviral; Endogenous Metabolite; Antibacterial; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology
	Oxytetracycline Hydrochloride (Dalimycin) 是由 Streptomyces rimosus 生产的，一种具有抗菌活性的四环素衍生物。它干扰氨酰-tRNA 与 mRNA-核糖体复合物的结合，从而阻止肽延伸并抑制蛋白质合成。
T3375	Verbascoside 毛蕊花苷,麦角甾苷,Kusaginin,Acteoside,TJC160	Apoptosis; PARP; Antibacterial; PKC; p53; HSV	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Microbiology/Virology
	Verbascoside (Kusaginin) 是从Lantana camara 中得到的糖苷类物质，是具有ATP 竞争性的PKC 抑制剂，IC50值为 25 µM，它还有抗炎，抗肿瘤，抗神经性疼痛等作用。
T7983	Isoborneol DL-Isoborneol,异冰片,异龙脑	HSV	Microbiology/Virology
	Isoborneol (DL-Isoborneol) 是存在于许多药用植物精油中的一种单萜醇，具有抗氧化和抗病毒特性，是 1 型单纯疱疹病毒(HSV-1)的有效抑制剂。
T6062	Brefeldin A BFA,布雷非德菌素 A,Ascotoxin,Cyanein,Decumbin	ATPase; Mitophagy; Antibiotic; Autophagy; HSV; CRISPR/Cas9	Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology
	Brefeldin A (Cyanein) 属于大环内酯类抗生素，是一种 ATPase 抑制剂 (IC50=0.2 μM)。Brefeldin A 可以诱导肿瘤细胞分化和凋亡，也具有抑制自噬的活性。
T0884	1-Docosanol Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol	Antifection; HSV	Microbiology/Virology
	1-Docosanol (Behenic alcohol) 是一种具有抗病毒活性的饱和 22 碳脂肪醇，局部用于治疗复发性单纯性唇疱疹发作并缓解相关疼痛并可能有助于更快地治愈疮。
T1131	Ivermectin MK-933,伊维菌素	Mitophagy; GluCls; P2X Receptor; SARS-CoV; HIV Protease; Antibiotic; Parasite; Autophagy; HSV	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ivermectin (MK-933) 是谷氨酸门控氯离子通道激活剂，具有抗寄生虫活性。它特异性抑制Impα/β1 介导的核导入，还抑制牛疱疹病毒 1 复制并抑制BoHV-1DNA 聚合酶的核输入。它具有很强的抗病毒活性。它也是P2X4和 α7nAChRs 的正异构效应物。
T0853L	Adenosine 5'-monophosphate monohydrate 5'-AMP,腺苷-5'-单磷酸一水合物,5'-AMP monohydrate,5'-Adenylic acid	AMPK; Adenosine Receptor; HSV	Chromatin/Epigenetic; GPCR/G Protein; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling
	Adenosine 5'-monophosphate monohydrate (5'-AMP) 是一种核苷酸，用作 RNA 中的单体。它是一个腺苷 A1受体激动剂，对HSV-1和HSV-2具有显著的抗病毒活性。
T1272	Cytarabine 阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite; Autophagy; HSV	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Cytarabine (Ara-C) 是一种核苷类似物，一种 DNA 合成抑制剂 (IC50=16 nM)。Cytarabine 可以抑制 DNA 聚合酶，诱导细胞周期阻滞、细胞自噬和凋亡。Cytarabine 具有抗肿瘤活性。
T2927	Trigonelline chloride Gynesine Hydrochloride,盐酸葫芦巴碱,Coffearine Hydrochloride,Nicotinic acid N-methylbetaine Hydrochloride,Trigonelline hydrochloride	Others; Antibacterial; Antifungal; HSV	Microbiology/Virology; Others
	Trigonelline chloride (Coffearine Hydrochloride) 是一种大量存在于咖啡中的生物碱，具有潜在抗糖尿病活性。它还具有抗HSV-1，抗菌和抗真菌活性。
T3813	20(R)-Ginsenoside Rh2 20(R)-人参皂苷 RH2,(20R)Ginsenoside Rh2,Ginsenoside Rh2,20(R)-人参皂苷Rh2	Apoptosis; MMP; HSV	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	20(R)-Ginsenoside Rh2 (Ginsenoside Rh2) 是人参皂苷 Rh2 的次要立体异构体，具有基质金属蛋白酶抑制作用。它有抗癌、抗炎和抗氧化活性。
T1506	Vidarabine Adenine Arabinoside,阿糖腺苷,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A	Nucleoside Antimetabolite/Analog; Tyrosine Kinases; DNA/RNA Synthesis; Antibiotic; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Vidarabine (Adenine Arabinoside) 是从链霉菌分离的核苷类抗生素，能抗单纯性疱疹和水痘-带状疱疹病毒。它对 HSV-1 和 HSV-2 的 IC50值分别为 9.3 μg/ml 和 11.3 μg/ml。
T2S1865	Octyl gallate Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯	Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction
	Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用，有选择性和敏感性的荧光特性，广泛用作食品添加剂。它对 HSV-1，水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。
T5429	Theaflavin 3,3'-digallate 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG	Virus Protease; Antioxidant; HIV Protease; HSV	Microbiology/Virology; oxidation-reduction; Proteases/Proteasome
	Theaflavin 3,3'-digallate (8-Gingerol) 是一种寨卡病毒蛋白酶抑制剂，IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制，可抑制 gp41 和 NS2B-3 蛋白酶的活性，并具有抗 HSV 和 HIV-1病毒活性。它是红茶中的主要多酚，有抗肿瘤作用。
T2822	Ginsenoside Rb1 Gypenoside Ⅲ,人参皂苷Rb1,人参皂苷 Rb1,Gypenoside III	ATPase; Mitophagy; IRAK; NF-κB; Autophagy; HSV	Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; NF-κB
	Ginsenoside Rb1 (Gypenoside Ⅲ) 是中药人参的成分，可能具有抑制或阻止肿瘤生长的特性。
T6742	2-Deoxy-D-glucose 2-Deoxy-D-arabino-hexose,2-deoxyglucose,D-Arabino-2-deoxyhexose,Ba 2758,D-2-脱氧葡萄糖,NSC 15193,2-DG,2-脱氧-D-葡萄糖	Apoptosis; Hexokinase; HSV	Apoptosis; Metabolism; Microbiology/Virology
	2-Deoxy-D-glucose (2-DG) 是葡萄糖的类似物，是一种糖酵解抑制剂。2-Deoxy-D-glucose 具有抗病毒活性，还具有抑制细胞增殖、诱导细胞凋亡的活性。
T7972	Gallic aldehyde 3,4,5-三羟基苯甲醛,五倍子醛	HSV	Microbiology/Virology
	Gallic aldehyde 对 HSV-1 显示出有效的抗病毒活性。
T6S1885	Benzoylmesaconine Mesaconine 14-benzoate,苯甲酰新乌头原碱	Others	Others
	Benzoylmesaconine (Mesaconine 14-benzoate) 是乌头汤最丰富的组分。其中乌头汤可用于研究类风湿性关节炎。
T2A2498	L-Lysine Aminutrin,Lysine Acid,lysine,L-赖氨酸,赖氨酸	Virus Protease; Endogenous Metabolite; Antifection	Metabolism; Microbiology/Virology
	L-Lysine (Aminutrin) 是一种人类必需氨基酸，能增加钙吸收，减少糖尿病相关疾病和改善肠道健康，可用于疱疹的研究。
T3795	Corilagin	Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology
	Corilagin 是一种鞣酸，有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长，MIC 为 25 μg/mL。它有抗肿瘤活性，可用于肝癌和卵巢癌。
T79987	Cangorinine E-1	HSV	Microbiology/Virology
	Cangorinine E-1 (compound 11) 为一种倍半萜类的二氢沉香呋喃衍生物，对 II 型单纯疱疹病毒(HSV)展现出轻度抑制效果。
TN4587	Mulberrofuran C	HSV	Microbiology/Virology
	Mulberrofuran C shows protective effects on t-BHP-induced oxidative stress with the EC50 value of 0.41 ± 0.48 uM ; it also shows protective effects on glutamate-induced cell death with the EC50 value of 16.50 ± 7.82 uM. Mulberrofuran C has antiviral effects against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2).
TN4585	Moronic acid	HIV Protease; Antifection; HSV	Microbiology/Virology; Proteases/Proteasome
	Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186) and was modified to develop more potent anti-AIDS agents. Moronic acid is a new structural lead for anti-EBV drug development, can substantially reduce the numbers of EBV particles produced by the cells after lytic induction. Morolic and moronic acids have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an...
T38441	Manzamine A hydrochloride
	Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM). Additionally, it targets vacuolar ATPases, leading to the inhibition of autophagy in pancreatic cancer cells. Manzamine A hydrochloride possesses antimalarial and anticancer properties, and also demonstrates potent activity against HSV-1[4].
T83693	Magainin 2 TFA MG2
	Magainin 2是一种从非洲爪蟾（X. laevis）皮肤中分离出的阳离子肽，具有宿主防御和抗菌活性。该化合物对细菌E. coli、K. pneumoniae、S. epidermidis、S. aureus及真菌C. albicans表现出活性（MICs分别为5、10、10、50和80 µg/ml）。Magainin 2（20 µM）能降低猕猴桃花粉的萌发率和平均管长。在被单纯疱疹病毒1型（HSV-1）或2型（HSV-2）感染的Vero细胞中，它可减少病毒复制（EC50s分别为22.16和19.8 µM），同时不影响细胞活性，其50%细胞毒性浓度值（CC50）大于100 µM。
TN6014	Norcepharadione B 鱼腥草
	Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3,
TN4456	Lucidadiol	AChR; HSV	Microbiology/Virology; Neuroscience
	Lucidadiol exhibits butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM, it also possesses inhibitory activity against acetylcholinesterase (AChE) with the percentage inhibition at 100 uM. Lucidadiol shows antiviral activity against i
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Oxytetracycline Dihydrate

Cat.No: T6624

Synonym: 土霉素二水合物,地霉素,Terramycin Dihydrate

Target: Others, Endogenous Metabolite, Antibacterial, Antibiotic, HSV

Cat.No: T3S1068

Synonym: trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,氧化白藜芦醇,Tetrahydroxystilbene

Target: Tyrosinase, Autophagy, HSV

Oxytetracycline

Cat.No: T0895

Synonym: 土霉素,Terramycin

Target: ribosome, Endogenous Metabolite, Antibacterial, Antibiotic, HSV

Cat.No: T6523

Synonym: 鸟苷,DL-Guanosine,Vernine,Guanozin

Target: Endogenous Metabolite, HSV

Cat.No: T5S0018

Synonym: 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid

Target: Parasite, HSV

Cat.No: TN1788

Target: Amylase

Cat.No: T5712

Synonym: 花薑酮,球姜酮

Target: Antioxidant, HSV

Cat.No: T3342

Target: Apoptosis, Others, Influenza Virus, COX, Acyltransferase, HSV

Oxytetracycline Hydrochloride

Cat.No: T21430

Synonym: Biosolvomycin,盐酸土霉素,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin

Target: Antiviral, Endogenous Metabolite, Antibacterial, HSV

Cat.No: T3375

Synonym: 毛蕊花苷,麦角甾苷,Kusaginin,Acteoside,TJC160

Target: Apoptosis, PARP, Antibacterial, PKC, p53, HSV

Cat.No: T7983

Synonym: DL-Isoborneol,异冰片,异龙脑

Target: HSV

Cat.No: T6062

Synonym: BFA,布雷非德菌素 A,Ascotoxin,Cyanein,Decumbin

Target: ATPase, Mitophagy, Antibiotic, Autophagy, HSV, CRISPR/Cas9

Cat.No: T0884

Synonym: Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol

Target: Antifection, HSV

Cat.No: T1131

Synonym: MK-933,伊维菌素

Target: Mitophagy, GluCls, P2X Receptor, SARS-CoV, HIV Protease, Antibiotic, Parasite, Autophagy, HSV

Adenosine 5'-monophosphate monohydrate

Cat.No: T0853L

Synonym: 5'-AMP,腺苷-5'-单磷酸一水合物,5'-AMP monohydrate,5'-Adenylic acid

Target: AMPK, Adenosine Receptor, HSV

Cat.No: T1272

Synonym: 阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, HSV

Trigonelline chloride

Cat.No: T2927

Synonym: Gynesine Hydrochloride,盐酸葫芦巴碱,Coffearine Hydrochloride,Nicotinic acid N-methylbetaine Hydrochloride,Trigonelline hydrochloride

Target: Others, Antibacterial, Antifungal, HSV

20(R)-Ginsenoside Rh2

Cat.No: T3813

Synonym: 20(R)-人参皂苷 RH2,(20R)Ginsenoside Rh2,Ginsenoside Rh2,20(R)-人参皂苷Rh2

Target: Apoptosis, MMP, HSV

Cat.No: T1506

Synonym: Adenine Arabinoside,阿糖腺苷,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A

Target: Nucleoside Antimetabolite/Analog, Tyrosine Kinases, DNA/RNA Synthesis, Antibiotic, HSV

Cat.No: T2S1865

Synonym: Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯

Target: Antioxidant, Influenza Virus, Reactive Oxygen Species, Antibacterial, Antifungal, HSV

Theaflavin 3,3'-digallate

Cat.No: T5429

Synonym: 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG

Target: Virus Protease, Antioxidant, HIV Protease, HSV

Ginsenoside Rb1

Cat.No: T2822

Synonym: Gypenoside Ⅲ,人参皂苷Rb1,人参皂苷 Rb1,Gypenoside III

Target: ATPase, Mitophagy, IRAK, NF-κB, Autophagy, HSV

2-Deoxy-D-glucose

Cat.No: T6742

Synonym: 2-Deoxy-D-arabino-hexose,2-deoxyglucose,D-Arabino-2-deoxyhexose,Ba 2758,D-2-脱氧葡萄糖,NSC 15193,2-DG,2-脱氧-D-葡萄糖

Target: Apoptosis, Hexokinase, HSV

Gallic aldehyde

Cat.No: T7972

Synonym: 3,4,5-三羟基苯甲醛,五倍子醛

Target: HSV

Benzoylmesaconine

Cat.No: T6S1885

Synonym: Mesaconine 14-benzoate,苯甲酰新乌头原碱

Target: Others

Cat.No: T2A2498

Synonym: Aminutrin,Lysine Acid,lysine,L-赖氨酸,赖氨酸

Target: Virus Protease, Endogenous Metabolite, Antifection

Cat.No: T3795

Target: Apoptosis, TLR, Reverse Transcriptase, Antibacterial, Autophagy

Cangorinine E-1

Cat.No: T79987

Target: HSV

Mulberrofuran C

Cat.No: TN4587

Target: HSV

Cat.No: TN4585

Target: HIV Protease, Antifection, HSV

Manzamine A hydrochloride

Cat.No: T38441

Cat.No: T83693

Synonym: MG2

Norcepharadione B

Cat.No: TN6014

Synonym: 鱼腥草

Cat.No: TN4456

Target: AChR, HSV

Cat.No: T35779

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