Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ganciclovir sodium (Cytovene IV sodium) 是核苷类似物和口服抗病毒药物,具有抗病毒活性,尤其是针对巨细胞病毒和单纯疱疹病毒 1 型。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 198 | 现货 | ||
100 mg | ¥ 289 | 现货 | ||
500 mg | ¥ 598 | 现货 | ||
1 g | ¥ 728 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 318 | 现货 |
产品描述 | Ganciclovir sodium (Cytovene IV sodium) is the sodium salt of Ganciclovir with antiviral activity, especially against cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1). |
靶点活性 | FHV-1:5.2 μM |
体外活性 | Ganciclovir showed activity against feline herpesvirus type-1 (FHV-1, IC50 = 5.2 microM)[1]. |
体内活性 | In adult rats, the intracochlear diffusion of ganciclovir was shown to achieve the same concentration as in blood. In gestating mice, transplacental diffusion was observed, with a fetal-to-maternal blood ratio of 0.5. In newborn mice, the plasma concentration profile of ganciclovir showed a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but became undetectable by 2 h after injection. Counts of white blood cells, red blood cells and platelets decreased significantly in ganciclovir-treated newborn mice[3]. |
别名 | RS-21592 sodium, Cytovene IV sodium, 2'-Nor-2'-deoxyguanosine sodium, BW 759 sodium, 更昔洛韦钠 |
分子量 | 278.22 |
分子式 | C9H13N5NaO4 |
CAS No. | 107910-75-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 40 mg/mL (144.29 mM)
DMSO: 4 mg/mL (14.43 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 3.5943 mL | 17.9714 mL | 35.9428 mL | 89.8569 mL |
5 mM | 0.7189 mL | 3.5943 mL | 7.1886 mL | 17.9714 mL | |
10 mM | 0.3594 mL | 1.7971 mL | 3.5943 mL | 8.9857 mL | |
H2O | 20 mM | 0.1797 mL | 0.8986 mL | 1.7971 mL | 4.4928 mL |
50 mM | 0.0719 mL | 0.3594 mL | 0.7189 mL | 1.7971 mL | |
100 mM | 0.0359 mL | 0.1797 mL | 0.3594 mL | 0.8986 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ganciclovir sodium 107910-75-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Others Nucleoside Antimetabolite/Analog Antifection HSV group orally active BW759 inhibit polymerase CNS penetration DNA serotype BW 759 RS-21592 sodium Herpes simplex virus Antibiotic replication Cytovene IV sodium 2'-Nor-2'-deoxyguanosine sodium BW 759 sodium herpes Ganciclovir BW-759 infection 更昔洛韦钠 Inhibitor viruse CMV Cytomegalovirus inhibitor