Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂,在感染性休克的啮齿动物模型中发挥有益作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 256 | 现货 | ||
25 mg | ¥ 413 | 现货 | ||
50 mg | ¥ 588 | 现货 | ||
100 mg | ¥ 882 | 现货 | ||
500 mg | ¥ 2,180 | 现货 |
产品描述 | S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1]. |
体外活性 | S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site. The effect of S-Methylisothiourea sulfate on iNOS activity can be reversed by excess L-arginine in a concentration-dependent manner. S-Methylisothiourea sulfate (up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase. S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages. S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells[1]. |
体内活性 | S-Methylisothiourea sulfate dose-dependently reverses (0.01-3 mg/kg) the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin [bacterial lipopolysaccharide (LPS), 10 mg/kg, i.v.] in anesthetized rats. Moreover, therapeutic administration of S-Methylisothiourea sulfate (5 mg/kg, i.p., given 2 hr after LPS, 10 mg/kg, i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS. S-Methylisothiourea sulfate (1 mg/kg, i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg, i.p.)[1]. |
动物实验 | S-Methylisothiourea sulfate (Male Wistar rats (260-320 g); 0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg; Intravenous injection) caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats and also inhibited iNOS activity measured in homogenates of lung[1]. |
别名 | (S)-Methylisothiourea sulfate, S-甲基异硫脲硫酸盐, S-甲基异硫脲半硫酸盐 |
分子量 | 139.18 |
分子式 | C2H6N2S·1/2H2O4S |
CAS No. | 867-44-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 60 mg/mL (431.09 mM), Sonication is recommended.
DMSO: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 7.1849 mL | 35.9247 mL | 71.8494 mL | 179.6235 mL |
5 mM | 1.437 mL | 7.1849 mL | 14.3699 mL | 35.9247 mL | |
10 mM | 0.7185 mL | 3.5925 mL | 7.1849 mL | 17.9624 mL | |
20 mM | 0.3592 mL | 1.7962 mL | 3.5925 mL | 8.9812 mL | |
50 mM | 0.1437 mL | 0.7185 mL | 1.437 mL | 3.5925 mL | |
100 mM | 0.0718 mL | 0.3592 mL | 0.7185 mL | 1.7962 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
S-Methylisothiourea sulfate 867-44-7 Immunology/Inflammation Microbiology/Virology NOS NO Synthase HSV septic (S)-Methylisothiourea sulfate S-Methylisothiourea blood Methylisothiourea Sulfate S-Methylisothiourea Sulfate shock iNOS Nitric oxide synthases S-甲基异硫脲硫酸盐 SMethylisothiourea sulfate Inhibitor Herpes simplex virus inhibit S Methylisothiourea sulfate hypotension pressure circulatory S-甲基异硫脲半硫酸盐 inhibitor